| Definition | Escherichia coli ED1a chromosome, complete genome. |
|---|---|
| Accession | NC_011745 |
| Length | 5,209,548 |
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The map label for this gene is helD [H]
Identifier: 218688798
GI number: 218688798
Start: 1021672
End: 1023726
Strand: Direct
Name: helD [H]
Synonym: ECED1_0985
Alternate gene names: 218688798
Gene position: 1021672-1023726 (Clockwise)
Preceding gene: 218688795
Following gene: 218688801
Centisome position: 19.61
GC content: 52.21
Gene sequence:
>2055_bases ATGGAACTGAAAGCGACAACGCTTGGAAAACGTCTGGCACAGCACCCTTACGATCGGGCGGTGATCCTCAATGCCGGGAT TAAAGTCTCCGGCGATCGCCACGAATACCTTATTCCTTTCAATCAATTACTGGCGATTCACTGTAAGCGCGGTCTGGTAT GGGGCGAACTGGAGTTTGTACTGCCGGACGAAAAAGTGGTGCGTCTGCACGGTACCGAATGGGGCGAGACGCAGCGTTTT TACCATCATCTTGATGCTCACTGGCGGCGGTGGAGTGGCGAGATGAGCGAAATTGCGTCTGGCGTTTTACGTCAGCAACT GGATTTGATTGCCACGCGCACCGGAGAAAATAAATGGCTGACGCGTGAGCAAACCTCTGGTATGCGGCAACAAATCCGCC AGGCTTTGTCGGCGTTACCATTGCCGGTTAACCGACTGGAAGAATTCGATAACTGCCGTGAGGCGTGGCGTAAATGTCAG GCCTGGTTGAAAGACATTGAAGGCGCTCGGTTGCAGCATAATCAGGCGTATACCGAAGCCATGCTTATCGAGTATGCGGA TTTTTTCCGCCAGGTCGAGTCTTCACCGCTGAATCCGGCGCAGGCCCGGGCAGTCGTTAATGGCGAGCATTCTTTGTTAG TGCTGGCTGGTGCAGGAAGCGGAAAAACGTCGGTGCTGGTGGCCCGTGCAGGCTGGTTGCTGGCGCGTGGTGAAGCGTCC CCTGAGCAAATTTTATTGCTGGCGTTTGGTCGCAAAGCCGCTGAAGAGATGGACGAGCGTATTCGAGAACGACTACATAC CGAAGACATTACCGCACGCACGTTTCATGCGCTGGCGCTGCATATTATTCAGCAGGGCAGCAAAAAAGTTCCGATAGTCA GCAAACTGGAAAATGATACCGCTGCCCGTCATGAACTTTTTATTGCTGAGTGGCGCAAGCAATGCAGCGAAAAGAAAGCG CAGGCGAAGGGCTGGCGGCAATGGCTGACGGAAGAAATGCAGTGGTCAGTGCCAGAAGGTAATTTCTGGGATGATGAAAA ATTACAGCGTCGTCTTGCCTCTCGCCTCGATCGCTGGGTAAGTCTGATGCGGATGCACGGTGGTGCACAGGCAGAAATGA TTGCCAGTGCACCCGAAGAGATTCGCGATCTGTTCAGTAAACGTATCAAGTTGATGGCCCCGTTATTAAAAGCCTGGAAA GGTGCGCTGAAGGCAGAAAATGCTGTCGATTTTTCGGGCCTTATTCACCAGGCGATTGTGATTCTGGAGAAAGGTCGCTT TATCAGCCCGTGGAAGCATATTCTGGTTGATGAATTTCAGGATATCTCGCCGCAGCGTGCAGCGTTGTTAGCGGCATTAC GCAAGCAAAATAGTCAAACGACGTTGTTCGCTGTTGGTGATGACTGGCAGGCGATTTACCGATTCAGCGGTGCGCAAATG TCGCTTACCACGGCTTTCCATGAAAACTTTGGTGAAGGTGATCGCTGTGATTTAGACACGACCTACCGTTTTAACAGTCG TATCGGTGAGGTGGCAAACAGGTTTATTCAGCAGAACCCAGGCCAGCTTAAAAAGCCGCTAAACAGCTTAACCAATGGAG ACAAAAAAGCCGTCACGTTATTGGATGAGGGTCAACTTGACGCTTTGCTGGATAAACTCTCTGGTTATGCCAAACCGGAA GAGCGCATTCTGATCCTGGCGCGTTACCATCACATGAGGCCTGCCAGCCTGGAAAAAGCAGCAACACGCTGGCCGAAGTT GCAAATCGACTTTATGACCATTCATGCCAGCAAAGGGCAACAGGCGGATTACGTCATCATCGTTGGCTTGCAGGAGGGGA GTGATGGTTTTCCGGCTGCGGCGCGGGAGTCGATTATGGAAGAGGCGCTACTGCCAGCGGTTGAGGATTTCCCGGACGCT GAAGAACGGCGGTTAATGTACGTGGCGCTGACCCGGGCACGCCATCGGGTATGGGCACTGTTTAACAAAGAGAATCCCTC TCCCTTTGTGGATATACTGAAAAATCTGGATGTGCCGGTGGCGAGAAAACCGTAA
Upstream 100 bases:
>100_bases TTCAGTAATGGGCGGCAATTGTAACGTTTTTTTGGGCTGGAGCACGTTTTCTCTGACGGTTACACTGATAAGAAATAATT TCGTGTGGATCTACAGAGTC
Downstream 100 bases:
>100_bases GAAACAGGTGGCGTTTGCCACCTGTGCAATATTACTTCAGACGGTCTGCGAGATAACGCTGATAATCGGGGATCAGAATA TCGACCGCGTCGTTAAAATG
Product: DNA helicase IV
Products: NA
Alternate protein names: 75 kDa helicase [H]
Number of amino acids: Translated: 684; Mature: 684
Protein sequence:
>684_residues MELKATTLGKRLAQHPYDRAVILNAGIKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPDEKVVRLHGTEWGETQRF YHHLDAHWRRWSGEMSEIASGVLRQQLDLIATRTGENKWLTREQTSGMRQQIRQALSALPLPVNRLEEFDNCREAWRKCQ AWLKDIEGARLQHNQAYTEAMLIEYADFFRQVESSPLNPAQARAVVNGEHSLLVLAGAGSGKTSVLVARAGWLLARGEAS PEQILLLAFGRKAAEEMDERIRERLHTEDITARTFHALALHIIQQGSKKVPIVSKLENDTAARHELFIAEWRKQCSEKKA QAKGWRQWLTEEMQWSVPEGNFWDDEKLQRRLASRLDRWVSLMRMHGGAQAEMIASAPEEIRDLFSKRIKLMAPLLKAWK GALKAENAVDFSGLIHQAIVILEKGRFISPWKHILVDEFQDISPQRAALLAALRKQNSQTTLFAVGDDWQAIYRFSGAQM SLTTAFHENFGEGDRCDLDTTYRFNSRIGEVANRFIQQNPGQLKKPLNSLTNGDKKAVTLLDEGQLDALLDKLSGYAKPE ERILILARYHHMRPASLEKAATRWPKLQIDFMTIHASKGQQADYVIIVGLQEGSDGFPAAARESIMEEALLPAVEDFPDA EERRLMYVALTRARHRVWALFNKENPSPFVDILKNLDVPVARKP
Sequences:
>Translated_684_residues MELKATTLGKRLAQHPYDRAVILNAGIKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPDEKVVRLHGTEWGETQRF YHHLDAHWRRWSGEMSEIASGVLRQQLDLIATRTGENKWLTREQTSGMRQQIRQALSALPLPVNRLEEFDNCREAWRKCQ AWLKDIEGARLQHNQAYTEAMLIEYADFFRQVESSPLNPAQARAVVNGEHSLLVLAGAGSGKTSVLVARAGWLLARGEAS PEQILLLAFGRKAAEEMDERIRERLHTEDITARTFHALALHIIQQGSKKVPIVSKLENDTAARHELFIAEWRKQCSEKKA QAKGWRQWLTEEMQWSVPEGNFWDDEKLQRRLASRLDRWVSLMRMHGGAQAEMIASAPEEIRDLFSKRIKLMAPLLKAWK GALKAENAVDFSGLIHQAIVILEKGRFISPWKHILVDEFQDISPQRAALLAALRKQNSQTTLFAVGDDWQAIYRFSGAQM SLTTAFHENFGEGDRCDLDTTYRFNSRIGEVANRFIQQNPGQLKKPLNSLTNGDKKAVTLLDEGQLDALLDKLSGYAKPE ERILILARYHHMRPASLEKAATRWPKLQIDFMTIHASKGQQADYVIIVGLQEGSDGFPAAARESIMEEALLPAVEDFPDA EERRLMYVALTRARHRVWALFNKENPSPFVDILKNLDVPVARKP >Mature_684_residues MELKATTLGKRLAQHPYDRAVILNAGIKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPDEKVVRLHGTEWGETQRF YHHLDAHWRRWSGEMSEIASGVLRQQLDLIATRTGENKWLTREQTSGMRQQIRQALSALPLPVNRLEEFDNCREAWRKCQ AWLKDIEGARLQHNQAYTEAMLIEYADFFRQVESSPLNPAQARAVVNGEHSLLVLAGAGSGKTSVLVARAGWLLARGEAS PEQILLLAFGRKAAEEMDERIRERLHTEDITARTFHALALHIIQQGSKKVPIVSKLENDTAARHELFIAEWRKQCSEKKA QAKGWRQWLTEEMQWSVPEGNFWDDEKLQRRLASRLDRWVSLMRMHGGAQAEMIASAPEEIRDLFSKRIKLMAPLLKAWK GALKAENAVDFSGLIHQAIVILEKGRFISPWKHILVDEFQDISPQRAALLAALRKQNSQTTLFAVGDDWQAIYRFSGAQM SLTTAFHENFGEGDRCDLDTTYRFNSRIGEVANRFIQQNPGQLKKPLNSLTNGDKKAVTLLDEGQLDALLDKLSGYAKPE ERILILARYHHMRPASLEKAATRWPKLQIDFMTIHASKGQQADYVIIVGLQEGSDGFPAAARESIMEEALLPAVEDFPDA EERRLMYVALTRARHRVWALFNKENPSPFVDILKNLDVPVARKP
Specific function: Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP [H]
COG id: COG0210
COG function: function code L; Superfamily I DNA and RNA helicases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]
Homologues:
Organism=Escherichia coli, GI1787196, Length=684, Percent_Identity=98.8304093567251, Blast_Score=1392, Evalue=0.0, Organism=Escherichia coli, GI2367296, Length=340, Percent_Identity=28.2352941176471, Blast_Score=99, Evalue=1e-21, Organism=Escherichia coli, GI48994965, Length=341, Percent_Identity=28.1524926686217, Blast_Score=93, Evalue=5e-20, Organism=Saccharomyces cerevisiae, GI6322369, Length=352, Percent_Identity=27.5568181818182, Blast_Score=94, Evalue=7e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000212 - InterPro: IPR014016 - InterPro: IPR022161 - InterPro: IPR003661 [H]
Pfam domain/function: PF12462 Nucleolin_N; PF00580 UvrD-helicase [H]
EC number: =3.6.4.12 [H]
Molecular weight: Translated: 77935; Mature: 77935
Theoretical pI: Translated: 8.66; Mature: 8.66
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MELKATTLGKRLAQHPYDRAVILNAGIKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFV CCCCHHHHHHHHHHCCCCCEEEEECCEEECCCCCEEECCHHHHHHHHHHCCCEEEEEEEE LPDEKVVRLHGTEWGETQRFYHHLDAHWRRWSGEMSEIASGVLRQQLDLIATRTGENKWL CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC TREQTSGMRQQIRQALSALPLPVNRLEEFDNCREAWRKCQAWLKDIEGARLQHNQAYTEA CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH MLIEYADFFRQVESSPLNPAQARAVVNGEHSLLVLAGAGSGKTSVLVARAGWLLARGEAS HHHHHHHHHHHHHCCCCCHHHHHEEECCCCEEEEEEECCCCCCEEEEEECCEEEECCCCC PEQILLLAFGRKAAEEMDERIRERLHTEDITARTFHALALHIIQQGSKKVPIVSKLENDT HHHEEEEHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCH AARHELFIAEWRKQCSEKKAQAKGWRQWLTEEMQWSVPEGNFWDDEKLQRRLASRLDRWV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH SLMRMHGGAQAEMIASAPEEIRDLFSKRIKLMAPLLKAWKGALKAENAVDFSGLIHQAIV HHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH ILEKGRFISPWKHILVDEFQDISPQRAALLAALRKQNSQTTLFAVGDDWQAIYRFSGAQM HHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCE SLTTAFHENFGEGDRCDLDTTYRFNSRIGEVANRFIQQNPGQLKKPLNSLTNGDKKAVTL EEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEE LDEGQLDALLDKLSGYAKPEERILILARYHHMRPASLEKAATRWPKLQIDFMTIHASKGQ ECCCCHHHHHHHHCCCCCCHHHEEEEEECCCCCCCHHHHHHHCCCCEEEEEEEEECCCCC QADYVIIVGLQEGSDGFPAAARESIMEEALLPAVEDFPDAEERRLMYVALTRARHRVWAL CCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHEEEHHHHHHHHHHEEEE FNKENPSPFVDILKNLDVPVARKP ECCCCCCHHHHHHHCCCCCCCCCC >Mature Secondary Structure MELKATTLGKRLAQHPYDRAVILNAGIKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFV CCCCHHHHHHHHHHCCCCCEEEEECCEEECCCCCEEECCHHHHHHHHHHCCCEEEEEEEE LPDEKVVRLHGTEWGETQRFYHHLDAHWRRWSGEMSEIASGVLRQQLDLIATRTGENKWL CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC TREQTSGMRQQIRQALSALPLPVNRLEEFDNCREAWRKCQAWLKDIEGARLQHNQAYTEA CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH MLIEYADFFRQVESSPLNPAQARAVVNGEHSLLVLAGAGSGKTSVLVARAGWLLARGEAS HHHHHHHHHHHHHCCCCCHHHHHEEECCCCEEEEEEECCCCCCEEEEEECCEEEECCCCC PEQILLLAFGRKAAEEMDERIRERLHTEDITARTFHALALHIIQQGSKKVPIVSKLENDT HHHEEEEHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCH AARHELFIAEWRKQCSEKKAQAKGWRQWLTEEMQWSVPEGNFWDDEKLQRRLASRLDRWV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH SLMRMHGGAQAEMIASAPEEIRDLFSKRIKLMAPLLKAWKGALKAENAVDFSGLIHQAIV HHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH ILEKGRFISPWKHILVDEFQDISPQRAALLAALRKQNSQTTLFAVGDDWQAIYRFSGAQM HHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCE SLTTAFHENFGEGDRCDLDTTYRFNSRIGEVANRFIQQNPGQLKKPLNSLTNGDKKAVTL EEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEE LDEGQLDALLDKLSGYAKPEERILILARYHHMRPASLEKAATRWPKLQIDFMTIHASKGQ ECCCCHHHHHHHHCCCCCCHHHEEEEEECCCCCCCHHHHHHHCCCCEEEEEEEEECCCCC QADYVIIVGLQEGSDGFPAAARESIMEEALLPAVEDFPDAEERRLMYVALTRARHRVWAL CCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHEEEHHHHHHHHHHEEEE FNKENPSPFVDILKNLDVPVARKP ECCCCCCHHHHHHHCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2542273; 8905232; 9278503 [H]