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The map label for this gene is era [H]

Identifier: 209695942

GI number: 209695942

Start: 2706343

End: 2707308

Strand: Reverse

Name: era [H]

Synonym: VSAL_I2524

Alternate gene names: 209695942

Gene position: 2707308-2706343 (Counterclockwise)

Preceding gene: 209695943

Following gene: 209695941

Centisome position: 81.42

GC content: 39.34

Gene sequence:

>966_bases
ATGTCAGATGACAAAGAATTCGATCTAGATGCGTACTTCTCATCAGAAGCTAAAACAGAATCTAGCGACAACCAACACTG
TGGCTTTATTGCTATCGTTGGTCGTCCAAACGTAGGTAAATCAACACTTCTAAACCAAATATTGGGACAGAAGATTTCGA
TTACATCTCGTAAACCTCAAACGACTCGTCACCGCATTATGGGTGTTGATACGGAAGGGGATTATCAAGCGATTTATATT
GATACGCCAGGTCTTCATATTGAAGAAAAGCGTGCGATTAACCGCTTAATGAACCGTGCTGCAAGCTCATCATTAAGTGA
TGTTAACTTGGTTTTATTCTTGGTAGATGGTACTCACTGGACACCAGACGATGAAATGGTATTGAATAAGCTGAGAAAAG
CTGGATTCCCTACTGTTCTATTGGTAAACAAAGTAGATAACGTTAAAGATAAAAATGACGTTATGGCTCATCTTCAAACG
ATGACTGAAAAAATGGACTTTGTTGACGTTGTGCCAATTTCAGCAAAATCAGGCTCTAATGTTGATGTTGTTCAAAAGCT
AGTTCGTGATCATTTACCAAAAGCAGTTCATCATTTCCCTGAAGAATACGTAACTGACCGTTCACAACGCTTTATGGCTT
CAGAGATCATTCGTGAAAAGCTGATGCGTTTTACGGGTGAAGAACTGCCATATTCGGTAACAGTAGAGATCGAACGTTTT
GATTACAATCCTAAAATGGATGGTTTTCATATTAATGGTTTGATCCTTGTTGAACGTCTTGGCCAAAAGAAAATGGTCGT
AGGTAAGAACGGCGAAAAGATCAAAGTCATTGGTCGTGAAGCTCGTCTTGATATGGAAGGGTTATTTGACCGCAAAGTGT
ATTTAGAACTTTGGGTTAAAGTTAAATCTGGTTGGGCTGATGATGAGCGAGCACTTCGTTCTCTTGGTTACATCGACGAT
TTATAA

Upstream 100 bases:

>100_bases
GTATCGTAGCAGGCTTGGATAAGCCTGTTATCGGCAAAGGAAGCAGTCGCCGCAAGGCAGAACAGTCGGCTGCTGACATA
GCATTAGGACAAGTAAACTA

Downstream 100 bases:

>100_bases
TCCTCTAGATATAAATAAGAGCTAAAACAAGATCCCATATAACTTAAGTAGATAAAATTATTTTAGTTATTTGGGATTTT
TTTGTTGTTATCAAAGTGTA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSDDKEFDLDAYFSSEAKTESSDNQHCGFIAIVGRPNVGKSTLLNQILGQKISITSRKPQTTRHRIMGVDTEGDYQAIYI
DTPGLHIEEKRAINRLMNRAASSSLSDVNLVLFLVDGTHWTPDDEMVLNKLRKAGFPTVLLVNKVDNVKDKNDVMAHLQT
MTEKMDFVDVVPISAKSGSNVDVVQKLVRDHLPKAVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIERF
DYNPKMDGFHINGLILVERLGQKKMVVGKNGEKIKVIGREARLDMEGLFDRKVYLELWVKVKSGWADDERALRSLGYIDD
L

Sequences:

>Translated_321_residues
MSDDKEFDLDAYFSSEAKTESSDNQHCGFIAIVGRPNVGKSTLLNQILGQKISITSRKPQTTRHRIMGVDTEGDYQAIYI
DTPGLHIEEKRAINRLMNRAASSSLSDVNLVLFLVDGTHWTPDDEMVLNKLRKAGFPTVLLVNKVDNVKDKNDVMAHLQT
MTEKMDFVDVVPISAKSGSNVDVVQKLVRDHLPKAVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIERF
DYNPKMDGFHINGLILVERLGQKKMVVGKNGEKIKVIGREARLDMEGLFDRKVYLELWVKVKSGWADDERALRSLGYIDD
L
>Mature_320_residues
SDDKEFDLDAYFSSEAKTESSDNQHCGFIAIVGRPNVGKSTLLNQILGQKISITSRKPQTTRHRIMGVDTEGDYQAIYID
TPGLHIEEKRAINRLMNRAASSSLSDVNLVLFLVDGTHWTPDDEMVLNKLRKAGFPTVLLVNKVDNVKDKNDVMAHLQTM
TEKMDFVDVVPISAKSGSNVDVVQKLVRDHLPKAVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIERFD
YNPKMDGFHINGLILVERLGQKKMVVGKNGEKIKVIGREARLDMEGLFDRKVYLELWVKVKSGWADDERALRSLGYIDDL

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=325, Percent_Identity=27.6923076923077, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1788919, Length=301, Percent_Identity=73.0897009966777, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI87082120, Length=154, Percent_Identity=32.4675324675325, Blast_Score=66, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646434, Length=310, Percent_Identity=22.9032258064516, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 36544; Mature: 36413

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDKEFDLDAYFSSEAKTESSDNQHCGFIAIVGRPNVGKSTLLNQILGQKISITSRKPQ
CCCCCCCCCHHEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCC
TTRHRIMGVDTEGDYQAIYIDTPGLHIEEKRAINRLMNRAASSSLSDVNLVLFLVDGTHW
CCHHHEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCC
TPDDEMVLNKLRKAGFPTVLLVNKVDNVKDKNDVMAHLQTMTEKMDFVDVVPISAKSGSN
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
VDVVQKLVRDHLPKAVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIERF
HHHHHHHHHHHCHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEE
DYNPKMDGFHINGLILVERLGQKKMVVGKNGEKIKVIGREARLDMEGLFDRKVYLELWVK
CCCCCCCCEEECCEEEEECCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHEEEHEEEH
VKSGWADDERALRSLGYIDDL
HHCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDDKEFDLDAYFSSEAKTESSDNQHCGFIAIVGRPNVGKSTLLNQILGQKISITSRKPQ
CCCCCCCCHHEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCC
TTRHRIMGVDTEGDYQAIYIDTPGLHIEEKRAINRLMNRAASSSLSDVNLVLFLVDGTHW
CCHHHEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCC
TPDDEMVLNKLRKAGFPTVLLVNKVDNVKDKNDVMAHLQTMTEKMDFVDVVPISAKSGSN
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
VDVVQKLVRDHLPKAVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIERF
HHHHHHHHHHHCHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEE
DYNPKMDGFHINGLILVERLGQKKMVVGKNGEKIKVIGREARLDMEGLFDRKVYLELWVK
CCCCCCCCEEECCEEEEECCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHEEEHEEEH
VKSGWADDERALRSLGYIDDL
HHCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]