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The map label for this gene is prlC [H]

Identifier: 218550780

GI number: 218550780

Start: 3568528

End: 3570570

Strand: Reverse

Name: prlC [H]

Synonym: EFER_3491

Alternate gene names: 218550780

Gene position: 3570570-3568528 (Counterclockwise)

Preceding gene: 218550789

Following gene: 218550779

Centisome position: 77.81

GC content: 54.82

Gene sequence:

>2043_bases
ATGACGAATCCGTTACTGACTCCCTTTGAATTGCCTCCGTTTTCTAAAATTCTCCCGGAACATGTCGTTCCAGCCGTGAC
GAAGGCATTGAATGACTGCCGCGAAAATGTGGAGCGCGTAGTAGCGCAAGGGGCACCGTACACCTGGGAAAATCTCTGCC
AGCCGCTGGCGGAAGTGGACGATGTGTTGGGGCGTATCTTCTCCCCGGTCAGCCACCTGAACTCGGTGAAAAATAGCCCG
GAACTGCGTGAAGCCTACGAACAAACCCTGCCACTGCTGTCGGAATACAGCACCTGGGTAGGGCAACATGAAGGGCTGTA
TAAAGCGTACCGCGATCTGCGCGATGGCGATCATTACGCCACGCTGAATACGGCGCAGAAGAAAGCAGTTGATAACGCCC
TGCGTGATTTTGAACTCTCTGGCATCGGTCTGCCGAAAGAGAAACAGCAACGCTACGGCGAAATTGCTACCCGTCTTTCC
GAACTGGGCAACCAGTACAGCAACAACGTCCTTGATGCGACGATGGGCTGGACCAAACTCGTTACCGACGAAGCGGAACT
GGCGGGTATGCCAGAAAGCGCGCTGGCGGCGGCAAAAGCCCAGGCCGAAGCGAAAGAACTGGAAGGCTACTTGCTGACGC
TGGATATCCCAAGCTATTTGCCGGTAATGACCTACTGCGACAACCAGGCCTTGCGTGAAGAGATGTATCGCGCTTACAGC
ACTCGCGCTTCCGATCAAGGCCCGAACGCCGGTAAGTGGGACAATAGCAAGGTGATGGAAGAGATCCTCGCTCTGCGTCA
CGAACTGGCGCAACTGCTGGGCTTTGAAAACTACGCCTTTAAATCTCTGGCTACCAAAATGGCGGAGAACCCGCAGCAGG
TGCTTGATTTCTTAACCGATCTGGCAAAACGCGCACGTCCGCAGGGCGAAAAAGAGCTGGCGCAACTGCGCGCCTTCGCC
AAAGCCGAATTTGACGTCGATGAGTTGCAGCCATGGGATATCGCGTACTACAGCGAAAAACAGAAACAGCACCTCTACAG
CATCAGCGACGAACAACTGCGTCCGTACTTCCCGGAAAACAAAGCGGTTAACGGCTTGTTTGAAGTGGTGAAACGTATTT
ACGGCATCACCGCTAAAGAGCGCAAAGATGTTGATGTCTGGCATCCGGATGTCCGTTTCTTCGAACTGTATGACGAGAAC
AACGAACTGCGCGGCAGCTTCTACCTCGACCTGTATGCCCGTGAGAACAAGCGCGGCGGGGCGTGGATGGATGACTGCGT
AGGCCAGATGCGTAAAGCCGACGGTTCGCTGCAAAAACCGGTCGCTTACCTGACATGTAACTTCAACCGCCCGGTGAATG
GTAAACCGGCGCTGTTTACCCATGACGAAGTAATCACGCTATTCCACGAGTTCGGTCATGGTCTGCATCATATGCTGACC
CGCATTGAAACCGCCGGTGTATCCGGGATCAGTGGGGTGCCGTGGGATGCGGTCGAACTGCCGAGCCAGTTTATGGAAAA
CTGGTGCTGGGAGCCGGAGGCGCTGGCGTTTATCTCCGGTCACTATGAGACTGGCGAACCGCTGCCGAAAGAACTGTTGG
ATAAAATGCTGGCGGCGAAGAACTACCAGGCGGCGCTGTTTATTCTGCGTCAGCTGGAATTCGGCCTGTTCGATTTCCGT
CTACATGCAGAATTCCGTCCGGATCAGGGGGCGAAAATCCTCGAAACTCTGGCAGAAATCAAGAAACTGGTTGCCGTTGT
ACCGTCTCCGTCATGGGGCCGTTTCCCGCACGCTTTCAGCCATATTTTCGCCGGTGGTTATGCGGCAGGTTACTACAGCT
ACCTGTGGGCTGACGTGCTGGCGGCAGATGCCTTCTCACGCTTTGAGGAAGAGGGTATTTTCAACCGAGAAACCGGGCAG
TCGTTCCTCGACAACATTCTGAGCCGTGGCGGTTCAGAAGAGCCGATGGATCTGTTCAAACGCTTCCGTGGGCGTGAACC
GCAACTGGATGCGATGCTGGAGCATTACGGCATTAAGGGCTGA

Upstream 100 bases:

>100_bases
CGTTTCTCATTGAAATTCACTACACTTAACCCCATGCTACACACATTATGTAAAGCGCCTGTTGAGCGCTTCCTTAACCT
CTTTAACCAGGACTGCGCTA

Downstream 100 bases:

>100_bases
TCATTCAGTGAAAATCTGTTTAATTGATGAAACAGGCGCCGGAGACGGCGCCTTATCTGTTCTGGCGTCCCGCTGGGGGC
TGGAGCACGATGAAGACAAC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFDVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDEN
NELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQ
SFLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFDVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDEN
NELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQ
SFLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG
>Mature_679_residues
TNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSPE
LREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSE
LGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYST
RASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFAK
AEFDVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENN
ELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTR
IETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRL
HAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQS
FLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=641, Percent_Identity=31.6692667706708, Blast_Score=320, Evalue=4e-87,
Organism=Homo sapiens, GI14149738, Length=642, Percent_Identity=31.4641744548287, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI156105687, Length=618, Percent_Identity=27.0226537216829, Blast_Score=206, Evalue=5e-53,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=99.8529411764706, Blast_Score=1407, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=687, Percent_Identity=32.3144104803493, Blast_Score=324, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI71999758, Length=574, Percent_Identity=25.7839721254355, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI32565901, Length=637, Percent_Identity=23.861852433281, Blast_Score=138, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319793, Length=693, Percent_Identity=29.1486291486291, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6322715, Length=697, Percent_Identity=23.3859397417504, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356111, Length=560, Percent_Identity=30.3571428571429, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI20129717, Length=614, Percent_Identity=25.4071661237785, Blast_Score=189, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77226; Mature: 77095

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
VTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFDVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCC
AWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
VTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFDVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCC
AWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]