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The map label for this gene is cbl [H]

Identifier: 218549292

GI number: 218549292

Start: 2002164

End: 2003114

Strand: Reverse

Name: cbl [H]

Synonym: EFER_1954

Alternate gene names: 218549292

Gene position: 2003114-2002164 (Counterclockwise)

Preceding gene: 218549293

Following gene: 218549286

Centisome position: 43.65

GC content: 47.11

Gene sequence:

>951_bases
GTGAATTTCCAACAACTCAAAATAATCCGTGAGGCGGCACGTCAGGATTTTAATCTGACTGAAGTCGCAAACATGCTTTA
TACATCCCAGTCTGGCGTAAGTCGGCATATTCGTGAGCTAGAAGATGAACTTGGCATTGAGATTTTCATCCGCAAAGGAA
AACGTCTGTTAGGTATGACGGAACCAGGCAAAGCGCTGTTAGTGATTGCAGAGCGTATTCTCAATGAGGCCAGTAATGTC
CGGCGGCTGGCGGATCTTTTTACTAACGATGCATCAGGTGTACTAACAATAGCGACAACGCATACTCAGGCGCGTTACAG
CTTGCCAGGTGTGATTAAAGCGTTTCGGGAATTATTTCCGGAAGTACGCCTTGAGTTGATTCAGGGGACACCACAAGAGA
TTGATGCATTATTGCAAAATGGTGGTGCAGATATTGGGATAGCCAGTGAACGGTTGAGTAATGATCCATTGCTGGTGGCA
TTTCCATGGTTTCGTTGGCATCACAGTCTGCTGGTACCAAATAATCATCCGCTGATAGCAGAAACGCCGCTCACCCTGGA
GGCTATCGCTAAATGGCCACTGATTACCTATCGTCAGGGGATTACCGGGCGTTCACGAATCGATGAGGCTTTTGCCCGAA
AAGGGTTAATCGCCGATGTGGTATTGAGTGCTCAGGATTCAGACGTCATAAAAACCTATGTTGAGTTGGGGTTGGGGATT
GGTCTGGTGGCGGAGCAATCAGGTGGTGAACAGGAAGAGAAGGGGCTAACACAGTTGGATACGCGTCACCTGTTTGATGC
CAACACTGTTTGGCTTGGCCTTAAGCGCGGACAACTGCAACGCAATTATGTCTGGCGATTTCTTGAGCTCTGTAATGCAG
GACTGTCTGTAGAGGATATTAAACGCCAGGTAATGGCAACAGAAGAAACAGAAATTGACTATCAGATATAA

Upstream 100 bases:

>100_bases
TGTTATTCCGCTTTGGAATAAGATGCAGGTTTTTATTATTTGTTCAGCCGGACATCAGACTTTAACAATAGCGTAATGTC
TGATGTATCCGGAGCGAACA

Downstream 100 bases:

>100_bases
AGCAAAAAGCCCGCTTTAAAAGCGGGCTTCTCAGAATTTGGCTCCTCTGACTGGACTCGAACCAGTGACATACGGATTAA
CAGTCCGCCGTTCTACCGAC

Product: transcriptional regulator Cbl

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNFQQLKIIREAARQDFNLTEVANMLYTSQSGVSRHIRELEDELGIEIFIRKGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDASGVLTIATTHTQARYSLPGVIKAFRELFPEVRLELIQGTPQEIDALLQNGGADIGIASERLSNDPLLVA
FPWFRWHHSLLVPNNHPLIAETPLTLEAIAKWPLITYRQGITGRSRIDEAFARKGLIADVVLSAQDSDVIKTYVELGLGI
GLVAEQSGGEQEEKGLTQLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMATEETEIDYQI

Sequences:

>Translated_316_residues
MNFQQLKIIREAARQDFNLTEVANMLYTSQSGVSRHIRELEDELGIEIFIRKGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDASGVLTIATTHTQARYSLPGVIKAFRELFPEVRLELIQGTPQEIDALLQNGGADIGIASERLSNDPLLVA
FPWFRWHHSLLVPNNHPLIAETPLTLEAIAKWPLITYRQGITGRSRIDEAFARKGLIADVVLSAQDSDVIKTYVELGLGI
GLVAEQSGGEQEEKGLTQLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMATEETEIDYQI
>Mature_316_residues
MNFQQLKIIREAARQDFNLTEVANMLYTSQSGVSRHIRELEDELGIEIFIRKGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDASGVLTIATTHTQARYSLPGVIKAFRELFPEVRLELIQGTPQEIDALLQNGGADIGIASERLSNDPLLVA
FPWFRWHHSLLVPNNHPLIAETPLTLEAIAKWPLITYRQGITGRSRIDEAFARKGLIADVVLSAQDSDVIKTYVELGLGI
GLVAEQSGGEQEEKGLTQLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMATEETEIDYQI

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=316, Percent_Identity=90.5063291139241, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1787530, Length=317, Percent_Identity=39.7476340694006, Blast_Score=247, Evalue=6e-67,
Organism=Escherichia coli, GI1788481, Length=295, Percent_Identity=27.7966101694915, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI157672245, Length=207, Percent_Identity=28.5024154589372, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081904, Length=210, Percent_Identity=30, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI2367136, Length=245, Percent_Identity=25.7142857142857, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693105, Length=235, Percent_Identity=25.1063829787234, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788887, Length=235, Percent_Identity=26.8085106382979, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790262, Length=249, Percent_Identity=25.7028112449799, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790208, Length=250, Percent_Identity=28, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=24.2798353909465, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35512; Mature: 35512

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLKIIREAARQDFNLTEVANMLYTSQSGVSRHIRELEDELGIEIFIRKGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEEECCCEEECCC
EPGKALLVIAERILNEASNVRRLADLFTNDASGVLTIATTHTQARYSLPGVIKAFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHH
EVRLELIQGTPQEIDALLQNGGADIGIASERLSNDPLLVAFPWFRWHHSLLVPNNHPLIA
HHHHHHHCCCHHHHHHHHHCCCCCCEEEHHHCCCCCEEEEECHHHHCCEEECCCCCCEEE
ETPLTLEAIAKWPLITYRQGITGRSRIDEAFARKGLIADVVLSAQDSDVIKTYVELGLGI
ECCCHHHHHHCCCHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHCCCC
GLVAEQSGGEQEEKGLTQLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
CEEECCCCCCHHHCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMATEETEIDYQI
HHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNFQQLKIIREAARQDFNLTEVANMLYTSQSGVSRHIRELEDELGIEIFIRKGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEEECCCEEECCC
EPGKALLVIAERILNEASNVRRLADLFTNDASGVLTIATTHTQARYSLPGVIKAFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHH
EVRLELIQGTPQEIDALLQNGGADIGIASERLSNDPLLVAFPWFRWHHSLLVPNNHPLIA
HHHHHHHCCCHHHHHHHHHCCCCCCEEEHHHCCCCCEEEEECHHHHCCEEECCCCCCEEE
ETPLTLEAIAKWPLITYRQGITGRSRIDEAFARKGLIADVVLSAQDSDVIKTYVELGLGI
ECCCHHHHHHCCCHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHCCCC
GLVAEQSGGEQEEKGLTQLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
CEEECCCCCCHHHCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMATEETEIDYQI
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]