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The map label for this gene is rnc [H]

Identifier: 209695943

GI number: 209695943

Start: 2707308

End: 2707979

Strand: Reverse

Name: rnc [H]

Synonym: VSAL_I2525

Alternate gene names: 209695943

Gene position: 2707979-2707308 (Counterclockwise)

Preceding gene: 209695944

Following gene: 209695942

Centisome position: 81.44

GC content: 41.52

Gene sequence:

>672_bases
ATGACATCTCCATTACAACGCCTAGAACGCAAAATAGGCTATAAATTTAATGATGAAGGCTTTCTTAAGTTAGCACTGAC
TCACCGTAGTGCTAACGGAACTCATAATGAACGTTTAGAATTTCTAGGCGATTCAATTTTGAGCTTTGTGGTTGCTGATG
AACTTTATCACCGTTTTCCTAAAGTGGATGAAGGTGATATGAGTCGTATGCGTGCAACGCTAGTTCGTGGTCATACTCTT
GCTGAGTTAGGTCGTGAATTTGAGTTAGGGGATTACCTATTTTTAGGCCCTGGCGAATTGAAAAGCGGTGGCTTCCGTCG
AGATTCAATTTTAGCGGATGCGGTTGAAGCGATCATTGGTGGTATTTATCTTGATAGTGATACCGAAGTCATTCGTCGAA
TTATTTTAGCATGGTACAAAACACGCTTAGATTCGATTGAACCAGGTATCTCTCAAAAAGATCCAAAAACACGTCTTCAA
GAATACCTACAAGGTCGTCGTAAGCCGTTACCAACGTACACTGTGACAAAAATTAAAGGTGAAGCTCATAATCAAGAGTT
CACTATTGAATGTATCGTAGCAGGCTTGGATAAGCCTGTTATCGGCAAAGGAAGCAGTCGCCGCAAGGCAGAACAGTCGG
CTGCTGACATAGCATTAGGACAAGTAAACTAA

Upstream 100 bases:

>100_bases
AGCTTTGAATTTGAACGTGGTAGCGATAGTATGCTGCCTTCCTTTATTCCTACTGGTGTTCGTTTTAACCGCATCGGTGG
CATAGACTGATTGAAATAAT

Downstream 100 bases:

>100_bases
TGTCAGATGACAAAGAATTCGATCTAGATGCGTACTTCTCATCAGAAGCTAAAACAGAATCTAGCGACAACCAACACTGT
GGCTTTATTGCTATCGTTGG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MTSPLQRLERKIGYKFNDEGFLKLALTHRSANGTHNERLEFLGDSILSFVVADELYHRFPKVDEGDMSRMRATLVRGHTL
AELGREFELGDYLFLGPGELKSGGFRRDSILADAVEAIIGGIYLDSDTEVIRRIILAWYKTRLDSIEPGISQKDPKTRLQ
EYLQGRRKPLPTYTVTKIKGEAHNQEFTIECIVAGLDKPVIGKGSSRRKAEQSAADIALGQVN

Sequences:

>Translated_223_residues
MTSPLQRLERKIGYKFNDEGFLKLALTHRSANGTHNERLEFLGDSILSFVVADELYHRFPKVDEGDMSRMRATLVRGHTL
AELGREFELGDYLFLGPGELKSGGFRRDSILADAVEAIIGGIYLDSDTEVIRRIILAWYKTRLDSIEPGISQKDPKTRLQ
EYLQGRRKPLPTYTVTKIKGEAHNQEFTIECIVAGLDKPVIGKGSSRRKAEQSAADIALGQVN
>Mature_222_residues
TSPLQRLERKIGYKFNDEGFLKLALTHRSANGTHNERLEFLGDSILSFVVADELYHRFPKVDEGDMSRMRATLVRGHTLA
ELGREFELGDYLFLGPGELKSGGFRRDSILADAVEAIIGGIYLDSDTEVIRRIILAWYKTRLDSIEPGISQKDPKTRLQE
YLQGRRKPLPTYTVTKIKGEAHNQEFTIECIVAGLDKPVIGKGSSRRKAEQSAADIALGQVN

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=236, Percent_Identity=30.9322033898305, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI155030234, Length=236, Percent_Identity=30.9322033898305, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1788920, Length=205, Percent_Identity=72.1951219512195, Blast_Score=320, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI17506883, Length=231, Percent_Identity=31.6017316017316, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI193202651, Length=231, Percent_Identity=31.6017316017316, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17137682, Length=228, Percent_Identity=28.9473684210526, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25036; Mature: 24905

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPLQRLERKIGYKFNDEGFLKLALTHRSANGTHNERLEFLGDSILSFVVADELYHRFP
CCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KVDEGDMSRMRATLVRGHTLAELGREFELGDYLFLGPGELKSGGFRRDSILADAVEAIIG
CCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHC
GIYLDSDTEVIRRIILAWYKTRLDSIEPGISQKDPKTRLQEYLQGRRKPLPTYTVTKIKG
CCEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECC
EAHNQEFTIECIVAGLDKPVIGKGSSRRKAEQSAADIALGQVN
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TSPLQRLERKIGYKFNDEGFLKLALTHRSANGTHNERLEFLGDSILSFVVADELYHRFP
CCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KVDEGDMSRMRATLVRGHTLAELGREFELGDYLFLGPGELKSGGFRRDSILADAVEAIIG
CCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHC
GIYLDSDTEVIRRIILAWYKTRLDSIEPGISQKDPKTRLQEYLQGRRKPLPTYTVTKIKG
CCEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECC
EAHNQEFTIECIVAGLDKPVIGKGSSRRKAEQSAADIALGQVN
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA