| Definition | Escherichia fergusonii ATCC 35469 chromosome, complete genome. |
|---|---|
| Accession | NC_011740 |
| Length | 4,588,711 |
Click here to switch to the map view.
The map label for this gene is topA [H]
Identifier: 218549035
GI number: 218549035
Start: 1728898
End: 1731495
Strand: Reverse
Name: topA [H]
Synonym: EFER_1683
Alternate gene names: 218549035
Gene position: 1731495-1728898 (Counterclockwise)
Preceding gene: 218549037
Following gene: 218549034
Centisome position: 37.73
GC content: 51.15
Gene sequence:
>2598_bases ATGGGTAAAGCTCTCGTCATCGTTGAGTCCCCGGCAAAAGCCAAAACGATCAACAAGTATCTGGGTAATGACTATGTGGT GAAATCCAGTGTTGGTCATATCCGTGATTTGCCGACCAGTGGCTCAACCGCTAAAAAGAGCGCCGACTCTACCTCCACCA AAACGGCTAAAAAGCCTAAAAAGGATGAACGTGGCGCTCTGGTCAACCGTATGGGGGTTGATCCATGGCACAACTGGGAG GCGCACTATGAAGTGCTGCCTGGTAAAGAGAAAGTTGTCTCTGAACTCAAACAATTGGCTGAAAAAGCCGATCACATCTA TCTCGCAACCGACCTTGACCGCGAAGGGGAAGCCATTGCCTGGCACCTGCGGGAAGTAATTGGTGGTGATGATGCGCGCT ATAGTCGCGTTGTCTTTAATGAAATCACGAAAAACGCGATTCGTCAGGCCTTTGAAAAGCCTGGAGAGTTAAATATTGAT CGTGTAAATGCCCAGCAGGCGCGTCGCTTTATGGACCGCGTGGTGGGATATATGGTCTCTCCACTGCTGTGGAAAAAGAT CGCCCGCGGTCTCTCCGCGGGAAGGGTACAGTCCGTTGCTGTTCGTCTGGTGGTGGAGCGTGAGCGTGAAATTAAAGCCT TCGTCCCGGAAGAATTCTGGGAAGTAGACGCTAATACCACGACGCCTTCTGGCGATGCACTGGCATTACAGGTTACTCAT CAGAACGACAAACCGTTCCGCCCGGTCAACAAAGAACAAACTCAGGCTGCGGTAAGTCTGCTGGAAAAAGCGCGCTACAG CGTGCTGGAACGTGAAGACAAACCGACAACCAGTAAACCTGGCGCTCCTTTTATTACCTCTACGCTGCAACAAGCTGCCA GCACCCGTCTTGGTTTTGGCGTGAAAAAAACCATGATGATGGCGCAGCGTTTGTATGAAGCAGGCTATATCACTTACATG CGTACCGACTCCACCAACCTGAGTCAGGACGCAGTAAATATGGTTCGCGGTTATATCAGCGATAATTTTGGTAAGAAATA TCTGCCGGAAAGTCCGAATCAGTACGCCAGCAAAGAAAACTCACAGGAAGCGCACGAAGCGATTCGTCCTTCTGACGTCA ATGTGATGGCGGAATCGCTGAAGGATATGGAAGCAGATGCGCAGAAACTGTACCAGTTAATCTGGCGTCAGTTCGTTGCC TGCCAGATGACCCCAGCGAAATATGACTCCACGACGCTGACCGTTGGTGCGGGCGATTTCCGCCTGAAAGCACGCGGTCG TATTTTGCGCTTTGATGGCTGGACGAAAGTGATGCCTGCGCTGCGTAAAGGCGATGAAGATCGTATCTTACCGGCAGTCG ATAAAGGCGATGCTCTGACGCTCGTTGAACTGACACCAGCCCAGCACTTTACCAAGCCGCCAGCCCGTTTCAGTGAAGCA TCGCTGGTTAAAGAGCTGGAAAAACGCGGTATCGGTCGTCCGTCTACCTACGCGTCGATCATTTCGACCATTCAGGATCG TGGCTATGTGCGAGTAGAAAATCGTCGTTTCTATGCGGAAAAAATGGGCGAAATCGTCACCGATCGCCTGGAAGAGAATT TCCGTGAGTTAATGAACTACGACTTCACCGCACAGATGGAAAACAGCCTCGACCAGGTGGCAAATCACGAAGCAGAGTGG AAAGCTGTACTGGATCACTTCTTCTCGGATTTCACTCAGCAGCTTGATAAAGCTGAAAAAGATCCGGAAGAGGGTGGTAT GCGCCCAAATCAGATGGTTCTGACCAGCATCGACTGCCCGACCTGTGGTCGCAAAATGGGGATTCGTACCGCCAGCACGG GGGTATTCCTGGGCTGTTCCGGCTATGCGCTGCCACCGAAAGAGCGTTGCAAAACAACCATTAACCTGGTACCGGAAAAC GAAGTTCTTAACGTGCTGGAAGGCGAAGACGCAGAAACCAACGCTTTGCGCGCCAAACGTCGTTGCCCGAAATGTGGCAC GGCGATGGACAGCTATCTCATCGATCCGAAACGTAAATTGCATGTCTGTGGTAATAACCCAACCTGCGACGGTTACGAAA TCGAAGAGGGCGAATTCCGCATTAAAGGTTATGACGGGCCGATCGTTGAGTGTGAAAAATGTGGTTCTGAAATGCACCTG AAAATGGGGCGCTTCGGTAAGTACATGGCCTGCACTAACGAAGAGTGTAAAAACACGCGTAAGATTTTACGTAATGGCGA AGTTGCGCCGCCGAAAGAAGATCCAGTTCCACTGCCAGAGCTGCCGTGTGAAAAATCGGATGCTTATTTCGTGCTGCGTG ACGGTGCTGCTGGCGTCTTCCTTGCGGCTAACACCTTCCCGAAATCGCGTGAAACACGTGCGCCGCTGGTGGAAGAACTT TATCGCTTCCGCGACCGTCTGCCAGAAAAACTGCGCTATCTGGCGGATGCACCGCAGCAGGACCCAGCTGGTAATAAATC GATGGTCCGCTTTAGCCGCAAAACGAAGCAGCAATATGTCTCTTCGGAAAAAGAGGGTAAAGCTACTGGATGGTCCGCAT TCTACATTGATGGTAAGTGGGTCGAAGGTAAGAAATAA
Upstream 100 bases:
>100_bases TATCCGCCAGTTGCGAAACCATATCGACGTTTCGTCGCCAGCGGAAGGTGAATCAACGTGCGACGCATTCCTGGAAGAAT CAAATTAGGTAAAGGTGAAT
Downstream 100 bases:
>100_bases TTACCCACGGTAGCCAACTCCTCCAAAAGGGTCGCGGATGCGACCCTTTTTCGTGTAATTTCACTATTTTTTAATACTAT CTATACAGCAAAGATATAAA
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 865; Mature: 864
Protein sequence:
>865_residues MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWE AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNID RVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANTTTPSGDALALQVTH QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYM RTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEA SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEN EVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL KMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL YRFRDRLPEKLRYLADAPQQDPAGNKSMVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEGKK
Sequences:
>Translated_865_residues MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWE AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNID RVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANTTTPSGDALALQVTH QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYM RTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEA SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEN EVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL KMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL YRFRDRLPEKLRYLADAPQQDPAGNKSMVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEGKK >Mature_864_residues GKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEA HYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNIDR VNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANTTTPSGDALALQVTHQ NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMR TDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEAS LVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWK AVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENE VLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLK MGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELY RFRDRLPEKLRYLADAPQQDPAGNKSMVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEGKK
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=609, Percent_Identity=25.4515599343186, Blast_Score=150, Evalue=7e-36, Organism=Homo sapiens, GI4507635, Length=514, Percent_Identity=27.431906614786, Blast_Score=147, Evalue=3e-35, Organism=Escherichia coli, GI1787529, Length=865, Percent_Identity=98.8439306358381, Blast_Score=1788, Evalue=0.0, Organism=Escherichia coli, GI1788061, Length=644, Percent_Identity=22.8260869565217, Blast_Score=122, Evalue=9e-29, Organism=Caenorhabditis elegans, GI32563869, Length=565, Percent_Identity=24.7787610619469, Blast_Score=132, Evalue=8e-31, Organism=Caenorhabditis elegans, GI17555378, Length=505, Percent_Identity=25.5445544554455, Blast_Score=129, Evalue=6e-30, Organism=Drosophila melanogaster, GI24585251, Length=618, Percent_Identity=24.4336569579288, Blast_Score=139, Evalue=1e-32, Organism=Drosophila melanogaster, GI24640096, Length=508, Percent_Identity=26.1811023622047, Blast_Score=124, Evalue=3e-28,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR013263 - InterPro: IPR006171 [H]
Pfam domain/function: PF08272 Topo_Zn_Ribbon; PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 97393; Mature: 97262
Theoretical pI: Translated: 8.55; Mature: 8.55
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 4.4 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPK CCCEEEEEECCCHHHHHHHHHCCCEEEECCCCHHHCCCCCCCCHHCCCCCCCCHHCCCCC KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA CCHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH WHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVS HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHH PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANTTTPSGDALALQVTH HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEEEE QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCE RLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEA EEEECCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHCCCCCCCHHHH SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY HHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC DFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEEECCCC TCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKR CCCHHHCCEEECCCEEEECCCCCCCCHHHCCCEEEECCCHHHHHHHCCCCCHHHHHHHHH RCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL CCCCCCCHHHHHHCCCCCEEEEECCCCCCCCEEECCCCEEEECCCCCCHHHHHCCCHHHH KMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVF HHHCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEE LAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPAGNKSMVRFSRKTKQQYV EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH SSEKEGKATGWSAFYIDGKWVEGKK CCCCCCCCCCCEEEEEECEECCCCC >Mature Secondary Structure GKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPK CCEEEEEECCCHHHHHHHHHCCCEEEECCCCHHHCCCCCCCCHHCCCCCCCCHHCCCCC KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA CCHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH WHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVS HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHH PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANTTTPSGDALALQVTH HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEEEE QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCE RLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEA EEEECCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHCCCCCCCHHHH SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY HHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC DFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEEECCCC TCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKR CCCHHHCCEEECCCEEEECCCCCCCCHHHCCCEEEECCCHHHHHHHCCCCCHHHHHHHHH RCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL CCCCCCCHHHHHHCCCCCEEEEECCCCCCCCEEECCCCEEEECCCCCCHHHHHCCCHHHH KMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVF HHHCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEE LAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPAGNKSMVRFSRKTKQQYV EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH SSEKEGKATGWSAFYIDGKWVEGKK CCCCCCCCCCCEEEEEECEECCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 3029379; 9097039; 9278503; 3032952; 8114910; 7779808 [H]