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The map label for this gene is umuC [H]

Identifier: 218549259

GI number: 218549259

Start: 1973225

End: 1974493

Strand: Reverse

Name: umuC [H]

Synonym: EFER_1919

Alternate gene names: 218549259

Gene position: 1974493-1973225 (Counterclockwise)

Preceding gene: 218549260

Following gene: 218549258

Centisome position: 43.03

GC content: 50.43

Gene sequence:

>1269_bases
ATGTTTGCCCTTTGTGACGTGAATTCGTTTTATGCCAGCTGCGAGGTCGTGTTTCGCCCGGATTTATGGGGAAAACCGGT
GGTTGTGCTTTCCAATAACGATGGTTGCGTCATTGCCCGCAGTGCAGAAGCAAAAGCACTCGGTGTCAAAATGGGGGAGC
CCTATTTTAAACAAAAGGATCTGTTTCATCGCAGTGGTGTGGTCTGTTTCAGCAGTAACTATGAACTCTATGCCGATATG
AGCAACCGGGTGATGTGTACGTTGGAGGAGTTGTCGCCCAGAGTCGAAATTTACAGTATCGATGAAGCATTTTGTGATTT
AACCGGTGTGCGTAACTGCCGGGATTTAACAGATTTTGGTCGTGAAATTCGCCAGACCCTTTTTCAGCGTACACATCTAA
CGGTTGGCGTCGGCATTGCACAAACCAAGACGCTGGCCAAACTCGCCAACCATGCGGCTAAAAAATGGCAAAGACAAACT
GGGGGCGTGGTGGATTTATCGAACCGCGAGCGTCAGCGCAAATTAATGGCGGTACTTCCGGTTGAGGAAGTCTGGGGGAT
TGGCCGACGCATCAGCAAAAAGCTGGAGGCGATGGGAATAAAAACCGTACTTGATCTCGCGGATACGGATATCCGCTTTA
TTCGAAAACACTTTAATGTGGTGCTTGAAAGAACAGTACGGGAGTTGCGTGGTGAACCTTGCCTGGAGCTGGAAGAATTT
GCGCCAGCAAAACAAGAGATCATCTGCTCGCGGTCGTTTGGCGAACGCGTAACCGACTATGAGGCGATGCGCCAGGCTAT
ATGCAGTTATGCCTCACGCGCGGCAGAAAAACTGCGTAGCGAGCACCAGTATTGCCGCTTTATCTCCACGTTTGTAAAAA
CATCGCCGTTTTCGCTTAATGAACCGTATTACAGCAATAGCGCTTCGGTGAAGCTGCTGACGCCCACTCAGGACAGCAGG
GATATTATTAAGGCGGCGATCCGATGCCTGGATGCAATATGGCAAGAGGAGCATCGCTACCAGAAAGCGGGGGTGATGTT
GGGGGATTTTTTTAGTCGTGGAGTGGCGCAACTGAATTTGTTTGATGACAACGCACCGCGCGCTGGTAGTGAGGAGTTGA
TGGCTGTGCTCGACATGCTCAATGCCAGGGAAGGTCGTGGCACGCTCTATTTTGCCGGGCAGGGCATCCAGCAAGAGTGG
AAGATGAAGCGTGGGATGTTGTCACCACGATATACAACACGAGCCTCGGATCTTCTTTGTGTAAGGTAA

Upstream 100 bases:

>100_bases
TTGTGCCGATGAACAGTTCTTATTCGCCCATTACTCTTGGCAGCGAAGAATCGCTGAACGTATTTGGGGTAGTCACGCAT
GTGGTGAAGGCCGTACGCTG

Downstream 100 bases:

>100_bases
ACATGGTCTGGCAACAATGTATCGAATATACATGATTGACCTGATTTTTATATCACTTCCAATTCGCTAATATCTAATAC
AAGAACATAAAAATTATCGG

Product: DNA polymerase V subunit UmuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MFALCDVNSFYASCEVVFRPDLWGKPVVVLSNNDGCVIARSAEAKALGVKMGEPYFKQKDLFHRSGVVCFSSNYELYADM
SNRVMCTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRQTLFQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
GGVVDLSNRERQRKLMAVLPVEEVWGIGRRISKKLEAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIICSRSFGERVTDYEAMRQAICSYASRAAEKLRSEHQYCRFISTFVKTSPFSLNEPYYSNSASVKLLTPTQDSR
DIIKAAIRCLDAIWQEEHRYQKAGVMLGDFFSRGVAQLNLFDDNAPRAGSEELMAVLDMLNAREGRGTLYFAGQGIQQEW
KMKRGMLSPRYTTRASDLLCVR

Sequences:

>Translated_422_residues
MFALCDVNSFYASCEVVFRPDLWGKPVVVLSNNDGCVIARSAEAKALGVKMGEPYFKQKDLFHRSGVVCFSSNYELYADM
SNRVMCTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRQTLFQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
GGVVDLSNRERQRKLMAVLPVEEVWGIGRRISKKLEAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIICSRSFGERVTDYEAMRQAICSYASRAAEKLRSEHQYCRFISTFVKTSPFSLNEPYYSNSASVKLLTPTQDSR
DIIKAAIRCLDAIWQEEHRYQKAGVMLGDFFSRGVAQLNLFDDNAPRAGSEELMAVLDMLNAREGRGTLYFAGQGIQQEW
KMKRGMLSPRYTTRASDLLCVR
>Mature_422_residues
MFALCDVNSFYASCEVVFRPDLWGKPVVVLSNNDGCVIARSAEAKALGVKMGEPYFKQKDLFHRSGVVCFSSNYELYADM
SNRVMCTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRQTLFQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
GGVVDLSNRERQRKLMAVLPVEEVWGIGRRISKKLEAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIICSRSFGERVTDYEAMRQAICSYASRAAEKLRSEHQYCRFISTFVKTSPFSLNEPYYSNSASVKLLTPTQDSR
DIIKAAIRCLDAIWQEEHRYQKAGVMLGDFFSRGVAQLNLFDDNAPRAGSEELMAVLDMLNAREGRGTLYFAGQGIQQEW
KMKRGMLSPRYTTRASDLLCVR

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=422, Percent_Identity=89.5734597156398, Blast_Score=802, Evalue=0.0,
Organism=Escherichia coli, GI1786425, Length=217, Percent_Identity=27.1889400921659, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47994; Mature: 47994

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALCDVNSFYASCEVVFRPDLWGKPVVVLSNNDGCVIARSAEAKALGVKMGEPYFKQKD
CEEEECCHHHHEEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEECCCCCCHHHHHH
LFHRSGVVCFSSNYELYADMSNRVMCTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
HHHHCCEEEEECCCEEEEECCCCEEEEHHHCCCCEEEEECHHHHHHHHCCCCHHHHHHHH
REIRQTLFQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNRERQRKLMAVLP
HHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCC
VEEVWGIGRRISKKLEAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLELEEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
APAKQEIICSRSFGERVTDYEAMRQAICSYASRAAEKLRSEHQYCRFISTFVKTSPFSLN
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EPYYSNSASVKLLTPTQDSRDIIKAAIRCLDAIWQEEHRYQKAGVMLGDFFSRGVAQLNL
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEE
FDDNAPRAGSEELMAVLDMLNAREGRGTLYFAGQGIQQEWKMKRGMLSPRYTTRASDLLC
ECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEE
VR
EC
>Mature Secondary Structure
MFALCDVNSFYASCEVVFRPDLWGKPVVVLSNNDGCVIARSAEAKALGVKMGEPYFKQKD
CEEEECCHHHHEEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEECCCCCCHHHHHH
LFHRSGVVCFSSNYELYADMSNRVMCTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
HHHHCCEEEEECCCEEEEECCCCEEEEHHHCCCCEEEEECHHHHHHHHCCCCHHHHHHHH
REIRQTLFQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNRERQRKLMAVLP
HHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCC
VEEVWGIGRRISKKLEAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLELEEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
APAKQEIICSRSFGERVTDYEAMRQAICSYASRAAEKLRSEHQYCRFISTFVKTSPFSLN
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EPYYSNSASVKLLTPTQDSRDIIKAAIRCLDAIWQEEHRYQKAGVMLGDFFSRGVAQLNL
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEE
FDDNAPRAGSEELMAVLDMLNAREGRGTLYFAGQGIQQEWKMKRGMLSPRYTTRASDLLC
ECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEE
VR
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]