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The map label for this gene is atsA [H]

Identifier: 218687893

GI number: 218687893

Start: 16675

End: 18204

Strand: Direct

Name: atsA [H]

Synonym: ECED1_0016

Alternate gene names: 218687893

Gene position: 16675-18204 (Clockwise)

Preceding gene: 218687892

Following gene: 218687894

Centisome position: 0.32

GC content: 44.58

Gene sequence:

>1530_bases
TTGGTTATGATTTCTAATTTTTATCAGGGAATAATTATGCAGAAAACGTTAATGGCCAGTTTGATCGGCCTTGCAGTTTG
CACAGGGAATGCTTTTAGTCCTGCCTTAGCCGCAGAGGCTAAACAACCTAATTTAGTCATTATTATGGCGGATGATTTAG
GTTATGGCGATTTAGCAACATATGGTCATCAGATCGTTAAAACACCTAATATCGACAGGCTTGCCCAGGAAGGGGTCAAA
TTTACTGACTACTATGCCCCCGCTCCTTTAAGTTCACCTTCACGCGCAGGGCTATTAACCGGCCGGATGCCATTTCGTAC
TGGAATTCGCTCATGGATTCCTTCAGGCAAAGATGTTGCCTTAGGGCGTAACGAACTCACGATTGCTAATCTACTCAAAG
CGCAAGGGTACGACACGGCAATGATGGGTAAGCTGCATCTGAATGCAGGCGGCGATCGCACCGATCAGCCACAAGCACAA
GATATGGGCTTTGATTACTCACTGGTTAATACGGCGGGCTTTGTTACCGACGCCACGCTGGATAACGCTAAAGAACGCCC
GCGTTATGGCATGGTTTACCCGACAGGCTGGCTACGTAACGGGCAACCCACTCCACGAGCTGATAAAATGAGCGGTGAGT
ATGTCAGTTCGGAAGTCGTCAACTGGCTGGATAACAAAAAGGACAGCAAGCCTTTCTTCCTCTATGTTGCTTTTACCGAA
GTGCATAGCCCCCTGGCTTCGCCCAAAAAATACCTCGACATGTACTCACAATATATGAGCGCGTATCAGAAGCAGCATCC
TGATTTATTTTATGGCGACTGGGCAGACAAACCCTGGCGTGGTGTGGGGGAATATTATGCCAATATCAGCTATCTGGATG
CACAGGTTGGAAAAGTGCTGGATAAAATCAAAGCGATGGGTGAAGAAGATAACACAATCGTTATTTTTACCAGTGATAAC
GGTCCGGTAACGCGTGAAGCGCGCAAAGTGTATGAGCTGAATTTGGCAGGGGAAACGGATGGATTACGCGGTCGCAAGGA
TAACCTTTGGGAAGGCGGAATTCGTGTTCCAGCCATTATTAAATATGGTAAACATCTACCACAGGGAATGGTTTCAGATA
CACCCGTTTATGGTCTGGACTGGATGCCTACTTTAGCGAAAATGATGAACTTCAAATTACCTACAGACCGTACTTTCGAT
GGTGAATCGCTGGTTCCTGTTCTTGAGCAAAAAGCATTGAAACGCGAAAAGCCATTAATTTTCGGGATTGATATGCCATT
CCAGGATGATCCAACCGATGAATGGGCGATCCGTGATGGTGACTGGAAGATGATTATCGATCGCAATAATAAACCGAAAT
ATCTCTACAATCTGAAATCTGATCGTTATGAAACACTTAATCTGAACGGTAAAAAAACAGATATTGAAAAACAGATGTAT
GGTAAGTTTTTAAAATATAAAACTGATATTGATAATGATTCTCTAATGAAAGCCAGAGGTGATAAACCAGAAGTGGTGAC
CTGGGGCTAA

Upstream 100 bases:

>100_bases
GCCTGGAAGTTCTATCCTCGCTGGAAAGCTAGTGTGACGTGGCGTTATTTCGATAATAAGCTGGGCTACGATGGCTTTGG
CGATCAAATGATTTATATGC

Downstream 100 bases:

