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The map label for this gene is lysP [H]

Identifier: 209397992

GI number: 209397992

Start: 3023404

End: 3024873

Strand: Reverse

Name: lysP [H]

Synonym: ECH74115_3292

Alternate gene names: 209397992

Gene position: 3024873-3023404 (Counterclockwise)

Preceding gene: 209399117

Following gene: 209396460

Centisome position: 54.29

GC content: 53.4

Gene sequence:

>1470_bases
ATGGTTTCCGAAACTAAAACCACAGAAGCGCCGGGCTTACGCCGTGAATTAAAGGCGCGTCACCTGACGATGATTGCCAT
TGGCGGTTCCATCGGTACAGGTCTTTTTGTTGCCTCTGGCGCAACGATTTCTCAGGCAGGTCCGGGCGGGGCATTGCTCT
CGTATATGTTGATTGGCCTGATGGTTTACTTCCTGATGACCAGTCTCGGTGAACTGGCTGCATATATGCCGGTTTCCGGT
TCGTTTGCCACTTACGGTCAGAACTATGTTGAAGAGGGCTTTGGCTTCGCGCTGGGCTGGAACTACTGGTACAACTGGGC
GGTGACTATTGCCGTTGACCTGGTTGCAGCTCAGCTGGTCATGAGCTGGTGGTTCCCGGATACACCGGGCTGGATCTGGA
GTGCGTTGTTCCTCGGCGTTATCTTCCTGCTGAACTACATCTCTGTTCGCGGCTTTGGTGAAGCGGAATACTGGTTCTCA
CTGATCAAAGTCACGACAGTTATTGTCTTTATCATCGTTGGCGTGCTGATGATTATCGGTATCTTCAAAGGCGCGCAGCC
TGCGGGCTGGAGCAACTGGACAATCGGCGAAGCGCCGTTTGCTGGTGGTTTTGCGGCGATGATCGGCGTAGCTATGATTG
TCGGCTTCTCTTTCCAGGGAACCGAGCTGATCGGTATTGCTGCAGGCGAGTCCGAAGATCCGGGGAAAAACATTCCACGC
GCGGTACGTCAGGTGTTCTGGCGAATCCTGTTGTTCTATGTGTTCGCGATCCTGATTATCAGCCTGATTATTCCGTACAC
CGATCCGAGCCTGCTGCGTAACGATGTTAAAGACATCAGCGTTAGTCCGTTCACCCTGGTGTTCCAGCACGCGGGTCTGC
TCTCTGCTGCGGCGGTGATGAACGCAGTTATTCTGACGGCGGTGCTGTCAGCGGGTAACTCCGGTATGTATGCGTCTACT
CGTATGCTGTACACCCTGGCGTGTGACGGTAAAGCGCCGCGCATTTTCGCTAAACTGTCGCGTGGTGGCGTGCCGCGTAA
TGCGCTGTATGCGACGACGGTGATTGCCGGTCTGTGCTTCCTGACCTCCATGTTTGGCAACCAGACGGTATACCTGTGGC
TGCTGAATACCTCCGGGATGACCGGTTTTATCGCCTGGCTGGGGATTGCCATTAGCCACTATCGCTTCCGTCGCGGTTAC
GTATTGCAGGGACACGACATTAACGATCTGCCGTACCGTTCAGGTTTCTTCCCATTGGGGCCGATCTTCGCATTCATTCT
GTGTCTGATTATCACTTTGGGCCAGAACTACGAAGCGTTCCTGAAAGATACCATTGACTGGGGCGGCGTAGCGGCAACGT
ATATTGGTATCCCGCTGTTCCTGATTATTTGGTTCGGCTACAAGCTGATTAAAGGAACCCACTTCGTACGCTACAGCGAA
ATGAAGTTCCCGCAGAACGATAAGAAATAA

Upstream 100 bases:

>100_bases
GCGATCATGAAGGTGTCTTATAACCGTGTATTTCTGCCGGAAGGATTGCCAATCGTCTGCTACAATCGCGCCTCATTTTT
TAGATGGATAGCATTTTTGT

Downstream 100 bases:

>100_bases
GTTTCTCCCTTCCTTGCTAAGCCCTCTCAACCGAGAGGGCTTTTTCAATTCCATTTCCCTGACAAATCATGCGGATATAA
AATTTAACATTTGGATTGAT

Product: lysine transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYMLIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFS
LIKVTTVIVFIIVGVLMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPGKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGHDINDLPYRSGFFPLGPIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSE
MKFPQNDKK

Sequences:

>Translated_489_residues
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYMLIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFS
LIKVTTVIVFIIVGVLMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPGKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGHDINDLPYRSGFFPLGPIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSE
MKFPQNDKK
>Mature_489_residues
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYMLIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFS
LIKVTTVIVFIIVGVLMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPGKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGHDINDLPYRSGFFPLGPIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSE
MKFPQNDKK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=369, Percent_Identity=24.9322493224932, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1788480, Length=489, Percent_Identity=99.7955010224949, Blast_Score=979, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=438, Percent_Identity=40.1826484018265, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=39.0804597701149, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1786789, Length=418, Percent_Identity=37.799043062201, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI1786302, Length=408, Percent_Identity=35.5392156862745, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI1790653, Length=422, Percent_Identity=35.0710900473934, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789017, Length=392, Percent_Identity=34.1836734693878, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI87081915, Length=400, Percent_Identity=34.25, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786602, Length=406, Percent_Identity=36.6995073891626, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87081869, Length=395, Percent_Identity=24.0506329113924, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082250, Length=236, Percent_Identity=28.8135593220339, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI87082023, Length=335, Percent_Identity=23.2835820895522, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=389, Percent_Identity=24.6786632390745, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=474, Percent_Identity=36.4978902953587, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324990, Length=487, Percent_Identity=34.9075975359343, Blast_Score=308, Evalue=9e-85,
Organism=Saccharomyces cerevisiae, GI6324061, Length=495, Percent_Identity=33.7373737373737, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6322892, Length=475, Percent_Identity=36.8421052631579, Blast_Score=292, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6324059, Length=476, Percent_Identity=35.5042016806723, Blast_Score=286, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6324924, Length=483, Percent_Identity=33.3333333333333, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6321629, Length=502, Percent_Identity=30.0796812749004, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6324553, Length=429, Percent_Identity=35.4312354312354, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6319824, Length=472, Percent_Identity=29.2372881355932, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321053, Length=464, Percent_Identity=29.3103448275862, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322967, Length=470, Percent_Identity=31.4893617021277, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6320717, Length=482, Percent_Identity=27.5933609958506, Blast_Score=227, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6319543, Length=474, Percent_Identity=29.535864978903, Blast_Score=222, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6319542, Length=472, Percent_Identity=27.3305084745763, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6324981, Length=490, Percent_Identity=31.2244897959184, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320251, Length=480, Percent_Identity=26.0416666666667, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=493, Percent_Identity=27.789046653144, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6320364, Length=562, Percent_Identity=25.8007117437722, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI281366235, Length=396, Percent_Identity=23.7373737373737, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI116007820, Length=396, Percent_Identity=23.7373737373737, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221512776, Length=358, Percent_Identity=24.0223463687151, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24666159, Length=358, Percent_Identity=24.0223463687151, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53563; Mature: 53563

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYMLIGL
CCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHH
MVYFLMTSLGELAAYMPVSGSFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLV
HHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHH
MSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFSLIKVTTVIVFIIVGVLMIIG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPGKNIPR
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHH
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCF
HHHHHHHHHHCCCCCCEEHHEEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVLQGHDINDLPYRSGFFPLG
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHH
PIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSE
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
MKFPQNDKK
CCCCCCCCC
>Mature Secondary Structure
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYMLIGL
CCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHH
MVYFLMTSLGELAAYMPVSGSFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLV
HHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHH
MSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFSLIKVTTVIVFIIVGVLMIIG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPGKNIPR
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHH
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCF
HHHHHHHHHHCCCCCCEEHHEEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVLQGHDINDLPYRSGFFPLG
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHH
PIFAFILCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLIIWFGYKLIKGTHFVRYSE
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
MKFPQNDKK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]