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The map label for this gene is mutL [H]

Identifier: 209398397

GI number: 209398397

Start: 5326337

End: 5328184

Strand: Direct

Name: mutL [H]

Synonym: ECH74115_5686

Alternate gene names: 209398397

Gene position: 5326337-5328184 (Clockwise)

Preceding gene: 209396446

Following gene: 209400590

Centisome position: 95.59

GC content: 56.49

Gene sequence:

>1848_bases
ATGCCAATTCAGGTCTTACCGCCACAACTGGCGAACCAGATTGCCGCAGGTGAGGTGGTCGAGCGACCTGCGTCGGTAGT
CAAAGAACTGGTGGAAAACAGCCTCGATGCAGGTGCGACGCGTATCGATATTGATATCGAACGCGGTGGGGCGAAACTTA
TCCGCATTCGTGATAACGGCTGTGGTATCAAAAAAGACGAGCTGGCGCTGGCGCTGGCGCGTCATGCCACCAGTAAAATC
GCCTCTCTGGACGATCTCGAAGCCATTATCAGCCTGGGCTTTCGCGGTGAGGCGCTGGCGAGTATCAGTTCGGTTTCCCG
CCTGACGCTCACTTCACGCACCGCAGAACAGCAGGAAGCCTGGCAGGCCTATGCCGAAGGGCGCGATATGGACGTGACGG
TTAAACCGGCGGCGCATCCGGTGGGAACGACGCTGGAGGTACTGGACCTGTTCTACAACACCCCGGCGCGGCGCAAATTC
CTGCGCACCGAGAAAACCGAATTTAACCATATCGATGAAATCATCCGCCGCATCGCACTGGCGCGTTTCGACGTCACGAT
CAACCTGTCGCATAACGGCAAAATCGTACGCCAGTACCGCGCGGTGCCGGAAGGCGGGCAAAAAGAACGGCGCTTAGGCG
CGATTTGTGGCACCGCTTTTCTCGAACAAGCGCTGGCGATTGAATGGCAACACGGCGATCTCACGCTGCGCGGCTGGGTG
GCCGATCCAAATCACACCACGCCCGCACTGGCGGAAATTCAGTATTGCTACGTGAATGGTCGCATGATGCGCGATCGCCT
GATCAATCACGCGATCCGCCAGGCCTGTGAAGACAAACTGGGGGCCGATCAGCAACCTGCATTTGTGTTGTATCTGGAGA
TCGACCCGCATCAGGTGGACGTCAACGTGCACCCCGCCAAACACGAAGTGCGTTTTCATCAGTCGCGTCTGGTGCATGAC
TTTATCTATCAGGGCGTGCTGAGCGTGCTACAACAGCAACTGGAAACGCCGCTACCGCTGGACGATGAACCCCAACCTGC
ACCGCGTCCCATTCCGGAAAACCGCGTGGCGGCGGGGCGCAATCACTTTGCTGAACCGGCAGTTCGTGAGCCAGTAGCTC
CGCGCTACACTCCTGCGCCAGCATCAGGTAGTCGTCCGGCTGCCCCCTGGCCGAATGCGCAGCCAGGTTACCAGAAACAG
CAAGGTGAAGTGTATCGCCAGCTTTTGCAAACGCCCGCGCCGATGCAAAAACCAAAAGCGCCGGAACCGCAGGAACCTGC
ACTTGCGGCGAACAGTCAGAGTTTTGGTCGGGTACTGACTATCGTCCATTCCGACTGTGCGTTGCTGGAGCGCGACGGCA
ACATTTCACTTTTAGCCTTGCCAGTGGCAGAACGTTGGCTGCGTCAGGTACAACTGACGCCGGGTGAAGCGCCCGTTTGC
GCCCAGCCGTTGCTGATTCCGTTGCGGCTAAAAGTTTCTGGCGAAGAAAAATCGGCATTAGAAAAAGCGCAGTCTGCCCT
GGCGGAATTGGGTATTGATTTCCAGTCAGATGCACAGCATGTGACCATCAGGGCCGTGCCTTTACCCTTACGCCAACAAA
ATTTACAAATCTTGATTCCTGAACTGATAGGCTACCTAGCGAAGCAGTCCGTATTCGAACCTGGCAATATTGCGCAGTGG
ATTGCACGAAATCTGATGAGCGAACATGCGCAGTGGTCAATGGCACAGGCCATAACCCTGCTGGCGGACGTGGAACGGTT
ATGTCCGCAACTTGTGAAAACGCCGCCGGGTGGTCTGTTACAATCTGTTGATTTACATCCGGCGATAAAAGCCCTGAAAG
ATGAGTGA

Upstream 100 bases:

>100_bases
CCTTGCGCATCCGATGCAATCTGCGCCGCAGGGTGCAACGGCACAAACTGCCAGTACGGTGACGACGCCAGATCGCACGC
TGCCAAACTAAGGACGATTG

Downstream 100 bases:

>100_bases
TATCAGTAAGGCGAGCCTGCCTAAGGCGATTTTTTTGATGGGGCCGACGGCCTCCGGTAAAACGGCGTTAGCCATTGAGC
TGCGTAAAATTTTACCAGTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKI
ASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKF
LRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWV
ADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD
FIYQGVLSVLQQQLETPLPLDDEPQPAPRPIPENRVAAGRNHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQ
QGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQVQLTPGEAPVC
AQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQW
IARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE

Sequences:

>Translated_615_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKI
ASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKF
LRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWV
ADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD
FIYQGVLSVLQQQLETPLPLDDEPQPAPRPIPENRVAAGRNHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQ
QGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQVQLTPGEAPVC
AQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQW
IARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE
>Mature_614_residues
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIA
SLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFL
RTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVA
DPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDF
IYQGVLSVLQQQLETPLPLDDEPQPAPRPIPENRVAAGRNHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQ
GEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQVQLTPGEAPVCA
QPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQWI
ARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=339, Percent_Identity=35.9882005899705, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI4505911, Length=318, Percent_Identity=31.7610062893082, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI189458898, Length=318, Percent_Identity=31.7610062893082, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI189458896, Length=313, Percent_Identity=30.9904153354633, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4505913, Length=333, Percent_Identity=27.027027027027, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI310128478, Length=333, Percent_Identity=27.027027027027, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI263191589, Length=245, Percent_Identity=31.0204081632653, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI91992160, Length=362, Percent_Identity=24.585635359116, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI91992162, Length=362, Percent_Identity=24.585635359116, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=23.3898305084746, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790612, Length=615, Percent_Identity=98.8617886178862, Blast_Score=1237, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71991825, Length=326, Percent_Identity=36.8098159509202, Blast_Score=191, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=25.8720930232558, Blast_Score=121, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=340, Percent_Identity=34.7058823529412, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=361, Percent_Identity=29.0858725761773, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6325093, Length=290, Percent_Identity=25.1724137931034, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=404, Percent_Identity=25, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17136968, Length=329, Percent_Identity=34.6504559270517, Blast_Score=188, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.3305322128852, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67946; Mature: 67814

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
CGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIAL
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHH
ARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWV
HHEEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEE
ADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
CCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEE
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRPIPENRVAAGR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCC
NHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKPKA
CCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
PEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQVQLTPGEAPVC
CCCCCCCCCCCCCCHHHEEEEHCCCHHEEECCCCEEEEEEHHHHHHHHHEECCCCCCCCC
AQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIP
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEHH
ELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QSVDLHPAIKALKDE
HCCCCCHHHHHHCCC
>Mature Secondary Structure 
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
CGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIAL
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHH
ARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWV
HHEEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEE
ADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
CCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEE
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRPIPENRVAAGR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCC
NHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKPKA
CCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
PEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLALPVAERWLRQVQLTPGEAPVC
CCCCCCCCCCCCCCHHHEEEEHCCCHHEEECCCCEEEEEEHHHHHHHHHEECCCCCCCCC
AQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIP
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEHH
ELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QSVDLHPAIKALKDE
HCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA