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The map label for this gene is xylH

Identifier: 209398987

GI number: 209398987

Start: 4582995

End: 4584176

Strand: Direct

Name: xylH

Synonym: ECH74115_4944

Alternate gene names: 209398987

Gene position: 4582995-4584176 (Clockwise)

Preceding gene: 209399539

Following gene: 209398178

Centisome position: 82.25

GC content: 54.06

Gene sequence:

>1182_bases
ATGTCGAAAAGCAATCCGTCTGAAGTGAAATTGGCCGTACCGACATCCGGTGGCTTCTCCGGGCTGAAATCACTGAATTT
GCAGGTCTTCGTGATGATTGCAGCTATCATCGCAATCATGCTGTTCTTTACCTGGACCACCGATGGTGCCTACTTAAGCG
CCCGTAACGTCTCCAACCTGTTACGCCAGACCGCGATTACCGGCATCCTCGCGGTAGGAATGGTGTTCGTCATAATTTCT
GCTGAAATCGACCTTTCCGTCGGCTCAATGATGGGGCTATTAGGTGGCGTCGCGGCGATTTGTGACGTCTGGCTAGGCTG
GCCTTTGCCACTTACCATCATTGTGACGTTGGTTCTGGGACTGCTTCTCGGTGCCTGGAACGGATGGTGGGTCGCGTACC
GCAAAGTCCCTTCATTTATTGTCACTCTCGCGGGCATGTTGGCATTTCGCGGCATACTCATTGGCATCACCAACGGCACG
ACTGTATCCCCCACCAGCGCCGCGATGTCACAAATTGGGCAAAGCTATCTCCCCGCCAGCACCGGCTTCATCATTGGCGC
GCTTGGCTTAATGGCTTTTGTTGGCTGGCAATGGCGCGGAAGAATGCGCCGTCAGGCTTTGGGTTTGCAGTCTCCAGCCT
CTACCGCAGTAGTCGGTCGCCAGGCTTTAACCGCTATCATCGTATTAGGCGCAATCTGGCTGTTGAATGATTACCGTGGC
GTTCCTACTCCTGTTCTGCTGCTGACGTTGCTGTTACTCGGCGGAATGTTTATGGCAACGCGGACAGCATTTGGACGACG
CATTTATGCCATCGGCGGCAATCTGGAAGCAGCACGTCTCTCCGGAATTAACGTTGAACGCACCAAACTTGCCGTGTTCG
CTATTAACGGATTAATGGTAGCCATCGCCGGATTAATCCTCAGTTCTCGACTTGGCGCTGGTTCACCTTCTGCGGGGAAT
ATCGCCGAGCTGGACGCAATTGCAGCATGCGTGATTGGCGGCACCAGTCTGGCAGGCGGCGTCGGGAGCGTGGCTGGAGC
GGTAATGGGGGCATTCATCATGGCTTCACTGGATAACGGTATGAGTATGATGGATGTACCGACCTTCTGGCAGTATATCG
TTAAAGGTGCGATTCTGTTGCTGGCAGTATGGATGGACTCCGCAACCAAACGCCGTTCTTGA

Upstream 100 bases:

>100_bases
CGTGTACTAGTAATGCATGAAGGGAAACTAAAAGCCAACCTGATAAATCATAACCTGACTCAGGAGCAGGTGATGGAAGC
CGCATTGAGGAGCGAACATC

Downstream 100 bases:

>100_bases
TTTTGATAAAAATTTTCTCAAAGCCGGTAACGTATTACCGGTTTTGAGTTTTTGCATGATTCAGCAGGAAAAGAACCATG
TTTACTAAACGTCACCGCAT

Product: D-xylose ABC transporter, permease protein

Products: ADP; phosphate; xylose [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSKSNPSEVKLAVPTSGGFSGLKSLNLQVFVMIAAIIAIMLFFTWTTDGAYLSARNVSNLLRQTAITGILAVGMVFVIIS
AEIDLSVGSMMGLLGGVAAICDVWLGWPLPLTIIVTLVLGLLLGAWNGWWVAYRKVPSFIVTLAGMLAFRGILIGITNGT
TVSPTSAAMSQIGQSYLPASTGFIIGALGLMAFVGWQWRGRMRRQALGLQSPASTAVVGRQALTAIIVLGAIWLLNDYRG
VPTPVLLLTLLLLGGMFMATRTAFGRRIYAIGGNLEAARLSGINVERTKLAVFAINGLMVAIAGLILSSRLGAGSPSAGN
IAELDAIAACVIGGTSLAGGVGSVAGAVMGAFIMASLDNGMSMMDVPTFWQYIVKGAILLLAVWMDSATKRRS

Sequences:

>Translated_393_residues
MSKSNPSEVKLAVPTSGGFSGLKSLNLQVFVMIAAIIAIMLFFTWTTDGAYLSARNVSNLLRQTAITGILAVGMVFVIIS
AEIDLSVGSMMGLLGGVAAICDVWLGWPLPLTIIVTLVLGLLLGAWNGWWVAYRKVPSFIVTLAGMLAFRGILIGITNGT
TVSPTSAAMSQIGQSYLPASTGFIIGALGLMAFVGWQWRGRMRRQALGLQSPASTAVVGRQALTAIIVLGAIWLLNDYRG
VPTPVLLLTLLLLGGMFMATRTAFGRRIYAIGGNLEAARLSGINVERTKLAVFAINGLMVAIAGLILSSRLGAGSPSAGN
IAELDAIAACVIGGTSLAGGVGSVAGAVMGAFIMASLDNGMSMMDVPTFWQYIVKGAILLLAVWMDSATKRRS
>Mature_392_residues
SKSNPSEVKLAVPTSGGFSGLKSLNLQVFVMIAAIIAIMLFFTWTTDGAYLSARNVSNLLRQTAITGILAVGMVFVIISA
EIDLSVGSMMGLLGGVAAICDVWLGWPLPLTIIVTLVLGLLLGAWNGWWVAYRKVPSFIVTLAGMLAFRGILIGITNGTT
VSPTSAAMSQIGQSYLPASTGFIIGALGLMAFVGWQWRGRMRRQALGLQSPASTAVVGRQALTAIIVLGAIWLLNDYRGV
PTPVLLLTLLLLGGMFMATRTAFGRRIYAIGGNLEAARLSGINVERTKLAVFAINGLMVAIAGLILSSRLGAGSPSAGNI
AELDAIAACVIGGTSLAGGVGSVAGAVMGAFIMASLDNGMSMMDVPTFWQYIVKGAILLLAVWMDSATKRRS

Specific function: Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane

COG id: COG4214

COG function: function code G; ABC-type xylose transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. AraH/rbsC subfamily

Homologues:

Organism=Escherichia coli, GI1789992, Length=393, Percent_Identity=100, Blast_Score=759, Evalue=0.0,
Organism=Escherichia coli, GI1790191, Length=359, Percent_Identity=35.933147632312, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI145693152, Length=341, Percent_Identity=31.3782991202346, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788896, Length=161, Percent_Identity=39.7515527950311, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI87082395, Length=345, Percent_Identity=30.4347826086957, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1787793, Length=345, Percent_Identity=31.0144927536232, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790524, Length=152, Percent_Identity=39.4736842105263, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788471, Length=376, Percent_Identity=30.8510638297872, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI145693214, Length=311, Percent_Identity=31.5112540192926, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787794, Length=157, Percent_Identity=31.2101910828025, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XYLH_ECO57 (P0AGI6)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A86032
- PIR:   C91185
- RefSeq:   NP_290153.1
- RefSeq:   NP_312478.1
- ProteinModelPortal:   P0AGI6
- EnsemblBacteria:   EBESCT00000024560
- EnsemblBacteria:   EBESCT00000056884
- GeneID:   915611
- GeneID:   961041
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4993
- KEGG:   ecs:ECs4451
- GeneTree:   EBGT00050000010180
- HOGENOM:   HBG663180
- OMA:   MTDGAYL
- ProtClustDB:   CLSK880725
- BioCyc:   ECOL83334:ECS4451-MONOMER
- InterPro:   IPR001851

Pfam domain/function: PF02653 BPD_transp_2

EC number: NA

Molecular weight: Translated: 41032; Mature: 40900

Theoretical pI: Translated: 10.82; Mature: 10.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12758518)-; HASH(0x11d32ce8)-; HASH(0x128c64b0)-; HASH(0x1078f3c0)-; HASH(0x10e21ba8)-; HASH(0x125fb878)-; HASH(0x1263ccf8)-; HASH(0x12823128)-; HASH(0x1258edcc)-; HASH(0x128aa8a4)-; HASH(0x11b01d1c)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSNPSEVKLAVPTSGGFSGLKSLNLQVFVMIAAIIAIMLFFTWTTDGAYLSARNVSNL
CCCCCCCCEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHH
LRQTAITGILAVGMVFVIISAEIDLSVGSMMGLLGGVAAICDVWLGWPLPLTIIVTLVLG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LLLGAWNGWWVAYRKVPSFIVTLAGMLAFRGILIGITNGTTVSPTSAAMSQIGQSYLPAS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCHHHCCCC
TGFIIGALGLMAFVGWQWRGRMRRQALGLQSPASTAVVGRQALTAIIVLGAIWLLNDYRG
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
VPTPVLLLTLLLLGGMFMATRTAFGRRIYAIGGNLEAARLSGINVERTKLAVFAINGLMV
CCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHCCCCCCCHHEEEEHHHHHHHH
AIAGLILSSRLGAGSPSAGNIAELDAIAACVIGGTSLAGGVGSVAGAVMGAFIMASLDNG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHCCC
MSMMDVPTFWQYIVKGAILLLAVWMDSATKRRS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
SKSNPSEVKLAVPTSGGFSGLKSLNLQVFVMIAAIIAIMLFFTWTTDGAYLSARNVSNL
CCCCCCCEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHH
LRQTAITGILAVGMVFVIISAEIDLSVGSMMGLLGGVAAICDVWLGWPLPLTIIVTLVLG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LLLGAWNGWWVAYRKVPSFIVTLAGMLAFRGILIGITNGTTVSPTSAAMSQIGQSYLPAS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCHHHCCCC
TGFIIGALGLMAFVGWQWRGRMRRQALGLQSPASTAVVGRQALTAIIVLGAIWLLNDYRG
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
VPTPVLLLTLLLLGGMFMATRTAFGRRIYAIGGNLEAARLSGINVERTKLAVFAINGLMV
CCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHCCCCCCCHHEEEEHHHHHHHH
AIAGLILSSRLGAGSPSAGNIAELDAIAACVIGGTSLAGGVGSVAGAVMGAFIMASLDNG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHCCC
MSMMDVPTFWQYIVKGAILLLAVWMDSATKRRS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; xylose [Periplasm]; H2O [C]

Specific reaction: ATP + xylose [Periplasm] + H2O = ADP + phosphate + xylose [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796