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The map label for this gene is folM [H]

Identifier: 218548792

GI number: 218548792

Start: 1470959

End: 1471681

Strand: Reverse

Name: folM [H]

Synonym: EFER_1431

Alternate gene names: 218548792

Gene position: 1471681-1470959 (Counterclockwise)

Preceding gene: 218548793

Following gene: 218548790

Centisome position: 32.07

GC content: 48.69

Gene sequence:

>723_bases
ATGGGTCATTCCCGCGCATTCCCTGTTCTTATTACGGGTGGAGGCCGTCGCATCGGCCTCGCTCTCGCATGGCATTTTAT
CAATCAAAAACAACCTGTAATTGTCAGTTACCGAACACACTACCCGGCAATTGATGGTTTGAAGAAGGCCGGTGCGCTTT
GTATTCAGGCTGATTTCTCCACAGATGAAGGTATATTAGCATTTGCTGAACAGGTAAAAGCTGCAACACCGGGTTTACGG
GCGATTTTGCATAACGCCAGTGCCTGGATGGCAGAGAAGCCGGGGATTCCACTCCCGGACGTTTTATCATGCATGATGCA
GATCCATGTTAGCGCGCCGTACTTACTCAACCATGCACTGGAACCGTTACTGCGCGGCCATGGACACGCAGCGAGCGATA
TTATCCACTTCACTGATTACGTCGTCGAACGCGGTAGCGATAAACATATCGCCTATGCTGCAAGTAAAGCCGCGCTGGAT
AATATGACCAGGTCGTTTGCCCGCAAACTGGCGCCTGAAGTTAAAGTCAATGCTATTGCACCATCGCTGATTTTATTTAA
CGAACATGACGATGCGGAGTATCGCCAGCAGGCACTGAATAAATCACTGATGAAAACCGCACCTGGTGAAAAGGAAGTAA
TTGAATTAGTTGATTATTTGCTCACAAGCTGTTTTGTTACCGGGCGTAGTTTTCCCCTGGATGGTGGTCGTCATCTGCGT
TAA

Upstream 100 bases:

>100_bases
GAAATGGTGCTGATTAGTTTACTGTTAGTCGCGGCTATTCCTGCGACGTGGATACTGGTGGGATAACATGAATCCCATCG
TTTGACGCTAAGGAGCTACG

Downstream 100 bases:

>100_bases
TGCAGTTTTATCCAGCAGAAAATTAACAACCATGCGCTAAGCCCCCAGCAGATAACCGCCCCTCCGAGTGCTGCGGGCAG
GCGCATAAATCCGGTGAGAT

Product: short chain dehydrogenase

Products: NA

Alternate protein names: DHFR [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MGHSRAFPVLITGGGRRIGLALAWHFINQKQPVIVSYRTHYPAIDGLKKAGALCIQADFSTDEGILAFAEQVKAATPGLR
AILHNASAWMAEKPGIPLPDVLSCMMQIHVSAPYLLNHALEPLLRGHGHAASDIIHFTDYVVERGSDKHIAYAASKAALD
NMTRSFARKLAPEVKVNAIAPSLILFNEHDDAEYRQQALNKSLMKTAPGEKEVIELVDYLLTSCFVTGRSFPLDGGRHLR

Sequences:

>Translated_240_residues
MGHSRAFPVLITGGGRRIGLALAWHFINQKQPVIVSYRTHYPAIDGLKKAGALCIQADFSTDEGILAFAEQVKAATPGLR
AILHNASAWMAEKPGIPLPDVLSCMMQIHVSAPYLLNHALEPLLRGHGHAASDIIHFTDYVVERGSDKHIAYAASKAALD
NMTRSFARKLAPEVKVNAIAPSLILFNEHDDAEYRQQALNKSLMKTAPGEKEVIELVDYLLTSCFVTGRSFPLDGGRHLR
>Mature_239_residues
GHSRAFPVLITGGGRRIGLALAWHFINQKQPVIVSYRTHYPAIDGLKKAGALCIQADFSTDEGILAFAEQVKAATPGLRA
ILHNASAWMAEKPGIPLPDVLSCMMQIHVSAPYLLNHALEPLLRGHGHAASDIIHFTDYVVERGSDKHIAYAASKAALDN
MTRSFARKLAPEVKVNAIAPSLILFNEHDDAEYRQQALNKSLMKTAPGEKEVIELVDYLLTSCFVTGRSFPLDGGRHLR

Specific function: Catalyzes the reduction of dihydrofolate to tetrahydrofolate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787891, Length=240, Percent_Identity=88.75, Blast_Score=447, Evalue=1e-127,
Organism=Drosophila melanogaster, GI23397609, Length=247, Percent_Identity=28.3400809716599, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.5.1.3 [H]

Molecular weight: Translated: 26272; Mature: 26140

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHSRAFPVLITGGGRRIGLALAWHFINQKQPVIVSYRTHYPAIDGLKKAGALCIQADFS
CCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCEEEEECCC
TDEGILAFAEQVKAATPGLRAILHNASAWMAEKPGIPLPDVLSCMMQIHVSAPYLLNHAL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
EPLLRGHGHAASDIIHFTDYVVERGSDKHIAYAASKAALDNMTRSFARKLAPEVKVNAIA
HHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PSLILFNEHDDAEYRQQALNKSLMKTAPGEKEVIELVDYLLTSCFVTGRSFPLDGGRHLR
CEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
GHSRAFPVLITGGGRRIGLALAWHFINQKQPVIVSYRTHYPAIDGLKKAGALCIQADFS
CCCCCCEEEEECCCCEEHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCEEEEECCC
TDEGILAFAEQVKAATPGLRAILHNASAWMAEKPGIPLPDVLSCMMQIHVSAPYLLNHAL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
EPLLRGHGHAASDIIHFTDYVVERGSDKHIAYAASKAALDNMTRSFARKLAPEVKVNAIA
HHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PSLILFNEHDDAEYRQQALNKSLMKTAPGEKEVIELVDYLLTSCFVTGRSFPLDGGRHLR
CEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA