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The map label for this gene is pstP [H]

Identifier: 213691003

GI number: 213691003

Start: 96252

End: 97946

Strand: Reverse

Name: pstP [H]

Synonym: Blon_0081

Alternate gene names: 213691003

Gene position: 97946-96252 (Counterclockwise)

Preceding gene: 213691004

Following gene: 213691002

Centisome position: 3.46

GC content: 65.78

Gene sequence:

>1695_bases
ATGCCAAAATCCGCCGCTTCACAACCGCTGTTCCTGTATTCCACCACGGTGTCCGATGTGGGCACCGTGCGCGCGAACAA
CCAGGATTCCTCCTTCGCCGGCGAGCATCTCATCGCCATCTGCGACGGCATGGGCGGTCACGCCGGCGGCGACACGGCAT
CCTCCATCGCCATCCGGTCGCTGGCCCACATCGAACGGGACGACACCGACGGCGATGTCGCGGTGATCGCCCATATGATG
GAGACCTCCGTCATGGCCGCGCATGACGCCATCGTCGGCAAGGCCAAGCGCGAACGCAAACTCGCCGGCATGGGCACCAC
CGTCACCGCGGTGGCGTTGGTGGCCGGCTACTGGATCATCGCCCACATCGGCGATTCGCGCGCCTATCTGCTGCGCGATG
GTCATCTGGGCCGCGTCACCTGCGACCACAGCTACGTGCAGCATCTCATCAACACCGGCCGTATCACCCCATCCGAAGCC
AAGAATCACCCGCAGCGCAACGTCGTGATGCGTGTGCTCGGCGACTTCGACATCGACCCGCACCCGGACATCTCCATACG
CCGCGCCCATCCCGCCGACCGCTGGCTGCTGTGTTCGGACGGCCTGTGCGGCGTGCTGGAGGACTCCACCATCGCGGAGA
CGATGACCGCGCTGTCCGATCAGGGCGAATGCGCGCAGCGTCTGGTGCAGATGGCGCTGCGGGCGGGCAGCACCGATAAC
GTCACGGCCGTCATCGCGGACGCCACGTTGGCGTTGGACGCCGACGCGTTCGACCTGCCCCACCAAACGCCGTTGGTCGG
CGGCGCCGCCAGCCGCAATCTCGAGCCGATTGCGGACATCGTCAACGCGCCGGTGGCCACCGCTCCCGCGCTGCGCGAGG
ACGATTCGCCCGCACAACGCGCCGCGGCGCTGATCCAGCCAGCCAGCGCGCATGAGGCGGAGCCCGCGCAGACCACGGCC
GAACCGTCGTCCGCGCGCGTGGTCCAGCCATCCACGGTCCGCGAGGAGACCGGCGAGCGGGCCAATCCCGATACCGGTGA
GATTCCGGTGGTGCAGAAGCCGGACGGGCGCTTGTCCGCCGATCCGAACGACCCGGACGTGGCCAAGGCCATCCGCGACG
AGCAGATCGAGCAGAAGAAGGTCACACGCACCAGGAAACGCCGCAACAGGCTCGCCGTGATCGTCGCCTGCATTCTTGCC
GCACTGGCGTTGGCCGGTGCCGGCTGGGGCGCGTACACGTGGAGCCAGGCGCATTATTACGTGGGCAACGCCAACGGCAC
GGTGGCCATCTACCGTGGCGTGCCGACCAATCTTTTCGGGCTTGAGCTTTCGCACGAAGTCGAGACCACCGACATCGCCA
TCGCGCAGCTGCCGCAATCATGGCGCGACCAACTGAGCCAAGGCATCACGGTCGGTTCGCTGGACGAAGCACAGTCGCAT
GTGGGCATCATCCGCACCGAAATGCGCAAACTGGCCAAGCAGCAGGAAGCCGACGTCGCCAAGAAGGCTGAGGCGTCCAA
TTCCCCGGACAGTTCCAAAGACAGTTCCCAGAGCGATTCCAAGGACAGCACCAAGGATTCGTCCAGCCAGTCCGGCTCCT
CGTCAGACAAGTCCGGTTCGTCAAGCTCATCCGATTCCTCAGATAAATCCGGTATCGGAGCGGCCGACAACGCGGCCACG
GGGGATGCACGATGA

Upstream 100 bases:

>100_bases
GGGACCGTGGTCAACCAGCAGCGCATCAACCGTCCCACCATCCTGCCCGCCCGTATCCCGGTGCGCATCGGCGCCACCAC
CTTCGAACTGAGGTAGCCGC

Downstream 100 bases:

>100_bases
TCGCTACCCGTCTACGTCAGATTTCCTTGTTGCTGATTGCCATGGCAATCAGTGCGTTGGCGTTCATCCAGATGTTCCAA
CGCACCGCCGGCGAATTCCC

Product: protein phosphatase 2C domain protein

Products: NA

Alternate protein names: Mycobacterial Ser/Thr phosphatase; Mstp; Possible serine/threonine phosphatase Ppp [H]

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MPKSAASQPLFLYSTTVSDVGTVRANNQDSSFAGEHLIAICDGMGGHAGGDTASSIAIRSLAHIERDDTDGDVAVIAHMM
ETSVMAAHDAIVGKAKRERKLAGMGTTVTAVALVAGYWIIAHIGDSRAYLLRDGHLGRVTCDHSYVQHLINTGRITPSEA
KNHPQRNVVMRVLGDFDIDPHPDISIRRAHPADRWLLCSDGLCGVLEDSTIAETMTALSDQGECAQRLVQMALRAGSTDN
VTAVIADATLALDADAFDLPHQTPLVGGAASRNLEPIADIVNAPVATAPALREDDSPAQRAAALIQPASAHEAEPAQTTA
EPSSARVVQPSTVREETGERANPDTGEIPVVQKPDGRLSADPNDPDVAKAIRDEQIEQKKVTRTRKRRNRLAVIVACILA
ALALAGAGWGAYTWSQAHYYVGNANGTVAIYRGVPTNLFGLELSHEVETTDIAIAQLPQSWRDQLSQGITVGSLDEAQSH
VGIIRTEMRKLAKQQEADVAKKAEASNSPDSSKDSSQSDSKDSTKDSSSQSGSSSDKSGSSSSSDSSDKSGIGAADNAAT
GDAR

Sequences:

>Translated_564_residues
MPKSAASQPLFLYSTTVSDVGTVRANNQDSSFAGEHLIAICDGMGGHAGGDTASSIAIRSLAHIERDDTDGDVAVIAHMM
ETSVMAAHDAIVGKAKRERKLAGMGTTVTAVALVAGYWIIAHIGDSRAYLLRDGHLGRVTCDHSYVQHLINTGRITPSEA
KNHPQRNVVMRVLGDFDIDPHPDISIRRAHPADRWLLCSDGLCGVLEDSTIAETMTALSDQGECAQRLVQMALRAGSTDN
VTAVIADATLALDADAFDLPHQTPLVGGAASRNLEPIADIVNAPVATAPALREDDSPAQRAAALIQPASAHEAEPAQTTA
EPSSARVVQPSTVREETGERANPDTGEIPVVQKPDGRLSADPNDPDVAKAIRDEQIEQKKVTRTRKRRNRLAVIVACILA
ALALAGAGWGAYTWSQAHYYVGNANGTVAIYRGVPTNLFGLELSHEVETTDIAIAQLPQSWRDQLSQGITVGSLDEAQSH
VGIIRTEMRKLAKQQEADVAKKAEASNSPDSSKDSSQSDSKDSTKDSSSQSGSSSDKSGSSSSSDSSDKSGIGAADNAAT
GDAR
>Mature_563_residues
PKSAASQPLFLYSTTVSDVGTVRANNQDSSFAGEHLIAICDGMGGHAGGDTASSIAIRSLAHIERDDTDGDVAVIAHMME
TSVMAAHDAIVGKAKRERKLAGMGTTVTAVALVAGYWIIAHIGDSRAYLLRDGHLGRVTCDHSYVQHLINTGRITPSEAK
NHPQRNVVMRVLGDFDIDPHPDISIRRAHPADRWLLCSDGLCGVLEDSTIAETMTALSDQGECAQRLVQMALRAGSTDNV
TAVIADATLALDADAFDLPHQTPLVGGAASRNLEPIADIVNAPVATAPALREDDSPAQRAAALIQPASAHEAEPAQTTAE
PSSARVVQPSTVREETGERANPDTGEIPVVQKPDGRLSADPNDPDVAKAIRDEQIEQKKVTRTRKRRNRLAVIVACILAA
LALAGAGWGAYTWSQAHYYVGNANGTVAIYRGVPTNLFGLELSHEVETTDIAIAQLPQSWRDQLSQGITVGSLDEAQSHV
GIIRTEMRKLAKQQEADVAKKAEASNSPDSSKDSSQSDSKDSTKDSSSQSGSSSDKSGSSSSSDSSDKSGIGAADNAATG
DAR

Specific function: The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (pknA, pknB, pknD, pknE and pknF) and the penicillin-binding protein PBPA [H]

COG id: COG0631

COG function: function code T; Serine/threonine protein phosphatase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential). Note=May be localized to the outside of the cell [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045 [H]

Pfam domain/function: PF00481 PP2C [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 59453; Mature: 59322

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKSAASQPLFLYSTTVSDVGTVRANNQDSSFAGEHLIAICDGMGGHAGGDTASSIAIRS
CCCCCCCCCEEEEECCCCCCCEEEECCCCCCHHCCEEEEEECCCCCCCCCCHHHHHHHHH
LAHIERDDTDGDVAVIAHMMETSVMAAHDAIVGKAKRERKLAGMGTTVTAVALVAGYWII
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEE
AHIGDSRAYLLRDGHLGRVTCDHSYVQHLINTGRITPSEAKNHPQRNVVMRVLGDFDIDP
EEECCCCEEEEECCCCCEEEECHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCC
HPDISIRRAHPADRWLLCSDGLCGVLEDSTIAETMTALSDQGECAQRLVQMALRAGSTDN
CCCCEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
VTAVIADATLALDADAFDLPHQTPLVGGAASRNLEPIADIVNAPVATAPALREDDSPAQR
EEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHH
AAALIQPASAHEAEPAQTTAEPSSARVVQPSTVREETGERANPDTGEIPVVQKPDGRLSA
HHHHHCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHCCCCCCCCCCCCCEEECCCCCCCC
DPNDPDVAKAIRDEQIEQKKVTRTRKRRNRLAVIVACILAALALAGAGWGAYTWSQAHYY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEE
VGNANGTVAIYRGVPTNLFGLELSHEVETTDIAIAQLPQSWRDQLSQGITVGSLDEAQSH
EECCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHCCCEECCHHHHHHH
VGIIRTEMRKLAKQQEADVAKKAEASNSPDSSKDSSQSDSKDSTKDSSSQSGSSSDKSGS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SSSSDSSDKSGIGAADNAATGDAR
CCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKSAASQPLFLYSTTVSDVGTVRANNQDSSFAGEHLIAICDGMGGHAGGDTASSIAIRS
CCCCCCCCEEEEECCCCCCCEEEECCCCCCHHCCEEEEEECCCCCCCCCCHHHHHHHHH
LAHIERDDTDGDVAVIAHMMETSVMAAHDAIVGKAKRERKLAGMGTTVTAVALVAGYWII
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEE
AHIGDSRAYLLRDGHLGRVTCDHSYVQHLINTGRITPSEAKNHPQRNVVMRVLGDFDIDP
EEECCCCEEEEECCCCCEEEECHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCC
HPDISIRRAHPADRWLLCSDGLCGVLEDSTIAETMTALSDQGECAQRLVQMALRAGSTDN
CCCCEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCC
VTAVIADATLALDADAFDLPHQTPLVGGAASRNLEPIADIVNAPVATAPALREDDSPAQR
EEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHH
AAALIQPASAHEAEPAQTTAEPSSARVVQPSTVREETGERANPDTGEIPVVQKPDGRLSA
HHHHHCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHCCCCCCCCCCCCCEEECCCCCCCC
DPNDPDVAKAIRDEQIEQKKVTRTRKRRNRLAVIVACILAALALAGAGWGAYTWSQAHYY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEE
VGNANGTVAIYRGVPTNLFGLELSHEVETTDIAIAQLPQSWRDQLSQGITVGSLDEAQSH
EECCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHCCCEECCHHHHHHH
VGIIRTEMRKLAKQQEADVAKKAEASNSPDSSKDSSQSDSKDSTKDSSSQSGSSSDKSGS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SSSSDSSDKSGIGAADNAATGDAR
CCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]