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The map label for this gene is uppS [H]

Identifier: 209695847

GI number: 209695847

Start: 2593958

End: 2594731

Strand: Reverse

Name: uppS [H]

Synonym: VSAL_I2423

Alternate gene names: 209695847

Gene position: 2594731-2593958 (Counterclockwise)

Preceding gene: 209695848

Following gene: 209695846

Centisome position: 78.03

GC content: 39.41

Gene sequence:

>774_bases
ATGACCAATCACATTCACACAGAAGCCTTATCATTAGATATATTGCCAAAACACATTGCGGTAATTATGGATGGTAATGG
GCGCTGGGCAAAAGCTCAGGGTAAACCTCGTGTATTTGGTCATAAGGCTGGGGTTGATGCGGTAAGAAAAACCATATCAG
CGGCCAGTAAATTAGGGATTAATGCCATTACTCTGTTTGCTTTTAGCAGTGAGAATTGGCGTCGTCCAGAAGAAGAAGTG
AGTGTTCTCATGGAGTTGTTTATCACGGTACTTTCCCGTGAAGTAAAACGTCTTCATAAAAATAATATTCAGTTGCGTGT
TATAGGTAATACCTCTCAATTTAGCTCTCGTCTTCAAAAGAAGATTTTAGAAGCAGAAGCATTAACACTTGAAAATTCAG
GTTTAGTGTTAAATATTGCGGCTAATTATGGTGGAAAATGGGATATTACCCAAGCAGTGCAACGTCTTGCTTATCAAGTT
GAGCAAGGTAATTTACAGGCAGATAATATTAACGAAGCATTGATCGCTTCGAAACTGACGATGTCAGATTTGCCTGATGT
GGATTTGATGATAAGAACCAGTGGTGAATGCCGGATCAGTAACTTTATGTTATGGCAGATGGCTTATGCTGAGTTTTACT
TCACTGACCAATATTGGCCTGATTTTAATGAACAAAGTTTAGCGAATGCAGTTGCTTGGTTTGTTAGTCGAGAAAGACGA
TTTGGTTGTACCGGTGAGCAAATCCAAGCTCTTATGAACGAAAAGGATCGATAA

Upstream 100 bases:

>100_bases
AGGCTGATTTTTATCTATTTTTAGTGGTATGATGACGGCGATGAACACTGTAAGAAGCGCTATGTGCAGACATCAGCGCT
TTTATTTTTAAGGGAGTTAT

Downstream 100 bases:

>100_bases
AGTTTGAAACAGCGTATAATTACAGCCCTTATTTTAGCTCCTCTAGTTATTGCCGGTATTTTCATGCTGCCAATGCAAGG
TTTTTTAATCGCGATTATGG

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MTNHIHTEALSLDILPKHIAVIMDGNGRWAKAQGKPRVFGHKAGVDAVRKTISAASKLGINAITLFAFSSENWRRPEEEV
SVLMELFITVLSREVKRLHKNNIQLRVIGNTSQFSSRLQKKILEAEALTLENSGLVLNIAANYGGKWDITQAVQRLAYQV
EQGNLQADNINEALIASKLTMSDLPDVDLMIRTSGECRISNFMLWQMAYAEFYFTDQYWPDFNEQSLANAVAWFVSRERR
FGCTGEQIQALMNEKDR

Sequences:

>Translated_257_residues
MTNHIHTEALSLDILPKHIAVIMDGNGRWAKAQGKPRVFGHKAGVDAVRKTISAASKLGINAITLFAFSSENWRRPEEEV
SVLMELFITVLSREVKRLHKNNIQLRVIGNTSQFSSRLQKKILEAEALTLENSGLVLNIAANYGGKWDITQAVQRLAYQV
EQGNLQADNINEALIASKLTMSDLPDVDLMIRTSGECRISNFMLWQMAYAEFYFTDQYWPDFNEQSLANAVAWFVSRERR
FGCTGEQIQALMNEKDR
>Mature_256_residues
TNHIHTEALSLDILPKHIAVIMDGNGRWAKAQGKPRVFGHKAGVDAVRKTISAASKLGINAITLFAFSSENWRRPEEEVS
VLMELFITVLSREVKRLHKNNIQLRVIGNTSQFSSRLQKKILEAEALTLENSGLVLNIAANYGGKWDITQAVQRLAYQVE
QGNLQADNINEALIASKLTMSDLPDVDLMIRTSGECRISNFMLWQMAYAEFYFTDQYWPDFNEQSLANAVAWFVSRERRF
GCTGEQIQALMNEKDR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=36.7713004484305, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=36.7713004484305, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=61.4035087719298, Blast_Score=304, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI71993029, Length=223, Percent_Identity=37.219730941704, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323748, Length=226, Percent_Identity=33.1858407079646, Blast_Score=118, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=221, Percent_Identity=30.316742081448, Blast_Score=108, Evalue=7e-25,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=36.8421052631579, Blast_Score=140, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29109; Mature: 28977

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNHIHTEALSLDILPKHIAVIMDGNGRWAKAQGKPRVFGHKAGVDAVRKTISAASKLGI
CCCCEECHHEEEEECCCEEEEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCC
NAITLFAFSSENWRRPEEEVSVLMELFITVLSREVKRLHKNNIQLRVIGNTSQFSSRLQK
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHH
KILEAEALTLENSGLVLNIAANYGGKWDITQAVQRLAYQVEQGNLQADNINEALIASKLT
HHHHHHHEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
MSDLPDVDLMIRTSGECRISNFMLWQMAYAEFYFTDQYWPDFNEQSLANAVAWFVSRERR
HCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHCC
FGCTGEQIQALMNEKDR
CCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNHIHTEALSLDILPKHIAVIMDGNGRWAKAQGKPRVFGHKAGVDAVRKTISAASKLGI
CCCEECHHEEEEECCCEEEEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCC
NAITLFAFSSENWRRPEEEVSVLMELFITVLSREVKRLHKNNIQLRVIGNTSQFSSRLQK
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHH
KILEAEALTLENSGLVLNIAANYGGKWDITQAVQRLAYQVEQGNLQADNINEALIASKLT
HHHHHHHEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
MSDLPDVDLMIRTSGECRISNFMLWQMAYAEFYFTDQYWPDFNEQSLANAVAWFVSRERR
HCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHCC
FGCTGEQIQALMNEKDR
CCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA