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The map label for this gene is xdhA [H]

Identifier: 209550441

GI number: 209550441

Start: 2913259

End: 2915598

Strand: Direct

Name: xdhA [H]

Synonym: Rleg2_2862

Alternate gene names: 209550441

Gene position: 2913259-2915598 (Clockwise)

Preceding gene: 209550440

Following gene: 209550442

Centisome position: 64.2

GC content: 63.42

Gene sequence:

>2340_bases
ATGGACAAGTCCACCTTCGAAAACCCCAAGGTCGTCATCTCCGGCCCCATGCACGGTTCGCTCCGTCATGATTCAGCGCA
TAAGCATGTCACCGGAAGCGCCGATTATATCGATGATATTCCCGAACCTGCCGGCCTGCTGCACGGCGCGCTCGGCCTCT
CCGATCGGGCGCATGCCGAAATCATCAACATCGATCTGTCCGCCGTCGCCGCCTATCCCGGCGTCGTCTGGGTCTTCACC
GGCAAGGATGTGCCCGGCGTCAACGACACCAGCTCCAACGGCAGCCATGACGAGCCGCTGCTCGCCGAAACCTTGGTTCA
GTTCCACGGCCAGCCGATCTTTGCCGTCATCGCCGAAACACGGGACGCTGCCCGCCGGGCTGCACGGCTGGCAAAAATCG
ACTATCGCGACCTGCCGCACTGGCACGATATCGACGGCGCGCTCGCCAATGGCGGCCCGCTGGTCATCACCCCGATGACG
CTGCAGCGCGGCGAGCCGGAAACGGAAATGCCGAATGCCGCCATGCGTCTGAAGGGCCAGATGCGCATCGGCGGGCAGGA
GCATTTCTATCTCGAAGGCCATATCGCCATGGCGATCCCCGGCGAGGACGACGAGGTCACCGTCTGGTCTTCGACGCAGC
ATCCGAGCGAGATCCAGCACATCGTCGGCCACGTGCTCGATATCCCGTCCAACGCCGTCACCGTCAACGTGCGCCGCTTG
GGCGGCGGCTTCGGCGGCAAGGAAACGCAAGGCAACCAGTTCGCAGCGCTCGCGGCGATCGCCGCCAAGAAGCTCGGCCG
CGCCATCAAATTCCGCCCGGACCGCGACGAGGATATGAGCGCCACCGGCAAGCGCCATGATTTCCTCGTCGACTACGAAG
TGGGCTTCGATGCCGAGGGCCGCATCCACGCGCTCGATGCGACGTACGCGGCGCGCTGCGGCTTCTCCTCGGATCTCTCC
GGACCGGTGACCGACCGTGCGCTTTTCCACGCCGATTCCAGCTATTTCTATCCGCATGTGCATCTGCAGTCGAAACCGCT
GAAGACGCATACCGTCTCCAACACCGCCTTCCGCGGCTTCGGCGGACCGCAGGGCATGCTCGGCGCCGAGCGTGTCATCG
AGGAGATCGCCTATGCCCTCGGCAAGGACCCGCTCGATATCCGAAAACTGAATTTCTACGGCCAGCCGGGCTCCGGGCGC
ACGCTGACGCCCTACCACCAGGAGGTCGAGGACAATATCATCGCCCGTATCGTCGAGGAGTTGGAGGAAACGGCCGAATA
CCGGGCGCGGCGCAACGCCATCATCGGCTTCAACCGCGACAGCCGCTATATCAGAAAAGGCATCGCCCTGACCCCGGTGA
AATTCGGCATCTCTTTCACCATGACCGCTTTCAACCAGGCGGGAGCCCTCGTCCACATCTATCAGGACGGCTCGATCCAT
CTGAACCACGGCGGCACCGAAATGGGCCAGGGCCTTTATACCAAGGTGGCGCAGGTACTGGCCGACAGTTTTCAGGTCGA
TATCTCTAGGGTGAAGATCACCGCGACGACGACTGCCAAGGTGCCGAACACTTCGGCCACCGCCGCCTCCTCCGGCTCGG
ATCTGAACGGCATGGCAGCCTATGACGCCGCCCGCCAGATCAAGGAACGGCTAATAGCCTTTGCCGCCGAAAAATGGGAT
GTGGCGCCCTCCGACGTCGTCTTCCTGCCGAACCGTGTGCGCGTCGGCGAGATCGAGATCCCCTTCCCCGATTTCATCAA
GCAGGCCTATTTCGCCCGCGTTCAGCTGTCCGCCGCCGGCTTTTACAAGACGCCGAAGATCCACTGGGACCGCAAGGCCG
GCCGCGGCACACCCTTCTATTATTTCGCCTATGGCGCCGCCTGCACCGAGGTCTCGATCGATACGCTGACCGGCGAATAT
CTGATCGACCGCACCGATATTCTCCACGATGTCGGCCGCTCGCTGAACCCGGCGATCGACCTCGGCCAGGTCGAGGGCGC
TTTCGTCCAAGGCATGGGCTGGCTGACGACGGAAGAGCTCTGGTGGGATGATAAGGGGCGGCTGCGCACCCATGCGCCAT
CCACCTACAAGATCCCGCTCGCCTCCGACCGCCCGAAGATCTTCAACGTGCGCCTGGCCGAATGGTCGGAAAACACGGAA
GCCACCATCGGCCGCTCCAAGGCCGTCGGCGAACCACCCTTCATGCTGGCGATCTCGGTGCTGGAAGCGCTGTCGATGGC
GGTGGCCAGCGTGGCGGATTACAAAGTCTGCCCCAGGCTCGACGCCCCGGCCACGCCGGAACGGGTGCTGATGGCGGTGG
AGCGGATGAAGCGGGTGTAG

Upstream 100 bases:

>100_bases
GGAGAAGGTGCCCGATAGGGCGGATGAGGGGGGCGAGCGGCACTAAGCCGCGAGCGCCTGGAGCATCTGCGACGGGCAAT
CTTTCGGCAGGGAGATGTTA

Downstream 100 bases:

>100_bases
GATGGCGGCGAAAAATGCCCGATCCCGAAGACATCAGGAAAAGACGTCCCGGCAAAACTCTGCAGGCTCGCAAATTGCGC
CAAACCGAAACTGAAGAGGA

Product: xanthine dehydrogenase, molybdopterin binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MDKSTFENPKVVISGPMHGSLRHDSAHKHVTGSADYIDDIPEPAGLLHGALGLSDRAHAEIINIDLSAVAAYPGVVWVFT
GKDVPGVNDTSSNGSHDEPLLAETLVQFHGQPIFAVIAETRDAARRAARLAKIDYRDLPHWHDIDGALANGGPLVITPMT
LQRGEPETEMPNAAMRLKGQMRIGGQEHFYLEGHIAMAIPGEDDEVTVWSSTQHPSEIQHIVGHVLDIPSNAVTVNVRRL
GGGFGGKETQGNQFAALAAIAAKKLGRAIKFRPDRDEDMSATGKRHDFLVDYEVGFDAEGRIHALDATYAARCGFSSDLS
GPVTDRALFHADSSYFYPHVHLQSKPLKTHTVSNTAFRGFGGPQGMLGAERVIEEIAYALGKDPLDIRKLNFYGQPGSGR
TLTPYHQEVEDNIIARIVEELEETAEYRARRNAIIGFNRDSRYIRKGIALTPVKFGISFTMTAFNQAGALVHIYQDGSIH
LNHGGTEMGQGLYTKVAQVLADSFQVDISRVKITATTTAKVPNTSATAASSGSDLNGMAAYDAARQIKERLIAFAAEKWD
VAPSDVVFLPNRVRVGEIEIPFPDFIKQAYFARVQLSAAGFYKTPKIHWDRKAGRGTPFYYFAYGAACTEVSIDTLTGEY
LIDRTDILHDVGRSLNPAIDLGQVEGAFVQGMGWLTTEELWWDDKGRLRTHAPSTYKIPLASDRPKIFNVRLAEWSENTE
ATIGRSKAVGEPPFMLAISVLEALSMAVASVADYKVCPRLDAPATPERVLMAVERMKRV

Sequences:

>Translated_779_residues
MDKSTFENPKVVISGPMHGSLRHDSAHKHVTGSADYIDDIPEPAGLLHGALGLSDRAHAEIINIDLSAVAAYPGVVWVFT
GKDVPGVNDTSSNGSHDEPLLAETLVQFHGQPIFAVIAETRDAARRAARLAKIDYRDLPHWHDIDGALANGGPLVITPMT
LQRGEPETEMPNAAMRLKGQMRIGGQEHFYLEGHIAMAIPGEDDEVTVWSSTQHPSEIQHIVGHVLDIPSNAVTVNVRRL
GGGFGGKETQGNQFAALAAIAAKKLGRAIKFRPDRDEDMSATGKRHDFLVDYEVGFDAEGRIHALDATYAARCGFSSDLS
GPVTDRALFHADSSYFYPHVHLQSKPLKTHTVSNTAFRGFGGPQGMLGAERVIEEIAYALGKDPLDIRKLNFYGQPGSGR
TLTPYHQEVEDNIIARIVEELEETAEYRARRNAIIGFNRDSRYIRKGIALTPVKFGISFTMTAFNQAGALVHIYQDGSIH
LNHGGTEMGQGLYTKVAQVLADSFQVDISRVKITATTTAKVPNTSATAASSGSDLNGMAAYDAARQIKERLIAFAAEKWD
VAPSDVVFLPNRVRVGEIEIPFPDFIKQAYFARVQLSAAGFYKTPKIHWDRKAGRGTPFYYFAYGAACTEVSIDTLTGEY
LIDRTDILHDVGRSLNPAIDLGQVEGAFVQGMGWLTTEELWWDDKGRLRTHAPSTYKIPLASDRPKIFNVRLAEWSENTE
ATIGRSKAVGEPPFMLAISVLEALSMAVASVADYKVCPRLDAPATPERVLMAVERMKRV
>Mature_779_residues
MDKSTFENPKVVISGPMHGSLRHDSAHKHVTGSADYIDDIPEPAGLLHGALGLSDRAHAEIINIDLSAVAAYPGVVWVFT
GKDVPGVNDTSSNGSHDEPLLAETLVQFHGQPIFAVIAETRDAARRAARLAKIDYRDLPHWHDIDGALANGGPLVITPMT
LQRGEPETEMPNAAMRLKGQMRIGGQEHFYLEGHIAMAIPGEDDEVTVWSSTQHPSEIQHIVGHVLDIPSNAVTVNVRRL
GGGFGGKETQGNQFAALAAIAAKKLGRAIKFRPDRDEDMSATGKRHDFLVDYEVGFDAEGRIHALDATYAARCGFSSDLS
GPVTDRALFHADSSYFYPHVHLQSKPLKTHTVSNTAFRGFGGPQGMLGAERVIEEIAYALGKDPLDIRKLNFYGQPGSGR
TLTPYHQEVEDNIIARIVEELEETAEYRARRNAIIGFNRDSRYIRKGIALTPVKFGISFTMTAFNQAGALVHIYQDGSIH
LNHGGTEMGQGLYTKVAQVLADSFQVDISRVKITATTTAKVPNTSATAASSGSDLNGMAAYDAARQIKERLIAFAAEKWD
VAPSDVVFLPNRVRVGEIEIPFPDFIKQAYFARVQLSAAGFYKTPKIHWDRKAGRGTPFYYFAYGAACTEVSIDTLTGEY
LIDRTDILHDVGRSLNPAIDLGQVEGAFVQGMGWLTTEELWWDDKGRLRTHAPSTYKIPLASDRPKIFNVRLAEWSENTE
ATIGRSKAVGEPPFMLAISVLEALSMAVASVADYKVCPRLDAPATPERVLMAVERMKRV

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=759, Percent_Identity=42.6877470355731, Blast_Score=570, Evalue=1e-162,
Organism=Homo sapiens, GI71773480, Length=771, Percent_Identity=37.7431906614786, Blast_Score=481, Evalue=1e-135,
Organism=Escherichia coli, GI1789230, Length=779, Percent_Identity=27.4711168164313, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1789246, Length=789, Percent_Identity=25.2217997465146, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI1786478, Length=727, Percent_Identity=25.0343878954608, Blast_Score=116, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17540638, Length=772, Percent_Identity=40.4145077720207, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI32566215, Length=725, Percent_Identity=33.1034482758621, Blast_Score=342, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI17539860, Length=734, Percent_Identity=30.9264305177112, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI17737937, Length=771, Percent_Identity=40.7263294422827, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24647199, Length=761, Percent_Identity=31.4060446780552, Blast_Score=329, Evalue=6e-90,
Organism=Drosophila melanogaster, GI24647193, Length=768, Percent_Identity=31.7708333333333, Blast_Score=328, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24647201, Length=761, Percent_Identity=31.5374507227332, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24647197, Length=762, Percent_Identity=30.9711286089239, Blast_Score=299, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24647195, Length=762, Percent_Identity=30.9711286089239, Blast_Score=299, Evalue=6e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 85253; Mature: 85253

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKSTFENPKVVISGPMHGSLRHDSAHKHVTGSADYIDDIPEPAGLLHGALGLSDRAHAE
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCEE
IINIDLSAVAAYPGVVWVFTGKDVPGVNDTSSNGSHDEPLLAETLVQFHGQPIFAVIAET
EEEEEHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHH
RDAARRAARLAKIDYRDLPHWHDIDGALANGGPLVITPMTLQRGEPETEMPNAAMRLKGQ
HHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCHHEEEECE
MRIGGQEHFYLEGHIAMAIPGEDDEVTVWSSTQHPSEIQHIVGHVLDIPSNAVTVNVRRL
EEECCCEEEEEEEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEEEE
GGGFGGKETQGNQFAALAAIAAKKLGRAIKFRPDRDEDMSATGKRHDFLVDYEVGFDAEG
CCCCCCCCCCCCHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCC
RIHALDATYAARCGFSSDLSGPVTDRALFHADSSYFYPHVHLQSKPLKTHTVSNTAFRGF
CEEEECCHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCEEECCCCCCCCC
GGPQGMLGAERVIEEIAYALGKDPLDIRKLNFYGQPGSGRTLTPYHQEVEDNIIARIVEE
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
LEETAEYRARRNAIIGFNRDSRYIRKGIALTPVKFGISFTMTAFNQAGALVHIYQDGSIH
HHHHHHHHHHCCEEEEECCCHHHHHCCCEECEEEECCEEEEEECCCCCCEEEEEECCEEE
LNHGGTEMGQGLYTKVAQVLADSFQVDISRVKITATTTAKVPNTSATAASSGSDLNGMAA
EECCCCHHCCHHHHHHHHHHHHHHEEEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHH
YDAARQIKERLIAFAAEKWDVAPSDVVFLPNRVRVGEIEIPFPDFIKQAYFARVQLSAAG
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEECCCHHHHHHHHHHEEEEEECC
FYKTPKIHWDRKAGRGTPFYYFAYGAACTEVSIDTLTGEYLIDRTDILHDVGRSLNPAID
CCCCCCEEECCCCCCCCCEEEEEECCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCC
LGQVEGAFVQGMGWLTTEELWWDDKGRLRTHAPSTYKIPLASDRPKIFNVRLAEWSENTE
CCCCCCHHHCCCCCEEEHHEEECCCCCEEECCCCEEEEECCCCCCCEEEEEEECCCCCCC
ATIGRSKAVGEPPFMLAISVLEALSMAVASVADYKVCPRLDAPATPERVLMAVERMKRV
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDKSTFENPKVVISGPMHGSLRHDSAHKHVTGSADYIDDIPEPAGLLHGALGLSDRAHAE
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCEE
IINIDLSAVAAYPGVVWVFTGKDVPGVNDTSSNGSHDEPLLAETLVQFHGQPIFAVIAET
EEEEEHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHH
RDAARRAARLAKIDYRDLPHWHDIDGALANGGPLVITPMTLQRGEPETEMPNAAMRLKGQ
HHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCHHEEEECE
MRIGGQEHFYLEGHIAMAIPGEDDEVTVWSSTQHPSEIQHIVGHVLDIPSNAVTVNVRRL
EEECCCEEEEEEEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEEEE
GGGFGGKETQGNQFAALAAIAAKKLGRAIKFRPDRDEDMSATGKRHDFLVDYEVGFDAEG
CCCCCCCCCCCCHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCC
RIHALDATYAARCGFSSDLSGPVTDRALFHADSSYFYPHVHLQSKPLKTHTVSNTAFRGF
CEEEECCHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCEEECCCCCCCCC
GGPQGMLGAERVIEEIAYALGKDPLDIRKLNFYGQPGSGRTLTPYHQEVEDNIIARIVEE
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
LEETAEYRARRNAIIGFNRDSRYIRKGIALTPVKFGISFTMTAFNQAGALVHIYQDGSIH
HHHHHHHHHHCCEEEEECCCHHHHHCCCEECEEEECCEEEEEECCCCCCEEEEEECCEEE
LNHGGTEMGQGLYTKVAQVLADSFQVDISRVKITATTTAKVPNTSATAASSGSDLNGMAA
EECCCCHHCCHHHHHHHHHHHHHHEEEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHH
YDAARQIKERLIAFAAEKWDVAPSDVVFLPNRVRVGEIEIPFPDFIKQAYFARVQLSAAG
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEECCCHHHHHHHHHHEEEEEECC
FYKTPKIHWDRKAGRGTPFYYFAYGAACTEVSIDTLTGEYLIDRTDILHDVGRSLNPAID
CCCCCCEEECCCCCCCCCEEEEEECCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCC
LGQVEGAFVQGMGWLTTEELWWDDKGRLRTHAPSTYKIPLASDRPKIFNVRLAEWSENTE
CCCCCCHHHCCCCCEEEHHEEECCCCCEEECCCCEEEEECCCCCCCEEEEEEECCCCCCC
ATIGRSKAVGEPPFMLAISVLEALSMAVASVADYKVCPRLDAPATPERVLMAVERMKRV
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]