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The map label for this gene is uvrB

Identifier: 209695340

GI number: 209695340

Start: 2007661

End: 2009691

Strand: Direct

Name: uvrB

Synonym: VSAL_I1873

Alternate gene names: 209695340

Gene position: 2007661-2009691 (Clockwise)

Preceding gene: 209695330

Following gene: 209695341

Centisome position: 60.38

GC content: 39.0

Gene sequence:

>2031_bases
ATGACTAGTGCGTATGAATTAGTTTCAGACTATCAACCAGCAGGGGATCAACCTCAGGCAATTAAAACGTTAAATGAAGG
GCTAGAAAATGGTCTTGCTCATCAAACGTTGTTAGGGGTTACTGGATCAGGTAAAACATTCACACTGGCGAATGTGATTG
CTAAATCAGGTCGTCCTACCGTGATAATGGCACATAATAAGACATTAGCTGCTCAACTTTATGGTGAAATGAAAGCTTTT
TTCCCTAATAACGCTGTGGAATATTTTGTTTCTTATTTTGATTATTATCAACCAGAGGCTTATGTCCCAACCACGGATAC
CTTTATAGAAAAAGACTCATCGGTTAATGAGCATATCGAGCAAATGCGTCTCTCTGCGACAAAAGCATTATTAGAACGTA
AAGATGCGATTATTATCGCTTCTGTTTCTGCGATTTATGGTCTTGGCGATCCTCAAGCGTATTTAAGTATGATGCTGCAT
TTGAGTCGAGGGGATATCATTAACCAACGTGATATTTTACGTCGATTAGCTGAATTACAATATAAACGTAATGACATGGC
TTTTGAGCGAGGTACATTCCGTGTTCGTGGTGAGGTTTTGGATGTTTTTCCTGCAGAATCAGAGCATGAAGCGATTCGAA
TTGAGCTTTTTGATGATGAAGTTGAACGTATTAGTAAGTTTGACCCATTAACGGGTTCAATTATTACTAAAGACATGCCT
CGTTGTACTATATATCCGAAAACACACTACGTAACACCCAGAGAAAAAGTACTTGATGCCATTGAACAGATAAAAGTCGA
TTTGGCTGAGCGAAAAAAAGAATTATTAGCTAATAATAAGCTAGTTGAAGAACAAAGAATCTCACAACGAACTCAATTTG
ATATTGAAATGATGAATGAGCTTGGTTTTTGTTCTGGTATTGAAAACTATTCTCGTTATTTGAGTGGTCGTCCTCAAGGT
GAAGCGCCGCCCACTTTATTTGATTATTTACCTAAAGATGGCTTACTGATTATTGATGAATCCCACATTACCGTGTCTCA
AATAGGGGCAATGTACAAAGGTGATCGTTCACGTAAAGAGAATTTGGTTGAATACGGTTTTCGGTTACCTTCAGCATTAG
ATAACCGTCCTATGCGCTTTGATGAATTTGAAGCCCGTGCTCCACAAACGATTTACGTTTCTGCTACGCCTGGAAAGTAT
GAAATCGAAAAGTCGGGCTCTGATATTGCTGAGCAATTAGTAAGGCCTACTGGTTTACTTGATCCTATTATTGAAGTACG
CCCCGTTGGAACTCAAGTGGATGATTTATTATCTGAGATCAGAATTCGTACGAAAGTGGGTGAGAGAGTGTTGGTGACGA
CGCTTACCAAGCGTATGTCTGAAGATTTGACTGAATATCTTGCAGAGCATGGAGTGAAAGTTCGTTATTTACATTCTGAT
ATTGATACGGTTGAGCGTGTTGAGATCATCCGTGATTTGCGGTTAGGCAAGTTTGATGTGTTAGTCGGCATTAACTTATT
GCGTGAAGGCTTAGATATGCCTGAAGTGTCTTTAGTCGCGATTTTAGATGCAGATAAAGAAGGCTTCTTACGATCCGAAC
GATCATTAATTCAAGCGATAGGACGTGCTGCTCGTAATTTAGAAGGTAAAGCGATTTTATACGCAGATCGGATCACGGGC
TCAATGGAAAAAGCCATTGGAGAAACAGAAAGAAGACGTGAAAAACAGATATTACATAATGAAGCATTAGGTATTGTGCC
AACCGCATTGAAAAAAAATGTGGCTGATATTCTTGAATTGGGGGATATGACTAAGAATAAACGGAAAATAGTCGCACCTA
AAATGAAGCTATCAGAAGTGGCAGAAGAAGGAGCGAGTTATCAATCGATGACGCCGCAGCAATTAGAAAAAGAAGTTCAA
CGATTAGAAGCAAAAATGTATCAACATGCGAGAGATCTAGAGTTTGAACAGGCTGCTAAAGTAAGGGATGAGGTAGAGAA
ATTAAGGAATCAATTTATAACGAATAGTTAA

Upstream 100 bases:

>100_bases
GGGAAAACTTTTATCTTAATAAAGCGTTTCTATAAAAAAAGAGTAAGATTTGATAGTGTGTCTTTCTATAAAAGAGCAGT
GAAAATGTGGAGCAGTATAA

Downstream 100 bases:

>100_bases
TGACTATTTTGTAAATTATTGATTTTAAGAAAAAAGAAGCCAACCGTAATATACCGGTTGGCTTTATTGTTCATGTGAAA
GTAAATTTCACTAACAACGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MTSAYELVSDYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAKSGRPTVIMAHNKTLAAQLYGEMKAF
FPNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIEQMRLSATKALLERKDAIIIASVSAIYGLGDPQAYLSMMLH
LSRGDIINQRDILRRLAELQYKRNDMAFERGTFRVRGEVLDVFPAESEHEAIRIELFDDEVERISKFDPLTGSIITKDMP
RCTIYPKTHYVTPREKVLDAIEQIKVDLAERKKELLANNKLVEEQRISQRTQFDIEMMNELGFCSGIENYSRYLSGRPQG
EAPPTLFDYLPKDGLLIIDESHITVSQIGAMYKGDRSRKENLVEYGFRLPSALDNRPMRFDEFEARAPQTIYVSATPGKY
EIEKSGSDIAEQLVRPTGLLDPIIEVRPVGTQVDDLLSEIRIRTKVGERVLVTTLTKRMSEDLTEYLAEHGVKVRYLHSD
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQAIGRAARNLEGKAILYADRITG
SMEKAIGETERRREKQILHNEALGIVPTALKKNVADILELGDMTKNKRKIVAPKMKLSEVAEEGASYQSMTPQQLEKEVQ
RLEAKMYQHARDLEFEQAAKVRDEVEKLRNQFITNS

Sequences:

>Translated_676_residues
MTSAYELVSDYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAKSGRPTVIMAHNKTLAAQLYGEMKAF
FPNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIEQMRLSATKALLERKDAIIIASVSAIYGLGDPQAYLSMMLH
LSRGDIINQRDILRRLAELQYKRNDMAFERGTFRVRGEVLDVFPAESEHEAIRIELFDDEVERISKFDPLTGSIITKDMP
RCTIYPKTHYVTPREKVLDAIEQIKVDLAERKKELLANNKLVEEQRISQRTQFDIEMMNELGFCSGIENYSRYLSGRPQG
EAPPTLFDYLPKDGLLIIDESHITVSQIGAMYKGDRSRKENLVEYGFRLPSALDNRPMRFDEFEARAPQTIYVSATPGKY
EIEKSGSDIAEQLVRPTGLLDPIIEVRPVGTQVDDLLSEIRIRTKVGERVLVTTLTKRMSEDLTEYLAEHGVKVRYLHSD
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQAIGRAARNLEGKAILYADRITG
SMEKAIGETERRREKQILHNEALGIVPTALKKNVADILELGDMTKNKRKIVAPKMKLSEVAEEGASYQSMTPQQLEKEVQ
RLEAKMYQHARDLEFEQAAKVRDEVEKLRNQFITNS
>Mature_675_residues
TSAYELVSDYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAKSGRPTVIMAHNKTLAAQLYGEMKAFF
PNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIEQMRLSATKALLERKDAIIIASVSAIYGLGDPQAYLSMMLHL
SRGDIINQRDILRRLAELQYKRNDMAFERGTFRVRGEVLDVFPAESEHEAIRIELFDDEVERISKFDPLTGSIITKDMPR
CTIYPKTHYVTPREKVLDAIEQIKVDLAERKKELLANNKLVEEQRISQRTQFDIEMMNELGFCSGIENYSRYLSGRPQGE
APPTLFDYLPKDGLLIIDESHITVSQIGAMYKGDRSRKENLVEYGFRLPSALDNRPMRFDEFEARAPQTIYVSATPGKYE
IEKSGSDIAEQLVRPTGLLDPIIEVRPVGTQVDDLLSEIRIRTKVGERVLVTTLTKRMSEDLTEYLAEHGVKVRYLHSDI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQAIGRAARNLEGKAILYADRITGS
MEKAIGETERRREKQILHNEALGIVPTALKKNVADILELGDMTKNKRKIVAPKMKLSEVAEEGASYQSMTPQQLEKEVQR
LEAKMYQHARDLEFEQAAKVRDEVEKLRNQFITNS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=677, Percent_Identity=72.6735598227474, Blast_Score=1001, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_ALISL (B6EGH8)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263269.1
- GeneID:   6988150
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1873
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76638; Mature: 76506

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAYELVSDYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAKSGRPT
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHEEECCCCCEEHHHHHHHCCCCCE
VIMAHNKTLAAQLYGEMKAFFPNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIE
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHH
QMRLSATKALLERKDAIIIASVSAIYGLGDPQAYLSMMLHLSRGDIINQRDILRRLAELQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YKRNDMAFERGTFRVRGEVLDVFPAESEHEAIRIELFDDEVERISKFDPLTGSIITKDMP
HHHCCHHHHCCCEEEECCEEEECCCCCCCCEEEEEEECHHHHHHHHCCCCCCCHHCCCCC
RCTIYPKTHYVTPREKVLDAIEQIKVDLAERKKELLANNKLVEEQRISQRTQFDIEMMNE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LGFCSGIENYSRYLSGRPQGEAPPTLFDYLPKDGLLIIDESHITVSQIGAMYKGDRSRKE
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCHHHH
NLVEYGFRLPSALDNRPMRFDEFEARAPQTIYVSATPGKYEIEKSGSDIAEQLVRPTGLL
HHHHHHCCCCHHHCCCCCCCCHHHCCCCCEEEEEECCCCEEECCCCHHHHHHHHCCCCCC
DPIIEVRPVGTQVDDLLSEIRIRTKVGERVLVTTLTKRMSEDLTEYLAEHGVKVRYLHSD
CCHHHEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQAI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNLEGKAILYADRITGSMEKAIGETERRREKQILHNEALGIVPTALKKNVADILEL
HHHHHCCCCCEEEEEHHHCCHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GDMTKNKRKIVAPKMKLSEVAEEGASYQSMTPQQLEKEVQRLEAKMYQHARDLEFEQAAK
HCCCCCCCEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VRDEVEKLRNQFITNS
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSAYELVSDYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAKSGRPT
CCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHEEECCCCCEEHHHHHHHCCCCCE
VIMAHNKTLAAQLYGEMKAFFPNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIE
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHH
QMRLSATKALLERKDAIIIASVSAIYGLGDPQAYLSMMLHLSRGDIINQRDILRRLAELQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YKRNDMAFERGTFRVRGEVLDVFPAESEHEAIRIELFDDEVERISKFDPLTGSIITKDMP
HHHCCHHHHCCCEEEECCEEEECCCCCCCCEEEEEEECHHHHHHHHCCCCCCCHHCCCCC
RCTIYPKTHYVTPREKVLDAIEQIKVDLAERKKELLANNKLVEEQRISQRTQFDIEMMNE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LGFCSGIENYSRYLSGRPQGEAPPTLFDYLPKDGLLIIDESHITVSQIGAMYKGDRSRKE
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCHHHH
NLVEYGFRLPSALDNRPMRFDEFEARAPQTIYVSATPGKYEIEKSGSDIAEQLVRPTGLL
HHHHHHCCCCHHHCCCCCCCCHHHCCCCCEEEEEECCCCEEECCCCHHHHHHHHCCCCCC
DPIIEVRPVGTQVDDLLSEIRIRTKVGERVLVTTLTKRMSEDLTEYLAEHGVKVRYLHSD
CCHHHEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQAI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNLEGKAILYADRITGSMEKAIGETERRREKQILHNEALGIVPTALKKNVADILEL
HHHHHCCCCCEEEEEHHHCCHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GDMTKNKRKIVAPKMKLSEVAEEGASYQSMTPQQLEKEVQRLEAKMYQHARDLEFEQAAK
HCCCCCCCEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VRDEVEKLRNQFITNS
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA