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The map label for this gene is pccB [H]

Identifier: 209549474

GI number: 209549474

Start: 1925426

End: 1926958

Strand: Reverse

Name: pccB [H]

Synonym: Rleg2_1880

Alternate gene names: 209549474

Gene position: 1926958-1925426 (Counterclockwise)

Preceding gene: 209549475

Following gene: 209549473

Centisome position: 42.46

GC content: 62.75

Gene sequence:

>1533_bases
ATGAAGGAAATTCTCGAAGAACTGGAACGGCGCCGCGGCGTCGCCCGCCTCGGCGGTGGCAAGGCGCGCATCGACGCTCA
GCACAAGCGCGGCAAGCTGACAGCGCGCGAGCGCATCGACCTCTTCCTCGACGAAGGCTCCTTCGAGGAGTTCGACATGT
TCGTCGAACACCGCTCCACCGATTTCGGCATGGACAAGAGCCGTGTTGCCGGCGACGGCGTCGTTACCGGCTGGGGCACG
GTCAACGGCCGCACCGTGTTCGTCTTCGCCAAGGATTTCACCGTCTTCGGCGGCTCGCTTTCGGAAGCGCATGCCGAGAA
GATCATGAAGGTGCAGGACATGGCGCTGAAGAACCGCGCGCCGATCGTCGGCATCTACGATGCAGGCGGCGCCCGCATCC
AGGAGGGGGTGGCGGCGCTTGGCGGTTATGCCGAAGTGTTCCAGCGCAATGTGCTCGCCTCCGGCGTCATCCCGCAGATC
TCGGTGATCATGGGTCCCTGCGCCGGCGGCGACGTCTATTCGCCTGCGATGACCGATTTCATCTTCATGGTGCGCGATAC
GTCGTACATGTTCGTGACCGGGCCGGATGTGGTGAAAACCGTTACCAACGAGACGGTGACGGCGGAAGAACTCGGCGGCG
CCGTGGTCCACACGACGCGCTCTTCGATTGCTGATGGGGCCTATGAGAATGATGTGGAAACGCTGCTGCAGGTGCGACGG
CTGATCGATTTCCTGCCGCTGTCGAACACCGCGCCGCTGCCCGAGATCGAATGTTACCAGTCGGTGACAGAGGTCGACAT
GTCGCTCGACACGCTGGTGCCGGCCAGCGCCAACAAGCCATACGATATCAAGGAATTGATCCGGAAGGTGGCGGACGAGG
GGGATTTCTTCGAGGTCCAGGCGAGCTTTGCCGGCAATATCGTCTGCGGCTTCGGACGTGTCGAAGGCTCCACCGTCGGC
TTCGTCGCCAACCAGCCGATGGTACTGGCCGGCGTGCTGGACAGCGACGCCTCGCGCAAGGCGGCGCGCTTCGTGCGCTT
CTGCGACTGCTTCAACATTCCGATCGTCACCTTCGTCGACGTGCCGGGCTTCCTGCCGGGCACGGCGCAGGAATATGGCG
GTCTCATCAAACACGGCGCCAAGCTGCTTTTTGCCTATGCCGAAGCGACGGTGCCGAAGCTCACCGTCATCACCCGCAAG
GCCTTCGGCGGCGCCTATGACGTGATGGCGTCGAAGCATCTGCGCGGTGATCTCAACTATGCCTGGCCGACGGCGCAGAT
CGCCGTGATGGGCGCCAAGGGCGCAGTCGAGATCATCTTCCGCAAGGATATCGCCGATCCCGAGAAGATCGCCGCACATA
CGAAAATGTACGAGGACCGCTTCCTCTCGCCCTTTGTCGCCGCCGAGCGCGGTTATGTCGATGAGGTGATCATGCCGCAT
TCGACCCGCCGGCGGCTGGCGCGCGGGCTGAAGATGCTGCGCAACAAGGACCTCGCCAATCCCTGGAAGAAGCACGACAA
CATTCCGCTGTGA

Upstream 100 bases:

>100_bases
TGCCGACGAAATCCTGGCCGAGGACGTCGCGGCAAGGATACGCTCGGTTTTCTCACTCAGTGGACGCGGCCGCTAGCGCA
CAAGCGGCGAGGGAGATCGC

Downstream 100 bases:

>100_bases
CATCCGAAAATGAATCAAGCTGCCGGCTCAGGTGTTTGCCTGCTGTCGAAAAAGTGAACGGCCGTCAGCGATCCGTGTGT
TCAATCCCCGTCGGCGACGG

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKEILEELERRRGVARLGGGKARIDAQHKRGKLTARERIDLFLDEGSFEEFDMFVEHRSTDFGMDKSRVAGDGVVTGWGT
VNGRTVFVFAKDFTVFGGSLSEAHAEKIMKVQDMALKNRAPIVGIYDAGGARIQEGVAALGGYAEVFQRNVLASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTAEELGGAVVHTTRSSIADGAYENDVETLLQVRR
LIDFLPLSNTAPLPEIECYQSVTEVDMSLDTLVPASANKPYDIKELIRKVADEGDFFEVQASFAGNIVCGFGRVEGSTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDCFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYAEATVPKLTVITRK
AFGGAYDVMASKHLRGDLNYAWPTAQIAVMGAKGAVEIIFRKDIADPEKIAAHTKMYEDRFLSPFVAAERGYVDEVIMPH
STRRRLARGLKMLRNKDLANPWKKHDNIPL

Sequences:

>Translated_510_residues
MKEILEELERRRGVARLGGGKARIDAQHKRGKLTARERIDLFLDEGSFEEFDMFVEHRSTDFGMDKSRVAGDGVVTGWGT
VNGRTVFVFAKDFTVFGGSLSEAHAEKIMKVQDMALKNRAPIVGIYDAGGARIQEGVAALGGYAEVFQRNVLASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTAEELGGAVVHTTRSSIADGAYENDVETLLQVRR
LIDFLPLSNTAPLPEIECYQSVTEVDMSLDTLVPASANKPYDIKELIRKVADEGDFFEVQASFAGNIVCGFGRVEGSTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDCFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYAEATVPKLTVITRK
AFGGAYDVMASKHLRGDLNYAWPTAQIAVMGAKGAVEIIFRKDIADPEKIAAHTKMYEDRFLSPFVAAERGYVDEVIMPH
STRRRLARGLKMLRNKDLANPWKKHDNIPL
>Mature_510_residues
MKEILEELERRRGVARLGGGKARIDAQHKRGKLTARERIDLFLDEGSFEEFDMFVEHRSTDFGMDKSRVAGDGVVTGWGT
VNGRTVFVFAKDFTVFGGSLSEAHAEKIMKVQDMALKNRAPIVGIYDAGGARIQEGVAALGGYAEVFQRNVLASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTAEELGGAVVHTTRSSIADGAYENDVETLLQVRR
LIDFLPLSNTAPLPEIECYQSVTEVDMSLDTLVPASANKPYDIKELIRKVADEGDFFEVQASFAGNIVCGFGRVEGSTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDCFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYAEATVPKLTVITRK
AFGGAYDVMASKHLRGDLNYAWPTAQIAVMGAKGAVEIIFRKDIADPEKIAAHTKMYEDRFLSPFVAAERGYVDEVIMPH
STRRRLARGLKMLRNKDLANPWKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=62.7218934911243, Blast_Score=659, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=60.5313092979127, Blast_Score=647, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=501, Percent_Identity=30.938123752495, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1788655, Length=194, Percent_Identity=26.8041237113402, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=508, Percent_Identity=61.4173228346457, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=508, Percent_Identity=61.4173228346457, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=520, Percent_Identity=30.9615384615385, Blast_Score=239, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71997163, Length=364, Percent_Identity=23.6263736263736, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586065, Length=517, Percent_Identity=33.0754352030948, Blast_Score=244, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55803; Mature: 55803

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEILEELERRRGVARLGGGKARIDAQHKRGKLTARERIDLFLDEGSFEEFDMFVEHRST
CHHHHHHHHHHCCHHHCCCCCEEECCHHHCCCCCHHHCEEEEECCCCHHHHHHHHHHCCC
DFGMDKSRVAGDGVVTGWGTVNGRTVFVFAKDFTVFGGSLSEAHAEKIMKVQDMALKNRA
CCCCCHHHCCCCCEEEECCCCCCEEEEEEEECEEEECCCHHHHHHHHHHHHHHHHHHCCC
PIVGIYDAGGARIQEGVAALGGYAEVFQRNVLASGVIPQISVIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEHEECCCCCCCCCCHHHHHE
IFMVRDTSYMFVTGPDVVKTVTNETVTAEELGGAVVHTTRSSIADGAYENDVETLLQVRR
EEEEECCCEEEEECCHHHHHHCCCCEEHHHHCCEEEEECHHHHCCCCCHHHHHHHHHHHH
LIDFLPLSNTAPLPEIECYQSVTEVDMSLDTLVPASANKPYDIKELIRKVADEGDFFEVQ
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEE
ASFAGNIVCGFGRVEGSTVGFVANQPMVLAGVLDSDASRKAARFVRFCDCFNIPIVTFVD
ECCCCCEEEEECCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAYAEATVPKLTVITRKAFGGAYDVMASKHLRGDLNY
CCCCCCCCHHHHCHHHHHHHHHEEHHHHCCCCEEEEEEHHHCCCHHHHHHHHHHCCCCCC
AWPTAQIAVMGAKGAVEIIFRKDIADPEKIAAHTKMYEDRFLSPFVAAERGYVDEVIMPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCC
STRRRLARGLKMLRNKDLANPWKKHDNIPL
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKEILEELERRRGVARLGGGKARIDAQHKRGKLTARERIDLFLDEGSFEEFDMFVEHRST
CHHHHHHHHHHCCHHHCCCCCEEECCHHHCCCCCHHHCEEEEECCCCHHHHHHHHHHCCC
DFGMDKSRVAGDGVVTGWGTVNGRTVFVFAKDFTVFGGSLSEAHAEKIMKVQDMALKNRA
CCCCCHHHCCCCCEEEECCCCCCEEEEEEEECEEEECCCHHHHHHHHHHHHHHHHHHCCC
PIVGIYDAGGARIQEGVAALGGYAEVFQRNVLASGVIPQISVIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEHEECCCCCCCCCCHHHHHE
IFMVRDTSYMFVTGPDVVKTVTNETVTAEELGGAVVHTTRSSIADGAYENDVETLLQVRR
EEEEECCCEEEEECCHHHHHHCCCCEEHHHHCCEEEEECHHHHCCCCCHHHHHHHHHHHH
LIDFLPLSNTAPLPEIECYQSVTEVDMSLDTLVPASANKPYDIKELIRKVADEGDFFEVQ
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEE
ASFAGNIVCGFGRVEGSTVGFVANQPMVLAGVLDSDASRKAARFVRFCDCFNIPIVTFVD
ECCCCCEEEEECCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAYAEATVPKLTVITRKAFGGAYDVMASKHLRGDLNY
CCCCCCCCHHHHCHHHHHHHHHEEHHHHCCCCEEEEEEHHHCCCHHHHHHHHHHCCCCCC
AWPTAQIAVMGAKGAVEIIFRKDIADPEKIAAHTKMYEDRFLSPFVAAERGYVDEVIMPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCC
STRRRLARGLKMLRNKDLANPWKKHDNIPL
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]