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The map label for this gene is treA [H]

Identifier: 218549107

GI number: 218549107

Start: 1808434

End: 1810179

Strand: Direct

Name: treA [H]

Synonym: EFER_1759

Alternate gene names: 218549107

Gene position: 1808434-1810179 (Clockwise)

Preceding gene: 218549106

Following gene: 218549109

Centisome position: 39.41

GC content: 48.91

Gene sequence:

>1746_bases
TTGATGCCGCTTTATTCGGTATTCCACGAAGGAGAATCATTCATGAAAACACCTGCACATCGCGCCCATGCCACACTACC
CGGAGCTTTAAAAACGGTTACCACTGCCCTACTCCTGAGTCTTGCCAGCCAGGCCGCGAACGCAGAGGAACTCGCTGATA
CGCCTTTGCAACCACCAGATATTCTGTTAGGGCCGCTGTTCAACGATGTTCAGAGTGCAAAACTCTTCCCGGATCAGAAA
ACCTTTGCCGATGCAGTGCCAAAAAGCGATCCATTGATGATTCTGGCAGATTACCGGATGCAACGTAATCAAAGCGGTTT
TGATTTACGCCATTTTGTCAGCGTTAACTTTATTCTGCCAAAAGAAGGCGAAAAATATGTTCCTCCTGCGGGCCAATCAC
TACGTGAGCATATTGATGGCTTGTGGCCTGTACTAACCCGCACTACAGAGCGCACTGATAAATGGGATTCGTTGTTACCG
TTACCGGAACCTTATGTTGTGCCTGGTGGACGCTTTCGCGAGGTTTATTACTGGGACAGTTATTTCACCATGTTAGGGCT
TGCCGAGAGTGGACACTGGGATAAAGTTGCAGACATGGTGGCGAATTTTGCCTGGGAAATCGATACCTTTGGTCATATCC
CTAATGGCAACCGCAGTTATTACCTGAGCCGCTCACAACCACCCTTTTTCGCGTTTATGGTGGAGCTTCTGGCGCAAAAC
AAAGGGGATGATGCGCTGAAGCAATATCTGCCGCAGTTGCAAAAAGAGTATGCATACTGGATGGAAGGTACTGAGGATCT
ACAGCCAGGTGGACAAAATAAACGTGTAGTAAAACTGGAAGACGGCACTATTTTGAATCGATATTGGGATGATCGCGACA
CTCCACGCCCGGAATCCTGGAACGAAGATATTACGACCGCTAAAAGTAACCCTTCCCGCCCGGCCACTGAAGTTTATCGT
GATCTGCGTTCAGCCGCAGCTTCCGGTTGGGATTTCAGTTCCCGCTGGATGGATAATCCACAACAACTGAGCACGATTCG
TACTACCAGCATTGTTCCGGTCGATCTCAACGCCTTGTTATATAAGATGGAGAAGATACTTGCGCGTGCCAGCAAAGCTT
CAGGTGATGAGGCGATGGCGAGCCAGTATGAAAATCTGGCAACGGCGCGTCAGAAAGCCATTGAGCACTATTTATGGAAC
GACAAAGAAGGTTGGTACGCCGACTACGATCTAAAAAGCCACAAAGTCCGTAATCAACTTACTGCGGCAGCTCTCTTTCC
ACTTTATGTCAACGCAGCGGGTAAAGACCGTGCAGTAAAAGTCGCTGAGGCGACCAGGGCCCATCTGTTACAGCCTGGTG
GCCTTGCTACAACATCAGTAAAAAGTGGTCAACAGTGGGATGCGCCAAACGGCTGGGCGCCATTGCAATGGGTTGCTACT
GAAGGTTTGCAAAATTACGGTCAGCAAGATGTAGCGATGGCAGTTACCTGGCGTTTTTTAACCAATGTTCAGCATACCTA
TGATCGTGATAAAAAACTGGTGGAAAAATATGATGTCAGTACCACCGGTACTGGCGGAGGGGGTGGGGAGTATCCATTAC
AAGATGGTTTTGGCTGGAGTAATGGTGTCACTCTGAAAATGCTCGATCTGGTATGCCCGAAAGAGAAGCCTTGCGATAAC
GTTCCCCCGGAACCGGTCACTGAATCAAACCTTCAACCGTCGCAAACTGGTACGACGGCTAACTAA

Upstream 100 bases:

>100_bases
ATATCTCATACTTGCCGAATTTCTTTTGGTTAATCACCCTGTCTCGCAAAATCGCAACTGATTAATACAAATAACCAGAT
CATGAACTAAGGTTTTCTGA

Downstream 100 bases:

