Click here to switch to the map view.

The map label for this gene is paaX [H]

Identifier: 218548949

GI number: 218548949

Start: 1641634

End: 1642584

Strand: Reverse

Name: paaX [H]

Synonym: EFER_1597

Alternate gene names: 218548949

Gene position: 1642584-1641634 (Counterclockwise)

Preceding gene: 218548950

Following gene: 218548948

Centisome position: 35.8

GC content: 49.84

Gene sequence:

>951_bases
ATGAGTAAACTTGATACTTTTATCCAACATGCTGTAAACGCTGTTCCTGTCAGTGGCACATCTTTGATCTCCTCTCTGTA
TGGTGATTCACTTTCTCATCGTGGTGGAGAAATCTGGCTGGGTAGTCTGGCTGCTTTGCTGGAAGGGCTGGGATTTGGTG
AGCGTTTCGTCCGTACCGCTTTGTTTCGTCTTAATAAAGAAGGCTGGCTGGATGTTTCCCGCATCGGGCGACGCAGTTTC
TACAGTCTCAGTGATAAAGGCTTGCGGCTGACACGACGGGCAGAAAGTAAAATTTATCGTGCAGAGCAACCCGCATGGGA
TGGTAAATGGCTCCTGTTGCTCTCGGAGGGTTTAGATAAAGCAACGCTGACTGATGTCAAAAAGCAGTTGATCTGGCAAG
GTTTTGGCACACTGGCGCCCAGCCTGATGGCATCGCCGTCGCAAAAACTGGCCGATGTACAGACGCTTTTGCATGAAGCA
GGTGTGGCGGATAACGTGATTTGTTTTGAAGCGCAAATACCACTGGCGCTTTCTCGTGCAGCACTGCGTGCCAGAGTAGA
AGAGTGCTGGCATTTAACTGAACAAAATGCCATGTACGAAACCTTTATTCAGTCATTCCGCCCGCTTGTGCCGCTGTTAA
AAGAGGCGGCCGACGAGTTAACCCCGGAGCGTGCATTTCATATTCAGCTTTTACTGATCCATTTTTATCGCCGTGTCGTC
CTTAAAGACCCATTGTTGCCGGAGGAGTTGCTTCCGGCACACTGGGCAGGACATACGGCGCGTCAGCTGTGTATCAACAT
TTACCAGCGCGTAGCGCCTGCTGCTTTAGCGTTCGTTAGTGAAAAAGGTGAAACCTCGGTTGGTGAACTGCCTGCGCCGG
GAAGCCTGTATTTTCAACGTTTTGGCGGTTTGAACATTGAACAGGAGGCGTTATGCCAATTTATCAGATAG

Upstream 100 bases:

>100_bases
ATGTGTCGCCTGGTCCTGGTGGGTGAACTGCCAGGGCCAGAAGTCGATACGACCTGTGCTATGATTCATAAATCACAACA
ATAACAACAGACTGAATCGA

Downstream 100 bases:

>100_bases
ACGGTCTGACTCCGGTTGTACCAGAAGAGAGTTTTGTTCATCCGACAGCGGTATTGATCGGCGATGTTATTCTCGGCAAG
GGCGTTTACGTTGGACCAAA

Product: phenylacetic acid degradation DNA-binding transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSKLDTFIQHAVNAVPVSGTSLISSLYGDSLSHRGGEIWLGSLAALLEGLGFGERFVRTALFRLNKEGWLDVSRIGRRSF
YSLSDKGLRLTRRAESKIYRAEQPAWDGKWLLLLSEGLDKATLTDVKKQLIWQGFGTLAPSLMASPSQKLADVQTLLHEA
GVADNVICFEAQIPLALSRAALRARVEECWHLTEQNAMYETFIQSFRPLVPLLKEAADELTPERAFHIQLLLIHFYRRVV
LKDPLLPEELLPAHWAGHTARQLCINIYQRVAPAALAFVSEKGETSVGELPAPGSLYFQRFGGLNIEQEALCQFIR

