Click here to switch to the map view.

The map label for this gene is sppA [H]

Identifier: 209695598

GI number: 209695598

Start: 2317002

End: 2318855

Strand: Direct

Name: sppA [H]

Synonym: VSAL_I2157

Alternate gene names: 209695598

Gene position: 2317002-2318855 (Clockwise)

Preceding gene: 209695593

Following gene: 209695599

Centisome position: 69.68

GC content: 39.81

Gene sequence:

>1854_bases
ATGAAAGGGTTATTCCACTTCATAAGTAAATGTTTTCAGGCGATATGGAAGTTACTTTCCTTTACTCGTCAGCTAGTACT
TAATTTGTTTTTCTTGGCTTTTATCGGTGTCATTGCTTTTACTTTTTTAAGCACCGATGATATTCAACAAGATCAAACCG
TTGAGAAAAAAGCACTCATTCTGGATCTCTCTGGCCCAATTGTTGAAGAAAGTAAATTCAGAGAGCCACTAGAACGCGTT
ACGGCCGATTTACTCGGTAGCCAACGATCACAAGAAAACGTCTTATTCGATATCGTAGATACAATTCGCTATGCCGCTAA
AGATGATAATGTGTCAGGTTTAGTTCTTCATTTAAAAGAAATGAATGAAACAAGTCTAACTAAATTGCGTTATATCGCAA
AAGCCATCAATACATTTAAAGCGTCTGGTAAACCCGTCTATGCCATCGGTGATTATTACAACCAAAGCCAATACTATTTA
GCAAGTTACGCTGACAAAATTTTTATGGCTCCTGACGGCGCAGTCTTATTACGTGGCTACGGAGCTTACACTCTGTACTA
CAAAGATTTATTAGAAAAACTCAATGTATCGACACACGTTTTTCGCGTAGGTACTTATAAATCAGCCGTAGAACCTTACT
TACGTAATGACATGTCTGATGCTGCTAAAGCATCCACGTCAGCATGGCTAACTCAGCTTTGGGATGCGTATTTAGGTGAT
GTCTCAACCAATCGCCAAATTGACGCAAAAACATTAACGATGCCAATGGATCAGTTTATTGCAAAATTGACGGCATTAAA
TGGTGATTTATCACAAATGACGGTGGAACTTGGTTTAGTTGACAAGCTCGCTACTCGTCAAGAAGTTCGTAAAGACCTTA
TTACTGAATTTGGGTCAAATGGTTATGATAGCTTTAAACAAATAAGCTATTACGATTATCTCCCTCAAGTTCACCCTTCG
ATTATCCCTGATGCAAAAGACATTGCTGTTGTTGTCGCTAGTGGCGCAATTATGGATGGAACTCAACGTCAAGGTACTGT
CGGAGGCGATTCAACTGCCGCATTATTACGCCAAGCTCGTGATGATGATAATGTGAAAGCTGTCGTTTTGAGAGTAGATA
GCCCAGGAGGCAGTGCTTTTGCTTCTGAAATTATTCGTAACGAAGTTGATGCTCTACAAGAAGCAGGTAAGCCTGTTGTT
ATTTCTATGTCGAGTGTCGCTGCCTCTGGTGGTTATTGGATCTCCGCAAGTGCTGATAAGATCATTGCTCAACCAACAAC
GATTACTGGCTCTATTGGTATTTTTGGTATTTTAACCACTTTTGAAAAAGGGTTAGAAAAAATGGGTATCCACAGCGATG
GCATTTCGACATCACCTTTCAATGGCATTGGCCTTACTCGCCCGCTTGATAAAGACGTTGCTCAAGTCATGCAATTAGGT
ATTGAACATGGTTATTACCGATTCATTAAATTAGTCAGTGATCATCGTGATATGTCTTTAGATGCCGTTGATAATGTCGC
TCAAGGTCGAGTATGGACAGGGAAAGATGCCCTTGAACATGGTTTGATTGACCAGCTAGGGGATTTTGATGATGCTGTTC
AAGCTGCGGCTGAGCTCGCCAATATGGACGCATATAATCTGTTTTGGGTAAAAGAACCATTAACACCGATGGAACAATTT
CTTGAAGAGTTAAGCATGAGCTTAAATGTCAGTGTAAAAGCTGAATTATTTTCATTAGCGCCTGAAGCATTGCAACCAGC
CATAAGCAAAGTTGCAACAGATATCAACATGTTAAATAACTTTAATGACCCAAAAGGACAATATCTGTTCTGCCTCAATT
GCAGTAATCTGTAA

Upstream 100 bases:

>100_bases
AAATCAGTAAATCACTTTGATTCTCATTCACGCCTATAGTTACTTTCTACTTAAGTTAGAGTAGGATAAAAGCATAATGA
AATAAATAATAAGGACATAT

Downstream 100 bases:

>100_bases
AAGCATGACGAGCCCGACACATGTCGGGCTTTCTTTATGCAGAATGACCAGTATAATCCCACCACCTCCCATAACTCTGT
ACCGTTGTTATTATGGAAAG

Product: protease IV (endopeptidase IV)

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MKGLFHFISKCFQAIWKLLSFTRQLVLNLFFLAFIGVIAFTFLSTDDIQQDQTVEKKALILDLSGPIVEESKFREPLERV
TADLLGSQRSQENVLFDIVDTIRYAAKDDNVSGLVLHLKEMNETSLTKLRYIAKAINTFKASGKPVYAIGDYYNQSQYYL
ASYADKIFMAPDGAVLLRGYGAYTLYYKDLLEKLNVSTHVFRVGTYKSAVEPYLRNDMSDAAKASTSAWLTQLWDAYLGD
VSTNRQIDAKTLTMPMDQFIAKLTALNGDLSQMTVELGLVDKLATRQEVRKDLITEFGSNGYDSFKQISYYDYLPQVHPS
IIPDAKDIAVVVASGAIMDGTQRQGTVGGDSTAALLRQARDDDNVKAVVLRVDSPGGSAFASEIIRNEVDALQEAGKPVV
ISMSSVAASGGYWISASADKIIAQPTTITGSIGIFGILTTFEKGLEKMGIHSDGISTSPFNGIGLTRPLDKDVAQVMQLG
IEHGYYRFIKLVSDHRDMSLDAVDNVAQGRVWTGKDALEHGLIDQLGDFDDAVQAAAELANMDAYNLFWVKEPLTPMEQF
LEELSMSLNVSVKAELFSLAPEALQPAISKVATDINMLNNFNDPKGQYLFCLNCSNL

Sequences:

>Translated_617_residues
MKGLFHFISKCFQAIWKLLSFTRQLVLNLFFLAFIGVIAFTFLSTDDIQQDQTVEKKALILDLSGPIVEESKFREPLERV
TADLLGSQRSQENVLFDIVDTIRYAAKDDNVSGLVLHLKEMNETSLTKLRYIAKAINTFKASGKPVYAIGDYYNQSQYYL
ASYADKIFMAPDGAVLLRGYGAYTLYYKDLLEKLNVSTHVFRVGTYKSAVEPYLRNDMSDAAKASTSAWLTQLWDAYLGD
VSTNRQIDAKTLTMPMDQFIAKLTALNGDLSQMTVELGLVDKLATRQEVRKDLITEFGSNGYDSFKQISYYDYLPQVHPS
IIPDAKDIAVVVASGAIMDGTQRQGTVGGDSTAALLRQARDDDNVKAVVLRVDSPGGSAFASEIIRNEVDALQEAGKPVV
ISMSSVAASGGYWISASADKIIAQPTTITGSIGIFGILTTFEKGLEKMGIHSDGISTSPFNGIGLTRPLDKDVAQVMQLG
IEHGYYRFIKLVSDHRDMSLDAVDNVAQGRVWTGKDALEHGLIDQLGDFDDAVQAAAELANMDAYNLFWVKEPLTPMEQF
LEELSMSLNVSVKAELFSLAPEALQPAISKVATDINMLNNFNDPKGQYLFCLNCSNL
>Mature_617_residues
MKGLFHFISKCFQAIWKLLSFTRQLVLNLFFLAFIGVIAFTFLSTDDIQQDQTVEKKALILDLSGPIVEESKFREPLERV
TADLLGSQRSQENVLFDIVDTIRYAAKDDNVSGLVLHLKEMNETSLTKLRYIAKAINTFKASGKPVYAIGDYYNQSQYYL
ASYADKIFMAPDGAVLLRGYGAYTLYYKDLLEKLNVSTHVFRVGTYKSAVEPYLRNDMSDAAKASTSAWLTQLWDAYLGD
VSTNRQIDAKTLTMPMDQFIAKLTALNGDLSQMTVELGLVDKLATRQEVRKDLITEFGSNGYDSFKQISYYDYLPQVHPS
IIPDAKDIAVVVASGAIMDGTQRQGTVGGDSTAALLRQARDDDNVKAVVLRVDSPGGSAFASEIIRNEVDALQEAGKPVV
ISMSSVAASGGYWISASADKIIAQPTTITGSIGIFGILTTFEKGLEKMGIHSDGISTSPFNGIGLTRPLDKDVAQVMQLG
IEHGYYRFIKLVSDHRDMSLDAVDNVAQGRVWTGKDALEHGLIDQLGDFDDAVQAAAELANMDAYNLFWVKEPLTPMEQF
LEELSMSLNVSVKAELFSLAPEALQPAISKVATDINMLNNFNDPKGQYLFCLNCSNL