>100_bases
CCTGATAATCATAATAAATGTAATGTATGCCATTTAGGGCTATGCCCGCCTGATTCAGTGCTACGCATTGAATCAGGTTC
TTTTCGCGTTGAACAATATC

Product: putative Cerebroside-sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MVMISNFYQGIIMQKTLMASLIGLAVCTGNAFSPALAAEAKQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVK
FTDYYAPAPLSSPSRAGLLTGRMPFRTGIRSWIPSGKDVALGRNELTIANLLKAQGYDTAMMGKLHLNAGGDRTDQPQAQ
DMGFDYSLVNTAGFVTDATLDNAKERPRYGMVYPTGWLRNGQPTPRADKMSGEYVSSEVVNWLDNKKDSKPFFLYVAFTE
VHSPLASPKKYLDMYSQYMSAYQKQHPDLFYGDWADKPWRGVGEYYANISYLDAQVGKVLDKIKAMGEEDNTIVIFTSDN
GPVTREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHLPQGMVSDTPVYGLDWMPTLAKMMNFKLPTDRTFD
GESLVPVLEQKALKREKPLIFGIDMPFQDDPTDEWAIRDGDWKMIIDRNNKPKYLYNLKSDRYETLNLNGKKTDIEKQMY
GKFLKYKTDIDNDSLMKARGDKPEVVTWG

Sequences:

>Translated_509_residues
MVMISNFYQGIIMQKTLMASLIGLAVCTGNAFSPALAAEAKQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVK
FTDYYAPAPLSSPSRAGLLTGRMPFRTGIRSWIPSGKDVALGRNELTIANLLKAQGYDTAMMGKLHLNAGGDRTDQPQAQ
DMGFDYSLVNTAGFVTDATLDNAKERPRYGMVYPTGWLRNGQPTPRADKMSGEYVSSEVVNWLDNKKDSKPFFLYVAFTE
VHSPLASPKKYLDMYSQYMSAYQKQHPDLFYGDWADKPWRGVGEYYANISYLDAQVGKVLDKIKAMGEEDNTIVIFTSDN
GPVTREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHLPQGMVSDTPVYGLDWMPTLAKMMNFKLPTDRTFD
GESLVPVLEQKALKREKPLIFGIDMPFQDDPTDEWAIRDGDWKMIIDRNNKPKYLYNLKSDRYETLNLNGKKTDIEKQMY
GKFLKYKTDIDNDSLMKARGDKPEVVTWG
>Mature_509_residues
MVMISNFYQGIIMQKTLMASLIGLAVCTGNAFSPALAAEAKQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVK
FTDYYAPAPLSSPSRAGLLTGRMPFRTGIRSWIPSGKDVALGRNELTIANLLKAQGYDTAMMGKLHLNAGGDRTDQPQAQ
DMGFDYSLVNTAGFVTDATLDNAKERPRYGMVYPTGWLRNGQPTPRADKMSGEYVSSEVVNWLDNKKDSKPFFLYVAFTE
VHSPLASPKKYLDMYSQYMSAYQKQHPDLFYGDWADKPWRGVGEYYANISYLDAQVGKVLDKIKAMGEEDNTIVIFTSDN
GPVTREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHLPQGMVSDTPVYGLDWMPTLAKMMNFKLPTDRTFD
GESLVPVLEQKALKREKPLIFGIDMPFQDDPTDEWAIRDGDWKMIIDRNNKPKYLYNLKSDRYETLNLNGKKTDIEKQMY
GKFLKYKTDIDNDSLMKARGDKPEVVTWG

Specific function: Plays an important role in the mineralization of sulfates [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=466, Percent_Identity=31.5450643776824, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI146229329, Length=466, Percent_Identity=31.5450643776824, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI6005990, Length=466, Percent_Identity=31.5450643776824, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI146229324, Length=466, Percent_Identity=31.5450643776824, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI53831991, Length=455, Percent_Identity=30.1098901098901, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI58743319, Length=446, Percent_Identity=29.5964125560538, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI71852584, Length=432, Percent_Identity=31.25, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI109389362, Length=427, Percent_Identity=28.3372365339578, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI59797060, Length=488, Percent_Identity=26.4344262295082, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI38569407, Length=405, Percent_Identity=30.1234567901235, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI38569405, Length=444, Percent_Identity=28.8288288288288, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4503899, Length=401, Percent_Identity=27.930174563591, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI45430057, Length=396, Percent_Identity=29.040404040404, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI157266309, Length=444, Percent_Identity=26.3513513513513, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI71852586, Length=139, Percent_Identity=44.6043165467626, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI31742482, Length=153, Percent_Identity=43.7908496732026, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI146229327, Length=392, Percent_Identity=27.0408163265306, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI5360208, Length=339, Percent_Identity=27.1386430678466, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4557659, Length=335, Percent_Identity=27.1641791044776, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI39930577, Length=474, Percent_Identity=23.4177215189873, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI87081924, Length=531, Percent_Identity=25.2354048964218, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790112, Length=493, Percent_Identity=25.9634888438134, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790233, Length=371, Percent_Identity=30.188679245283, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17559078, Length=242, Percent_Identity=35.1239669421488, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI115533416, Length=424, Percent_Identity=24.2924528301887, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI115533418, Length=415, Percent_Identity=24.0963855421687, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24666109, Length=422, Percent_Identity=29.6208530805687, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24666175, Length=427, Percent_Identity=27.8688524590164, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI281366397, Length=451, Percent_Identity=28.6031042128603, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI281366395, Length=451, Percent_Identity=28.6031042128603, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24666163, Length=451, Percent_Identity=28.6031042128603, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI281363223, Length=425, Percent_Identity=28, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21356831, Length=405, Percent_Identity=24.1975308641975, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24647401, Length=449, Percent_Identity=23.6080178173719, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 57270; Mature: 57270

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00523 SULFATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMISNFYQGIIMQKTLMASLIGLAVCTGNAFSPALAAEAKQPNLVIIMADDLGYGDLAT
CEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEEEEECCCCCCHHHH
YGHQIVKTPNIDRLAQEGVKFTDYYAPAPLSSPSRAGLLTGRMPFRTGIRSWIPSGKDVA
HCCCEECCCCHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHCCCCCCEE
LGRNELTIANLLKAQGYDTAMMGKLHLNAGGDRTDQPQAQDMGFDYSLVNTAGFVTDATL
CCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCHHHCCCCEEECCCCCCEEECHH
DNAKERPRYGMVYPTGWLRNGQPTPRADKMSGEYVSSEVVNWLDNKKDSKPFFLYVAFTE
CCHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHH
VHSPLASPKKYLDMYSQYMSAYQKQHPDLFYGDWADKPWRGVGEYYANISYLDAQVGKVL
HHCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHH
DKIKAMGEEDNTIVIFTSDNGPVTREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAII
HHHHHCCCCCCEEEEEECCCCCCCHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHH
KYGKHLPQGMVSDTPVYGLDWMPTLAKMMNFKLPTDRTFDGESLVPVLEQKALKREKPLI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEE
FGIDMPFQDDPTDEWAIRDGDWKMIIDRNNKPKYLYNLKSDRYETLNLNGKKTDIEKQMY
EEECCCCCCCCCCCCEEECCCEEEEEECCCCCCEEEECCCCCEEEEECCCCCCHHHHHHH
GKFLKYKTDIDNDSLMKARGDKPEVVTWG
HHHHHEECCCCCCCHHHCCCCCCCEEECC
>Mature Secondary Structure
MVMISNFYQGIIMQKTLMASLIGLAVCTGNAFSPALAAEAKQPNLVIIMADDLGYGDLAT
CEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEEEEECCCCCCHHHH
YGHQIVKTPNIDRLAQEGVKFTDYYAPAPLSSPSRAGLLTGRMPFRTGIRSWIPSGKDVA
HCCCEECCCCHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHCCCCCCEE
LGRNELTIANLLKAQGYDTAMMGKLHLNAGGDRTDQPQAQDMGFDYSLVNTAGFVTDATL
CCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCHHHCCCCEEECCCCCCEEECHH
DNAKERPRYGMVYPTGWLRNGQPTPRADKMSGEYVSSEVVNWLDNKKDSKPFFLYVAFTE
CCHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHH
VHSPLASPKKYLDMYSQYMSAYQKQHPDLFYGDWADKPWRGVGEYYANISYLDAQVGKVL
HHCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHH
DKIKAMGEEDNTIVIFTSDNGPVTREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAII
HHHHHCCCCCCEEEEEECCCCCCCHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHH
KYGKHLPQGMVSDTPVYGLDWMPTLAKMMNFKLPTDRTFDGESLVPVLEQKALKREKPLI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEE
FGIDMPFQDDPTDEWAIRDGDWKMIIDRNNKPKYLYNLKSDRYETLNLNGKKTDIEKQMY
EEECCCCCCCCCCCCEEECCCEEEEEECCCCCCEEEECCCCCEEEEECCCCCCHHHHHHH
GKFLKYKTDIDNDSLMKARGDKPEVVTWG
HHHHHEECCCCCCCHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10336424 [H]