>100_bases
TTATTTGAACGGCCCCGCAGGGCCGTTTTCAGGTAAGTTATTCCCGTCGCAGGAGGCGAAATACGCCCAGCACCAGGATC
GCGCCAACCACCGCGACGAG

Product: trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MMPLYSVFHEGESFMKTPAHRAHATLPGALKTVTTALLLSLASQAANAEELADTPLQPPDILLGPLFNDVQSAKLFPDQK
TFADAVPKSDPLMILADYRMQRNQSGFDLRHFVSVNFILPKEGEKYVPPAGQSLREHIDGLWPVLTRTTERTDKWDSLLP
LPEPYVVPGGRFREVYYWDSYFTMLGLAESGHWDKVADMVANFAWEIDTFGHIPNGNRSYYLSRSQPPFFAFMVELLAQN
KGDDALKQYLPQLQKEYAYWMEGTEDLQPGGQNKRVVKLEDGTILNRYWDDRDTPRPESWNEDITTAKSNPSRPATEVYR
DLRSAAASGWDFSSRWMDNPQQLSTIRTTSIVPVDLNALLYKMEKILARASKASGDEAMASQYENLATARQKAIEHYLWN
DKEGWYADYDLKSHKVRNQLTAAALFPLYVNAAGKDRAVKVAEATRAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAT
EGLQNYGQQDVAMAVTWRFLTNVQHTYDRDKKLVEKYDVSTTGTGGGGGEYPLQDGFGWSNGVTLKMLDLVCPKEKPCDN
VPPEPVTESNLQPSQTGTTAN

Sequences:

>Translated_581_residues
MMPLYSVFHEGESFMKTPAHRAHATLPGALKTVTTALLLSLASQAANAEELADTPLQPPDILLGPLFNDVQSAKLFPDQK
TFADAVPKSDPLMILADYRMQRNQSGFDLRHFVSVNFILPKEGEKYVPPAGQSLREHIDGLWPVLTRTTERTDKWDSLLP
LPEPYVVPGGRFREVYYWDSYFTMLGLAESGHWDKVADMVANFAWEIDTFGHIPNGNRSYYLSRSQPPFFAFMVELLAQN
KGDDALKQYLPQLQKEYAYWMEGTEDLQPGGQNKRVVKLEDGTILNRYWDDRDTPRPESWNEDITTAKSNPSRPATEVYR
DLRSAAASGWDFSSRWMDNPQQLSTIRTTSIVPVDLNALLYKMEKILARASKASGDEAMASQYENLATARQKAIEHYLWN
DKEGWYADYDLKSHKVRNQLTAAALFPLYVNAAGKDRAVKVAEATRAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAT
EGLQNYGQQDVAMAVTWRFLTNVQHTYDRDKKLVEKYDVSTTGTGGGGGEYPLQDGFGWSNGVTLKMLDLVCPKEKPCDN
VPPEPVTESNLQPSQTGTTAN
>Mature_581_residues
MMPLYSVFHEGESFMKTPAHRAHATLPGALKTVTTALLLSLASQAANAEELADTPLQPPDILLGPLFNDVQSAKLFPDQK
TFADAVPKSDPLMILADYRMQRNQSGFDLRHFVSVNFILPKEGEKYVPPAGQSLREHIDGLWPVLTRTTERTDKWDSLLP
LPEPYVVPGGRFREVYYWDSYFTMLGLAESGHWDKVADMVANFAWEIDTFGHIPNGNRSYYLSRSQPPFFAFMVELLAQN
KGDDALKQYLPQLQKEYAYWMEGTEDLQPGGQNKRVVKLEDGTILNRYWDDRDTPRPESWNEDITTAKSNPSRPATEVYR
DLRSAAASGWDFSSRWMDNPQQLSTIRTTSIVPVDLNALLYKMEKILARASKASGDEAMASQYENLATARQKAIEHYLWN
DKEGWYADYDLKSHKVRNQLTAAALFPLYVNAAGKDRAVKVAEATRAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAT
EGLQNYGQQDVAMAVTWRFLTNVQHTYDRDKKLVEKYDVSTTGTGGGGGEYPLQDGFGWSNGVTLKMLDLVCPKEKPCDN
VPPEPVTESNLQPSQTGTTAN

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=546, Percent_Identity=34.981684981685, Blast_Score=264, Evalue=2e-70,
Organism=Escherichia coli, GI1787447, Length=562, Percent_Identity=82.3843416370107, Blast_Score=947, Evalue=0.0,
Organism=Escherichia coli, GI1789936, Length=501, Percent_Identity=51.497005988024, Blast_Score=515, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17542196, Length=520, Percent_Identity=33.4615384615385, Blast_Score=272, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17565078, Length=510, Percent_Identity=33.1372549019608, Blast_Score=251, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI25148109, Length=545, Percent_Identity=31.5596330275229, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI25141398, Length=531, Percent_Identity=32.5800376647834, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71987755, Length=403, Percent_Identity=30.7692307692308, Blast_Score=189, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6320204, Length=438, Percent_Identity=31.0502283105023, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319473, Length=479, Percent_Identity=31.7327766179541, Blast_Score=159, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24656680, Length=568, Percent_Identity=35.0352112676056, Blast_Score=279, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24656675, Length=568, Percent_Identity=35.0352112676056, Blast_Score=279, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24656661, Length=528, Percent_Identity=35.4166666666667, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI17933716, Length=528, Percent_Identity=35.4166666666667, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24656670, Length=528, Percent_Identity=35.4166666666667, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24656685, Length=485, Percent_Identity=35.4639175257732, Blast_Score=258, Evalue=1e-68,
Organism=Drosophila melanogaster, GI22024178, Length=528, Percent_Identity=31.25, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI45551104, Length=367, Percent_Identity=31.8801089918256, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI28573474, Length=315, Percent_Identity=28.8888888888889, Blast_Score=118, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 65157; Mature: 65157

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPLYSVFHEGESFMKTPAHRAHATLPGALKTVTTALLLSLASQAANAEELADTPLQPPD
CCCHHHHHHCCHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCC
ILLGPLFNDVQSAKLFPDQKTFADAVPKSDPLMILADYRMQRNQSGFDLRHFVSVNFILP
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEECCHHHCCCCCCCEEEEEEEEEEEC
KEGEKYVPPAGQSLREHIDGLWPVLTRTTERTDKWDSLLPLPEPYVVPGGRFREVYYWDS
CCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHCCHHHCCCCCCCCEECCCCCEEEEEEECH
YFTMLGLAESGHWDKVADMVANFAWEIDTFGHIPNGNRSYYLSRSQPPFFAFMVELLAQN
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
KGDDALKQYLPQLQKEYAYWMEGTEDLQPGGQNKRVVKLEDGTILNRYWDDRDTPRPESW
CCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCC
NEDITTAKSNPSRPATEVYRDLRSAAASGWDFSSRWMDNPQQLSTIRTTSIVPVDLNALL
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCEEEEECHHHHH
YKMEKILARASKASGDEAMASQYENLATARQKAIEHYLWNDKEGWYADYDLKSHKVRNQL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHH
TAAALFPLYVNAAGKDRAVKVAEATRAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAT
HHHHHHHHHEECCCCCCEEEHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCHHHHHH
EGLQNYGQQDVAMAVTWRFLTNVQHTYDRDKKLVEKYDVSTTGTGGGGGEYPLQDGFGWS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
NGVTLKMLDLVCPKEKPCDNVPPEPVTESNLQPSQTGTTAN
CCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMPLYSVFHEGESFMKTPAHRAHATLPGALKTVTTALLLSLASQAANAEELADTPLQPPD
CCCHHHHHHCCHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCC
ILLGPLFNDVQSAKLFPDQKTFADAVPKSDPLMILADYRMQRNQSGFDLRHFVSVNFILP
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEECCHHHCCCCCCCEEEEEEEEEEEC
KEGEKYVPPAGQSLREHIDGLWPVLTRTTERTDKWDSLLPLPEPYVVPGGRFREVYYWDS
CCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHCCHHHCCCCCCCCEECCCCCEEEEEEECH
YFTMLGLAESGHWDKVADMVANFAWEIDTFGHIPNGNRSYYLSRSQPPFFAFMVELLAQN
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
KGDDALKQYLPQLQKEYAYWMEGTEDLQPGGQNKRVVKLEDGTILNRYWDDRDTPRPESW
CCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCC
NEDITTAKSNPSRPATEVYRDLRSAAASGWDFSSRWMDNPQQLSTIRTTSIVPVDLNALL
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCEEEEECHHHHH
YKMEKILARASKASGDEAMASQYENLATARQKAIEHYLWNDKEGWYADYDLKSHKVRNQL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHH
TAAALFPLYVNAAGKDRAVKVAEATRAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAT
HHHHHHHHHEECCCCCCEEEHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCHHHHHH
EGLQNYGQQDVAMAVTWRFLTNVQHTYDRDKKLVEKYDVSTTGTGGGGGEYPLQDGFGWS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
NGVTLKMLDLVCPKEKPCDNVPPEPVTESNLQPSQTGTTAN
CCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA