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The map label for this gene is lysR [H]

Identifier: 218548521

GI number: 218548521

Start: 1189455

End: 1190369

Strand: Reverse

Name: lysR [H]

Synonym: EFER_1150

Alternate gene names: 218548521

Gene position: 1190369-1189455 (Counterclockwise)

Preceding gene: 218548523

Following gene: 218548520

Centisome position: 25.94

GC content: 48.85

Gene sequence:

>915_bases
ATGAAACTGCGCCACCTGGAAATCTTCTATGCTGTGATGACATGCGGGACACTTTCACGGGCAGCGGAATCGCTGAATAT
TTCCCAGCCGGCCGCCAGTAAAGCGTTAAAAAACGCTGAGCAAAAACTCGGTTTTCAGCTCTTTCAGCGAGTACGTGGCA
AGCTTCTTCCAACCAGCGAAGCGCTCACACTTTTTGAAAAAGCGCAGTCGATTTATCACGAACTCGACAACCTGCGACTG
CTGGCCGATAACCTGACGCGAGATCCGCGAGCCAGAATAGCCCTGGGATGCCTGCCAAGCCTGGGATTAAGTCTGGTGCC
AGAAATAGTCACTGCGTTTTACCAGCAGAATGCGAATCTGGTAATGACACTGACGACAGAACACACCGAAACGTTGGTTA
AAAAACTTGATCTCCGTGAGATTGATCTGGCCCTGACGCTACAGCCGATTCAACAGGGGGAGATTATGACGACGCTGATA
GCCGAAGTTCCGCTGGTTTATATAGACCGGGACTATCGCCAGGGCGCAGTAGAAATAGACAAGATTGACCAGCAACGCTG
GATTTCTCCCGGTCCCTATTCCCTTTCCGATGCAATAGCCAAACGGCGTGACTTTTTGACGACGCGCCTGAATGTCCAGA
CCTATTACATGGCGACGGAATTTGTAAAACGAGGAATGGGATGCAGTATTACCGATATTTTCTCTGCCCGTCATAACCTT
CCGGCAGAGACGATTCACCCCATCGAACCCCCAATGAAAATAGACCTTTGTTTGTTACGCCGTGCCGACGTTTCACTTAG
CCCTATTACACAAAAATTTGTCGATTTCCTTTGTCAGCAATTACGTCTTCAGCTGCGAGCCATTAACCTTGAGTTATACC
CTGAAAATAAAAAGTCAATTGCTCCTCAGGCCTAA

Upstream 100 bases:

>100_bases
ATTGTTACCAGAACAGGCGTTACAGATTAAATTTATGTTAACTTGGTGTTACCATGAAATGACTTTTTATCTACCGTCTA
TAACTCTGGGTTAACTCTTA

Downstream 100 bases:

>100_bases
ATGTTTTGACATAACCCCAACGCATTTATTAGCGGTGGATATCTCAAGTAATGAAAAAACGCATTGTAGTTATTGGCGGC
GGGGTAATTGGTCTGGCAAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKLRHLEIFYAVMTCGTLSRAAESLNISQPAASKALKNAEQKLGFQLFQRVRGKLLPTSEALTLFEKAQSIYHELDNLRL
LADNLTRDPRARIALGCLPSLGLSLVPEIVTAFYQQNANLVMTLTTEHTETLVKKLDLREIDLALTLQPIQQGEIMTTLI
AEVPLVYIDRDYRQGAVEIDKIDQQRWISPGPYSLSDAIAKRRDFLTTRLNVQTYYMATEFVKRGMGCSITDIFSARHNL
PAETIHPIEPPMKIDLCLLRRADVSLSPITQKFVDFLCQQLRLQLRAINLELYPENKKSIAPQA

Sequences:

>Translated_304_residues
MKLRHLEIFYAVMTCGTLSRAAESLNISQPAASKALKNAEQKLGFQLFQRVRGKLLPTSEALTLFEKAQSIYHELDNLRL
LADNLTRDPRARIALGCLPSLGLSLVPEIVTAFYQQNANLVMTLTTEHTETLVKKLDLREIDLALTLQPIQQGEIMTTLI
AEVPLVYIDRDYRQGAVEIDKIDQQRWISPGPYSLSDAIAKRRDFLTTRLNVQTYYMATEFVKRGMGCSITDIFSARHNL
PAETIHPIEPPMKIDLCLLRRADVSLSPITQKFVDFLCQQLRLQLRAINLELYPENKKSIAPQA
>Mature_304_residues
MKLRHLEIFYAVMTCGTLSRAAESLNISQPAASKALKNAEQKLGFQLFQRVRGKLLPTSEALTLFEKAQSIYHELDNLRL
LADNLTRDPRARIALGCLPSLGLSLVPEIVTAFYQQNANLVMTLTTEHTETLVKKLDLREIDLALTLQPIQQGEIMTTLI
AEVPLVYIDRDYRQGAVEIDKIDQQRWISPGPYSLSDAIAKRRDFLTTRLNVQTYYMATEFVKRGMGCSITDIFSARHNL
PAETIHPIEPPMKIDLCLLRRADVSLSPITQKFVDFLCQQLRLQLRAINLELYPENKKSIAPQA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=146, Percent_Identity=35.6164383561644, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081904, Length=170, Percent_Identity=32.3529411764706, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788887, Length=249, Percent_Identity=25.7028112449799, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790399, Length=165, Percent_Identity=28.4848484848485, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693105, Length=288, Percent_Identity=22.2222222222222, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788297, Length=247, Percent_Identity=24.2914979757085, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34453; Mature: 34453

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRHLEIFYAVMTCGTLSRAAESLNISQPAASKALKNAEQKLGFQLFQRVRGKLLPTSE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALTLFEKAQSIYHELDNLRLLADNLTRDPRARIALGCLPSLGLSLVPEIVTAFYQQNANL
HHHHHHHHHHHHHHHHHHEEHHHHCCCCCHHHEEHHCHHHHHHHHHHHHHHHHHHCCCCE
VMTLTTEHTETLVKKLDLREIDLALTLQPIQQGEIMTTLIAEVPLVYIDRDYRQGAVEID
EEEEECHHHHHHHHHCCHHHCCEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCEEHH
KIDQQRWISPGPYSLSDAIAKRRDFLTTRLNVQTYYMATEFVKRGMGCSITDIFSARHNL
HCCHHHCCCCCCCCHHHHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
PAETIHPIEPPMKIDLCLLRRADVSLSPITQKFVDFLCQQLRLQLRAINLELYPENKKSI
CCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
APQA
CCCC
>Mature Secondary Structure
MKLRHLEIFYAVMTCGTLSRAAESLNISQPAASKALKNAEQKLGFQLFQRVRGKLLPTSE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALTLFEKAQSIYHELDNLRLLADNLTRDPRARIALGCLPSLGLSLVPEIVTAFYQQNANL
HHHHHHHHHHHHHHHHHHEEHHHHCCCCCHHHEEHHCHHHHHHHHHHHHHHHHHHCCCCE
VMTLTTEHTETLVKKLDLREIDLALTLQPIQQGEIMTTLIAEVPLVYIDRDYRQGAVEID
EEEEECHHHHHHHHHCCHHHCCEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCEEHH
KIDQQRWISPGPYSLSDAIAKRRDFLTTRLNVQTYYMATEFVKRGMGCSITDIFSARHNL
HCCHHHCCCCCCCCHHHHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
PAETIHPIEPPMKIDLCLLRRADVSLSPITQKFVDFLCQQLRLQLRAINLELYPENKKSI
CCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
APQA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]