Click here to switch to the map view.

The map label for this gene is paaH [H]

Identifier: 218548953

GI number: 218548953

Start: 1645641

End: 1647068

Strand: Reverse

Name: paaH [H]

Synonym: EFER_1601

Alternate gene names: 218548953

Gene position: 1647068-1645641 (Counterclockwise)

Preceding gene: 218548954

Following gene: 218548952

Centisome position: 35.89

GC content: 53.15

Gene sequence:

>1428_bases
ATGATGATAAATGTGCAAACTGTGGCAGTGATTGGGAGCGGCACCATGGGGGCAGGCATTGCAGAAGTTGCCGCCAGTCA
TGGACATCAGGTTTTACTGTATGACATTTCTGCTGAAGCGCTGACCCGCGCAATAGACGGAATACACGCGCGGCTGAATT
CACGCGTGAAGCGGGGAAAACTGACCGCTGAAACCTGTGAACGCACATTGAAACGTCTGATCCCGGTGACCGATATTCAC
GCGCTGGCAGCAGCGGATCTGGTCATTGAAGCGGCGTCTGAACGTCTGGAAGTCAAAAAAGCGCTCTTTGCACAGCTGGC
GGAAGTTTGCCCGCCACAAACGCTATTGACCACTAACACATCTTCAATCTCTATAACCGCGATTGCTGCGGAGGTGAAAA
ATCCTGAACGTGTTGCGGGGCTGCATTTTTTTAACCCGGCACCGGTGATGAAGTTGGTGGAGGTGGTCAGTGGGCTGGCA
ACGGCGGCGGAAGTTGTCGAGCAGTTGTGTGAACTGACGTTAAGTTGGGGTAAGCAGCCTGTGCGCTGTCATTCGACCCC
TGGATTTATCGTTAACCGTGTTGCGCGTCCTTATTATTCCGAGGCCTGGCGGGCACTGGAAGAGCAGGTTGCTGCACCAG
AAGTGATTGACGCTGCGCTTCGCGATGGAGCTGGTTTCCCGATGGGGCCGCTGGAATTAACCGATCTGATTGGTCAGGAC
GTCAATTTTGCTGTCACCTGCTCGGTGTTTAACGCTTTCTGGCAGGAACGTCGTTTTCTCCCTTCGCTGGTGCAACAGGA
ACTGGTGATTGGTGGACGATTAGGCAAGAAAAGTGGGCTGGGCGTGTATGACTGGCGTGCGGAGCGTGAGGAAGTTGTTG
GCCTGGAAGCGGTAAGCGACAGTTTTAGTCCAATGAAAGTAGAAAATAAAAGTGACGGTGTCACGGAAATTGACGATGTT
TTATTGATTGAGACACAAGGCGAGACGGCACAGGCGCTGGCAACACGACTGGCACGCCCGGTGGTCGTGGTCGACAAAAT
GACGGGCAAGGTGGTGACCATTGCTGCGGCAGCGGTGAACCCGGACTCAGCGACTCGCAAGGCCATTTATTACCTGCAAC
AGCAGGGCAAAACAGTGCTGCAAATTGCTGATTACCCAGGAATGCTGATTTGGCGAACGGTAGCAATGATCATCAATGAA
GCCCTTGATGCGCTGCAAAAAGGTGTGGCCTCTGAACAGGATATCGATACCGCCATGCGTCTTGGGGTGAATTATCCATA
TGGCCCGCTTGCCTGGGGAGCGCAACTTGGCTGGCAGCGAATATTAAGGTTCCTGGAAAACCTACAACATCACTATGGCG
AAGAACGTTATCGTCCATGTTCATTGCTGCGCCAGCGGGCGCTTCTGGAGAGCGGTTATGAGTCATAA

Upstream 100 bases:

>100_bases
GAACGCGACTATCAGCGACTTGCCGGACGGAGCGCAGATTATCGTGAAGGTGTCAGTGCGTTCCTGGCTAAACGCTCACC
GCAGTTCACGGGGAAATAGC

Downstream 100 bases:

>100_bases
GGCCTGGCAAAATGCCCATGCAATGTATGAGAACGATGCCTGCGCCAAAGCACTTGGCATCGACATTATCTCAATGGATG
AAGGCTTTGCTGTAGTGACC

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVKRGKLTAETCERTLKRLIPVTDIH
ALAAADLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNTSSISITAIAAEVKNPERVAGLHFFNPAPVMKLVEVVSGLA
TAAEVVEQLCELTLSWGKQPVRCHSTPGFIVNRVARPYYSEAWRALEEQVAAPEVIDAALRDGAGFPMGPLELTDLIGQD
VNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREEVVGLEAVSDSFSPMKVENKSDGVTEIDDV
LLIETQGETAQALATRLARPVVVVDKMTGKVVTIAAAAVNPDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINE
ALDALQKGVASEQDIDTAMRLGVNYPYGPLAWGAQLGWQRILRFLENLQHHYGEERYRPCSLLRQRALLESGYES

Sequences:

>Translated_475_residues
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVKRGKLTAETCERTLKRLIPVTDIH
ALAAADLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNTSSISITAIAAEVKNPERVAGLHFFNPAPVMKLVEVVSGLA
TAAEVVEQLCELTLSWGKQPVRCHSTPGFIVNRVARPYYSEAWRALEEQVAAPEVIDAALRDGAGFPMGPLELTDLIGQD
VNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREEVVGLEAVSDSFSPMKVENKSDGVTEIDDV
LLIETQGETAQALATRLARPVVVVDKMTGKVVTIAAAAVNPDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINE
ALDALQKGVASEQDIDTAMRLGVNYPYGPLAWGAQLGWQRILRFLENLQHHYGEERYRPCSLLRQRALLESGYES
>Mature_475_residues
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVKRGKLTAETCERTLKRLIPVTDIH
ALAAADLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNTSSISITAIAAEVKNPERVAGLHFFNPAPVMKLVEVVSGLA
TAAEVVEQLCELTLSWGKQPVRCHSTPGFIVNRVARPYYSEAWRALEEQVAAPEVIDAALRDGAGFPMGPLELTDLIGQD
VNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREEVVGLEAVSDSFSPMKVENKSDGVTEIDDV
LLIETQGETAQALATRLARPVVVVDKMTGKVVTIAAAAVNPDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINE
ALDALQKGVASEQDIDTAMRLGVNYPYGPLAWGAQLGWQRILRFLENLQHHYGEERYRPCSLLRQRALLESGYES

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=295, Percent_Identity=41.6949152542373, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI296179427, Length=312, Percent_Identity=39.4230769230769, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI20127408, Length=286, Percent_Identity=33.9160839160839, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=32.5342465753425, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=32.5342465753425, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI115430219, Length=236, Percent_Identity=30.5084745762712, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1787661, Length=475, Percent_Identity=98.3157894736842, Blast_Score=958, Evalue=0.0,
Organism=Escherichia coli, GI1788682, Length=262, Percent_Identity=35.4961832061069, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=29.9625468164794, Blast_Score=134, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17553560, Length=290, Percent_Identity=40, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17549919, Length=294, Percent_Identity=40.1360544217687, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=39.7923875432526, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=34.5195729537367, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=34.5195729537367, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=34.5195729537367, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71985923, Length=321, Percent_Identity=29.2834890965732, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=33.4519572953737, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71985930, Length=290, Percent_Identity=29.6551724137931, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193203623, Length=199, Percent_Identity=27.1356783919598, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533614, Length=199, Percent_Identity=27.1356783919598, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=34.7368421052632, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=34.7368421052632, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=34.7368421052632, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45549573, Length=241, Percent_Identity=32.7800829875519, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20129993, Length=240, Percent_Identity=27.9166666666667, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 51828; Mature: 51828

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVKRGK
CEEEEEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
LTAETCERTLKRLIPVTDIHALAAADLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNT
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SSISITAIAAEVKNPERVAGLHFFNPAPVMKLVEVVSGLATAAEVVEQLCELTLSWGKQP
CCEEEEEEEECCCCCHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VRCHSTPGFIVNRVARPYYSEAWRALEEQVAAPEVIDAALRDGAGFPMGPLELTDLIGQD
EEECCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHCCC
VNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREEVVGLEAVSD
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
SFSPMKVENKSDGVTEIDDVLLIETQGETAQALATRLARPVVVVDKMTGKVVTIAAAAVN
CCCCCEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCEEEEECCCCCEEEEEEEECC
PDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINEALDALQKGVASEQDIDTAMR
CCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LGVNYPYGPLAWGAQLGWQRILRFLENLQHHYGEERYRPCSLLRQRALLESGYES
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMINVQTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVKRGK
CEEEEEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
LTAETCERTLKRLIPVTDIHALAAADLVIEAASERLEVKKALFAQLAEVCPPQTLLTTNT
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SSISITAIAAEVKNPERVAGLHFFNPAPVMKLVEVVSGLATAAEVVEQLCELTLSWGKQP
CCEEEEEEEECCCCCHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VRCHSTPGFIVNRVARPYYSEAWRALEEQVAAPEVIDAALRDGAGFPMGPLELTDLIGQD
EEECCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHCCC
VNFAVTCSVFNAFWQERRFLPSLVQQELVIGGRLGKKSGLGVYDWRAEREEVVGLEAVSD
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
SFSPMKVENKSDGVTEIDDVLLIETQGETAQALATRLARPVVVVDKMTGKVVTIAAAAVN
CCCCCEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCEEEEECCCCCEEEEEEEECC
PDSATRKAIYYLQQQGKTVLQIADYPGMLIWRTVAMIINEALDALQKGVASEQDIDTAMR
CCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LGVNYPYGPLAWGAQLGWQRILRFLENLQHHYGEERYRPCSLLRQRALLESGYES
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]