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The map label for this gene is uvrD [H]

Identifier: 209550144

GI number: 209550144

Start: 2601260

End: 2603737

Strand: Direct

Name: uvrD [H]

Synonym: Rleg2_2563

Alternate gene names: 209550144

Gene position: 2601260-2603737 (Clockwise)

Preceding gene: 209550135

Following gene: 209550146

Centisome position: 57.32

GC content: 63.52

Gene sequence:

>2478_bases
ATGAGCAATAGTTTCGACGATATTCCCTTCTTCGACGAAGAGCCGGGCGAGATGGCGCGCAAGCCGCAGCCGCCTGCCGC
GCCCGCCGGAAGGGCGCCCGCCACCGGTGGCATTGCCGCCCGCGCCATGGCGGCCCGCGATGGTGGCAGCCGGCCGGATT
ATCTCGCCGGGCTGAACCCCGAGCAAACCGAAGCCGTCGAAACCCTGGAAGGCCCGGTCCTCGTGCTTGCCGGCGCCGGC
ACCGGCAAGACGCGCGTGCTGACGACCCGCATTGCCCATATCCTCAATACCGGCCGCGCCTTCCCCTCACAGATCCTCGC
CGTCACCTTCACCAACAAGGCGGCCCGCGAGATGAAGGAGCGCATCGCGCTGCTGGTCGGCGGCGCCGTCGAAGGCATGC
CCTGGCTCGGCACCTTCCACTCGATCGGCGTCAAGCTTCTGCGCCGCCACGGCGAACTCGTCGGCCTGCGCTCCGATTTC
ACCATTCTTGACACCGATGACGTCGTCCGCCTGATCAAGCAGCTGATCCAGGCCGAAGGCCTCGACGACAAGCGCTGGCC
GGCCAAGCAGTTCGCCGGCATGATCGACACCTGGAAGAACAAGGGGCTCGGTCCGGCCGATATCCCCGAGGGCGACGCCC
GCGCCTTTGCCAACGGCCGCGGCCGCGACCTTTATTTCGCCTATCAGGCGCGCCTGACGACGCTGAACGCCTGCGACTTC
GGCGACCTGCTGATGCATCCGATCGCGATCTTCCGCAAGAACCCGGATCTTCTGAAGGAATATCACGGCCGCTTCCGCTA
TATCCTCGTCGACGAGTACCAGGACACCAACACCGCTCAATATATGTGGCTCCGGCTCCTCGCCCAGCGCGCCAAAGGCG
AGCCGCAGAACGTCTGCTGCGTCGGCGACGACGACCAGTCGATTTATGGCTGGCGCGGCGCCGAGGTCGACAATATCCTG
CGCTTCGAAAAGGATTTCCCAGGCGCCAAGGTCATCAAGCTCGAGCGTAATTACCGCTCGACCGAACATATCCTCGGTGC
CGCTGCCCACCTGATCGCCCATAATGAAGGGCGGCTTGGCAAGACGCTGTTCACCGACCGCTCCGATCCTGAAGACGTTA
AGGTGCAGGTGCACGCCTCCTGGGATTCGGAGGAGGAAGCCCGCGCCATCGGCGAGGAGATCGAGCAGCTTCAGCGCGGC
AAGCATCTGCTCAACGACATGGCGATCCTCGTGCGCGCCTCCTTCCAGATGCGCGAATTCGAAGACCGCTTCGTCACCCT
TGGCCTCAACTACCGCGTCATCGGCGGCCCGCGCTTCTACGAGCGCCTGGAAATCCGCGATGCCATGGCCTATTTCCGCC
TGGTCGCTCAAGCCTCCGACGACCTCGCCTTCGAGCGCATCATCAACACGCCGAAGCGCGGCCTCGGCGACACGACGGTG
CGCGCGCTGCATGACTATGCGAGAGCCCGCGATATCCCGATGCTGGCGGCCGCCGCCGACATCATCGAAACGGATGAGCT
GAAGCCGAAGGCGCGAAAAGCCCTCTTCGACGTGATTCAATCTTTCCGCCGATGGCAGGAACTGCTTGAAAACACACCGC
ATACCGAACTTGCCGAGCAGATCCTCGAAGAGTCCGGCTATACCGATATGTGGAAGAACGACAAGAGCGCCGAAGCGCCC
GGCCGCCTTGAGAACCTCAAGGAACTGATCCGCTCGATGGAAAGCTTCGAGTCGATGCGTGGCTTTCTCGAACACGTCTC
TCTCGTCATGGATGCCGAGACCAACGAGAACCTCGATGCCGTCTCGATCATGACGCTGCATTCGGCCAAGGGCCTGGAGT
TCGACACCGTCTTCCTGCCCGGCTGGGAGGAAGGCCTCTTTCCGCATCAGCGCTCGCTCGATGAAAGCGGCCGCGCCGGC
CTGGAGGAGGAACGTCGGCTCGCCTATGTCGGCATCACCCGCGCCAAGCACCGCTGCCACATCTGGTTCGTCTCCAACCG
CCGCATCCATGGGCTATGGCAATCGACCCTGCCCTCGCGTTTCCTCGACGAGCTGCCGGAAACCCATGTCGAGGTCGCCG
AAATGGAACAGAGCTATGGTGGCTACGGCCGCGGCGGCTACGGCCAGTCCCGCTTCGACAAGGCCGAGCCTTTTGCCAAT
TCCTATTCCACCCCCGGCTGGAAACGTGCCCAGGCCAACAAGACCGATGCCACGCGCGACAATTGGGGTTCCCGCTCCGG
CCACGCCGTCGAACGCATCGGCTATGGCGAAAGCGGCCCGAAGGGACGGACGATCGAAGGCGAACTGGTGGCAAAATCCA
CCTCGTCGGAGCCTTCACGCTTCACGCTTGGCGACCGCGTGTTCCATCTGAAATTCGGCAACGGCAACATCACCGGCATC
GAAGGCAACAAGCTGACGATCGAGTTCGACCGGGCCGGGCAGAAGCGGGTGCTGGACGGGTTCGTCGAGCGCGTGTGA

Upstream 100 bases:

>100_bases
GCTGCCGCCATGCGCAAACCCCTTGGGATAGCGGCGGTTTGGGAATGAAAGCAGAACATCTTTTCTGGTCTTTCCTTTCC
GAATCACTACATTACGCGCC

Downstream 100 bases:

>100_bases
TAATCACCTCGGCGCGACGCGAGACCCTTTACCCGAGCATCCGCATGCTGCCGAGCCCGAGGATATCGTTCATCAGGGCG
ATCCCCATCCCGACGGCGAC

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 825; Mature: 824

Protein sequence:

>825_residues
MSNSFDDIPFFDEEPGEMARKPQPPAAPAGRAPATGGIAARAMAARDGGSRPDYLAGLNPEQTEAVETLEGPVLVLAGAG
TGKTRVLTTRIAHILNTGRAFPSQILAVTFTNKAAREMKERIALLVGGAVEGMPWLGTFHSIGVKLLRRHGELVGLRSDF
TILDTDDVVRLIKQLIQAEGLDDKRWPAKQFAGMIDTWKNKGLGPADIPEGDARAFANGRGRDLYFAYQARLTTLNACDF
GDLLMHPIAIFRKNPDLLKEYHGRFRYILVDEYQDTNTAQYMWLRLLAQRAKGEPQNVCCVGDDDQSIYGWRGAEVDNIL
RFEKDFPGAKVIKLERNYRSTEHILGAAAHLIAHNEGRLGKTLFTDRSDPEDVKVQVHASWDSEEEARAIGEEIEQLQRG
KHLLNDMAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERLEIRDAMAYFRLVAQASDDLAFERIINTPKRGLGDTTV
RALHDYARARDIPMLAAAADIIETDELKPKARKALFDVIQSFRRWQELLENTPHTELAEQILEESGYTDMWKNDKSAEAP
GRLENLKELIRSMESFESMRGFLEHVSLVMDAETNENLDAVSIMTLHSAKGLEFDTVFLPGWEEGLFPHQRSLDESGRAG
LEEERRLAYVGITRAKHRCHIWFVSNRRIHGLWQSTLPSRFLDELPETHVEVAEMEQSYGGYGRGGYGQSRFDKAEPFAN
SYSTPGWKRAQANKTDATRDNWGSRSGHAVERIGYGESGPKGRTIEGELVAKSTSSEPSRFTLGDRVFHLKFGNGNITGI
EGNKLTIEFDRAGQKRVLDGFVERV

Sequences:

>Translated_825_residues
MSNSFDDIPFFDEEPGEMARKPQPPAAPAGRAPATGGIAARAMAARDGGSRPDYLAGLNPEQTEAVETLEGPVLVLAGAG
TGKTRVLTTRIAHILNTGRAFPSQILAVTFTNKAAREMKERIALLVGGAVEGMPWLGTFHSIGVKLLRRHGELVGLRSDF
TILDTDDVVRLIKQLIQAEGLDDKRWPAKQFAGMIDTWKNKGLGPADIPEGDARAFANGRGRDLYFAYQARLTTLNACDF
GDLLMHPIAIFRKNPDLLKEYHGRFRYILVDEYQDTNTAQYMWLRLLAQRAKGEPQNVCCVGDDDQSIYGWRGAEVDNIL
RFEKDFPGAKVIKLERNYRSTEHILGAAAHLIAHNEGRLGKTLFTDRSDPEDVKVQVHASWDSEEEARAIGEEIEQLQRG
KHLLNDMAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERLEIRDAMAYFRLVAQASDDLAFERIINTPKRGLGDTTV
RALHDYARARDIPMLAAAADIIETDELKPKARKALFDVIQSFRRWQELLENTPHTELAEQILEESGYTDMWKNDKSAEAP
GRLENLKELIRSMESFESMRGFLEHVSLVMDAETNENLDAVSIMTLHSAKGLEFDTVFLPGWEEGLFPHQRSLDESGRAG
LEEERRLAYVGITRAKHRCHIWFVSNRRIHGLWQSTLPSRFLDELPETHVEVAEMEQSYGGYGRGGYGQSRFDKAEPFAN
SYSTPGWKRAQANKTDATRDNWGSRSGHAVERIGYGESGPKGRTIEGELVAKSTSSEPSRFTLGDRVFHLKFGNGNITGI
EGNKLTIEFDRAGQKRVLDGFVERV
>Mature_824_residues
SNSFDDIPFFDEEPGEMARKPQPPAAPAGRAPATGGIAARAMAARDGGSRPDYLAGLNPEQTEAVETLEGPVLVLAGAGT
GKTRVLTTRIAHILNTGRAFPSQILAVTFTNKAAREMKERIALLVGGAVEGMPWLGTFHSIGVKLLRRHGELVGLRSDFT
ILDTDDVVRLIKQLIQAEGLDDKRWPAKQFAGMIDTWKNKGLGPADIPEGDARAFANGRGRDLYFAYQARLTTLNACDFG
DLLMHPIAIFRKNPDLLKEYHGRFRYILVDEYQDTNTAQYMWLRLLAQRAKGEPQNVCCVGDDDQSIYGWRGAEVDNILR
FEKDFPGAKVIKLERNYRSTEHILGAAAHLIAHNEGRLGKTLFTDRSDPEDVKVQVHASWDSEEEARAIGEEIEQLQRGK
HLLNDMAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERLEIRDAMAYFRLVAQASDDLAFERIINTPKRGLGDTTVR
ALHDYARARDIPMLAAAADIIETDELKPKARKALFDVIQSFRRWQELLENTPHTELAEQILEESGYTDMWKNDKSAEAPG
RLENLKELIRSMESFESMRGFLEHVSLVMDAETNENLDAVSIMTLHSAKGLEFDTVFLPGWEEGLFPHQRSLDESGRAGL
EEERRLAYVGITRAKHRCHIWFVSNRRIHGLWQSTLPSRFLDELPETHVEVAEMEQSYGGYGRGGYGQSRFDKAEPFANS
YSTPGWKRAQANKTDATRDNWGSRSGHAVERIGYGESGPKGRTIEGELVAKSTSSEPSRFTLGDRVFHLKFGNGNITGIE
GNKLTIEFDRAGQKRVLDGFVERV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=650, Percent_Identity=42.9230769230769, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI48994965, Length=651, Percent_Identity=38.863287250384, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1787196, Length=349, Percent_Identity=29.7994269340974, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322369, Length=732, Percent_Identity=28.0054644808743, Blast_Score=201, Evalue=6e-52,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 92602; Mature: 92470

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSFDDIPFFDEEPGEMARKPQPPAAPAGRAPATGGIAARAMAARDGGSRPDYLAGLNP
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
EQTEAVETLEGPVLVLAGAGTGKTRVLTTRIAHILNTGRAFPSQILAVTFTNKAAREMKE
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHH
RIALLVGGAVEGMPWLGTFHSIGVKLLRRHGELVGLRSDFTILDTDDVVRLIKQLIQAEG
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEEECCHHHHHHHHHHHHHCC
LDDKRWPAKQFAGMIDTWKNKGLGPADIPEGDARAFANGRGRDLYFAYQARLTTLNACDF
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCEEEEEEEEEEEEECCCCH
GDLLMHPIAIFRKNPDLLKEYHGRFRYILVDEYQDTNTAQYMWLRLLAQRAKGEPQNVCC
HHHHHHHHHHHCCCHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEE
VGDDDQSIYGWRGAEVDNILRFEKDFPGAKVIKLERNYRSTEHILGAAAHLIAHNEGRLG
ECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCC
KTLFTDRSDPEDVKVQVHASWDSEEEARAIGEEIEQLQRGKHLLNDMAILVRASFQMREF
CHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDRFVTLGLNYRVIGGPRFYERLEIRDAMAYFRLVAQASDDLAFERIINTPKRGLGDTTV
CCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHH
RALHDYARARDIPMLAAAADIIETDELKPKARKALFDVIQSFRRWQELLENTPHTELAEQ
HHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ILEESGYTDMWKNDKSAEAPGRLENLKELIRSMESFESMRGFLEHVSLVMDAETNENLDA
HHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCE
VSIMTLHSAKGLEFDTVFLPGWEEGLFPHQRSLDESGRAGLEEERRLAYVGITRAKHRCH
EEEEEEECCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHEEEEEEEECCCCEEE
IWFVSNRRIHGLWQSTLPSRFLDELPETHVEVAEMEQSYGGYGRGGYGQSRFDKAEPFAN
EEEEECCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
SYSTPGWKRAQANKTDATRDNWGSRSGHAVERIGYGESGPKGRTIEGELVAKSTSSEPSR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCE
FTLGDRVFHLKFGNGNITGIEGNKLTIEFDRAGQKRVLDGFVERV
EEECCEEEEEEECCCEEEEECCCEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SNSFDDIPFFDEEPGEMARKPQPPAAPAGRAPATGGIAARAMAARDGGSRPDYLAGLNP
CCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
EQTEAVETLEGPVLVLAGAGTGKTRVLTTRIAHILNTGRAFPSQILAVTFTNKAAREMKE
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHH
RIALLVGGAVEGMPWLGTFHSIGVKLLRRHGELVGLRSDFTILDTDDVVRLIKQLIQAEG
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEEECCHHHHHHHHHHHHHCC
LDDKRWPAKQFAGMIDTWKNKGLGPADIPEGDARAFANGRGRDLYFAYQARLTTLNACDF
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCEEEEEEEEEEEEECCCCH
GDLLMHPIAIFRKNPDLLKEYHGRFRYILVDEYQDTNTAQYMWLRLLAQRAKGEPQNVCC
HHHHHHHHHHHCCCHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEE
VGDDDQSIYGWRGAEVDNILRFEKDFPGAKVIKLERNYRSTEHILGAAAHLIAHNEGRLG
ECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCC
KTLFTDRSDPEDVKVQVHASWDSEEEARAIGEEIEQLQRGKHLLNDMAILVRASFQMREF
CHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDRFVTLGLNYRVIGGPRFYERLEIRDAMAYFRLVAQASDDLAFERIINTPKRGLGDTTV
CCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHH
RALHDYARARDIPMLAAAADIIETDELKPKARKALFDVIQSFRRWQELLENTPHTELAEQ
HHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ILEESGYTDMWKNDKSAEAPGRLENLKELIRSMESFESMRGFLEHVSLVMDAETNENLDA
HHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCE
VSIMTLHSAKGLEFDTVFLPGWEEGLFPHQRSLDESGRAGLEEERRLAYVGITRAKHRCH
EEEEEEECCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHEEEEEEEECCCCEEE
IWFVSNRRIHGLWQSTLPSRFLDELPETHVEVAEMEQSYGGYGRGGYGQSRFDKAEPFAN
EEEEECCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
SYSTPGWKRAQANKTDATRDNWGSRSGHAVERIGYGESGPKGRTIEGELVAKSTSSEPSR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCE
FTLGDRVFHLKFGNGNITGIEGNKLTIEFDRAGQKRVLDGFVERV
EEECCEEEEEEECCCEEEEECCCEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA