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The map label for this gene is xdhB [H]

Identifier: 209550440

GI number: 209550440

Start: 2911578

End: 2913044

Strand: Direct

Name: xdhB [H]

Synonym: Rleg2_2861

Alternate gene names: 209550440

Gene position: 2911578-2913044 (Clockwise)

Preceding gene: 209550439

Following gene: 209550441

Centisome position: 64.16

GC content: 64.89

Gene sequence:

>1467_bases
ATGAACGACAGCATCCGCTTCATCCTGAACGGCGAGAATATCGCGCTCACCGATGTCGGGCCGACCGAGACGCTTCTCGA
TTTTCTGCGGCTGAGGCGGCGGCTGACGGGAACCAAGGAAGGATGCGCGGAAGGCGATTGCGGCGCCTGCACCGTCCTCG
TCGGGCGGCTCGCCGACGGCAAGCTCGCTTATGAATCGGTCAATGCCTGCATTCGCTTCATGGGCTCGCTGCACGCCACC
CATGTGGTGACGGTCGAACATCTTGCCGGCCGGGACGGCGCGCTGCATCCGGTGCAGCAGGCGCTGGTCGATTGCCATGG
CTCGCAATGCGGCTTCTGCACCCCGGGCTTCGTCATGTCGCTCTATGGCCTCTGGCTGACGAAGGAAAAACCCGGCCGCC
GCGAGATCGAAAAAGCGCTGCAAGGCAATCTCTGTCGCTGCACCGGCTACGAGCCGATCGTCAAGGCGGCCGAGCAGGTG
AGCCTGACACGGCCGAGCGCGCTCTTCGACCCGCTGGAGCGAACGCGCTCGGAAATCATCGCACGGCTCTGGGCCATGCA
GGCAAGCGGCACCATCCGGATTGCCAACGGTGAAGACCGGCTGATCGTGCCGGCTTCGCTTCAGGCACTGGCGGAAGTCC
TCGCTGAGGAGCCCGACGCGACCGTCATCGCCGGCTCCACCGATGTCGGTCTCTGGGTGACGAAGCAGATGCGCCGGCTG
AGCCCGGTCGTTTTCATCAATCATTTGAGCGAACTGCAGTCAGTCGCGGAAGCCGAGGACGGCGTCACCATCGGCGCCGG
CGTCAGCTACAGCAGGGCCTTCGAAGCGATCGCCAGAAAAATCCCGGCACTCGGACGGTTGATCGACCGCATCGGCGGCG
AGCAGGTGCGCAACATGGGCACGATCGGCGGCAATATCGCTAACGGTTCGCCGATCGGCGACAGCCCCCCGCCGCTGATT
GCGCTGGGCGCGACGCTGACGCTGCGCTCCCTGGAAGGTCAGCGCAAAATGCCGCTCGAGGATTTCTTCATCGCCTATGG
CAAACAGGATCGCAGGCCCGGCGAATTCGTCGAAAGCGTCTTCGTGCCCTACCCCAAGCCAACCAGCCGCTTTGCCACCT
ACAAAATCACCAAGCGCCGCGACGAGGACATCACCGCCGTACTCGGCGCCTTCCTGCTGACGCTCGATGAAGCCGAAGTG
GTCACCGACATCCGCATCGCCTTCGGCGGCATGGCCGCAACGCCGAAACGCGCCCGGACCGTCGAGGCCGAACTGATGGG
CAAACCATGGACGGAAGCGACGATCGAAGCCGCCCGCCCCGCCTTCGACGCTGACTACCAGCCGCTGACCGACTGGCGCG
CCACGGCGGACTACCGCCAGCTGACGGCGAAGAACCTGCTGACGCGCTTCTACCTGGAAACGGTGGGCGCGCCGGCGGAG
CTGAAGCGGTTTGAGGAGGTGGCGTGA

Upstream 100 bases:

>100_bases
CTCGCCAGCGACGCCGCCCGCCAGGTGACCGGAACGCACATCTCGATTGACGGTGGCTGGACGGCGGCTTAACCATTTGG
AAAAAACAACCGGGAATATC

Downstream 100 bases:

>100_bases
TGGACATCTCGACCATCGGCGCCAACCGCCCCCCTCATCCGCCTGCCGGCGCCTTCTCCCCGCTGGGGAGAAGAGACAGG
GGGCAACGTCTCGACTCCCT

Product: xanthine dehydrogenase, small subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNDSIRFILNGENIALTDVGPTETLLDFLRLRRRLTGTKEGCAEGDCGACTVLVGRLADGKLAYESVNACIRFMGSLHAT
HVVTVEHLAGRDGALHPVQQALVDCHGSQCGFCTPGFVMSLYGLWLTKEKPGRREIEKALQGNLCRCTGYEPIVKAAEQV
SLTRPSALFDPLERTRSEIIARLWAMQASGTIRIANGEDRLIVPASLQALAEVLAEEPDATVIAGSTDVGLWVTKQMRRL
SPVVFINHLSELQSVAEAEDGVTIGAGVSYSRAFEAIARKIPALGRLIDRIGGEQVRNMGTIGGNIANGSPIGDSPPPLI
ALGATLTLRSLEGQRKMPLEDFFIAYGKQDRRPGEFVESVFVPYPKPTSRFATYKITKRRDEDITAVLGAFLLTLDEAEV
VTDIRIAFGGMAATPKRARTVEAELMGKPWTEATIEAARPAFDADYQPLTDWRATADYRQLTAKNLLTRFYLETVGAPAE
LKRFEEVA

Sequences:

>Translated_488_residues
MNDSIRFILNGENIALTDVGPTETLLDFLRLRRRLTGTKEGCAEGDCGACTVLVGRLADGKLAYESVNACIRFMGSLHAT
HVVTVEHLAGRDGALHPVQQALVDCHGSQCGFCTPGFVMSLYGLWLTKEKPGRREIEKALQGNLCRCTGYEPIVKAAEQV
SLTRPSALFDPLERTRSEIIARLWAMQASGTIRIANGEDRLIVPASLQALAEVLAEEPDATVIAGSTDVGLWVTKQMRRL
SPVVFINHLSELQSVAEAEDGVTIGAGVSYSRAFEAIARKIPALGRLIDRIGGEQVRNMGTIGGNIANGSPIGDSPPPLI
ALGATLTLRSLEGQRKMPLEDFFIAYGKQDRRPGEFVESVFVPYPKPTSRFATYKITKRRDEDITAVLGAFLLTLDEAEV
VTDIRIAFGGMAATPKRARTVEAELMGKPWTEATIEAARPAFDADYQPLTDWRATADYRQLTAKNLLTRFYLETVGAPAE
LKRFEEVA
>Mature_488_residues
MNDSIRFILNGENIALTDVGPTETLLDFLRLRRRLTGTKEGCAEGDCGACTVLVGRLADGKLAYESVNACIRFMGSLHAT
HVVTVEHLAGRDGALHPVQQALVDCHGSQCGFCTPGFVMSLYGLWLTKEKPGRREIEKALQGNLCRCTGYEPIVKAAEQV
SLTRPSALFDPLERTRSEIIARLWAMQASGTIRIANGEDRLIVPASLQALAEVLAEEPDATVIAGSTDVGLWVTKQMRRL
SPVVFINHLSELQSVAEAEDGVTIGAGVSYSRAFEAIARKIPALGRLIDRIGGEQVRNMGTIGGNIANGSPIGDSPPPLI
ALGATLTLRSLEGQRKMPLEDFFIAYGKQDRRPGEFVESVFVPYPKPTSRFATYKITKRRDEDITAVLGAFLLTLDEAEV
VTDIRIAFGGMAATPKRARTVEAELMGKPWTEATIEAARPAFDADYQPLTDWRATADYRQLTAKNLLTRFYLETVGAPAE
LKRFEEVA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=520, Percent_Identity=31.5384615384615, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI71773480, Length=522, Percent_Identity=30.2681992337165, Blast_Score=199, Evalue=5e-51,
Organism=Escherichia coli, GI1789231, Length=277, Percent_Identity=31.7689530685921, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1789232, Length=161, Percent_Identity=38.5093167701863, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1786480, Length=169, Percent_Identity=34.3195266272189, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540638, Length=535, Percent_Identity=29.1588785046729, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17539860, Length=466, Percent_Identity=28.5407725321888, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32566215, Length=384, Percent_Identity=28.90625, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI17737937, Length=484, Percent_Identity=32.6446280991736, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24647201, Length=507, Percent_Identity=28.5996055226824, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24647199, Length=501, Percent_Identity=28.5429141716567, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24647197, Length=513, Percent_Identity=27.4853801169591, Blast_Score=155, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24647193, Length=509, Percent_Identity=26.9155206286837, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24647195, Length=508, Percent_Identity=26.3779527559055, Blast_Score=141, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 53222; Mature: 53222