Sequences:

>Translated_316_residues
MSKLDTFIQHAVNAVPVSGTSLISSLYGDSLSHRGGEIWLGSLAALLEGLGFGERFVRTALFRLNKEGWLDVSRIGRRSF
YSLSDKGLRLTRRAESKIYRAEQPAWDGKWLLLLSEGLDKATLTDVKKQLIWQGFGTLAPSLMASPSQKLADVQTLLHEA
GVADNVICFEAQIPLALSRAALRARVEECWHLTEQNAMYETFIQSFRPLVPLLKEAADELTPERAFHIQLLLIHFYRRVV
LKDPLLPEELLPAHWAGHTARQLCINIYQRVAPAALAFVSEKGETSVGELPAPGSLYFQRFGGLNIEQEALCQFIR
>Mature_315_residues
SKLDTFIQHAVNAVPVSGTSLISSLYGDSLSHRGGEIWLGSLAALLEGLGFGERFVRTALFRLNKEGWLDVSRIGRRSFY
SLSDKGLRLTRRAESKIYRAEQPAWDGKWLLLLSEGLDKATLTDVKKQLIWQGFGTLAPSLMASPSQKLADVQTLLHEAG
VADNVICFEAQIPLALSRAALRARVEECWHLTEQNAMYETFIQSFRPLVPLLKEAADELTPERAFHIQLLLIHFYRRVVL
KDPLLPEELLPAHWAGHTARQLCINIYQRVAPAALAFVSEKGETSVGELPAPGSLYFQRFGGLNIEQEALCQFIR

Specific function: Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'- WWTRTGATTCGYGWT-3'. Binding of paaX is specifically inhibited by phenylacetyl-coenzyme A [H]

COG id: COG3327

COG function: function code K; Phenylacetic acid-responsive transcriptional repressor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787666, Length=316, Percent_Identity=99.0506329113924, Blast_Score=638, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012906
- InterPro:   IPR013225
- InterPro:   IPR011965 [H]

Pfam domain/function: PF07848 PaaX; PF08223 PaaX_C [H]

EC number: NA

Molecular weight: Translated: 35339; Mature: 35208

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLDTFIQHAVNAVPVSGTSLISSLYGDSLSHRGGEIWLGSLAALLEGLGFGERFVRTA
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
LFRLNKEGWLDVSRIGRRSFYSLSDKGLRLTRRAESKIYRAEQPAWDGKWLLLLSEGLDK
HHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCH
ATLTDVKKQLIWQGFGTLAPSLMASPSQKLADVQTLLHEAGVADNVICFEAQIPLALSRA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHH
ALRARVEECWHLTEQNAMYETFIQSFRPLVPLLKEAADELTPERAFHIQLLLIHFYRRVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LKDPLLPEELLPAHWAGHTARQLCINIYQRVAPAALAFVSEKGETSVGELPAPGSLYFQR
HCCCCCCHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
FGGLNIEQEALCQFIR
HCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SKLDTFIQHAVNAVPVSGTSLISSLYGDSLSHRGGEIWLGSLAALLEGLGFGERFVRTA
CHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
LFRLNKEGWLDVSRIGRRSFYSLSDKGLRLTRRAESKIYRAEQPAWDGKWLLLLSEGLDK
HHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCH
ATLTDVKKQLIWQGFGTLAPSLMASPSQKLADVQTLLHEAGVADNVICFEAQIPLALSRA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHH
ALRARVEECWHLTEQNAMYETFIQSFRPLVPLLKEAADELTPERAFHIQLLLIHFYRRVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LKDPLLPEELLPAHWAGHTARQLCINIYQRVAPAALAFVSEKGETSVGELPAPGSLYFQR
HCCCCCCHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
FGGLNIEQEALCQFIR
HCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]