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The map label for this gene is sufC [H]

Identifier: 218548732

GI number: 218548732

Start: 1407006

End: 1407752

Strand: Direct

Name: sufC [H]

Synonym: EFER_1370

Alternate gene names: 218548732

Gene position: 1407006-1407752 (Clockwise)

Preceding gene: 218548731

Following gene: 218548733

Centisome position: 30.66

GC content: 49.93

Gene sequence:

>747_bases
ATGTTAAGTATTAAAGATTTACACGTCAGCGTGGAAGATAAAACTATCCTGCGTGGGTTAAGCCTCGACGTTCGTCCCGG
CGAAGTTCACGCCATTATGGGGCCAAACGGTTCTGGCAAAAGTACCTTATCGGCAACGCTTGCTGGGCGAGAAGATTATG
AGGTGACGGGCGGCACGGTTGAGTTCAAAGGCAAAGATTTGCTTGCGCTGTCGCCGGAAGATCGTGCAGGTGAAGGCATC
TTTATGGCCTTCCAGTATCCGGTGGAAATTCCCGGCGTCAGTAACCAGTTTTTCCTGCAAACGGCACTTAATGCGGTGCG
CAGCTATCGCGGCCAGGAAACGCTCGACCGCTTTGATTTTCAGGATTTGATGGAAGAGAAAATCGCTCTCCTGAAGATGC
CGGAGGATTTATTAACCCGTTCGGTAAATGTTGGTTTTTCCGGCGGCGAGAAAAAGCGCAACGATATTTTGCAAATGGCG
GTGCTGGAACCGGAGTTATGCATTCTTGATGAGTCGGACTCCGGGCTGGATATTGACGCATTAAAAGTGGTTGCCGATGG
CGTGAACTCGCTGCGTGACGGCAAGCGTTCATTCATCATTGTTACGCACTACCAACGCATTCTCGACTACATCAAGCCTG
ATTATGTCCATGTGCTGTATCAGGGACGAATTGTGAAATCCGGCGATTTCACATTGGTCAAACAACTGGAGGAGCAGGGT
TATGGCTGGCTTACCGAACAGCAGTAA

Upstream 100 bases:

>100_bases
TTGCAAAGATGTGTTCTCGGAACTGCCGCTGGAATTTGCCGTTGAAGCACAAAAACTCCTCGCCATCAGTCTTGAACACA
GCGTCGGATAAGGAATAAAC

Downstream 100 bases:

>100_bases
CGCGCTGCAACAGTGGCATCACTTGTTTGAAGCTGAGGGTGCAAAACGCTCCCCGCAAGCACAGCAGCATTTACAACAAT
TGCTGCGTACCGGACTGCCG

Product: cysteine desulfurase ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLSIKDLHVSVEDKTILRGLSLDVRPGEVHAIMGPNGSGKSTLSATLAGREDYEVTGGTVEFKGKDLLALSPEDRAGEGI
FMAFQYPVEIPGVSNQFFLQTALNAVRSYRGQETLDRFDFQDLMEEKIALLKMPEDLLTRSVNVGFSGGEKKRNDILQMA
VLEPELCILDESDSGLDIDALKVVADGVNSLRDGKRSFIIVTHYQRILDYIKPDYVHVLYQGRIVKSGDFTLVKQLEEQG
YGWLTEQQ

Sequences:

>Translated_248_residues
MLSIKDLHVSVEDKTILRGLSLDVRPGEVHAIMGPNGSGKSTLSATLAGREDYEVTGGTVEFKGKDLLALSPEDRAGEGI
FMAFQYPVEIPGVSNQFFLQTALNAVRSYRGQETLDRFDFQDLMEEKIALLKMPEDLLTRSVNVGFSGGEKKRNDILQMA
VLEPELCILDESDSGLDIDALKVVADGVNSLRDGKRSFIIVTHYQRILDYIKPDYVHVLYQGRIVKSGDFTLVKQLEEQG
YGWLTEQQ
>Mature_248_residues
MLSIKDLHVSVEDKTILRGLSLDVRPGEVHAIMGPNGSGKSTLSATLAGREDYEVTGGTVEFKGKDLLALSPEDRAGEGI
FMAFQYPVEIPGVSNQFFLQTALNAVRSYRGQETLDRFDFQDLMEEKIALLKMPEDLLTRSVNVGFSGGEKKRNDILQMA
VLEPELCILDESDSGLDIDALKVVADGVNSLRDGKRSFIIVTHYQRILDYIKPDYVHVLYQGRIVKSGDFTLVKQLEEQG
YGWLTEQQ

Specific function: Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May f

COG id: COG0396

COG function: function code O; ABC-type transport system involved in Fe-S cluster assembly, ATPase component

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI42741659, Length=239, Percent_Identity=28.0334728033473, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI9961252, Length=239, Percent_Identity=28.0334728033473, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4505771, Length=239, Percent_Identity=28.0334728033473, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI9961250, Length=239, Percent_Identity=28.0334728033473, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI156105685, Length=217, Percent_Identity=26.7281105990783, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787972, Length=248, Percent_Identity=99.1935483870968, Blast_Score=500, Evalue=1e-143,
Organism=Escherichia coli, GI1789864, Length=240, Percent_Identity=25, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI48994883, Length=249, Percent_Identity=29.3172690763052, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788761, Length=224, Percent_Identity=27.6785714285714, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786654, Length=245, Percent_Identity=25.7142857142857, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1786698, Length=207, Percent_Identity=27.536231884058, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787105, Length=221, Percent_Identity=29.4117647058824, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1787759, Length=243, Percent_Identity=27.5720164609054, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17541710, Length=236, Percent_Identity=29.6610169491525, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI193209708, Length=237, Percent_Identity=29.535864978903, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193202349, Length=234, Percent_Identity=30.3418803418803, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71996809, Length=221, Percent_Identity=25.3393665158371, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17567269, Length=237, Percent_Identity=25.3164556962025, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24641565, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85816269, Length=223, Percent_Identity=26.457399103139, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24580553, Length=223, Percent_Identity=26.457399103139, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI85724864, Length=223, Percent_Identity=26.457399103139, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24580555, Length=223, Percent_Identity=26.457399103139, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281363262, Length=220, Percent_Identity=28.6363636363636, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24653245, Length=220, Percent_Identity=28.6363636363636, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR010230 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 27632; Mature: 27632

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSIKDLHVSVEDKTILRGLSLDVRPGEVHAIMGPNGSGKSTLSATLAGREDYEVTGGTV
CCCEEEEEEEECCHHHHHCCCEECCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCEE
EFKGKDLLALSPEDRAGEGIFMAFQYPVEIPGVSNQFFLQTALNAVRSYRGQETLDRFDF
EECCCEEEEECCCCCCCCEEEEEEECCEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCCH
QDLMEEKIALLKMPEDLLTRSVNVGFSGGEKKRNDILQMAVLEPELCILDESDSGLDIDA
HHHHHHHHHHHCCCHHHHHCEECCCCCCCCHHHHHHHHHEECCCCEEEEECCCCCCCHHH
LKVVADGVNSLRDGKRSFIIVTHYQRILDYIKPDYVHVLYQGRIVKSGDFTLVKQLEEQG
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCEEEEEEECEEEECCCHHHHHHHHHCC
YGWLTEQQ
CCEECCCC
>Mature Secondary Structure
MLSIKDLHVSVEDKTILRGLSLDVRPGEVHAIMGPNGSGKSTLSATLAGREDYEVTGGTV
CCCEEEEEEEECCHHHHHCCCEECCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCEE
EFKGKDLLALSPEDRAGEGIFMAFQYPVEIPGVSNQFFLQTALNAVRSYRGQETLDRFDF
EECCCEEEEECCCCCCCCEEEEEEECCEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCCH
QDLMEEKIALLKMPEDLLTRSVNVGFSGGEKKRNDILQMAVLEPELCILDESDSGLDIDA
HHHHHHHHHHHCCCHHHHHCEECCCCCCCCHHHHHHHHHEECCCCEEEEECCCCCCCHHH
LKVVADGVNSLRDGKRSFIIVTHYQRILDYIKPDYVHVLYQGRIVKSGDFTLVKQLEEQG
HHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCEEEEEEECEEEECCCHHHHHHHHHCC
YGWLTEQQ
CCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 10322040 [H]