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=621, Percent_Identity=47.5040257648953, Blast_Score=563, Evalue=1e-161,
Organism=Escherichia coli, GI1787527, Length=171, Percent_Identity=29.8245614035088, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 68032; Mature: 68032

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLFHFISKCFQAIWKLLSFTRQLVLNLFFLAFIGVIAFTFLSTDDIQQDQTVEKKALI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEEE
LDLSGPIVEESKFREPLERVTADLLGSQRSQENVLFDIVDTIRYAAKDDNVSGLVLHLKE
EECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHH
MNETSLTKLRYIAKAINTFKASGKPVYAIGDYYNQSQYYLASYADKIFMAPDGAVLLRGY
CCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCEEEECCCCEEEEECC
GAYTLYYKDLLEKLNVSTHVFRVGTYKSAVEPYLRNDMSDAAKASTSAWLTQLWDAYLGD
CHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
VSTNRQIDAKTLTMPMDQFIAKLTALNGDLSQMTVELGLVDKLATRQEVRKDLITEFGSN
CCCCCEECCHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYDSFKQISYYDYLPQVHPSIIPDAKDIAVVVASGAIMDGTQRQGTVGGDSTAALLRQAR
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHC
DDDNVKAVVLRVDSPGGSAFASEIIRNEVDALQEAGKPVVISMSSVAASGGYWISASADK
CCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCEEEECCCCC
IIAQPTTITGSIGIFGILTTFEKGLEKMGIHSDGISTSPFNGIGLTRPLDKDVAQVMQLG
EEECCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
IEHGYYRFIKLVSDHRDMSLDAVDNVAQGRVWTGKDALEHGLIDQLGDFDDAVQAAAELA
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCHHHHHHHHHHHHCCHHHHHHHHHHHH
NMDAYNLFWVKEPLTPMEQFLEELSMSLNVSVKAELFSLAPEALQPAISKVATDINMLNN
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEHHHHHHCCHHHHHHHHHHHHHHHHHHHC
FNDPKGQYLFCLNCSNL
CCCCCCCEEEEEECCCC
>Mature Secondary Structure
MKGLFHFISKCFQAIWKLLSFTRQLVLNLFFLAFIGVIAFTFLSTDDIQQDQTVEKKALI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEEE
LDLSGPIVEESKFREPLERVTADLLGSQRSQENVLFDIVDTIRYAAKDDNVSGLVLHLKE
EECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHH
MNETSLTKLRYIAKAINTFKASGKPVYAIGDYYNQSQYYLASYADKIFMAPDGAVLLRGY
CCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCEEEECCCCEEEEECC
GAYTLYYKDLLEKLNVSTHVFRVGTYKSAVEPYLRNDMSDAAKASTSAWLTQLWDAYLGD
CHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
VSTNRQIDAKTLTMPMDQFIAKLTALNGDLSQMTVELGLVDKLATRQEVRKDLITEFGSN
CCCCCEECCHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYDSFKQISYYDYLPQVHPSIIPDAKDIAVVVASGAIMDGTQRQGTVGGDSTAALLRQAR
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHC
DDDNVKAVVLRVDSPGGSAFASEIIRNEVDALQEAGKPVVISMSSVAASGGYWISASADK
CCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCEEEECCCCC
IIAQPTTITGSIGIFGILTTFEKGLEKMGIHSDGISTSPFNGIGLTRPLDKDVAQVMQLG
EEECCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
IEHGYYRFIKLVSDHRDMSLDAVDNVAQGRVWTGKDALEHGLIDQLGDFDDAVQAAAELA
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCHHHHHHHHHHHHCCHHHHHHHHHHHH
NMDAYNLFWVKEPLTPMEQFLEELSMSLNVSVKAELFSLAPEALQPAISKVATDINMLNN
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEHHHHHHCCHHHHHHHHHHHHHHHHHHHC
FNDPKGQYLFCLNCSNL
CCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3522590; 9097039; 9278503; 7973728 [H]