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The map label for this gene is ptrB [H]

Identifier: 218548594

GI number: 218548594

Start: 1269504

End: 1271579

Strand: Direct

Name: ptrB [H]

Synonym: EFER_1228

Alternate gene names: 218548594

Gene position: 1269504-1271579 (Clockwise)

Preceding gene: 218548593

Following gene: 218548598

Centisome position: 27.67

GC content: 47.83

Gene sequence:

>2076_bases
ATGCTACCGAAAGCTAACCGAATACCCCATGAGTTAACGCTACATGGCGACACGCGCATCGATAATTATTTCTGGCTGCG
GGATGACACCCGCTCGCAGCCAGAAGTGCTGGAGTATCTCAAAGATGAAAATGCGTACGGACACCAAATTATGTCTACGC
AGCAGGCGCTCCAGGAGCGGGTATTAAAGGAGATTATCGACCGTATTCCGCCGCGAGAAGAATCAGCACCCTATGTGAAA
AACGGTTATCGCTATCGTCATATTTACGAACCAGGTTGCGAATACGCCATTTATCAACGCCAGTCGGTGCTCAGTGAAGA
GTGGGATGAGTGGACCACATTACTGGATGCGAACAAACGCGCAGCACATAGTGAGTTTTATTCACTCGGTGGGCTTGCTA
TCTCGCCTGATAACACCATTATGGCACTGGCGGAAGATTATCTTTCACGGCGGCAATACGGCATTCGTTTTCGTAACCTG
CAAACCGGTAACTGGTATCCAGAATTGCTCGACAATGTGGCACCGGAATTTGTCTGGGCCAATGACTCGCTCACTTTTTA
TTATGTGCGAAAACATCCCACCACACTTTTGCCTTATCAGGTTTGGCGGCATAACGTTGGCACGCCATTCACTCACGATG
AGCTTATCTATGAAGAGAAAGACGACACGTTTTATGTCAGTCTGCACAAAACCACATCAAAACATTATGTGGTGATTCAT
CTGGCCAGTGCTACAACCAGCGAAGTGCAACTGTTGGACGCAGAATTAGCCGATGCCGAACCGTTTGTCTTTCTGCCAAG
ACGTAAAGATCACGAATACAGTCTCGACCACTATCAACATAAGTTTTATCTGCGTTCAAATCGAAATGGTAAAAACTTTG
GCCTTTACCGTACCCGGGTGCGTGATGAGCAGGCGTGGGAAGAACTGATCCCGCCGCGTGAAAACATTATGCTGGAAGGA
TTTACGCTGTTTACCGACTGGCTGGTGGTAGAGGAGAGGCAACGCGGCCTGACAAGTTTGCGGCAAATTAATCGCAAAAC
ACGGGAAGTGATTGGTATAGCCTTTGATGATCCTGCATATGTAACCTGGCTTGCTTACAATCCAGAACCTGAAACCTCGC
GTTTGCGCTATGGTTACTCCTCGATGACCACACCAGATACTTTATTTGAACTGGACATGGATACCGGTGAACGACGCGCC
CTTAAGCAGACAGAAGTGCCCGGTTTTAATCCTGATAACTATCGCAGTGAACATGTGTGGATTACGGCGAGAGATGGCGT
CGAAGTGCCAGTTTCTCTGGTTTACCATCGAAAACATTTTCGTAAGGGACAAAATCCGTTGCTGGTGTATGGCTATGGCT
CATACGGGGCAAGTATTGATGCGGATTTCAGTAGTAGCCGACTCAGCCTGTTGGATCGCGGGTTTGTTTACGCCATTGTG
CATGTGCGTGGAGGCGGTGAACTGGGGCAACAATGGTACGAAGATGGCAAGTTTCTCAAAAAGAAAAATACCTTCAACGA
CTATCTTGATGCTTGCGATGCGTTATTAAAACTGGGCTACGGTTCACCTTCACTTTGTTTCGGCATGGGAGGGAGTGCAG
GCGGGATGTTAATGGGGGTTGCCATTAATGAACGACCTGAACTGTTTCACGGTGTTATTGCGCAAGTTCCGTTTGTCGAT
GTACTGACAACAATGCTTGATGAGTCGATCCCTTTAACGACAGGAGAATTCGAAGAGTGGGGCAATCCGCAAGATCCCGA
GTATTACAGCTATATAAAAAGCTACAGCCCGTATGACAATGTTACTACGCAGGATTACCCCCATCTGCTGGTGACAACTG
GTCTGCATGATTCACAAGTACAATACTGGGAACCGGCAAAATGGGTCGCTAAACTGCGGGAATTAAAAACCGACAAAAAT
CTTTTACTGCTCTGTACAGACATGGATTCGGGGCATGGTGGGAAATCCGGGCGCTTTAAATCTTATGAAGGCGTAGCCCT
GGAGTTCGCATTTTTGATCGCACTGGCGCAGGGAACATTACCAGGCACTACGCACAATCACGCATTTCCCAGATAA

Upstream 100 bases:

>100_bases
TTGTCAGGTTAACGTCCCATCATAGAGTTGCATGTTTCGCTTGCATCCCGGGTGACTTTTGCCACCCTTATAGGATGTTT
CATTCAGAAAGAACAATAAC

Downstream 100 bases:

>100_bases
TGTTTCAGCGTTAACCGTAGTTCCGGGCTCATACTGTCGAGATTATTAAACAACCATCGCAGGTAGCCCGGATCACGTTC
AGCAATTTCAGAGACCGCTT

Product: protease 2

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 691; Mature: 691

Protein sequence:

>691_residues
MLPKANRIPHELTLHGDTRIDNYFWLRDDTRSQPEVLEYLKDENAYGHQIMSTQQALQERVLKEIIDRIPPREESAPYVK
NGYRYRHIYEPGCEYAIYQRQSVLSEEWDEWTTLLDANKRAAHSEFYSLGGLAISPDNTIMALAEDYLSRRQYGIRFRNL
QTGNWYPELLDNVAPEFVWANDSLTFYYVRKHPTTLLPYQVWRHNVGTPFTHDELIYEEKDDTFYVSLHKTTSKHYVVIH
LASATTSEVQLLDAELADAEPFVFLPRRKDHEYSLDHYQHKFYLRSNRNGKNFGLYRTRVRDEQAWEELIPPRENIMLEG
FTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAYVTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRA
LKQTEVPGFNPDNYRSEHVWITARDGVEVPVSLVYHRKHFRKGQNPLLVYGYGSYGASIDADFSSSRLSLLDRGFVYAIV
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCFGMGGSAGGMLMGVAINERPELFHGVIAQVPFVD
VLTTMLDESIPLTTGEFEEWGNPQDPEYYSYIKSYSPYDNVTTQDYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDKN
LLLLCTDMDSGHGGKSGRFKSYEGVALEFAFLIALAQGTLPGTTHNHAFPR

Sequences:

>Translated_691_residues
MLPKANRIPHELTLHGDTRIDNYFWLRDDTRSQPEVLEYLKDENAYGHQIMSTQQALQERVLKEIIDRIPPREESAPYVK
NGYRYRHIYEPGCEYAIYQRQSVLSEEWDEWTTLLDANKRAAHSEFYSLGGLAISPDNTIMALAEDYLSRRQYGIRFRNL
QTGNWYPELLDNVAPEFVWANDSLTFYYVRKHPTTLLPYQVWRHNVGTPFTHDELIYEEKDDTFYVSLHKTTSKHYVVIH
LASATTSEVQLLDAELADAEPFVFLPRRKDHEYSLDHYQHKFYLRSNRNGKNFGLYRTRVRDEQAWEELIPPRENIMLEG
FTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAYVTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRA
LKQTEVPGFNPDNYRSEHVWITARDGVEVPVSLVYHRKHFRKGQNPLLVYGYGSYGASIDADFSSSRLSLLDRGFVYAIV
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCFGMGGSAGGMLMGVAINERPELFHGVIAQVPFVD
VLTTMLDESIPLTTGEFEEWGNPQDPEYYSYIKSYSPYDNVTTQDYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDKN
LLLLCTDMDSGHGGKSGRFKSYEGVALEFAFLIALAQGTLPGTTHNHAFPR
>Mature_691_residues
MLPKANRIPHELTLHGDTRIDNYFWLRDDTRSQPEVLEYLKDENAYGHQIMSTQQALQERVLKEIIDRIPPREESAPYVK
NGYRYRHIYEPGCEYAIYQRQSVLSEEWDEWTTLLDANKRAAHSEFYSLGGLAISPDNTIMALAEDYLSRRQYGIRFRNL
QTGNWYPELLDNVAPEFVWANDSLTFYYVRKHPTTLLPYQVWRHNVGTPFTHDELIYEEKDDTFYVSLHKTTSKHYVVIH
LASATTSEVQLLDAELADAEPFVFLPRRKDHEYSLDHYQHKFYLRSNRNGKNFGLYRTRVRDEQAWEELIPPRENIMLEG
FTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAYVTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRA
LKQTEVPGFNPDNYRSEHVWITARDGVEVPVSLVYHRKHFRKGQNPLLVYGYGSYGASIDADFSSSRLSLLDRGFVYAIV
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCFGMGGSAGGMLMGVAINERPELFHGVIAQVPFVD
VLTTMLDESIPLTTGEFEEWGNPQDPEYYSYIKSYSPYDNVTTQDYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDKN
LLLLCTDMDSGHGGKSGRFKSYEGVALEFAFLIALAQGTLPGTTHNHAFPR

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=696, Percent_Identity=24.2816091954023, Blast_Score=188, Evalue=2e-47,
Organism=Homo sapiens, GI284172420, Length=477, Percent_Identity=30.8176100628931, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI284172413, Length=477, Percent_Identity=30.8176100628931, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI70778815, Length=477, Percent_Identity=30.8176100628931, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI284172438, Length=477, Percent_Identity=30.8176100628931, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI284172431, Length=477, Percent_Identity=30.8176100628931, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI108860692, Length=314, Percent_Identity=35.031847133758, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI108860686, Length=214, Percent_Identity=41.588785046729, Blast_Score=152, Evalue=1e-36,
Organism=Escherichia coli, GI1788150, Length=683, Percent_Identity=90.0439238653001, Blast_Score=1309, Evalue=0.0,
Organism=Drosophila melanogaster, GI24583414, Length=697, Percent_Identity=24.390243902439, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI221510989, Length=704, Percent_Identity=26.1363636363636, Blast_Score=162, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 79864; Mature: 79864

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPKANRIPHELTLHGDTRIDNYFWLRDDTRSQPEVLEYLKDENAYGHQIMSTQQALQER
CCCCCCCCCCEEEECCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
VLKEIIDRIPPREESAPYVKNGYRYRHIYEPGCEYAIYQRQSVLSEEWDEWTTLLDANKR
HHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCH
AAHSEFYSLGGLAISPDNTIMALAEDYLSRRQYGIRFRNLQTGNWYPELLDNVAPEFVWA
HHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHCCCCCEEEE
NDSLTFYYVRKHPTTLLPYQVWRHNVGTPFTHDELIYEEKDDTFYVSLHKTTSKHYVVIH
CCCEEEEEEECCCCEECCHHHHHCCCCCCCCCCCCEEECCCCEEEEEEEECCCCCEEEEE
LASATTSEVQLLDAELADAEPFVFLPRRKDHEYSLDHYQHKFYLRSNRNGKNFGLYRTRV
EECCCCCHHEEEEHHHCCCCCEEEECCCCCCCCCCCHHEEEEEEEECCCCCCCCEEEECC
RDEQAWEELIPPRENIMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAY
CCHHHHHHHCCCCHHEEEECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCE
VTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRALKQTEVPGFNPDNYRSEHVW
EEEEEECCCCCCHHEEECCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEE
ITARDGVEVPVSLVYHRKHFRKGQNPLLVYGYGSYGASIDADFSSSRLSLLDRGFVYAIV
EEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCCHHHHHHHCCEEEEEE
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCFGMGGSAGGMLMGV
EEECCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEE
AINERPELFHGVIAQVPFVDVLTTMLDESIPLTTGEFEEWGNPQDPEYYSYIKSYSPYDN
EECCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHCCCCCCC
VTTQDYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDKNLLLLCTDMDSGHGGKSGRFK
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCC
SYEGVALEFAFLIALAQGTLPGTTHNHAFPR
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLPKANRIPHELTLHGDTRIDNYFWLRDDTRSQPEVLEYLKDENAYGHQIMSTQQALQER
CCCCCCCCCCEEEECCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
VLKEIIDRIPPREESAPYVKNGYRYRHIYEPGCEYAIYQRQSVLSEEWDEWTTLLDANKR
HHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCH
AAHSEFYSLGGLAISPDNTIMALAEDYLSRRQYGIRFRNLQTGNWYPELLDNVAPEFVWA
HHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHCCCCCEEEE
NDSLTFYYVRKHPTTLLPYQVWRHNVGTPFTHDELIYEEKDDTFYVSLHKTTSKHYVVIH
CCCEEEEEEECCCCEECCHHHHHCCCCCCCCCCCCEEECCCCEEEEEEEECCCCCEEEEE
LASATTSEVQLLDAELADAEPFVFLPRRKDHEYSLDHYQHKFYLRSNRNGKNFGLYRTRV
EECCCCCHHEEEEHHHCCCCCEEEECCCCCCCCCCCHHEEEEEEEECCCCCCCCEEEECC
RDEQAWEELIPPRENIMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAY
CCHHHHHHHCCCCHHEEEECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCE
VTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRALKQTEVPGFNPDNYRSEHVW
EEEEEECCCCCCHHEEECCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEE
ITARDGVEVPVSLVYHRKHFRKGQNPLLVYGYGSYGASIDADFSSSRLSLLDRGFVYAIV
EEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCCHHHHHHHCCEEEEEE
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCFGMGGSAGGMLMGV
EEECCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEE
AINERPELFHGVIAQVPFVDVLTTMLDESIPLTTGEFEEWGNPQDPEYYSYIKSYSPYDN
EECCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHCCCCCCC
VTTQDYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDKNLLLLCTDMDSGHGGKSGRFK
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCC
SYEGVALEFAFLIALAQGTLPGTTHNHAFPR
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1769955; 9097040; 9278503 [H]