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The map label for this gene is gltC [H]

Identifier: 209549224

GI number: 209549224

Start: 1653441

End: 1654337

Strand: Reverse

Name: gltC [H]

Synonym: Rleg2_1625

Alternate gene names: 209549224

Gene position: 1654337-1653441 (Counterclockwise)

Preceding gene: 209549233

Following gene: 209549223

Centisome position: 36.46

GC content: 59.2

Gene sequence:

>897_bases
ATGGACATCGGACGTCTGCGGGCACTGCGCGAACTATCAATCCGCAAGACCATGGCCGCGGTGGCAGAGGCCTTGCACGT
TTCGCCTTCGGCAGTGTCGCAACAAATTGCGCTTCTCGAAGAAGAGGTCGGCATTCGGCTCGTCGAGCGACGCGGCCGGG
GCGTCGTGATGACACCTGCCGGCCAGCAGCTCGTACTGCGAGCAGAGAAAATTCTCATCGAAATCGAATCGGCAAAAGCA
GACATCGCCGAACTGAAAAGCGTCGTTTCCGGAGAACTCCGGGTGGCTGCTTTCCCCTCCGTAGCGGCTGCCGTCATTCC
AAAGGTCGTCTATGATTTAGCCGAACGACACCCGCACCTCACCGTTCAATTCGAAGAAATGGAGCCGGCCGAAAGCGTTG
CCGCGCTGCGGAGCTGGCAGACGGATGTCGCGATTATCGATGACCTGAACATGCCGACTGGCGCGCTCGATCCCAATATC
GAGACGATCTTCCTGATGGAGGACGTCTTCAACGTCATGGTCTCCAAGGATCACAGGCTCTCGGAACGGCCGACCGTTGG
CCTGCACGAGCTTCGGGAGGAGCGGTGGGCGATCGATACCGCTTCCGACACCTATACGAGGATGCTGGTGGAGGCCTGTC
AGGAAGACGGTTTCAAGCCTAACATCGTGGCGAGGTGCAAAGGGTTCGAGGTAACCATCGCCCTGATCCGGCAGAACTAC
GGTATTTCGATCCTGCCCGGCCTGCGCGCCAGCTACGATCTCGAAGACGTCTGGGTCTGCAGGCTCGTTCCAGAAATCCG
CCGGAAGATATTTCTCGCCTTCCGGAAAGAGGAAAAGCGCAGTCCGGCTCTCCAGGCATTCCTGGACCGGATGGCGGAGA
AACCGCCGCTCTCCTGA

Upstream 100 bases:

>100_bases
TTGTGAGGAACCTAGATCGAGCAACACACCAGAAAAAGTTAATATTATTTGCTTATACGTTCAGACGCGCTAATGATTCC
GCCGAACTGAGGAGATCGTT

Downstream 100 bases:

>100_bases
TCGAGCGCGCCAGCGCTCCGCGAGCGCCTCGTCGATAAATGCCGCTTCACCGATACCGCATCGTTTCGCGCCTCGACCGC
GCGAGTGGTCCCAATCGTAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MDIGRLRALRELSIRKTMAAVAEALHVSPSAVSQQIALLEEEVGIRLVERRGRGVVMTPAGQQLVLRAEKILIEIESAKA
DIAELKSVVSGELRVAAFPSVAAAVIPKVVYDLAERHPHLTVQFEEMEPAESVAALRSWQTDVAIIDDLNMPTGALDPNI
ETIFLMEDVFNVMVSKDHRLSERPTVGLHELREERWAIDTASDTYTRMLVEACQEDGFKPNIVARCKGFEVTIALIRQNY
GISILPGLRASYDLEDVWVCRLVPEIRRKIFLAFRKEEKRSPALQAFLDRMAEKPPLS

Sequences:

>Translated_298_residues
MDIGRLRALRELSIRKTMAAVAEALHVSPSAVSQQIALLEEEVGIRLVERRGRGVVMTPAGQQLVLRAEKILIEIESAKA
DIAELKSVVSGELRVAAFPSVAAAVIPKVVYDLAERHPHLTVQFEEMEPAESVAALRSWQTDVAIIDDLNMPTGALDPNI
ETIFLMEDVFNVMVSKDHRLSERPTVGLHELREERWAIDTASDTYTRMLVEACQEDGFKPNIVARCKGFEVTIALIRQNY
GISILPGLRASYDLEDVWVCRLVPEIRRKIFLAFRKEEKRSPALQAFLDRMAEKPPLS
>Mature_298_residues
MDIGRLRALRELSIRKTMAAVAEALHVSPSAVSQQIALLEEEVGIRLVERRGRGVVMTPAGQQLVLRAEKILIEIESAKA
DIAELKSVVSGELRVAAFPSVAAAVIPKVVYDLAERHPHLTVQFEEMEPAESVAALRSWQTDVAIIDDLNMPTGALDPNI
ETIFLMEDVFNVMVSKDHRLSERPTVGLHELREERWAIDTASDTYTRMLVEACQEDGFKPNIVARCKGFEVTIALIRQNY
GISILPGLRASYDLEDVWVCRLVPEIRRKIFLAFRKEEKRSPALQAFLDRMAEKPPLS

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=273, Percent_Identity=28.2051282051282, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787601, Length=247, Percent_Identity=24.6963562753036, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788748, Length=286, Percent_Identity=26.2237762237762, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790399, Length=304, Percent_Identity=24.6710526315789, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787879, Length=292, Percent_Identity=26.3698630136986, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787530, Length=252, Percent_Identity=24.6031746031746, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693105, Length=291, Percent_Identity=23.0240549828179, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367136, Length=288, Percent_Identity=24.3055555555556, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788887, Length=302, Percent_Identity=25.1655629139073, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081904, Length=181, Percent_Identity=27.6243093922652, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789506, Length=221, Percent_Identity=27.1493212669683, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790208, Length=248, Percent_Identity=23.3870967741935, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790262, Length=293, Percent_Identity=22.8668941979522, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33392; Mature: 33392

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIGRLRALRELSIRKTMAAVAEALHVSPSAVSQQIALLEEEVGIRLVERRGRGVVMTPA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHEEECCCCEEEECCC
GQQLVLRAEKILIEIESAKADIAELKSVVSGELRVAAFPSVAAAVIPKVVYDLAERHPHL
CCHHHHHHHHHHEEEHHHHCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
TVQFEEMEPAESVAALRSWQTDVAIIDDLNMPTGALDPNIETIFLMEDVFNVMVSKDHRL
EEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCC
SERPTVGLHELREERWAIDTASDTYTRMLVEACQEDGFKPNIVARCKGFEVTIALIRQNY
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCC
GISILPGLRASYDLEDVWVCRLVPEIRRKIFLAFRKEEKRSPALQAFLDRMAEKPPLS
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDIGRLRALRELSIRKTMAAVAEALHVSPSAVSQQIALLEEEVGIRLVERRGRGVVMTPA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHEEECCCCEEEECCC
GQQLVLRAEKILIEIESAKADIAELKSVVSGELRVAAFPSVAAAVIPKVVYDLAERHPHL
CCHHHHHHHHHHEEEHHHHCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
TVQFEEMEPAESVAALRSWQTDVAIIDDLNMPTGALDPNIETIFLMEDVFNVMVSKDHRL
EEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCC
SERPTVGLHELREERWAIDTASDTYTRMLVEACQEDGFKPNIVARCKGFEVTIALIRQNY
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCC
GISILPGLRASYDLEDVWVCRLVPEIRRKIFLAFRKEEKRSPALQAFLDRMAEKPPLS
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]