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The map label for this gene is cadA [H]

Identifier: 209695909

GI number: 209695909

Start: 2667505

End: 2669643

Strand: Reverse

Name: cadA [H]

Synonym: VSAL_I2491

Alternate gene names: 209695909

Gene position: 2669643-2667505 (Counterclockwise)

Preceding gene: 209695910

Following gene: 209695908

Centisome position: 80.29

GC content: 39.74

Gene sequence:

>2139_bases
ATGAATATTTTTGCTATCCTAAACCACTCAGGTGTTTTCTTTAAAGAAGAGCCAGTTCGCGAACTTCATGCTTCTTTAGA
AAAAGCAGGCTACAAAGTTGTTTACCCAGTAGACGCACAAGATTTGTATAAAATGGTTGAAATGAACCCACGTATTTGTG
GTGTGTTATTTGACTGGGATAAATACTCATTAGACTTATGTACTGAAATTAATGTCTTGAATGAAAAATTGCCTTTGTAT
GCCTTTGCAAACCAACATTCAACGTTAGATATTTCATTAACGGATTTACGTCTAAATCTTCATTTCTTCGAATATGCATT
AGGCATGGCCGATGATATCGCTCTGAAAATTAATCAAGCGACTGAAGAATACATAGATCAAATCATGCCTCCTTTTACTA
AGGCACTATTCAAATATGTAGAAGAAGGTAAATATACGTTCTGTACTCCGGGTCACATGGGCGGTACTGCTTTCCAAAAA
AGTCCAGCAGGCAGCATCTTCTATGATTTCTACGGTCCAAACGCATTTAAAGCGGATGTCTCAATTTCAATGCCTGAACT
AGGTTCATTGCTTGATCACTCTGGTCCTCATAAAGAAGCAGAAGAGTATATTGCTCGCACGTTTAATGCAGACAGCTCTT
ACATCGTAACGAACGGTACGTCTACTTCAAATAAAATTGTAGGTATGTTTTCTGCACCAGCAGGCAGCACAGTACTTGTT
GACCGTAACTGTCACAAATCTTTGACTCACATGATGATGATGAGTGATGTAACCCCTATCTATTTCCGTCCAACGCGTAA
CGCTTACGGTATTTTAGGTGGCATTCCTCAAAGTGAATTCACTCGTGAAGTGATTGAAGCAAAAGTAGCAGCAACACCAA
ACGCAACTATGCCTGGTTATGCGGTTATTACTAACTCTACTTACGATGGCTTGTTGTATAACACTCAATACATCAAAGAA
ACGCTAGACACTAAATTCATCCACTTCGACAGTGCTTGGGTTCCTTACACTAACTTCAACTCTATTTACGAAGGTAAATG
TGGTATGAGTGGTGAAGCGATGCCGGGTAAAGTGTTCTATGAAACACAATCAACTCATAAATTATTGGCTGCGTTCTCTC
AAGCATCAATGATCCACGTGAAAGGTGAGTTTGATAAAGAATCTTTCAACGAAGCCTTCATGATGCACACATCAACATCA
CCTCAATACGGTATTGTTGCATCAACAGAAATTGCTGCGGCGATGATGCGCGGTAATACAGGTAAGAAACTGATCCAAGA
CTCTATTGACCGTGCGATTCGTTTCCGTAAAGAGATCAAACGTCTAGAAAGTGAAAGTGACAGCTGGTTCTTCGATGTAT
GGCAACCAGAAAATATCGATACAACAGAATGTTGGAAACTGGATCCTAAAGATACATGGCATGGTTTTAAAGACATCGAT
GATGACCACATGTACCTTGATCCAATCAAAGTAACGCTATTAACTCCAGGAATGAACGAAAATAGCGAAATGAGTGAAAC
AGGTATCCCTGCTTCTATCGTTGCTAAATACTTAGATGAACACGGTATTGTAGTAGAGAAAACAGGTCCATATAACCTAT
TATTCTTGTTCTCTATCGGTATTGATAAATCAAAAGCAATGCAATTACTGCGTGCGTTAACTGACTTTAAACGTGGCTAT
GATCTAAACTTAACAGTGAAAAACTTCTTACCTTCACTGTACAACGAAGATCCAAGCTTCTACGAAGGCATGCGCATTCA
AGAACTGGCACAAGGCATTCACGATCTTACTCGTCAATACCGTTTACCAGAATTGATGTTCAAAGCGTTTGATGTATTAC
CTGAACTAAAAGTAACGCCACACGCAGCATGGCAAGAAGAGCTACGCGGCAATGTGGAAGAAGTGAAACTGGAAGAAATG
GTTGGTCGCGTAAGTGCCAATATGATCCTTCCTTATCCTCCAGGTGTTCCACTAGTACTTCCTGGTGAAATGGTAACAAC
AGAATCTCGTCCAGTACTTGATTTCTTAGAGATGCTATGTGCAATCGGCGCTCATTACCCAGGTTTTGAAACGGATATTC
ACGGTGTATATGCTCAAAAAGATGGCAGTTACACAGTGAAAGTATTAAAAGAAGATTAA

Upstream 100 bases:

>100_bases
AACACTTAACGCTACCAACTTAGTAAGTTTACCCCCTGGCGCTCCACTACCTCACCATCAAAAAGATGGGGAGCGCCTTG
TTTCGTCTTGGAGATATAAA

Downstream 100 bases:

>100_bases
GCCCTAGGGTTTTAAAGGATTATCGTTTATTTTAGGGCACGGAAGCCCTTACTCTATTTTAAATTATGGTGATGTTATGA
AACGTATTCTTTCCATTCAG

Product: lysine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 712; Mature: 712

Protein sequence:

>712_residues
MNIFAILNHSGVFFKEEPVRELHASLEKAGYKVVYPVDAQDLYKMVEMNPRICGVLFDWDKYSLDLCTEINVLNEKLPLY
AFANQHSTLDISLTDLRLNLHFFEYALGMADDIALKINQATEEYIDQIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQK
SPAGSIFYDFYGPNAFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADSSYIVTNGTSTSNKIVGMFSAPAGSTVLV
DRNCHKSLTHMMMMSDVTPIYFRPTRNAYGILGGIPQSEFTREVIEAKVAATPNATMPGYAVITNSTYDGLLYNTQYIKE
TLDTKFIHFDSAWVPYTNFNSIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMIHVKGEFDKESFNEAFMMHTSTS
PQYGIVASTEIAAAMMRGNTGKKLIQDSIDRAIRFRKEIKRLESESDSWFFDVWQPENIDTTECWKLDPKDTWHGFKDID
DDHMYLDPIKVTLLTPGMNENSEMSETGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKSKAMQLLRALTDFKRGY
DLNLTVKNFLPSLYNEDPSFYEGMRIQELAQGIHDLTRQYRLPELMFKAFDVLPELKVTPHAAWQEELRGNVEEVKLEEM
VGRVSANMILPYPPGVPLVLPGEMVTTESRPVLDFLEMLCAIGAHYPGFETDIHGVYAQKDGSYTVKVLKED

Sequences:

>Translated_712_residues
MNIFAILNHSGVFFKEEPVRELHASLEKAGYKVVYPVDAQDLYKMVEMNPRICGVLFDWDKYSLDLCTEINVLNEKLPLY
AFANQHSTLDISLTDLRLNLHFFEYALGMADDIALKINQATEEYIDQIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQK
SPAGSIFYDFYGPNAFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADSSYIVTNGTSTSNKIVGMFSAPAGSTVLV
DRNCHKSLTHMMMMSDVTPIYFRPTRNAYGILGGIPQSEFTREVIEAKVAATPNATMPGYAVITNSTYDGLLYNTQYIKE
TLDTKFIHFDSAWVPYTNFNSIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMIHVKGEFDKESFNEAFMMHTSTS
PQYGIVASTEIAAAMMRGNTGKKLIQDSIDRAIRFRKEIKRLESESDSWFFDVWQPENIDTTECWKLDPKDTWHGFKDID
DDHMYLDPIKVTLLTPGMNENSEMSETGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKSKAMQLLRALTDFKRGY
DLNLTVKNFLPSLYNEDPSFYEGMRIQELAQGIHDLTRQYRLPELMFKAFDVLPELKVTPHAAWQEELRGNVEEVKLEEM
VGRVSANMILPYPPGVPLVLPGEMVTTESRPVLDFLEMLCAIGAHYPGFETDIHGVYAQKDGSYTVKVLKED
>Mature_712_residues
MNIFAILNHSGVFFKEEPVRELHASLEKAGYKVVYPVDAQDLYKMVEMNPRICGVLFDWDKYSLDLCTEINVLNEKLPLY
AFANQHSTLDISLTDLRLNLHFFEYALGMADDIALKINQATEEYIDQIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQK
SPAGSIFYDFYGPNAFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADSSYIVTNGTSTSNKIVGMFSAPAGSTVLV
DRNCHKSLTHMMMMSDVTPIYFRPTRNAYGILGGIPQSEFTREVIEAKVAATPNATMPGYAVITNSTYDGLLYNTQYIKE
TLDTKFIHFDSAWVPYTNFNSIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMIHVKGEFDKESFNEAFMMHTSTS
PQYGIVASTEIAAAMMRGNTGKKLIQDSIDRAIRFRKEIKRLESESDSWFFDVWQPENIDTTECWKLDPKDTWHGFKDID
DDHMYLDPIKVTLLTPGMNENSEMSETGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKSKAMQLLRALTDFKRGY
DLNLTVKNFLPSLYNEDPSFYEGMRIQELAQGIHDLTRQYRLPELMFKAFDVLPELKVTPHAAWQEELRGNVEEVKLEEM
VGRVSANMILPYPPGVPLVLPGEMVTTESRPVLDFLEMLCAIGAHYPGFETDIHGVYAQKDGSYTVKVLKED

Specific function: Appears To Play A Role In pH Homeostasis By Consuming Protons And Neutralizing The Acidic By-Products Of Carbohydrate Fermentation. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1790573, Length=712, Percent_Identity=75.8426966292135, Blast_Score=1168, Evalue=0.0,
Organism=Escherichia coli, GI1786384, Length=710, Percent_Identity=68.7323943661972, Blast_Score=1078, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=735, Percent_Identity=36.4625850340136, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI87082193, Length=619, Percent_Identity=34.7334410339257, Blast_Score=346, Evalue=3e-96,
Organism=Escherichia coli, GI1786909, Length=628, Percent_Identity=33.9171974522293, Blast_Score=327, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 80353; Mature: 80353

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFAILNHSGVFFKEEPVRELHASLEKAGYKVVYPVDAQDLYKMVEMNPRICGVLFDWD
CEEEEEEECCCCEECCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCEEEEEEECC
KYSLDLCTEINVLNEKLPLYAFANQHSTLDISLTDLRLNLHFFEYALGMADDIALKINQA
CCCEEHHHHHHHHCCCCCEEEEECCCCEEEEEEEEEEEEHHHHHHHHCCCCCEEEEECHH
TEEYIDQIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQKSPAGSIFYDFYGPNAFKADV
HHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEECE
SISMPELGSLLDHSGPHKEAEEYIARTFNADSSYIVTNGTSTSNKIVGMFSAPAGSTVLV
EECCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLTHMMMMSDVTPIYFRPTRNAYGILGGIPQSEFTREVIEAKVAATPNATMPGY
ECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCE
AVITNSTYDGLLYNTQYIKETLDTKFIHFDSAWVPYTNFNSIYEGKCGMSGEAMPGKVFY
EEEECCCCCCEEECHHHHHHHHCCEEEEECCCCCCCCCCCCEECCCCCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGEFDKESFNEAFMMHTSTSPQYGIVASTEIAAAMMRGNT
ECCHHHHHHHHHCCCCEEEEECCCCCHHCCCEEEEEECCCCCCCEEEHHHHHHHHHCCCC
GKKLIQDSIDRAIRFRKEIKRLESESDSWFFDVWQPENIDTTECWKLDPKDTWHGFKDID
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCHHHCCCCCCCC
DDHMYLDPIKVTLLTPGMNENSEMSETGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHCCEEEECCCCEEEEEEEEEC
IDKSKAMQLLRALTDFKRGYDLNLTVKNFLPSLYNEDPSFYEGMRIQELAQGIHDLTRQY
CCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHH
RLPELMFKAFDVLPELKVTPHAAWQEELRGNVEEVKLEEMVGRVSANMILPYPPGVPLVL
CCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEE
PGEMVTTESRPVLDFLEMLCAIGAHYPGFETDIHGVYAQKDGSYTVKVLKED
CCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEECC
>Mature Secondary Structure
MNIFAILNHSGVFFKEEPVRELHASLEKAGYKVVYPVDAQDLYKMVEMNPRICGVLFDWD
CEEEEEEECCCCEECCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCEEEEEEECC
KYSLDLCTEINVLNEKLPLYAFANQHSTLDISLTDLRLNLHFFEYALGMADDIALKINQA
CCCEEHHHHHHHHCCCCCEEEEECCCCEEEEEEEEEEEEHHHHHHHHCCCCCEEEEECHH
TEEYIDQIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQKSPAGSIFYDFYGPNAFKADV
HHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEECE
SISMPELGSLLDHSGPHKEAEEYIARTFNADSSYIVTNGTSTSNKIVGMFSAPAGSTVLV
EECCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLTHMMMMSDVTPIYFRPTRNAYGILGGIPQSEFTREVIEAKVAATPNATMPGY
ECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCE
AVITNSTYDGLLYNTQYIKETLDTKFIHFDSAWVPYTNFNSIYEGKCGMSGEAMPGKVFY
EEEECCCCCCEEECHHHHHHHHCCEEEEECCCCCCCCCCCCEECCCCCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGEFDKESFNEAFMMHTSTSPQYGIVASTEIAAAMMRGNT
ECCHHHHHHHHHCCCCEEEEECCCCCHHCCCEEEEEECCCCCCCEEEHHHHHHHHHCCCC
GKKLIQDSIDRAIRFRKEIKRLESESDSWFFDVWQPENIDTTECWKLDPKDTWHGFKDID
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCHHHCCCCCCCC
DDHMYLDPIKVTLLTPGMNENSEMSETGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHCCEEEECCCCEEEEEEEEEC
IDKSKAMQLLRALTDFKRGYDLNLTVKNFLPSLYNEDPSFYEGMRIQELAQGIHDLTRQY
CCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHH
RLPELMFKAFDVLPELKVTPHAAWQEELRGNVEEVKLEEMVGRVSANMILPYPPGVPLVL
CCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEE
PGEMVTTESRPVLDFLEMLCAIGAHYPGFETDIHGVYAQKDGSYTVKVLKED
CCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]