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The map label for this gene is atoB [H]

Identifier: 218548316

GI number: 218548316

Start: 958103

End: 959287

Strand: Reverse

Name: atoB [H]

Synonym: EFER_0935

Alternate gene names: 218548316

Gene position: 959287-958103 (Counterclockwise)

Preceding gene: 218548317

Following gene: 218548314

Centisome position: 20.91

GC content: 54.35

Gene sequence:

>1185_bases
ATGAAAAATTGTGTCATCGTCAGTGCGGTACGTACTGCCATCGGTAGCTTTAACGGTTCACTAGCCTCCACCAGCGCCAT
CGACCTGGGGGCAACGGTGATCCAGGCCGCTATAGAACGCGCAAATATCGATTCACAACACGTTGATGAAGTGATTATGG
GTAACGTGTTGCAAGCCGGGCTGGGGCAAAATCCGGCACGTCAGGCACTGCTAAAAAGCGGACTGGCAGAAACGGTATGT
GGCTTCACGGTCAATAAAGTGTGTGGTTCGGGTCTCAAAAGTGTGGCGCTTGCCGCCCAGGCGATTCAGGCAGGTCAGGC
GCAGAGCATCGTAGCAGGTGGAATGGAGAACATGAGTTTGGCGCCCTACTTACTCGATGCAAAAGCACGATCGGGTTATC
GTCTGGGAGACGGACAGGTTTATGACGTAATCCTGCGCGATGGCCTGATGTGCGCCACCCATGGTTATCATATGGGAATT
ACCGCCGAAAACGTGGCTAAGGAGTACGGGATCACCCGTGAAATGCAGGATGAAATGGCGCTACATTCACAGCGTAAAGC
GGCAGCCGCAATTGAGTCCGGTGCTTTTACAGCCGAAATCGTCCCGGTAAATGTTGTCACCCGGAAGAAAACCCTCGTCT
TCAGTCAAGACGAATTCCCGAAAGCGGATTCTACGGCTGAATCATTAGGCGCATTGCGCCCGGCCTTCGATAAAGCCGGA
ACTGTCACCGCCGGGAACGCGTCTGGCATTAACGACGGTGCTGCCGCACTGGTGATTATGGAAGAATCTGCGGCACTGGC
AGCAGGCCTTACCCCACTGGCACGCATTAAAAGTTATGCCAGCGGCGGCGTGGCTCCCTCAATGATGGGGTTGGGGCCAG
TACCTGCCACGCAAAAAGCGTTACAACTGGCGGGGCTGCAACTGGCAGACATTGATCTTATCGAAGCCAATGAAGCATTT
GCCGCGCAGTTCCTTGCCGTTGGGAAAACACTGGGCTTTGATCCTGAGAAAGTGAATGTCAACGGCGGGGCCATCGCGCT
GGGGCATCCTATCGGCGCCAGCGGTGCGCGTATTCTGGTCACACTATTACATGCAATGCAGGCACGCGATAAAACGCTGG
GTCTGGCAACGTTGTGCATTGGCGGCGGTCAAGGAATTGCGATGGTGATTGAACGATTGAATTAA

Upstream 100 bases:

>100_bases
GACATCATGGGCTATTGCATTACTGCCCTGCTCTTCTCCGGTGTCATTTTCATTATTGGTTTAACGCTGTTCTGACGGCA
ACTTTATAAAAGGAAGAAAA

Downstream 100 bases:

>100_bases
CAAATCAGAACCACTCGCATGGCGGGTGGTTATCTGTTTCAGCCACGATGCGCCAGAAACAGACTAAGTCAGAAAAGTAA
AGGGCCGAATTTTCGGCCCT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIQAAIERANIDSQHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGI
TAENVAKEYGITREMQDEMALHSQRKAAAAIESGAFTAEIVPVNVVTRKKTLVFSQDEFPKADSTAESLGALRPAFDKAG
TVTAGNASGINDGAAALVIMEESAALAAGLTPLARIKSYASGGVAPSMMGLGPVPATQKALQLAGLQLADIDLIEANEAF
AAQFLAVGKTLGFDPEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN

Sequences:

>Translated_394_residues
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIQAAIERANIDSQHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGI
TAENVAKEYGITREMQDEMALHSQRKAAAAIESGAFTAEIVPVNVVTRKKTLVFSQDEFPKADSTAESLGALRPAFDKAG
TVTAGNASGINDGAAALVIMEESAALAAGLTPLARIKSYASGGVAPSMMGLGPVPATQKALQLAGLQLADIDLIEANEAF
AAQFLAVGKTLGFDPEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN
>Mature_394_residues
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIQAAIERANIDSQHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGI
TAENVAKEYGITREMQDEMALHSQRKAAAAIESGAFTAEIVPVNVVTRKKTLVFSQDEFPKADSTAESLGALRPAFDKAG
TVTAGNASGINDGAAALVIMEESAALAAGLTPLARIKSYASGGVAPSMMGLGPVPATQKALQLAGLQLADIDLIEANEAF
AAQFLAVGKTLGFDPEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=54.1025641025641, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=45.2020202020202, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=43.1818181818182, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI4501853, Length=401, Percent_Identity=41.3965087281795, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=33.1764705882353, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=33.1632653061224, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=96.9543147208122, Blast_Score=741, Evalue=0.0,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=57.6530612244898, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.7920792079208, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=43.3915211970075, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=35.6973995271868, Blast_Score=205, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=46.5648854961832, Blast_Score=329, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=44.0203562340967, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=42.6395939086294, Blast_Score=283, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17535917, Length=404, Percent_Identity=33.9108910891089, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.3943661971831, Blast_Score=184, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=44.4723618090452, Blast_Score=303, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=37.7833753148615, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=53.8071065989848, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=47.0737913486005, Blast_Score=313, Evalue=9e-86,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=43.3673469387755, Blast_Score=290, Evalue=9e-79,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=32.2352941176471, Blast_Score=174, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40327; Mature: 40327

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIQAAIERANIDSQHVDEVIMGNVLQAG
CCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
LGQNPARQALLKSGLAETVCGFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSL
CCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
APYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGITAENVAKEYGITREMQDEMA
CCEEEECCCCCCCCCCCCCEEEHHHHCCEEEEECCEEECCCHHHHHHHHCCCHHHHHHHH
LHSQRKAAAAIESGAFTAEIVPVNVVTRKKTLVFSQDEFPKADSTAESLGALRPAFDKAG
HHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEECCCCCCCCCCHHHHHHHHCHHHCCCC
TVTAGNASGINDGAAALVIMEESAALAAGLTPLARIKSYASGGVAPSMMGLGPVPATQKA
CEECCCCCCCCCCCEEEEEEECCCHHHHCCCHHHHHHHHHCCCCCCHHHCCCCCCHHHHH
LQLAGLQLADIDLIEANEAFAAQFLAVGKTLGFDPEKVNVNGGAIALGHPIGASGARILV
HHHHCCEEECEEEEECCHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHHHHH
TLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN
HHHHHHHHCCHHCCEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIQAAIERANIDSQHVDEVIMGNVLQAG
CCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
LGQNPARQALLKSGLAETVCGFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSL
CCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
APYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGITAENVAKEYGITREMQDEMA
CCEEEECCCCCCCCCCCCCEEEHHHHCCEEEEECCEEECCCHHHHHHHHCCCHHHHHHHH
LHSQRKAAAAIESGAFTAEIVPVNVVTRKKTLVFSQDEFPKADSTAESLGALRPAFDKAG
HHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEECCCCCCCCCCHHHHHHHHCHHHCCCC
TVTAGNASGINDGAAALVIMEESAALAAGLTPLARIKSYASGGVAPSMMGLGPVPATQKA
CEECCCCCCCCCCCEEEEEEECCCHHHHCCCHHHHHHHHHCCCCCCHHHCCCCCCHHHHH
LQLAGLQLADIDLIEANEAFAAQFLAVGKTLGFDPEKVNVNGGAIALGHPIGASGARILV
HHHHCCEEECEEEEECCHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHHHHH
TLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN
HHHHHHHHCCHHCCEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]