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The map label for this gene is folB [H]

Identifier: 209397022

GI number: 209397022

Start: 4046833

End: 4047201

Strand: Reverse

Name: folB [H]

Synonym: ECH74115_4370

Alternate gene names: 209397022

Gene position: 4047201-4046833 (Counterclockwise)

Preceding gene: 209395880

Following gene: 209399983

Centisome position: 72.63

GC content: 50.68

Gene sequence:

>369_bases
ATGGATATTGTATTTATAGAGCAACTTTCGGTAATCACCACTATTGGTGTTTACGACTGGGAACAGACCATCGAACAGAA
ATTAGTGTTCGATATCGAAATGGCGTGGGATAACCGTAAAGCGGCAAAAAGCGATAATGTGGCGGATTGCCTCAGCTACG
CTGACATTGCAGAAACGGTGGTCAGCCACGTCGAGGGGGCACGTTTTGCGCTGGTGGAGCGCGTGGCGGAAGAGGTGGCA
GAGCTGCTGTTAGCACGCTTCAACTCGCCGTGGGTGCGTATCAAACTCAGCAAGCCAGGCGCAGTGGCGCGGGCGGCGAA
TGTTGGCGTAATCATTGAGCGTGGCAATAATCTGAAAGAAAATAATTAA

Upstream 100 bases:

>100_bases
GTTCCGTTTTGAAAATTCGTGTTAAACGATGAATCTGTGGATAATACGCACATTTCGCCGGAAGTGGTATCCGGGTTAGC
CAAAAAGCGAGCAGGTCGTG

Downstream 100 bases:

>100_bases
TTTTACAGCTGTTAAACCAAACGGTTATAACCTGGTCATACTGCAGTAGTTCGGACAAGCGTTACATTTTTATAATTTAG
GGGTTTATTGATGAGCGATA

Product: bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 122; Mature: 122

Protein sequence:

>122_residues
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDNVADCLSYADIAETVVSHVEGARFALVERVAEEVA
ELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKENN

Sequences:

>Translated_122_residues
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDNVADCLSYADIAETVVSHVEGARFALVERVAEEVA
ELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKENN
>Mature_122_residues
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDNVADCLSYADIAETVVSHVEGARFALVERVAEEVA
ELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKENN

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=122, Percent_Identity=99.1803278688525, Blast_Score=244, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13619; Mature: 13619

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDNVADCLSYADIAETV
CCEEEHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
VSHVEGARFALVERVAEEVAELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKE
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCEEEEECCCCCCC
NN
CC
>Mature Secondary Structure
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDNVADCLSYADIAETV
CCEEEHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
VSHVEGARFALVERVAEEVAELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKE
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCEEEEECCCCCCC
NN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]