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The map label for this gene is mazG [H]

Identifier: 209549233

GI number: 209549233

Start: 1664691

End: 1665536

Strand: Reverse

Name: mazG [H]

Synonym: Rleg2_1634

Alternate gene names: 209549233

Gene position: 1665536-1664691 (Counterclockwise)

Preceding gene: 209549234

Following gene: 209549224

Centisome position: 36.7

GC content: 62.65

Gene sequence:

>846_bases
ATGGAACCTTCCAAAGATATTTCCCGGCTGATCGAGATCATGGCGGCGCTGCGCCATCCCGAAACCGGCTGTCCCTGGGA
CATCGAGCAGAGCTTCGAGACGATCAAGCCCTATACGATCGAGGAAGCCTATGAGGTCTCCGACGCGATCGAGCGGGGCG
ATATGGACGATCTCTGCGACGAGCTCGGCGACCTGCTGCTGCAGGTGGTCTTCCATGCCCGCATGGCCGAGGAGGCCGGC
GAATTCTCCTTCGGCGACGTCGTCAACGCCATCACCACCAAGATGATCCGCCGCCACCCGCACGTCTTTGCCCGCTCGGA
GGCCGACACGCCCGACGCGGTGAAGATCCAGTGGGACGAGATCAAGCAGGCGGAGAAACGCGAGCGCGCCGAGCGCCGGG
CAAGGCGCGGCATTACCGAGGATTTCAAGGGCGGGTTCCTGGGGTCCGTGCAGCGCAGCTTCCCGGCCTTGACGGAAGCG
CTGAAACTGCAGGAACGTGCCGCCAAGGTCGGCTTCGACTGGTCTGCCCCGGAACCGATCCTCGACAAGATCGAGGAGGA
GATCGACGAATTGCGGGTGGCATTACGCGAAGGCGACCGGGGGAAGGTCAGCGACGAGCTGGGGGATCTGATCTTTGCGG
TCGTCAATATCGGCCGGCATGTGAAGACCGATCCGGAACAGGCGCTGCGCGGGACGAATACGAAGTTTCGGCGTCGTTTC
AGTCACATCGAGCAGGTTCTTGATCAAGAAGGCGAGACGCTGGAAGCGGCGACGCTGGAGCGTATGGAGGAAATCTGGCA
GGCGGCGAAGGCAATTGAGCGGGCGGTGACGGCTGGAGCTGAGTGA

Upstream 100 bases:

>100_bases
GACGGGGCAGACCGCCCGCATCAAGGCCCGCTACGACGCGCTGTCTTCCACCTACCAGTCGTCGAAGAGCGCCAACGATA
TTCCCCTTAACTGAGGCACC

Downstream 100 bases:

>100_bases
GATGGCGTGGGGTTCAGCCGCACCCTCCGTCATGCTCGGCCATGAGCCGAGCATCCACACGACACCCACCAGCAGCCGCG
GCATGGATCCTCGGCTCAAG

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MEPSKDISRLIEIMAALRHPETGCPWDIEQSFETIKPYTIEEAYEVSDAIERGDMDDLCDELGDLLLQVVFHARMAEEAG
EFSFGDVVNAITTKMIRRHPHVFARSEADTPDAVKIQWDEIKQAEKRERAERRARRGITEDFKGGFLGSVQRSFPALTEA
LKLQERAAKVGFDWSAPEPILDKIEEEIDELRVALREGDRGKVSDELGDLIFAVVNIGRHVKTDPEQALRGTNTKFRRRF
SHIEQVLDQEGETLEAATLERMEEIWQAAKAIERAVTAGAE

Sequences:

>Translated_281_residues
MEPSKDISRLIEIMAALRHPETGCPWDIEQSFETIKPYTIEEAYEVSDAIERGDMDDLCDELGDLLLQVVFHARMAEEAG
EFSFGDVVNAITTKMIRRHPHVFARSEADTPDAVKIQWDEIKQAEKRERAERRARRGITEDFKGGFLGSVQRSFPALTEA
LKLQERAAKVGFDWSAPEPILDKIEEEIDELRVALREGDRGKVSDELGDLIFAVVNIGRHVKTDPEQALRGTNTKFRRRF
SHIEQVLDQEGETLEAATLERMEEIWQAAKAIERAVTAGAE
>Mature_281_residues
MEPSKDISRLIEIMAALRHPETGCPWDIEQSFETIKPYTIEEAYEVSDAIERGDMDDLCDELGDLLLQVVFHARMAEEAG
EFSFGDVVNAITTKMIRRHPHVFARSEADTPDAVKIQWDEIKQAEKRERAERRARRGITEDFKGGFLGSVQRSFPALTEA
LKLQERAAKVGFDWSAPEPILDKIEEEIDELRVALREGDRGKVSDELGDLIFAVVNIGRHVKTDPEQALRGTNTKFRRRF
SHIEQVLDQEGETLEAATLERMEEIWQAAKAIERAVTAGAE

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=266, Percent_Identity=48.8721804511278, Blast_Score=257, Evalue=7e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31877; Mature: 31877

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPSKDISRLIEIMAALRHPETGCPWDIEQSFETIKPYTIEEAYEVSDAIERGDMDDLCD
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHH
ELGDLLLQVVFHARMAEEAGEFSFGDVVNAITTKMIRRHPHVFARSEADTPDAVKIQWDE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCEEEEHHH
IKQAEKRERAERRARRGITEDFKGGFLGSVQRSFPALTEALKLQERAAKVGFDWSAPEPI
HHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LDKIEEEIDELRVALREGDRGKVSDELGDLIFAVVNIGRHVKTDPEQALRGTNTKFRRRF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHH
SHIEQVLDQEGETLEAATLERMEEIWQAAKAIERAVTAGAE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEPSKDISRLIEIMAALRHPETGCPWDIEQSFETIKPYTIEEAYEVSDAIERGDMDDLCD
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHH
ELGDLLLQVVFHARMAEEAGEFSFGDVVNAITTKMIRRHPHVFARSEADTPDAVKIQWDE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCEEEEHHH
IKQAEKRERAERRARRGITEDFKGGFLGSVQRSFPALTEALKLQERAAKVGFDWSAPEPI
HHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LDKIEEEIDELRVALREGDRGKVSDELGDLIFAVVNIGRHVKTDPEQALRGTNTKFRRRF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHH
SHIEQVLDQEGETLEAATLERMEEIWQAAKAIERAVTAGAE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]