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The map label for this gene is phoP [H]

Identifier: 218549147

GI number: 218549147

Start: 1854891

End: 1855562

Strand: Direct

Name: phoP [H]

Synonym: EFER_1800

Alternate gene names: 218549147

Gene position: 1854891-1855562 (Clockwise)

Preceding gene: 218549146

Following gene: 218549148

Centisome position: 40.42

GC content: 44.79

Gene sequence:

>672_bases
ATGCGTGTGTTGGTTGTCGAAGATAATCCATTGTTGCGTCATCACCTGAAAGTACAGCTTCAGGATGCCGGACATCAGGT
CGACGATGCGGAGGATGCTAAAGAGGCTGATTATTTCCTTAATGAGCATGAACCAGATATCGCAATTATCGATCTTGGTC
TTCCCGATGAAGATGGTCTTTCATTGATTCGTCGCTGGCGTAGTAATGATATTTCACTGCCTGTTCTGGTATTAACCGCC
CGTGAAGGCTGGCAGGATAAAGTGGAAGTGTTGAGTGCCGGGGCAGATGATTACGTCACCAAACCGTTTCATATTGAAGA
GGTGATTGCCCGTATGCAGGCATTACTGCGCCGTAATAGTGGTCTTGCCTCTCAGGTAATCTCCTTGCCACCATTCCAGG
TTGATCTCTCCCGCCGGGAATTATCAATCAATAATGAGATCATTAAACTTACCGCTTTTGAATACACCATTATGGAAACG
TTGATTCGTAATAATGGCAAAGTGGTGAGTAAAGACTCATTAATGTTGCAACTCTACCCGGATGCAGAATTACGTGAAAG
CCACACTATTGATGTATTAATGGGGCGACTACGTAAAAAAATTCAGGCCCAGTATCCGGATGAGGTCATTACCACTGTGC
GTGGTCAGGGATATTTATTCGAACTTCACTGA

Upstream 100 bases:

>100_bases
TTCACTTTACCTCCCTTCCCGCTGGTTTATTGAATGTTTACCCCCACAAACACATAATCGCGTTACACTAATTTCATAAT
TAAGACAGGGAGAAATAAAA

Downstream 100 bases:

>100_bases
TGAAAAAACTATTGCGTCATATTTTTCCCCTGTCGTTACGGCTGCGTTTTTTGCTGGCAACGGCAGCGGTTGTTCTGGTG
CTTTCACTGGCTTATGGCAT

Product: DNA-binding transcriptional regulator PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRVLVVEDNPLLRHHLKVQLQDAGHQVDDAEDAKEADYFLNEHEPDIAIIDLGLPDEDGLSLIRRWRSNDISLPVLVLTA
REGWQDKVEVLSAGADDYVTKPFHIEEVIARMQALLRRNSGLASQVISLPPFQVDLSRRELSINNEIIKLTAFEYTIMET
LIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPDEVITTVRGQGYLFELH

Sequences:

>Translated_223_residues
MRVLVVEDNPLLRHHLKVQLQDAGHQVDDAEDAKEADYFLNEHEPDIAIIDLGLPDEDGLSLIRRWRSNDISLPVLVLTA
REGWQDKVEVLSAGADDYVTKPFHIEEVIARMQALLRRNSGLASQVISLPPFQVDLSRRELSINNEIIKLTAFEYTIMET
LIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPDEVITTVRGQGYLFELH
>Mature_223_residues
MRVLVVEDNPLLRHHLKVQLQDAGHQVDDAEDAKEADYFLNEHEPDIAIIDLGLPDEDGLSLIRRWRSNDISLPVLVLTA
REGWQDKVEVLSAGADDYVTKPFHIEEVIARMQALLRRNSGLASQVISLPPFQVDLSRRELSINNEIIKLTAFEYTIMET
LIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPDEVITTVRGQGYLFELH

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=94.1441441441441, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=36.6071428571429, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=35.7798165137615, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=33.9285714285714, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=34.6491228070175, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=30, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=36.0730593607306, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.4410480349345, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=31.8385650224215, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.9559471365639, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=29.3103448275862, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI145693140, Length=227, Percent_Identity=26.8722466960352, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=33.9622641509434, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25490; Mature: 25490

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVEDNPLLRHHLKVQLQDAGHQVDDAEDAKEADYFLNEHEPDIAIIDLGLPDEDGL
CEEEEECCCCCEEHHEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHH
SLIRRWRSNDISLPVLVLTAREGWQDKVEVLSAGADDYVTKPFHIEEVIARMQALLRRNS
HHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCC
GLASQVISLPPFQVDLSRRELSINNEIIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYP
CCHHHHHCCCCCEEECCCCEEECCCCEEEEEEHHHHHHHHHHHCCCCEEECCCEEEEECC
DAELRESHTIDVLMGRLRKKIQAQYPDEVITTVRGQGYLFELH
CCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MRVLVVEDNPLLRHHLKVQLQDAGHQVDDAEDAKEADYFLNEHEPDIAIIDLGLPDEDGL
CEEEEECCCCCEEHHEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHH
SLIRRWRSNDISLPVLVLTAREGWQDKVEVLSAGADDYVTKPFHIEEVIARMQALLRRNS
HHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCC
GLASQVISLPPFQVDLSRRELSINNEIIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYP
CCHHHHHCCCCCEEECCCCEEECCCCEEEEEEHHHHHHHHHHHCCCCEEECCCEEEEECC
DAELRESHTIDVLMGRLRKKIQAQYPDEVITTVRGQGYLFELH
CCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA