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The map label for this gene is lpxD [H]

Identifier: 209695841

GI number: 209695841

Start: 2586375

End: 2587394

Strand: Reverse

Name: lpxD [H]

Synonym: VSAL_I2417

Alternate gene names: 209695841

Gene position: 2587394-2586375 (Counterclockwise)

Preceding gene: 209695842

Following gene: 209695840

Centisome position: 77.81

GC content: 40.49

Gene sequence:

>1020_bases
ATGACTCGTATTACGCTTGCTAAATTGGCAGAAAAATTAGGTGCAACCGTTCATGGTAACGGTGATGTTATTGTACATTC
GATTGCTTCGATGAATAAAGCAAGAGAAGGAGACATTACGTTTCTTTCGAATGCAAAATATCGTAAGCAGTTAGCTGAGT
GCCAAGCATCTGCAGTAATAGTAAAAGAAGCAGATGTTGAATTTTGCCAATCGAATGCATTAATAATGCGAGACCCATAT
TTAGGCTTTGCTCTAGCTGCACAGGCATTGGATACAACGCCTGCACCAGCTACGGATATCGCCCCTTCAGCTTATATTGC
AGCTGATGCAATTATTGGTAAAGGGGTCGCTATTGGACACAATGCAGTCATTGAGTCAAAAGCGGTGATTGCAGATGGAG
CGATTATTGGTTCTGGTTGTTTTATTGGACAAGAAGCAAAGATAGGTGAAAATACCAAGCTTTGGGCTAATGTTTCAATC
TATCATCGAGTTGAAATCGGAAAATCCTGTTTAGTACAAGCTGGCACTGTTATTGGTTCTGATGGTTTTGGTTATGCAAA
CGATCGTGGCACTTGGGTTAAGATCCCACAATTAGGCACTGTTATTATTGGTGATAATGTGGAAATTGGTGCAAATGCAG
CAATTGACCGTGGTGCGATTGATAATACGATTATTGAAAGTAATGTAATTATTGATAATCACATTCAAATCGCTCATAAC
GTACAAATCGGATCTGGTTCAGCGATGGCTGGTGGTACTATTGTTGCCGGCAGCACAAAAATTGGTAAACATTGTATCAT
CGGTGGCGGTTCGGTTATTAACGGTCACATTGAAATCACAGATGGCGTAACGATTACTGGCATGGGAATGGTAATGAGAG
GCATCTCTGAGAAGGGAATGTACTCATCTGGTATTCCACTTCAGCCGAATAAAGAATGGCGTAAAACCGCGACACGAGTT
CATAAAATTGATGATATGAATAAGCGTTTGAAAGCGGTAGAAAAAAAACTGGTTGATTAA

Upstream 100 bases:

>100_bases
AAGGCTACGATATGGTTGTTGATGCAGCAACTCTACTTTGGGCACAACCTGAAGACAACCTATCAGAAAAAGTAATCAAA
GCAATTAAATAAGGTTGAAT

Downstream 100 bases:

>100_bases
GCTCAGTTTTTCAACATTCTAATTAATAAGTATTGGTCTGCATTTTGCAGGCCTTTGTCTATCTATTATTACTCTATTTG
AGCTACACTATTACTCAGAT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTRITLAKLAEKLGATVHGNGDVIVHSIASMNKAREGDITFLSNAKYRKQLAECQASAVIVKEADVEFCQSNALIMRDPY
LGFALAAQALDTTPAPATDIAPSAYIAADAIIGKGVAIGHNAVIESKAVIADGAIIGSGCFIGQEAKIGENTKLWANVSI
YHRVEIGKSCLVQAGTVIGSDGFGYANDRGTWVKIPQLGTVIIGDNVEIGANAAIDRGAIDNTIIESNVIIDNHIQIAHN
VQIGSGSAMAGGTIVAGSTKIGKHCIIGGGSVINGHIEITDGVTITGMGMVMRGISEKGMYSSGIPLQPNKEWRKTATRV
HKIDDMNKRLKAVEKKLVD

Sequences:

>Translated_339_residues
MTRITLAKLAEKLGATVHGNGDVIVHSIASMNKAREGDITFLSNAKYRKQLAECQASAVIVKEADVEFCQSNALIMRDPY
LGFALAAQALDTTPAPATDIAPSAYIAADAIIGKGVAIGHNAVIESKAVIADGAIIGSGCFIGQEAKIGENTKLWANVSI
YHRVEIGKSCLVQAGTVIGSDGFGYANDRGTWVKIPQLGTVIIGDNVEIGANAAIDRGAIDNTIIESNVIIDNHIQIAHN
VQIGSGSAMAGGTIVAGSTKIGKHCIIGGGSVINGHIEITDGVTITGMGMVMRGISEKGMYSSGIPLQPNKEWRKTATRV
HKIDDMNKRLKAVEKKLVD
>Mature_338_residues
TRITLAKLAEKLGATVHGNGDVIVHSIASMNKAREGDITFLSNAKYRKQLAECQASAVIVKEADVEFCQSNALIMRDPYL
GFALAAQALDTTPAPATDIAPSAYIAADAIIGKGVAIGHNAVIESKAVIADGAIIGSGCFIGQEAKIGENTKLWANVSIY
HRVEIGKSCLVQAGTVIGSDGFGYANDRGTWVKIPQLGTVIIGDNVEIGANAAIDRGAIDNTIIESNVIIDNHIQIAHNV
QIGSGSAMAGGTIVAGSTKIGKHCIIGGGSVINGHIEITDGVTITGMGMVMRGISEKGMYSSGIPLQPNKEWRKTATRVH
KIDDMNKRLKAVEKKLVD

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=337, Percent_Identity=61.7210682492582, Blast_Score=438, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 35539; Mature: 35408

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRITLAKLAEKLGATVHGNGDVIVHSIASMNKAREGDITFLSNAKYRKQLAECQASAVI
CCEEEHHHHHHHHCCEEECCCCEEEEEHHHHCCCCCCCEEEECCCHHHHHHHHHHHCEEE
VKEADVEFCQSNALIMRDPYLGFALAAQALDTTPAPATDIAPSAYIAADAIIGKGVAIGH
EEECCHHHHCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEECC
NAVIESKAVIADGAIIGSGCFIGQEAKIGENTKLWANVSIYHRVEIGKSCLVQAGTVIGS
CCEECCCEEEECCEEEECCEEECCCCCCCCCCEEEEEEEEEEEEECCHHHHHCCCEEECC
DGFGYANDRGTWVKIPQLGTVIIGDNVEIGANAAIDRGAIDNTIIESNVIIDNHIQIAHN
CCCCCCCCCCCEEECCCCCEEEECCCEEECCCCCCCCCCCCCEEEECCEEEECCEEEEEE
VQIGSGSAMAGGTIVAGSTKIGKHCIIGGGSVINGHIEITDGVTITGMGMVMRGISEKGM
EEECCCCCCCCCEEEECCCCCCCEEEEECCEEEEEEEEEECCEEEEEHHHHHHCCCCCCC
YSSGIPLQPNKEWRKTATRVHKIDDMNKRLKAVEKKLVD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRITLAKLAEKLGATVHGNGDVIVHSIASMNKAREGDITFLSNAKYRKQLAECQASAVI
CEEEHHHHHHHHCCEEECCCCEEEEEHHHHCCCCCCCEEEECCCHHHHHHHHHHHCEEE
VKEADVEFCQSNALIMRDPYLGFALAAQALDTTPAPATDIAPSAYIAADAIIGKGVAIGH
EEECCHHHHCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEECC
NAVIESKAVIADGAIIGSGCFIGQEAKIGENTKLWANVSIYHRVEIGKSCLVQAGTVIGS
CCEECCCEEEECCEEEECCEEECCCCCCCCCCEEEEEEEEEEEEECCHHHHHCCCEEECC
DGFGYANDRGTWVKIPQLGTVIIGDNVEIGANAAIDRGAIDNTIIESNVIIDNHIQIAHN
CCCCCCCCCCCEEECCCCCEEEECCCEEECCCCCCCCCCCCCEEEECCEEEECCEEEEEE
VQIGSGSAMAGGTIVAGSTKIGKHCIIGGGSVINGHIEITDGVTITGMGMVMRGISEKGM
EEECCCCCCCCCEEEECCCCCCCEEEEECCEEEEEEEEEECCEEEEEHHHHHHCCCCCCC
YSSGIPLQPNKEWRKTATRVHKIDDMNKRLKAVEKKLVD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA