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The map label for this gene is tyrP [H]

Identifier: 209695252

GI number: 209695252

Start: 1891303

End: 1892475

Strand: Direct

Name: tyrP [H]

Synonym: VSAL_I1774

Alternate gene names: 209695252

Gene position: 1891303-1892475 (Clockwise)

Preceding gene: 209695250

Following gene: 209695253

Centisome position: 56.88

GC content: 38.19

Gene sequence:

>1173_bases
ATGAAGTCAAAAGTATTCGGAAGTTCACTTATAATTGCAGGAACGACCATCGGTGCAGGCATGCTAGCCTTGCCATTAGT
CTCGGCAAGTCTTGGATTCTTTACAGCAAGTGTATTAATGATAGCCATTTGGGCAGTGATGAGCTATACGAGTTTGCTGA
TGCTAGAAGTTCATCAGCACAGTGATCGTTCAGCAACATTGCATAGCTTAGCTTTGCAGTTTCTGGGAAAGAATGGACAA
CGACTGGCTACCTTTTCGATGCTTTTTCTTTTTTACGCTTTATGTGCCGCTTACATTGCCGGAGGCAGTGAGCAATTTCA
CACCAAAATTAATCAACTCTCTTTTATTTCATTATCGAAAACGAGTTCAACGATTCTATTCACCCTTATTATCGCGTTCA
TTATTTCACTAGGCACAAAAACCGTCGATTTTATTAATCGTGGGTTATTTAGCTTAAAAATCGTAATGCTAATTGCGATA
CTCTTCTTCTTAACCCCGAATATTAGTGGCGAGTACTTATTAGCATTACCGGTTGAACAAGGCGTTTTCATTACGGCTTT
ACCTGTAGTGTTTACCTCTTTTGGTTTCCACGGAAGTATTCCTTCGATAGTGAAATACTTAGAACTTGATATTAAGAAAA
TTAAAATCAGTTTATTGGTTGGATCATCAATTCCACTTGTCATTTACCTTTTTTGGCAAGGCATTACACTTGGTCTATTG
TCGCAAAGTGAATTCTCAACGATAAATAGCTTAACCGCCTTTATAACGACGATTCAAAACTCGATAGATAAAGCTTACAT
TCAACAAGCCTTGTCCTTATTTGCCGATCTCGCTTTGATCACGTCATTTATAGGAGTCAGTCTTGGATTGTTTGACTTTT
TACGTGATTCATCTAAAAAATGGCAACAATCTACCATTATTACGGCATTACTAACTTACACTCCTCCCTTGTTATTTGCT
TTGTTTTATCCACAAGGATTTATTATGGCACTAGGGTATGCCGCTATTGCACTTGTTATTTTAGCGTTATTTTTGCCTGT
TGCTTTGGTTGTTTCTGCACGAAAAGTACATACAGGCACTCATTACCAAGTAGCAAGTAAGAACTTGGGGTTAATCGTAG
CGGTCATCCTTGGAATAACAATAATTGGCTGCCAAATAGTGGTATCACTCTAA

Upstream 100 bases:

>100_bases
CACCTAGTGTATTCTTATTATTACAATAATTTGAATTAGAGATAAATAGGCAGTACATTCGCATCACTAACAAAGTATTA
CAGAAGAAAAGAGACAGTCT

Downstream 100 bases:

>100_bases
ATATAATGACTAATAATAGTTTTATTAATTGAAGTCTGAACTATCATTAAAAGTTATAAACACTCGTTTTTATGAGTGTT
TTTACTTTTATGTTTTGCAT

Product: tyrosine-specific transport protein (tyrosine permease)

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKSKVFGSSLIIAGTTIGAGMLALPLVSASLGFFTASVLMIAIWAVMSYTSLLMLEVHQHSDRSATLHSLALQFLGKNGQ
RLATFSMLFLFYALCAAYIAGGSEQFHTKINQLSFISLSKTSSTILFTLIIAFIISLGTKTVDFINRGLFSLKIVMLIAI
LFFLTPNISGEYLLALPVEQGVFITALPVVFTSFGFHGSIPSIVKYLELDIKKIKISLLVGSSIPLVIYLFWQGITLGLL
SQSEFSTINSLTAFITTIQNSIDKAYIQQALSLFADLALITSFIGVSLGLFDFLRDSSKKWQQSTIITALLTYTPPLLFA
LFYPQGFIMALGYAAIALVILALFLPVALVVSARKVHTGTHYQVASKNLGLIVAVILGITIIGCQIVVSL

Sequences:

>Translated_390_residues
MKSKVFGSSLIIAGTTIGAGMLALPLVSASLGFFTASVLMIAIWAVMSYTSLLMLEVHQHSDRSATLHSLALQFLGKNGQ
RLATFSMLFLFYALCAAYIAGGSEQFHTKINQLSFISLSKTSSTILFTLIIAFIISLGTKTVDFINRGLFSLKIVMLIAI
LFFLTPNISGEYLLALPVEQGVFITALPVVFTSFGFHGSIPSIVKYLELDIKKIKISLLVGSSIPLVIYLFWQGITLGLL
SQSEFSTINSLTAFITTIQNSIDKAYIQQALSLFADLALITSFIGVSLGLFDFLRDSSKKWQQSTIITALLTYTPPLLFA
LFYPQGFIMALGYAAIALVILALFLPVALVVSARKVHTGTHYQVASKNLGLIVAVILGITIIGCQIVVSL
>Mature_390_residues
MKSKVFGSSLIIAGTTIGAGMLALPLVSASLGFFTASVLMIAIWAVMSYTSLLMLEVHQHSDRSATLHSLALQFLGKNGQ
RLATFSMLFLFYALCAAYIAGGSEQFHTKINQLSFISLSKTSSTILFTLIIAFIISLGTKTVDFINRGLFSLKIVMLIAI
LFFLTPNISGEYLLALPVEQGVFITALPVVFTSFGFHGSIPSIVKYLELDIKKIKISLLVGSSIPLVIYLFWQGITLGLL
SQSEFSTINSLTAFITTIQNSIDKAYIQQALSLFADLALITSFIGVSLGLFDFLRDSSKKWQQSTIITALLTYTPPLLFA
LFYPQGFIMALGYAAIALVILALFLPVALVVSARKVHTGTHYQVASKNLGLIVAVILGITIIGCQIVVSL

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=398, Percent_Identity=45.2261306532663, Blast_Score=340, Evalue=9e-95,
Organism=Escherichia coli, GI1790145, Length=406, Percent_Identity=31.7733990147783, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1789552, Length=354, Percent_Identity=27.683615819209, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42236; Mature: 42236

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKVFGSSLIIAGTTIGAGMLALPLVSASLGFFTASVLMIAIWAVMSYTSLLMLEVHQH
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SDRSATLHSLALQFLGKNGQRLATFSMLFLFYALCAAYIAGGSEQFHTKINQLSFISLSK
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECC
TSSTILFTLIIAFIISLGTKTVDFINRGLFSLKIVMLIAILFFLTPNISGEYLLALPVEQ
CCHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
GVFITALPVVFTSFGFHGSIPSIVKYLELDIKKIKISLLVGSSIPLVIYLFWQGITLGLL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHC
SQSEFSTINSLTAFITTIQNSIDKAYIQQALSLFADLALITSFIGVSLGLFDFLRDSSKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
WQQSTIITALLTYTPPLLFALFYPQGFIMALGYAAIALVILALFLPVALVVSARKVHTGT
HHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HYQVASKNLGLIVAVILGITIIGCQIVVSL
CEEECCCCCHHHHHHHHHHHHHHHHHEEEC
>Mature Secondary Structure
MKSKVFGSSLIIAGTTIGAGMLALPLVSASLGFFTASVLMIAIWAVMSYTSLLMLEVHQH
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SDRSATLHSLALQFLGKNGQRLATFSMLFLFYALCAAYIAGGSEQFHTKINQLSFISLSK
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECC
TSSTILFTLIIAFIISLGTKTVDFINRGLFSLKIVMLIAILFFLTPNISGEYLLALPVEQ
CCHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
GVFITALPVVFTSFGFHGSIPSIVKYLELDIKKIKISLLVGSSIPLVIYLFWQGITLGLL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHC
SQSEFSTINSLTAFITTIQNSIDKAYIQQALSLFADLALITSFIGVSLGLFDFLRDSSKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
WQQSTIITALLTYTPPLLFALFYPQGFIMALGYAAIALVILALFLPVALVVSARKVHTGT
HHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HYQVASKNLGLIVAVILGITIIGCQIVVSL
CEEECCCCCHHHHHHHHHHHHHHHHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]