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The map label for this gene is thrS [H]

Identifier: 209549439

GI number: 209549439

Start: 1894104

End: 1896110

Strand: Reverse

Name: thrS [H]

Synonym: Rleg2_1845

Alternate gene names: 209549439

Gene position: 1896110-1894104 (Counterclockwise)

Preceding gene: 209549440

Following gene: 209549437

Centisome position: 41.78

GC content: 60.49

Gene sequence:

>2007_bases
ATGTCTGAAGCCATTTTCCTGACATTTCCCGATGGTTCCGTGCGCAGCTTCCCGGCTGGCGCGACCGGCAGGGATGTCGC
CGAATCCATTTCCAAGTCGCTCGCCAAGAGCGCCGTCGCCATTGCGATCGATGGCACAGTGCAAGACCTTTCCGATACCG
TCGCCGACGGCAAGATCGAGATCATCACCCGCAAGGACGGCCGTGCGCTGGAGCTTATCCGGCATGACGCCGCACACGTG
ATGGCTGAAGCCGTGCAGGAACTTTGGCCCGGCACGCAGGTGACGATCGGCCCGGTCATCGAAAACGGTTTCTATTACGA
CTTCGCCAAGAACGAGCCCTTTACGCCCGATGATCTGCCGAAGATCGAAAAGAAGATGAAGGAGATCATTGCTCGCAATG
CGCCCTTCACCAAGCAGATCTGGTCGCGCGAAAAGGCCAAGGAAGTCTTTGCGGCCAAGGGCGAAAACTACAAGGTAGAA
CTTGTCGATGCGATCCCGGCAGGGCAGGATCTGAAGATCTACAATCAGGGCGATTGGTTCGACCTTTGCCGCGGTCCGCA
CATGGCCTCCACCGGCCAGGTCGGCACGGCCTTCAAGCTGATGAAGGTTGCCGGCGCCTATTGGCGCGGCGACAGCAACA
ACGCCATGCTGTCACGCATCTACGGCACGGCATGGGCTGACCAGGCCGATCTCGACAACTATCTGCATATGCTGGCGGAA
GCTGAAAAGCGCGACCACCGCAAGCTCGGCCGCGAAATGGACCTGTTCCATTTCCAGGAGGAAGGCCCGGGTGTGGTCTT
CTGGCATGGCAAGGGCTGGCGCATCTTCCAGGCGCTCGTCTCCTATATGCGTCGCCGGCTCGCCGTCGACTATGAAGAAG
TCAACGCGCCGCAGGTGCTCGACACCGCGCTCTGGGAAACCTCGGGGCATTGGGGCTGGTATCAGGAAAACATGTTCGCC
GTGAAATCGGCGCATGCGATGACGCATCCGGAAGACAAGGAAGCGGATAACCGCGTCTTTGCGCTGAAGCCGATGAACTG
CCCCGGCCACGTGCAGATCTTCAAGCATGGGCTGAAGTCCTATCGCGAACTGCCGATCCGCCTCGCCGAATTCGGCCTGG
TACATCGCTACGAGCCTTCGGGCGCGCTGCACGGGCTGATGCGTGTGCGCGGCTTCACGCAGGACGACGCGCACATCTTC
TGCACCGACGAGCAGATGGCAGCCGAATGCCTGAAGATCAACGATCTCATCCTGTCGGTCTATGAAGACTTCGGCTTCAA
GGAAATCGTCGTCAAGCTTTCCACCCGGCCGGAAAAGCGTGTCGGTTCCGACGCACTCTGGGATCGCGCCGAAGCCGTGA
TGACCGACGTGTTGAAAACGATCGAGGCGCAGTCCGAGGGCCGCATCAAGACCGGCATTCTGCCGGGCGAGGGCGCCTTC
TACGGGCCGAAGTTCGAATACACGCTGAAGGATGCGATCGGCCGTGAATGGCAGTGCGGCACGACGCAGGTCGATTTTAA
TCTGCCTGAGCGATTCGGCGCCTTCTATATCGACAGCAACTCCGAAAAGACGCAGCCGGTGATGATCCATCGCGCCATCT
GCGGCTCAATGGAACGCTTCCTCGGTATCCTGATCGAAAACTTCGCCGGCCATCTGCCGCTCTGGGTGTCGCCGCTGCAG
GTGGTGGTCGCGACAATCACTTCGGAAGCCGACGCTTACGGGCTTGAAGTAGCCGAGGCGCTGCGCGAGGCCGGTCTCAA
CGTCGAGACCGATTTCCGCAACGAGAAGATCAACTACAAGGTCCGCGAACACTCGGTCACCAAGGTGCCCGTCATCATCG
TCTGCGGCAGGAAGGAAGCCGAGGAGCGCACGGTCAACATCCGCCGCCTCGGCAGCCAGGACCAGGTTTCGATGGGGCTC
GACGCCGCCGTCGACAGCCTTGCCTTGGAAGCGACACCGCCAGACGTCCGTCGCAAGGCCGAAGCAAAGAAAGCCAGGGC
GGCCTGA

Upstream 100 bases:

>100_bases
CGGCAAATCTGAGTATCAGGCGGCAGCGCTTCCAACGAACGGCGGCGCTTCCGTTTCAACCACCCGCATTCGTTGGCGGG
ACTGGACAAGGAGAATTTCG

Downstream 100 bases:

>100_bases
AAACGCCTCTATCCGACAGCGCCACCGGCGCTGTCGGAGGATCTGGGAGGCGCTGAACAGCCGCGTCTACCGCAAGGGTC
TGCTGGCCCGCCTCTATGAG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MSEAIFLTFPDGSVRSFPAGATGRDVAESISKSLAKSAVAIAIDGTVQDLSDTVADGKIEIITRKDGRALELIRHDAAHV
MAEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPDDLPKIEKKMKEIIARNAPFTKQIWSREKAKEVFAAKGENYKVE
LVDAIPAGQDLKIYNQGDWFDLCRGPHMASTGQVGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWADQADLDNYLHMLAE
AEKRDHRKLGREMDLFHFQEEGPGVVFWHGKGWRIFQALVSYMRRRLAVDYEEVNAPQVLDTALWETSGHWGWYQENMFA
VKSAHAMTHPEDKEADNRVFALKPMNCPGHVQIFKHGLKSYRELPIRLAEFGLVHRYEPSGALHGLMRVRGFTQDDAHIF
CTDEQMAAECLKINDLILSVYEDFGFKEIVVKLSTRPEKRVGSDALWDRAEAVMTDVLKTIEAQSEGRIKTGILPGEGAF
YGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDSNSEKTQPVMIHRAICGSMERFLGILIENFAGHLPLWVSPLQ
VVVATITSEADAYGLEVAEALREAGLNVETDFRNEKINYKVREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQDQVSMGL
DAAVDSLALEATPPDVRRKAEAKKARAA

Sequences:

>Translated_668_residues
MSEAIFLTFPDGSVRSFPAGATGRDVAESISKSLAKSAVAIAIDGTVQDLSDTVADGKIEIITRKDGRALELIRHDAAHV
MAEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPDDLPKIEKKMKEIIARNAPFTKQIWSREKAKEVFAAKGENYKVE
LVDAIPAGQDLKIYNQGDWFDLCRGPHMASTGQVGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWADQADLDNYLHMLAE
AEKRDHRKLGREMDLFHFQEEGPGVVFWHGKGWRIFQALVSYMRRRLAVDYEEVNAPQVLDTALWETSGHWGWYQENMFA
VKSAHAMTHPEDKEADNRVFALKPMNCPGHVQIFKHGLKSYRELPIRLAEFGLVHRYEPSGALHGLMRVRGFTQDDAHIF
CTDEQMAAECLKINDLILSVYEDFGFKEIVVKLSTRPEKRVGSDALWDRAEAVMTDVLKTIEAQSEGRIKTGILPGEGAF
YGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDSNSEKTQPVMIHRAICGSMERFLGILIENFAGHLPLWVSPLQ
VVVATITSEADAYGLEVAEALREAGLNVETDFRNEKINYKVREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQDQVSMGL
DAAVDSLALEATPPDVRRKAEAKKARAA
>Mature_667_residues
SEAIFLTFPDGSVRSFPAGATGRDVAESISKSLAKSAVAIAIDGTVQDLSDTVADGKIEIITRKDGRALELIRHDAAHVM
AEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPDDLPKIEKKMKEIIARNAPFTKQIWSREKAKEVFAAKGENYKVEL
VDAIPAGQDLKIYNQGDWFDLCRGPHMASTGQVGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWADQADLDNYLHMLAEA
EKRDHRKLGREMDLFHFQEEGPGVVFWHGKGWRIFQALVSYMRRRLAVDYEEVNAPQVLDTALWETSGHWGWYQENMFAV
KSAHAMTHPEDKEADNRVFALKPMNCPGHVQIFKHGLKSYRELPIRLAEFGLVHRYEPSGALHGLMRVRGFTQDDAHIFC
TDEQMAAECLKINDLILSVYEDFGFKEIVVKLSTRPEKRVGSDALWDRAEAVMTDVLKTIEAQSEGRIKTGILPGEGAFY
GPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDSNSEKTQPVMIHRAICGSMERFLGILIENFAGHLPLWVSPLQV
VVATITSEADAYGLEVAEALREAGLNVETDFRNEKINYKVREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQDQVSMGLD
AAVDSLALEATPPDVRRKAEAKKARAA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=632, Percent_Identity=37.8164556962025, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI38202255, Length=633, Percent_Identity=38.3886255924171, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI20070344, Length=646, Percent_Identity=37.6160990712074, Blast_Score=410, Evalue=1e-114,
Organism=Escherichia coli, GI1788013, Length=647, Percent_Identity=49.613601236476, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=655, Percent_Identity=39.0839694656489, Blast_Score=456, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI71984192, Length=655, Percent_Identity=39.0839694656489, Blast_Score=456, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322112, Length=663, Percent_Identity=38.4615384615385, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322654, Length=409, Percent_Identity=34.718826405868, Blast_Score=256, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24583839, Length=635, Percent_Identity=39.5275590551181, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24583842, Length=635, Percent_Identity=39.5275590551181, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI28574141, Length=635, Percent_Identity=39.5275590551181, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 74853; Mature: 74722

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAIFLTFPDGSVRSFPAGATGRDVAESISKSLAKSAVAIAIDGTVQDLSDTVADGKIE
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHCCCEEE
IITRKDGRALELIRHDAAHVMAEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPDDLP
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCHH
KIEKKMKEIIARNAPFTKQIWSREKAKEVFAAKGENYKVELVDAIPAGQDLKIYNQGDWF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEECCCHH
DLCRGPHMASTGQVGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWADQADLDNYLHMLAE
HHHCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
AEKRDHRKLGREMDLFHFQEEGPGVVFWHGKGWRIFQALVSYMRRRLAVDYEEVNAPQVL
HHHHHHHHHCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHCCCCHHH
DTALWETSGHWGWYQENMFAVKSAHAMTHPEDKEADNRVFALKPMNCPGHVQIFKHGLKS
HHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
YRELPIRLAEFGLVHRYEPSGALHGLMRVRGFTQDDAHIFCTDEQMAAECLKINDLILSV
HHHCCHHHHHHCCEEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHH
YEDFGFKEIVVKLSTRPEKRVGSDALWDRAEAVMTDVLKTIEAQSEGRIKTGILPGEGAF
HHHCCCEEEEEEECCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCC
YGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDSNSEKTQPVMIHRAICGSMERF
CCCCEEEEHHHHCCCCCCCCCEEEECCCHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHH
LGILIENFAGHLPLWVSPLQVVVATITSEADAYGLEVAEALREAGLNVETDFRNEKINYK
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCEE
VREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQDQVSMGLDAAVDSLALEATPPDVRRKA
EECCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHCHHHHHHHHEECCCCHHHHHHH
EAKKARAA
HHHHHCCC
>Mature Secondary Structure 
SEAIFLTFPDGSVRSFPAGATGRDVAESISKSLAKSAVAIAIDGTVQDLSDTVADGKIE
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHCCCEEE
IITRKDGRALELIRHDAAHVMAEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPDDLP
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCHH
KIEKKMKEIIARNAPFTKQIWSREKAKEVFAAKGENYKVELVDAIPAGQDLKIYNQGDWF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEECCCHH
DLCRGPHMASTGQVGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWADQADLDNYLHMLAE
HHHCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
AEKRDHRKLGREMDLFHFQEEGPGVVFWHGKGWRIFQALVSYMRRRLAVDYEEVNAPQVL
HHHHHHHHHCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHCCCCHHH
DTALWETSGHWGWYQENMFAVKSAHAMTHPEDKEADNRVFALKPMNCPGHVQIFKHGLKS
HHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
YRELPIRLAEFGLVHRYEPSGALHGLMRVRGFTQDDAHIFCTDEQMAAECLKINDLILSV
HHHCCHHHHHHCCEEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHH
YEDFGFKEIVVKLSTRPEKRVGSDALWDRAEAVMTDVLKTIEAQSEGRIKTGILPGEGAF
HHHCCCEEEEEEECCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCC
YGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDSNSEKTQPVMIHRAICGSMERF
CCCCEEEEHHHHCCCCCCCCCEEEECCCHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHH
LGILIENFAGHLPLWVSPLQVVVATITSEADAYGLEVAEALREAGLNVETDFRNEKINYK
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCEE
VREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQDQVSMGLDAAVDSLALEATPPDVRRKA
EECCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHCHHHHHHHHEECCCCHHHHHHH
EAKKARAA
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA