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The map label for this gene is ttdR

Identifier: 209395880

GI number: 209395880

Start: 4047937

End: 4048869

Strand: Reverse

Name: ttdR

Synonym: ECH74115_4372

Alternate gene names: 209395880

Gene position: 4048869-4047937 (Counterclockwise)

Preceding gene: 209400727

Following gene: 209397022

Centisome position: 72.66

GC content: 49.62

Gene sequence:

>933_bases
ATGCTGAATAGCTGGCCTTTAGCCAAAGACTTGCAGGTACTGGTAGAAATCGTCCACAGCGGGAGTTTTAGTGCTGCAGC
GGCGACGCTTGGGCAAACGCCTGCATTTGTCACCAAGCGGATCCAAATCCTTGAAAATACGCTGGCAACAACGCTGCTGA
ACCGCTCCGCTCGCGGCGTGGCGCTGACTGAAAGTGGCCAACGTTGTTACGAACATGCGCTGGAAATCCTCACCCAATAT
CAGCGACTGGTCGATGACGTCACGCAAATCAAAACGCGCCCGGAGGGGATGATTCGTATTGGTTGCAGTTTTGGTTTTGG
GCGCAGCCATATTGCGCCAGCCATTACCGAACTTATGCGCAATTATCCTGAGTTACAGGTGTATTTTGAATTGTTCGATC
GGCAAATTGATTTAGTGCAGGATAATATTGATCTGGATATTCGTATTAATGACGAAATTCCTGATTATTATATTGCGCAT
CTGTTAACGAAAAATAAAAGAATATTATGCGCAGCACCTGAGTATCTGCAAAAATATCCGCAGCCACAATCCCTACAGGA
ATTAAGTCGTCATGACTGTCTGGTGACCAAAGAGCGCGATATGACCCACGGAATATGGGAGTTGGGGAACGGTCAGGAGA
AAAAATCGGTGAAGGTTAGCGGGCATCTTTCCTCCAATAGCGGCGAGATTGTGCTGCAATGGGCGCTGGAGGGCAAAGGG
ATTATGCTGCGTTCCGAGTGGGATGTGTTGCCGTTTCTGGAGAGTGGCAAACTGGTGCAAGTATTGCCGGAGTATGCACA
AAGCGCCAATATCTGGGCTGTTTACCGGGAGCCGCTCTATCGCAGCATGAAATTACGTGTCTGCGTGGAATTTCTGGCGG
CATGGTGCCAGCAACGGCTGGGCAAACCCGATGAAGGCTATCAGGTCATGTAG

Upstream 100 bases:

>100_bases
GTGAATCAACGCGAAAATAAGAATGAATATTGCGCCAGAGCAGGGAATGGCAATGTTTTGCGAAATACACTGCGCTTATC
ACAACTGCGGATAATTAACG

Downstream 100 bases:

>100_bases
ATCCACCAGAAATCACTCGGGATCCTTTTCGCGCTTTCTTTTGAATTTCGTCCAGATTTTTGTCTCCTGACGACGCCACA
GACGCTGGATGTTGTCATGA

Product: transcriptional activator TtdR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MLNSWPLAKDLQVLVEIVHSGSFSAAAATLGQTPAFVTKRIQILENTLATTLLNRSARGVALTESGQRCYEHALEILTQY
QRLVDDVTQIKTRPEGMIRIGCSFGFGRSHIAPAITELMRNYPELQVYFELFDRQIDLVQDNIDLDIRINDEIPDYYIAH
LLTKNKRILCAAPEYLQKYPQPQSLQELSRHDCLVTKERDMTHGIWELGNGQEKKSVKVSGHLSSNSGEIVLQWALEGKG
IMLRSEWDVLPFLESGKLVQVLPEYAQSANIWAVYREPLYRSMKLRVCVEFLAAWCQQRLGKPDEGYQVM

Sequences:

>Translated_310_residues
MLNSWPLAKDLQVLVEIVHSGSFSAAAATLGQTPAFVTKRIQILENTLATTLLNRSARGVALTESGQRCYEHALEILTQY
QRLVDDVTQIKTRPEGMIRIGCSFGFGRSHIAPAITELMRNYPELQVYFELFDRQIDLVQDNIDLDIRINDEIPDYYIAH
LLTKNKRILCAAPEYLQKYPQPQSLQELSRHDCLVTKERDMTHGIWELGNGQEKKSVKVSGHLSSNSGEIVLQWALEGKG
IMLRSEWDVLPFLESGKLVQVLPEYAQSANIWAVYREPLYRSMKLRVCVEFLAAWCQQRLGKPDEGYQVM
>Mature_310_residues
MLNSWPLAKDLQVLVEIVHSGSFSAAAATLGQTPAFVTKRIQILENTLATTLLNRSARGVALTESGQRCYEHALEILTQY
QRLVDDVTQIKTRPEGMIRIGCSFGFGRSHIAPAITELMRNYPELQVYFELFDRQIDLVQDNIDLDIRINDEIPDYYIAH
LLTKNKRILCAAPEYLQKYPQPQSLQELSRHDCLVTKERDMTHGIWELGNGQEKKSVKVSGHLSSNSGEIVLQWALEGKG
IMLRSEWDVLPFLESGKLVQVLPEYAQSANIWAVYREPLYRSMKLRVCVEFLAAWCQQRLGKPDEGYQVM

Specific function: Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1789440, Length=310, Percent_Identity=99.6774193548387, Blast_Score=643, Evalue=0.0,
Organism=Escherichia coli, GI87081978, Length=291, Percent_Identity=49.1408934707904, Blast_Score=278, Evalue=3e-76,
Organism=Escherichia coli, GI1786401, Length=298, Percent_Identity=28.1879194630872, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI145693193, Length=292, Percent_Identity=29.1095890410959, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789639, Length=290, Percent_Identity=27.2413793103448, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787128, Length=298, Percent_Identity=24.1610738255034, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787589, Length=272, Percent_Identity=23.5294117647059, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787601, Length=166, Percent_Identity=28.3132530120482, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786448, Length=240, Percent_Identity=24.1666666666667, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788706, Length=183, Percent_Identity=28.4153005464481, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789173, Length=266, Percent_Identity=26.3157894736842, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): TTDR_ECO57 (Q8XBK9)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   F85966
- PIR:   G91121
- RefSeq:   NP_289635.1
- RefSeq:   NP_311970.1
- ProteinModelPortal:   Q8XBK9
- SMR:   Q8XBK9
- EnsemblBacteria:   EBESCT00000026357
- EnsemblBacteria:   EBESCT00000060190
- GeneID:   916169
- GeneID:   961971
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4413
- KEGG:   ecs:ECs3943
- GeneTree:   EBGT00050000008331
- HOGENOM:   HBG685425
- OMA:   KERNNAF
- ProtClustDB:   PRK09801
- BioCyc:   ECOL83334:ECS3943-MONOMER
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate

EC number: NA

Molecular weight: Translated: 35341; Mature: 35341

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNSWPLAKDLQVLVEIVHSGSFSAAAATLGQTPAFVTKRIQILENTLATTLLNRSARGV
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
ALTESGQRCYEHALEILTQYQRLVDDVTQIKTRPEGMIRIGCSFGFGRSHIAPAITELMR
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHH
NYPELQVYFELFDRQIDLVQDNIDLDIRINDEIPDYYIAHLLTKNKRILCAAPEYLQKYP
CCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECHHHHHHCC
QPQSLQELSRHDCLVTKERDMTHGIWELGNGQEKKSVKVSGHLSSNSGEIVLQWALEGKG
CCHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEEECCCE
IMLRSEWDVLPFLESGKLVQVLPEYAQSANIWAVYREPLYRSMKLRVCVEFLAAWCQQRL
EEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
GKPDEGYQVM
CCCCCCCCCC
>Mature Secondary Structure
MLNSWPLAKDLQVLVEIVHSGSFSAAAATLGQTPAFVTKRIQILENTLATTLLNRSARGV
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
ALTESGQRCYEHALEILTQYQRLVDDVTQIKTRPEGMIRIGCSFGFGRSHIAPAITELMR
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHH
NYPELQVYFELFDRQIDLVQDNIDLDIRINDEIPDYYIAHLLTKNKRILCAAPEYLQKYP
CCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECHHHHHHCC
QPQSLQELSRHDCLVTKERDMTHGIWELGNGQEKKSVKVSGHLSSNSGEIVLQWALEGKG
CCHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEEECCCE
IMLRSEWDVLPFLESGKLVQVLPEYAQSANIWAVYREPLYRSMKLRVCVEFLAAWCQQRL
EEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
GKPDEGYQVM
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796