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The map label for this gene is mtaD1 [H]

Identifier: 209695037

GI number: 209695037

Start: 1632486

End: 1633874

Strand: Direct

Name: mtaD1 [H]

Synonym: VSAL_I1532

Alternate gene names: 209695037

Gene position: 1632486-1633874 (Clockwise)

Preceding gene: 209695036

Following gene: 209695038

Centisome position: 49.09

GC content: 38.08

Gene sequence:

>1389_bases
ATGAAGCTTAAAAGCTTGGTATTGAGTATTAGTGCAATATTGTTGGGCGGTTGTGGAACGACTATTGAAAAACAAGATTA
TAACGCTGATTTGATTATTAATAATGGACAAATATTAACGATTAATTCTTCAATGCAAGTTATCGATAATGGTGTTGTTG
TGGTTAAAAACAATAAGATCATTGCCGTCGGTACCGCTGAATTATTAGAACAATACCAAGCACCTAAAGTGATTGATGCA
GAAGATGGTATCGTTATGCCAGGTATGATAAATAGCCATAACCATTTACCGATGATCGCTTTTCGAGGTTTAGGAGAGGA
GGGTATTTCAAATCGCTTATTTGCGTATTTTTTCCCATTAGAATCTGAGAAATTAAGCAGAGAACTAATTTATAGCGCAA
CTAAATTAGGGGCGATTGATTTAGCTCAAAGTGGAGTAACAACTTACGCTGATATGTATTACCACATGGATGAAATGGCA
ATTAAATTTCCGGTGGTAGATGCTAAGCAACCTTATGGGGGAATAGAATACGCGGAATCATTTATTAATGAATATAAAAA
TGATCCTCTAATTACGCCGGCGTATGCGCCTCATGCTGTTTACACCGTAAGTAAAGATAAGCTTCAAGAGATTAATGGAT
TATCAGAGAAATACGATGTGCCCGTGTTAATTCACGTTGCTGAGTTTCCAAACGAAGAACAAAGAGTCAAAGACACGACA
AAAGCAACATCACCCGTTGAATATTTAGATGAAATAGGGGTACTTGATGAACGTGTTGTTATTGCTCACGGTATTCACCT
ATCTCAACGTGATCAAGCATTGTTGAAAAAATCCGACGTTGGTGTCTCTTACAATCCAATGGCGAATGCCAAAGGAGCGA
CAGGGATTGCCCCAGCCTGGGACATGTATCGAGCTGACATGAGAATCGGCTTAGGTACTGATGGACCTATGAGCTCAAAT
CAAGTCGATTTATGGCGAACATTAAGCTACGCCGCAAATATGCAGCGTTTGAAACACTCTGATAGAACAATCATGATCCC
TGAACAAGTCATTGAAATGGCAACACTTGGTGGAGCAAAAGCACTTCATATGGAAGATGAAATTGGCTCGTTAGAAGTTG
GGAAAAAAGCGGATATTGTGATTGTAGAAACACAATCAGCGAACATGATGCCAAGTTATGATCCGTATGCTACGTTGGTC
TATCAAGCAAACCCGGGTAATGTTGATACCACGATTGTTAATGGCAAGATAATTATGGAAAACAGAGAAATGTTGACTGT
GAAATTGGATGATATTCGAGACAGTGTTGAAGAGTTTGAAAATGATATTGCTGTATTTGCAAAAGAGTTATCTAAAAAAG
CAATTAAATCGAAAAGTTTAATGGATTAG

Upstream 100 bases:

>100_bases
TAGCATGTAGATTGTAATGTATATTACAAATAAAGATAAATATTTCCCCCAGATATTTATCTTTATATTCATTATGGGGA
AAAATTATTAAGGTTTAGGA

Downstream 100 bases:

>100_bases
ACAATGTAATCCTTATTTTATTATTAATATAGCCCGCAGTATTGTGGGCTTTTTTATGTCTAAAATACTTAAATTTCATA
TTGTTAAAGGTGTTTAATTT

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase 1 [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKLKSLVLSISAILLGGCGTTIEKQDYNADLIINNGQILTINSSMQVIDNGVVVVKNNKIIAVGTAELLEQYQAPKVIDA
EDGIVMPGMINSHNHLPMIAFRGLGEEGISNRLFAYFFPLESEKLSRELIYSATKLGAIDLAQSGVTTYADMYYHMDEMA
IKFPVVDAKQPYGGIEYAESFINEYKNDPLITPAYAPHAVYTVSKDKLQEINGLSEKYDVPVLIHVAEFPNEEQRVKDTT
KATSPVEYLDEIGVLDERVVIAHGIHLSQRDQALLKKSDVGVSYNPMANAKGATGIAPAWDMYRADMRIGLGTDGPMSSN
QVDLWRTLSYAANMQRLKHSDRTIMIPEQVIEMATLGGAKALHMEDEIGSLEVGKKADIVIVETQSANMMPSYDPYATLV
YQANPGNVDTTIVNGKIIMENREMLTVKLDDIRDSVEEFENDIAVFAKELSKKAIKSKSLMD

Sequences:

>Translated_462_residues
MKLKSLVLSISAILLGGCGTTIEKQDYNADLIINNGQILTINSSMQVIDNGVVVVKNNKIIAVGTAELLEQYQAPKVIDA
EDGIVMPGMINSHNHLPMIAFRGLGEEGISNRLFAYFFPLESEKLSRELIYSATKLGAIDLAQSGVTTYADMYYHMDEMA
IKFPVVDAKQPYGGIEYAESFINEYKNDPLITPAYAPHAVYTVSKDKLQEINGLSEKYDVPVLIHVAEFPNEEQRVKDTT
KATSPVEYLDEIGVLDERVVIAHGIHLSQRDQALLKKSDVGVSYNPMANAKGATGIAPAWDMYRADMRIGLGTDGPMSSN
QVDLWRTLSYAANMQRLKHSDRTIMIPEQVIEMATLGGAKALHMEDEIGSLEVGKKADIVIVETQSANMMPSYDPYATLV
YQANPGNVDTTIVNGKIIMENREMLTVKLDDIRDSVEEFENDIAVFAKELSKKAIKSKSLMD
>Mature_462_residues
MKLKSLVLSISAILLGGCGTTIEKQDYNADLIINNGQILTINSSMQVIDNGVVVVKNNKIIAVGTAELLEQYQAPKVIDA
EDGIVMPGMINSHNHLPMIAFRGLGEEGISNRLFAYFFPLESEKLSRELIYSATKLGAIDLAQSGVTTYADMYYHMDEMA
IKFPVVDAKQPYGGIEYAESFINEYKNDPLITPAYAPHAVYTVSKDKLQEINGLSEKYDVPVLIHVAEFPNEEQRVKDTT
KATSPVEYLDEIGVLDERVVIAHGIHLSQRDQALLKKSDVGVSYNPMANAKGATGIAPAWDMYRADMRIGLGTDGPMSSN
QVDLWRTLSYAANMQRLKHSDRTIMIPEQVIEMATLGGAKALHMEDEIGSLEVGKKADIVIVETQSANMMPSYDPYATLV
YQANPGNVDTTIVNGKIIMENREMLTVKLDDIRDSVEEFENDIAVFAKELSKKAIKSKSLMD

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=335, Percent_Identity=22.3880597014925, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1789249, Length=407, Percent_Identity=25.0614250614251, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319963, Length=340, Percent_Identity=24.4117647058824, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24643849, Length=342, Percent_Identity=26.3157894736842, Blast_Score=105, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 51010; Mature: 51010

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKSLVLSISAILLGGCGTTIEKQDYNADLIINNGQILTINSSMQVIDNGVVVVKNNKI
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCEEEEECCCCEEECCCEEEEECCEE
IAVGTAELLEQYQAPKVIDAEDGIVMPGMINSHNHLPMIAFRGLGEEGISNRLFAYFFPL
EEEEHHHHHHHHCCCCEEECCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECC
ESEKLSRELIYSATKLGAIDLAQSGVTTYADMYYHMDEMAIKFPVVDAKQPYGGIEYAES
CHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHH
FINEYKNDPLITPAYAPHAVYTVSKDKLQEINGLSEKYDVPVLIHVAEFPNEEQRVKDTT
HHHHHCCCCEECCCCCCCEEEEECHHHHHHHCCCHHHCCCCEEEEEECCCCHHHHHHHHH
KATSPVEYLDEIGVLDERVVIAHGIHLSQRDQALLKKSDVGVSYNPMANAKGATGIAPAW
CCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEECCCCCCCCCCCCCCCH
DMYRADMRIGLGTDGPMSSNQVDLWRTLSYAANMQRLKHSDRTIMIPEQVIEMATLGGAK
HHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCE
ALHMEDEIGSLEVGKKADIVIVETQSANMMPSYDPYATLVYQANPGNVDTTIVNGKIIME
EEEECCCCCCEECCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEECEEEEE
NREMLTVKLDDIRDSVEEFENDIAVFAKELSKKAIKSKSLMD
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLKSLVLSISAILLGGCGTTIEKQDYNADLIINNGQILTINSSMQVIDNGVVVVKNNKI
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCEEEEECCCCEEECCCEEEEECCEE
IAVGTAELLEQYQAPKVIDAEDGIVMPGMINSHNHLPMIAFRGLGEEGISNRLFAYFFPL
EEEEHHHHHHHHCCCCEEECCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECC
ESEKLSRELIYSATKLGAIDLAQSGVTTYADMYYHMDEMAIKFPVVDAKQPYGGIEYAES
CHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHH
FINEYKNDPLITPAYAPHAVYTVSKDKLQEINGLSEKYDVPVLIHVAEFPNEEQRVKDTT
HHHHHCCCCEECCCCCCCEEEEECHHHHHHHCCCHHHCCCCEEEEEECCCCHHHHHHHHH
KATSPVEYLDEIGVLDERVVIAHGIHLSQRDQALLKKSDVGVSYNPMANAKGATGIAPAW
CCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEECCCCCCCCCCCCCCCH
DMYRADMRIGLGTDGPMSSNQVDLWRTLSYAANMQRLKHSDRTIMIPEQVIEMATLGGAK
HHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCE
ALHMEDEIGSLEVGKKADIVIVETQSANMMPSYDPYATLVYQANPGNVDTTIVNGKIIME
EEEECCCCCCEECCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEECEEEEE
NREMLTVKLDDIRDSVEEFENDIAVFAKELSKKAIKSKSLMD
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA