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The map label for this gene is mdtP

Identifier: 209399819

GI number: 209399819

Start: 5227450

End: 5228916

Strand: Reverse

Name: mdtP

Synonym: ECH74115_5588

Alternate gene names: 209399819

Gene position: 5228916-5227450 (Counterclockwise)

Preceding gene: 209399505

Following gene: 209396005

Centisome position: 93.84

GC content: 55.83

Gene sequence:

>1467_bases
ATGATCAATCGTCAACTTTCACGTCTGCTGTTGTGCAGCATTCTCGGCAGCACGACGCTGATTTCCGGCTGTGCCCTGGT
ACGCAAGGATTCTGCGCCTCATCAACAGCTCAAACCGGAACAAATCAAACTGGCCGATGATATTCATCTTGCCAGCTCCG
GCTGGCCGCAGGCGCAGTGGTGGAAACAACTCAATGACCCGCAGCTGGATGCGCTGATCCAACGGACGCTAAGTGGTTCA
CACACCCTCGCCGAAGCGAAACTGCGGGAAGAAAAAGCGCAGTCCCAGGCCGATTTGTTAGATGCCGGTTCACAATTACA
GGTCGCAGCGTTAGGGATGCTCAACCGCCAACGCGTCTCGGCGAACGGCTTTTTAAGCCCTTATGCGATGGATGCGCCAG
CACTGGGTATGGACGGGCCGTACTATACGGAAGCCACAGTCGGTTTGTTTGCCGGACTGGATCTTGATTTGTGGGGTGTG
CATCGCTCAGCGGTTACCGCCGCCATTGGCGCGCATAATGCCGCGCTGGCAGAAACCGCAGCAGTAGAGCTATCGCTGAC
CACGGGCGTAGCGCAGCTTTATTACAGTATGCAGGCCAGCTATCAGATGCTCGATCTGTTAGAACAAACTCGCGATGTGA
TTGATTACGCGGTGAAAGCGCACCAAAGTAAAGTGGCGCACGGTCTGGAAGCGCAAGTGCCTTTCCACGGCGCGCGGGCA
CAGATTCTGGCGGTCGATAAACAAATTGCTGCCGTTAAAGGGCAAATCACCGAAACGCGAGAATCTCTGCGTGCATTGAT
TGGCGCGGGAGCCAGCGATATGCCGGAGATCAAACCAGTGGCATTACCACGAGTCCAGACCGGTATTCCGGCGACACTCT
CTTATGAGTTGCTCGCCAGACGCCCGGATCTGCAAGCCATGCGCTGGTATGTTCAGGCGTCATTAGATCAGGTGGATTCC
GCGCGGGCGCTGTTCTACCCAAGCTTTGATATCAAAGCGTTTTTCGGTCTGGACTCCATCCACCTGGATACCTTATTCAA
AAAAACCAGTCGCCAGTTCAACTTCATCCCGGGTCTGAAATTGCCGCTGTTTGACGGTGGACGGTTGAATGCCAATCTCG
AAGGCACTCGCGCCGCCAGCAACATGATGATTGAACGTTACAACCAGTCAGTACTGAACGCGGTGCGTGACGTTGCCGTC
AACGGCACGCGTCTGCAAACGCTCAACGACGAGCGAGAAATGCAGGCTGAACGCGTGGAAGCAACGCGCTTCACCCAGCG
CGCTGCCGAGGCCGCCTATCAGCGCGGCTTAACCAGCCGCTTACAGGCTACCGAAGCCCGGTTGCCGGTGCTTGCCGAAG
AGATGTCATTACTGATGCTGGACAGCCGCCGGGTGATCCAAAGCATTCAGTTGATGAAATCGCTGGGCAGCGGGTATCAG
GCGGCTCCCGTCGTCGAGAAAAAATAA

Upstream 100 bases:

>100_bases
TAAAACAGGAGCAACACGTCTGCCAGCTTTTCGCCCGCTTGCCAGACTGGACAGCCCCGGCATTAACGCCCGCCACGGAA
CAGGCACAAGGAGCCACGCA

Downstream 100 bases:

>100_bases
AATGTCTGCCGTGTGATGGCTGTCACGCGGTATTTCGTTTCGTCACGTCAAAACTGACGACAGCCTGTTTTTCGTCAGAG
TTTTGAATAAATAGTGCCCG

Product: putative outer membrane efflux protein MdtP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGS
HTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGV
HRSAVTAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA
QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPRVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDS
ARALFYPSFDIKAFFGLDSIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAV
NGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGSGYQ
AAPVVEKK

Sequences:

>Translated_488_residues
MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGS
HTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGV
HRSAVTAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA
QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPRVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDS
ARALFYPSFDIKAFFGLDSIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAV
NGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGSGYQ
AAPVVEKK
>Mature_488_residues
MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGS
HTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGV
HRSAVTAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA
QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPRVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDS
ARALFYPSFDIKAFFGLDSIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAV
NGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGSGYQ
AAPVVEKK

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family

Homologues:

Organism=Escherichia coli, GI2367348, Length=488, Percent_Identity=97.9508196721311, Blast_Score=954, Evalue=0.0,
Organism=Escherichia coli, GI1786785, Length=462, Percent_Identity=27.0562770562771, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MDTP_ECO57 (Q8X5R9)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B86102
- PIR:   F91261
- RefSeq:   NP_290713.1
- RefSeq:   NP_313089.1
- ProteinModelPortal:   Q8X5R9
- SMR:   Q8X5R9
- EnsemblBacteria:   EBESCT00000029174
- EnsemblBacteria:   EBESCT00000057084
- GeneID:   914272
- GeneID:   960044
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5680
- KEGG:   ecs:ECs5062
- GeneTree:   EBGT00050000009375
- HOGENOM:   HBG759011
- OMA:   YLPIFDG
- ProtClustDB:   PRK09915
- BioCyc:   ECOL83334:ECS5062-MONOMER
- InterPro:   IPR003423
- InterPro:   IPR010131
- TIGRFAMs:   TIGR01845

Pfam domain/function: PF02321 OEP

EC number: NA

Molecular weight: Translated: 53511; Mature: 53511

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN ; PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQW
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEHHCEEECCCCCCHHHH
WKQLNDPQLDALIQRTLSGSHTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVS
HHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCC
ANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGVHRSAVTAAIGAHNAALAETA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCHHHHHHH
AVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPRVQTGIPATLSYELLAR
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHC
RPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDSIHLDTLFKKTSRQFNFIPGLK
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCHHHHHHHHHHHCCCEECCCCCC
LPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAVNGTRLQTLNDEREMQAERVE
CCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHH
ATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGSGYQ
HHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AAPVVEKK
CCCCCCCC
>Mature Secondary Structure
MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQW
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEHHCEEECCCCCCHHHH
WKQLNDPQLDALIQRTLSGSHTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVS
HHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCC
ANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGVHRSAVTAAIGAHNAALAETA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCHHHHHHH
AVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPRVQTGIPATLSYELLAR
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHC
RPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDSIHLDTLFKKTSRQFNFIPGLK
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCHHHHHHHHHHHCCCEECCCCCC
LPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAVNGTRLQTLNDEREMQAERVE
CCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHH
ATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGSGYQ
HHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AAPVVEKK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796