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The map label for this gene is prs [H]

Identifier: 212224554

GI number: 212224554

Start: 1280533

End: 1281372

Strand: Reverse

Name: prs [H]

Synonym: TON_1403

Alternate gene names: 212224554

Gene position: 1281372-1280533 (Counterclockwise)

Preceding gene: 212224555

Following gene: 212224553

Centisome position: 69.35

GC content: 55.48

Gene sequence:

>840_bases
ATGATAGTGGTCGGAAGCGGTGCGAGGCACCTGGAGGACGAGATAAGGAAGCTCGGCGGTGAGGTTCTCGACGTCGAGAT
TAAGAAGTTCCCGGATGGGGAGAAGTATGTTCGCGTTTTTGGCTCGGGCGATGAGGCCCTTGTGGTTCAGTCGACATTTA
AGCCGCAGGATGAGAACCTCATCGAGCTGCTCCTCATAGGCGACGCCCTCCGCGAGAGGGGCTTTGAGAACCTCAGTGCC
ATTGTCCCATACCTAGCCTATTCCAGGCAGGACAGGGTTACAAGGGAGGGCGAACCGGTAAGCGTTAGGGCTATCATGAG
AGCGCTTGGCCTCTACTACGACGAGCTTTACGTCTTTGATCTGCACAATCCCGAAACTCTCAGGTTCTTCCCAGGTAAGG
CGGTGAACCTCTCGCCGGCAAGGGCGATAGCTGAGTACTTCGGCGAGAAACTCGGCGATGGTATAATCCTTGCCCCGGAC
AAGGGTGCCCGGGAGAGGGCTAGAGTGGTTGCCGAGAAGCTCGGGCTGGAGTACAGCCACTTCGAGAAGAGGAGGATTTC
CCCAACTGAGGTTCAGATGTGGCCAGTTGATATCGACGTGAAAGGCAAAAACGTGCTTATAGTGGACGACATCATAAGCA
CGGGCGGCACGATGGTTAGAGCCGCGAACCTGCTCAGGGAGATGGGTGCTGAGAAGATATTCGTGGCGGCAACGCACGGC
GTCTTCGCTGAGGGTGCAATAGAGAGAGTTAGTAAAGCCGTGGATGAGCTCGCCGTAACCAACACAATACCGACGCCGGT
TTCGAGGATAAGCATAGTGCCGGATATAGTGAGTCTTTAG

Upstream 100 bases:

>100_bases
TCTGGCCGGTCTGATTGCCGTTCTCCTGGCATAACGGTGGGTTTATAAGGCCTGGGTTAAACATGGAAGTGGCAAGATCC
GCGGTTATGGGGTGATGCTC

Downstream 100 bases:

>100_bases
TGGGGGATTCCCATTGAAATTCGGGAAGCTTGCTTCTCTTGTCATTTTTCTCTCCTTTGCAGGGGCGGGGATTATGCTGG
TCTTCTCGGTGGCTTTTGAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MIVVGSGARHLEDEIRKLGGEVLDVEIKKFPDGEKYVRVFGSGDEALVVQSTFKPQDENLIELLLIGDALRERGFENLSA
IVPYLAYSRQDRVTREGEPVSVRAIMRALGLYYDELYVFDLHNPETLRFFPGKAVNLSPARAIAEYFGEKLGDGIILAPD
KGARERARVVAEKLGLEYSHFEKRRISPTEVQMWPVDIDVKGKNVLIVDDIISTGGTMVRAANLLREMGAEKIFVAATHG
VFAEGAIERVSKAVDELAVTNTIPTPVSRISIVPDIVSL

Sequences:

>Translated_279_residues
MIVVGSGARHLEDEIRKLGGEVLDVEIKKFPDGEKYVRVFGSGDEALVVQSTFKPQDENLIELLLIGDALRERGFENLSA
IVPYLAYSRQDRVTREGEPVSVRAIMRALGLYYDELYVFDLHNPETLRFFPGKAVNLSPARAIAEYFGEKLGDGIILAPD
KGARERARVVAEKLGLEYSHFEKRRISPTEVQMWPVDIDVKGKNVLIVDDIISTGGTMVRAANLLREMGAEKIFVAATHG
VFAEGAIERVSKAVDELAVTNTIPTPVSRISIVPDIVSL
>Mature_279_residues
MIVVGSGARHLEDEIRKLGGEVLDVEIKKFPDGEKYVRVFGSGDEALVVQSTFKPQDENLIELLLIGDALRERGFENLSA
IVPYLAYSRQDRVTREGEPVSVRAIMRALGLYYDELYVFDLHNPETLRFFPGKAVNLSPARAIAEYFGEKLGDGIILAPD
KGARERARVVAEKLGLEYSHFEKRRISPTEVQMWPVDIDVKGKNVLIVDDIISTGGTMVRAANLLREMGAEKIFVAATHG
VFAEGAIERVSKAVDELAVTNTIPTPVSRISIVPDIVSL

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=273, Percent_Identity=31.8681318681319, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI84875539, Length=276, Percent_Identity=32.2463768115942, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4506127, Length=271, Percent_Identity=30.9963099630996, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI28557709, Length=271, Percent_Identity=29.8892988929889, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4506133, Length=308, Percent_Identity=29.8701298701299, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI194018537, Length=294, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787458, Length=264, Percent_Identity=32.9545454545455, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25149168, Length=273, Percent_Identity=30.03663003663, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17554702, Length=273, Percent_Identity=30.03663003663, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17554704, Length=271, Percent_Identity=29.8892988929889, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71989924, Length=273, Percent_Identity=30.03663003663, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17570245, Length=260, Percent_Identity=27.3076923076923, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321776, Length=256, Percent_Identity=29.296875, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320946, Length=274, Percent_Identity=26.6423357664234, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319403, Length=273, Percent_Identity=27.1062271062271, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324511, Length=67, Percent_Identity=43.2835820895522, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322667, Length=179, Percent_Identity=24.5810055865922, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355239, Length=273, Percent_Identity=32.967032967033, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45551540, Length=296, Percent_Identity=30.7432432432432, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 30836; Mature: 30836

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVVGSGARHLEDEIRKLGGEVLDVEIKKFPDGEKYVRVFGSGDEALVVQSTFKPQDENL
CEEECCCCHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCCCCH
IELLLIGDALRERGFENLSAIVPYLAYSRQDRVTREGEPVSVRAIMRALGLYYDELYVFD
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEEE
LHNPETLRFFPGKAVNLSPARAIAEYFGEKLGDGIILAPDKGARERARVVAEKLGLEYSH
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCHHH
FEKRRISPTEVQMWPVDIDVKGKNVLIVDDIISTGGTMVRAANLLREMGAEKIFVAATHG
HHHHCCCCCEEEEEEEEEEECCCEEEEEEHHHHCCCHHHHHHHHHHHCCCCEEEEEECCC
VFAEGAIERVSKAVDELAVTNTIPTPVSRISIVPDIVSL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECHHHHCC
>Mature Secondary Structure
MIVVGSGARHLEDEIRKLGGEVLDVEIKKFPDGEKYVRVFGSGDEALVVQSTFKPQDENL
CEEECCCCHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCCCCH
IELLLIGDALRERGFENLSAIVPYLAYSRQDRVTREGEPVSVRAIMRALGLYYDELYVFD
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEEE
LHNPETLRFFPGKAVNLSPARAIAEYFGEKLGDGIILAPDKGARERARVVAEKLGLEYSH
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCHHH
FEKRRISPTEVQMWPVDIDVKGKNVLIVDDIISTGGTMVRAANLLREMGAEKIFVAATHG
HHHHCCCCCEEEEEEEEEEECCCEEEEEEHHHHCCCHHHHHHHHHHHCCCCEEEEEECCC
VFAEGAIERVSKAVDELAVTNTIPTPVSRISIVPDIVSL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA