Click here to switch to the map view.

The map label for this gene is pepA [H]

Identifier: 209554384

GI number: 209554384

Start: 705827

End: 707194

Strand: Reverse

Name: pepA [H]

Synonym: UUR10_0589

Alternate gene names: 209554384

Gene position: 707194-705827 (Counterclockwise)

Preceding gene: 209554061

Following gene: 209554115

Centisome position: 80.87

GC content: 31.87

Gene sequence:

>1368_bases
ATGACATTAAACGAAAAAAAAGAATTTGTTTATGAACTAAAAGCTGTTAAAAAAGATCACAACCTAAAAGGTTTTGAAAA
AAATACAGCTGAACACGTTGTTTTTGGTGAAGTATATCAAAAACAACATTACCTAATTCTAACACCAGATTTTGATTCAA
ACGAACTATCAAGATCATTAGTTAGCTTTTTAGAAAAATCACCTAAACCAGTTAGTGTTGATTTAAACTCATTTTTAGAT
CTTGTGCCAGAATCAAGACATGCATCTTTATTAAATGTTGTTGTTAGTGCATTAGAATATGTTGAAGTAACACCTTTTTC
ACTAAAATCTAAAGTTGAACCTAAAAACATTCATAATTTAGTAGTTGATGCAAAATATCATGATTTAATTGCTAAGTTAC
AAGTAATTGCTCAATCTCAGACAATTACAAGAACGCTACAAGATACACCAGCAAACTTAATGACTCCAGGTGATTTTGAA
GAACGTATTAAAGAATTGTTTAAAGATTTACCAGAAGTTAAAGTAAGTGTTTTATACCGTAAAGACTTAGAAGCAAAAGG
TATGAACGCTCACGTTGGAGTAGGTAAAGCTGCTGTAAGTGATAAAGCACAACCTCGTTTAGTTGTTGTTGAATACAATA
ATAATCCAGATACAGATGAAAAATATGCTTTTGTTGGTAAAGGTGTATGCTTTGACTCAGGTGGATATAATGTAAAAACT
GGATCACACATGCGTTGAATGAAGTTTGATATGTCAGGTTCTGCTATTGTAAGTATGACAGTAAGAGCTTTAGCTTTAAA
TAAAGAAAAAGTAAACGTTGTTGCTGTTTGTCCATTAGTATTAAACTTACTAGCACCAGAAGGTCAAAAACCAGATGATA
TCATTAAATCATATAATGGTAAAACAATTGAATTAGATAACACTGATGCTGAAGGTCGTTTAATTTTAGCTGATGCATTG
ACATATGCTGTTCGTGATTTAAAAGCATCTAAATTATTTGATATCGCAACATTAACTGGAGCAATGATTTTTGCTTTAGG
TGATACATACTCAGGTGTATGAGCAACAAATAATGATATTTGAAACGAAGTAGTTGTTGCCGCAGATTACGCTGGTGAAT
TAGTTTGAAGATTACCATTCCACAACGATTTCTTAAAAATGTTAAATTCAAATGTAGCTGATATTGCTAACTCAGTAACA
GACCCACGTGGTGGTTCTTCACGTGCTGCATGTTTCTTAAAAGAATTTACTGAAGGTGTTCCATATGCACACTTTGATAT
TGCAATTACTGCAGATGTTGGTCATAAAGGAACAGGTGTAATGTTAAGAACATTCTACCGTATTGCTCAAAACCAAAAGT
TTAATTAA

Upstream 100 bases:

>100_bases
ATAATTATGTATCTTAAAATTAACGTCGTACATAATTTGAATAAAAGCATTATAATATAAGAATATTAAAACTATAAATA
TCAAAGAAGGAACGGAATTT

Downstream 100 bases:

>100_bases
TTTAAATTTTATTGAATTAGATAAAGAAAAAGAAGCGAATTAAACTCGCTTCTTTTTTGTTTTAAAAGGTTCTCATCAAA
GAATTTAAAAAAATTCATTA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MTLNEKKEFVYELKAVKKDHNLKGFEKNTAEHVVFGEVYQKQHYLILTPDFDSNELSRSLVSFLEKSPKPVSVDLNSFLD
LVPESRHASLLNVVVSALEYVEVTPFSLKSKVEPKNIHNLVVDAKYHDLIAKLQVIAQSQTITRTLQDTPANLMTPGDFE
ERIKELFKDLPEVKVSVLYRKDLEAKGMNAHVGVGKAAVSDKAQPRLVVVEYNNNPDTDEKYAFVGKGVCFDSGGYNVKT
GSHMRWMKFDMSGSAIVSMTVRALALNKEKVNVVAVCPLVLNLLAPEGQKPDDIIKSYNGKTIELDNTDAEGRLILADAL
TYAVRDLKASKLFDIATLTGAMIFALGDTYSGVWATNNDIWNEVVVAADYAGELVWRLPFHNDFLKMLNSNVADIANSVT
DPRGGSSRAACFLKEFTEGVPYAHFDIAITADVGHKGTGVMLRTFYRIAQNQKFN

Sequences:

>Translated_455_residues
MTLNEKKEFVYELKAVKKDHNLKGFEKNTAEHVVFGEVYQKQHYLILTPDFDSNELSRSLVSFLEKSPKPVSVDLNSFLD
LVPESRHASLLNVVVSALEYVEVTPFSLKSKVEPKNIHNLVVDAKYHDLIAKLQVIAQSQTITRTLQDTPANLMTPGDFE
ERIKELFKDLPEVKVSVLYRKDLEAKGMNAHVGVGKAAVSDKAQPRLVVVEYNNNPDTDEKYAFVGKGVCFDSGGYNVKT
GSHMR*MKFDMSGSAIVSMTVRALALNKEKVNVVAVCPLVLNLLAPEGQKPDDIIKSYNGKTIELDNTDAEGRLILADAL
TYAVRDLKASKLFDIATLTGAMIFALGDTYSGV*ATNNDI*NEVVVAADYAGELV*RLPFHNDFLKMLNSNVADIANSVT
DPRGGSSRAACFLKEFTEGVPYAHFDIAITADVGHKGTGVMLRTFYRIAQNQKFN
>Mature_454_residues
TLNEKKEFVYELKAVKKDHNLKGFEKNTAEHVVFGEVYQKQHYLILTPDFDSNELSRSLVSFLEKSPKPVSVDLNSFLDL
VPESRHASLLNVVVSALEYVEVTPFSLKSKVEPKNIHNLVVDAKYHDLIAKLQVIAQSQTITRTLQDTPANLMTPGDFEE
RIKELFKDLPEVKVSVLYRKDLEAKGMNAHVGVGKAAVSDKAQPRLVVVEYNNNPDTDEKYAFVGKGVCFDSGGYNVKTG
SHMR*MKFDMSGSAIVSMTVRALALNKEKVNVVAVCPLVLNLLAPEGQKPDDIIKSYNGKTIELDNTDAEGRLILADALT
YAVRDLKASKLFDIATLTGAMIFALGDTYSGV*ATNNDI*NEVVVAADYAGELV*RLPFHNDFLKMLNSNVADIANSVTD
PRGGSSRAACFLKEFTEGVPYAHFDIAITADVGHKGTGVMLRTFYRIAQNQKFN

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=298, Percent_Identity=38.255033557047, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI47155554, Length=338, Percent_Identity=35.207100591716, Blast_Score=155, Evalue=8e-38,
Organism=Escherichia coli, GI1790710, Length=307, Percent_Identity=33.8762214983713, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI87082123, Length=334, Percent_Identity=33.2335329341317, Blast_Score=119, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17556903, Length=343, Percent_Identity=37.0262390670554, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17565172, Length=254, Percent_Identity=31.496062992126, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24661038, Length=291, Percent_Identity=33.6769759450172, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI21355725, Length=291, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21357381, Length=303, Percent_Identity=33.6633663366337, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI221379063, Length=303, Percent_Identity=33.6633663366337, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI221379062, Length=303, Percent_Identity=33.6633663366337, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI20129969, Length=370, Percent_Identity=26.2162162162162, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24662227, Length=340, Percent_Identity=26.1764705882353, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI161077148, Length=305, Percent_Identity=27.8688524590164, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI20130057, Length=305, Percent_Identity=27.8688524590164, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI20129963, Length=292, Percent_Identity=29.7945205479452, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI19922386, Length=301, Percent_Identity=27.5747508305648, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24646701, Length=374, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646703, Length=374, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21358201, Length=374, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355645, Length=291, Percent_Identity=25.085910652921, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24662223, Length=291, Percent_Identity=25.085910652921, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49744; Mature: 49613

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNEKKEFVYELKAVKKDHNLKGFEKNTAEHVVFGEVYQKQHYLILTPDFDSNELSRSL
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHCCCCEEEECCCCCCHHHHHHH
VSFLEKSPKPVSVDLNSFLDLVPESRHASLLNVVVSALEYVEVTPFSLKSKVEPKNIHNL
HHHHHCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCEE
VVDAKYHDLIAKLQVIAQSQTITRTLQDTPANLMTPGDFEERIKELFKDLPEVKVSVLYR
EEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHHEEEHHEE
KDLEAKGMNAHVGVGKAAVSDKAQPRLVVVEYNNNPDTDEKYAFVGKGVCFDSGGYNVKT
CCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCCEECC
GSHMRMKFDMSGSAIVSMTVRALALNKEKVNVVAVCPLVLNLLAPEGQKPDDIIKSYNGK
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCCCCHHHHHCCCCC
TIELDNTDAEGRLILADALTYAVRDLKASKLFDIATLTGAMIFALGDTYSGVATNNDINE
EEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCE
VVVAADYAGELVRLPFHNDFLKMLNSNVADIANSVTDPRGGSSRAACFLKEFTEGVPYAH
EEEEECCCCCEEECCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEE
FDIAITADVGHKGTGVMLRTFYRIAQNQKFN
EEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLNEKKEFVYELKAVKKDHNLKGFEKNTAEHVVFGEVYQKQHYLILTPDFDSNELSRSL
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHCCCCEEEECCCCCCHHHHHHH
VSFLEKSPKPVSVDLNSFLDLVPESRHASLLNVVVSALEYVEVTPFSLKSKVEPKNIHNL
HHHHHCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCEE
VVDAKYHDLIAKLQVIAQSQTITRTLQDTPANLMTPGDFEERIKELFKDLPEVKVSVLYR
EEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHHEEEHHEE
KDLEAKGMNAHVGVGKAAVSDKAQPRLVVVEYNNNPDTDEKYAFVGKGVCFDSGGYNVKT
CCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCCEECC
GSHMRMKFDMSGSAIVSMTVRALALNKEKVNVVAVCPLVLNLLAPEGQKPDDIIKSYNGK
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCCCCHHHHHCCCCC
TIELDNTDAEGRLILADALTYAVRDLKASKLFDIATLTGAMIFALGDTYSGVATNNDINE
EEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCE
VVVAADYAGELVRLPFHNDFLKMLNSNVADIANSVTDPRGGSSRAACFLKEFTEGVPYAH
EEEEECCCCCEEECCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEE
FDIAITADVGHKGTGVMLRTFYRIAQNQKFN
EEEEEEECCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]