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSIRFILNGENIALTDVGPTETLLDFLRLRRRLTGTKEGCAEGDCGACTVLVGRLADG
CCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCC
KLAYESVNACIRFMGSLHATHVVTVEHLAGRDGALHPVQQALVDCHGSQCGFCTPGFVMS
HHHHHHHHHHHHHHHHHHHHHEEEEHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
LYGLWLTKEKPGRREIEKALQGNLCRCTGYEPIVKAAEQVSLTRPSALFDPLERTRSEII
HHHHHEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ARLWAMQASGTIRIANGEDRLIVPASLQALAEVLAEEPDATVIAGSTDVGLWVTKQMRRL
HHHHHHCCCCEEEEECCCCCEEECHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHC
SPVVFINHLSELQSVAEAEDGVTIGAGVSYSRAFEAIARKIPALGRLIDRIGGEQVRNMG
CHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCC
TIGGNIANGSPIGDSPPPLIALGATLTLRSLEGQRKMPLEDFFIAYGKQDRRPGEFVESV
CCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHHH
FVPYPKPTSRFATYKITKRRDEDITAVLGAFLLTLDEAEVVTDIRIAFGGMAATPKRART
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHH
VEAELMGKPWTEATIEAARPAFDADYQPLTDWRATADYRQLTAKNLLTRFYLETVGAPAE
HHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LKRFEEVA
HHHHHHCC
>Mature Secondary Structure
MNDSIRFILNGENIALTDVGPTETLLDFLRLRRRLTGTKEGCAEGDCGACTVLVGRLADG
CCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCC
KLAYESVNACIRFMGSLHATHVVTVEHLAGRDGALHPVQQALVDCHGSQCGFCTPGFVMS
HHHHHHHHHHHHHHHHHHHHHEEEEHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
LYGLWLTKEKPGRREIEKALQGNLCRCTGYEPIVKAAEQVSLTRPSALFDPLERTRSEII
HHHHHEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ARLWAMQASGTIRIANGEDRLIVPASLQALAEVLAEEPDATVIAGSTDVGLWVTKQMRRL
HHHHHHCCCCEEEEECCCCCEEECHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHC
SPVVFINHLSELQSVAEAEDGVTIGAGVSYSRAFEAIARKIPALGRLIDRIGGEQVRNMG
CHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCC
TIGGNIANGSPIGDSPPPLIALGATLTLRSLEGQRKMPLEDFFIAYGKQDRRPGEFVESV
CCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHHH
FVPYPKPTSRFATYKITKRRDEDITAVLGAFLLTLDEAEVVTDIRIAFGGMAATPKRART
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHH
VEAELMGKPWTEATIEAARPAFDADYQPLTDWRATADYRQLTAKNLLTRFYLETVGAPAE
HHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LKRFEEVA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]