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The map label for this gene is yoaE [H]

Identifier: 218548626

GI number: 218548626

Start: 1296912

End: 1298498

Strand: Direct

Name: yoaE [H]

Synonym: EFER_1260

Alternate gene names: 218548626

Gene position: 1296912-1298498 (Clockwise)

Preceding gene: 218548619

Following gene: 218548631

Centisome position: 28.26

GC content: 50.47

Gene sequence:

>1587_bases
TTGTCATTCCTTAAGCAGGAGCTTGTCATGGAATTCTTAATGGACCCCTCGATATGGGCGGGTTTGCTCACGCTTGTCGT
TCTCGAGATTGTTCTCGGGATCGATAATCTGGTCTTCATCGCCATTCTTGCCGACAAACTGCCACCAAAACAGCGTGATA
AAGCGCGCTTACTGGGTTTATCGCTGGCGTTAATCATGCGTCTGGCGTTGTTGTCGATTATTTCGTGGATGGTGACGCTA
ACTAAGCCGCTGTTCTCAGTAATGGATTTCACCTTCTCAGGGCGTGACCTGATCATGCTGTTGGGGGGGATATTCTTATT
GTTCAAAGCCACAACGGAATTGCATGAACGGCTGGAGAATCGCGAGCATGACTCCGGGCATGGCAAAGGTTATGCCAGCT
TCTGGGTAGTGGTAACGCAAATTGTCATTCTGGACGCCGTGTTCTCACTTGATGCTGTAATTACTGCTGTAGGGATGGTA
AACCATCTGCCGGTAATGATGGCTGCCGTCGTGATAGCGATGGCTGTAATGCTCCTGGCCTCGAAACCGCTGACACGTTT
CGTCAACCAACATCCCACGGTTGTGGTGCTCTGCCTGAGCTTCCTGTTGATGATTGGTCTGAGTCTGGTCGCGGAAGGTT
TCGGCTTCCATATTCCGAAAGGTTACCTGTACGCGGCGATTGGTTTCTCGATCATCATCGAAGTGTTTAACCAGATTGCA
CGTCGTAACTTTATTCGCCACCAGTCAACTTTGCCTTTGCGGGCGCGTACAGCGGATGCCATTTTGCGATTGATGGGTGG
AAAACGTCAGGTAAATGTTCAGCACGATGGCGACAATCAGGTGGCAATACCGGTACCAGAAGGTGCATTTGCGGAAGAAG
AACGGTATATGATCAACGGAGTGTTGACTCTGGCTTCACGTTCTCTGCGTGGCATTATGACGCCGCGCGGGGAAATAAGT
TGGGTTGATGCCAACCTGAGTGTCGACGAAATCCGTCAGCAATTGCTCTCTTCTCCTCATAGTCTGTTCCCGGTTTGTCG
CGGTGAACTGGATGAAATCATCGGTATTGTGCGTGCCAAAGAGTTGCTGGTGGCATTGGAAGAAGGAGTGGATGTTGCGG
CAATTGCTTCGGCTTCTCCGGCCATTGTCGTGCCAGAAACTCTCGACCCAATCAACCTGTTGGGCGTTTTGCGCCGTGCT
CGTGGTAGTTTTGTTATCGTGACTAACGAGTTTGGCGTAGTTCAGGGGCTGGTTACACCGCTGGATGTGCTGGAAGCGAT
AGCTGGTGAGTTCCCGGATGCTGACGAAACGCCAGAAATTATCACTGATGGCGACGGCTGGCTGGTTAAAGGCGGAACGG
ATTTACATGCCTTACAGCAAGCCCTGGCGGTAGATCACCTGGTTGATGACGATGATGATATCGCTACCGTTGCTGGCCTG
GTGATTGCCGCAAATGGTCACATTCCCCGTATTGGTGATGTGATTGACGTTGGACCGTTGCATATCACTATTGTTGAAGC
TAACGACTATCGCGTTGATTTGGTTCGTATTGTTAAAGATAAACCGCTCAACGACGAAGACGAGTAA

Upstream 100 bases:

>100_bases
TTTTCATCTTCAGGCCGCAAAACGCCTGCCATTCTGGCAACTTTTGCCACTCTACTTATTTGCCTAAAGCTGTATCGCCT
GCGTTAATCCTGGCGTCAAT

Downstream 100 bases:

>100_bases
CGCTAACGTAATGGCATGACGGGGGTAACATGCCCGTTATGCCGGGTGCCCGGGGGCTGGCTTCCTGCCAGCCATTTGGG
AAAATCGCGCAGTGGCATTG

Product: membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MSFLKQELVMEFLMDPSIWAGLLTLVVLEIVLGIDNLVFIAILADKLPPKQRDKARLLGLSLALIMRLALLSIISWMVTL
TKPLFSVMDFTFSGRDLIMLLGGIFLLFKATTELHERLENREHDSGHGKGYASFWVVVTQIVILDAVFSLDAVITAVGMV
NHLPVMMAAVVIAMAVMLLASKPLTRFVNQHPTVVVLCLSFLLMIGLSLVAEGFGFHIPKGYLYAAIGFSIIIEVFNQIA
RRNFIRHQSTLPLRARTADAILRLMGGKRQVNVQHDGDNQVAIPVPEGAFAEEERYMINGVLTLASRSLRGIMTPRGEIS
WVDANLSVDEIRQQLLSSPHSLFPVCRGELDEIIGIVRAKELLVALEEGVDVAAIASASPAIVVPETLDPINLLGVLRRA
RGSFVIVTNEFGVVQGLVTPLDVLEAIAGEFPDADETPEIITDGDGWLVKGGTDLHALQQALAVDHLVDDDDDIATVAGL
VIAANGHIPRIGDVIDVGPLHITIVEANDYRVDLVRIVKDKPLNDEDE

Sequences:

>Translated_528_residues
MSFLKQELVMEFLMDPSIWAGLLTLVVLEIVLGIDNLVFIAILADKLPPKQRDKARLLGLSLALIMRLALLSIISWMVTL
TKPLFSVMDFTFSGRDLIMLLGGIFLLFKATTELHERLENREHDSGHGKGYASFWVVVTQIVILDAVFSLDAVITAVGMV
NHLPVMMAAVVIAMAVMLLASKPLTRFVNQHPTVVVLCLSFLLMIGLSLVAEGFGFHIPKGYLYAAIGFSIIIEVFNQIA
RRNFIRHQSTLPLRARTADAILRLMGGKRQVNVQHDGDNQVAIPVPEGAFAEEERYMINGVLTLASRSLRGIMTPRGEIS
WVDANLSVDEIRQQLLSSPHSLFPVCRGELDEIIGIVRAKELLVALEEGVDVAAIASASPAIVVPETLDPINLLGVLRRA
RGSFVIVTNEFGVVQGLVTPLDVLEAIAGEFPDADETPEIITDGDGWLVKGGTDLHALQQALAVDHLVDDDDDIATVAGL
VIAANGHIPRIGDVIDVGPLHITIVEANDYRVDLVRIVKDKPLNDEDE
>Mature_527_residues
SFLKQELVMEFLMDPSIWAGLLTLVVLEIVLGIDNLVFIAILADKLPPKQRDKARLLGLSLALIMRLALLSIISWMVTLT
KPLFSVMDFTFSGRDLIMLLGGIFLLFKATTELHERLENREHDSGHGKGYASFWVVVTQIVILDAVFSLDAVITAVGMVN
HLPVMMAAVVIAMAVMLLASKPLTRFVNQHPTVVVLCLSFLLMIGLSLVAEGFGFHIPKGYLYAAIGFSIIIEVFNQIAR
RNFIRHQSTLPLRARTADAILRLMGGKRQVNVQHDGDNQVAIPVPEGAFAEEERYMINGVLTLASRSLRGIMTPRGEISW
VDANLSVDEIRQQLLSSPHSLFPVCRGELDEIIGIVRAKELLVALEEGVDVAAIASASPAIVVPETLDPINLLGVLRRAR
GSFVIVTNEFGVVQGLVTPLDVLEAIAGEFPDADETPEIITDGDGWLVKGGTDLHALQQALAVDHLVDDDDDIATVAGLV
IAANGHIPRIGDVIDVGPLHITIVEANDYRVDLVRIVKDKPLNDEDE

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=254, Percent_Identity=23.6220472440945, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788119, Length=519, Percent_Identity=94.7976878612717, Blast_Score=965, Evalue=0.0,
Organism=Escherichia coli, GI87082033, Length=531, Percent_Identity=49.9058380414313, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1789197, Length=236, Percent_Identity=48.728813559322, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1790664, Length=241, Percent_Identity=26.5560165975104, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786879, Length=244, Percent_Identity=31.9672131147541, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693175, Length=236, Percent_Identity=30.5084745762712, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005496
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF03741 TerC [H]

EC number: NA

Molecular weight: Translated: 57643; Mature: 57512

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HEEECCCCCCCCCEEECCCEEEEEEECCCCEEHHHHEECCCCCCCCCC
>Mature Secondary Structure 
SFLKQELVMEFLMDPSIWAGLLTLVVLEIVLGIDNLVFIAILADKLPPKQRDKARLLGL
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHH
SLALIMRLALLSIISWMVTLTKPLFSVMDFTFSGRDLIMLLGGIFLLFKATTELHERLEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
REHDSGHGKGYASFWVVVTQIVILDAVFSLDAVITAVGMVNHLPVMMAAVVIAMAVMLLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKPLTRFVNQHPTVVVLCLSFLLMIGLSLVAEGFGFHIPKGYLYAAIGFSIIIEVFNQIA
CCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RRNFIRHQSTLPLRARTADAILRLMGGKRQVNVQHDGDNQVAIPVPEGAFAEEERYMING
HHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHH
VLTLASRSLRGIMTPRGEISWVDANLSVDEIRQQLLSSPHSLFPVCRGELDEIIGIVRAK
HHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ELLVALEEGVDVAAIASASPAIVVPETLDPINLLGVLRRARGSFVIVTNEFGVVQGLVTP
HHHHHHHCCCCEEEECCCCCCEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
LDVLEAIAGEFPDADETPEIITDGDGWLVKGGTDLHALQQALAVDHLVDDDDDIATVAGL
HHHHHHHHCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
VIAANGHIPRIGDVIDVGPLHITIVEANDYRVDLVRIVKDKPLNDEDE
HEEECCCCCCCCCEEECCCEEEEEEECCCCEEHHHHEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]