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The map label for this gene is mtaD [H]

Identifier: 209694857

GI number: 209694857

Start: 1437217

End: 1438626

Strand: Direct

Name: mtaD [H]

Synonym: VSAL_I1326

Alternate gene names: 209694857

Gene position: 1437217-1438626 (Clockwise)

Preceding gene: 209694854

Following gene: 209694858

Centisome position: 43.22

GC content: 39.5

Gene sequence:

>1410_bases
ATGTATTTAAGAAAATCACTGCTTGCTGTCGCTATTGCCGCAGGCTCATTATTTTCGTTTTCGGCAAGTTCAGCGCAACA
AGTTGACTTGATGATTACTGATGCAACGTTACTAACAATGAACGATTCGAAAGAGACATTTGAGAATGGTGTTGTCGTTA
TTTCTGGTAATAAAATTATTGCTGTGGGCGACAAAAGCATAGCCTCTAAATATGCCGCAAAAACGGTATTAGACGTCGAT
GGTGATATTGTTTTACCGGGTTTAATTAACACACATACACACGCTTCTATGACCGTTTTTCGTTCATTAGGTGATGACGT
TCTAGATCGTTTACACCGTTATGTCTTCCCTTTAGAGAAAAAGTTAGTGTCACGCGATATGGTTCGTATTGGTGCTAATT
TAGGAAATGTAGAAATGGTAAAAGGGGGCGTTACCACTTATGCTGATATGTACTACTTTGAAGATGAAGTCGCGAAAACG
GTTGATAAAATTGGCATGCGTGCAATTCTAGGTGAAAGTGTCATTAAATTTCCAGTAGCAGATGCTGCTAATGCAGAAGA
AGGGATTCAATACGCAGTAAACTTTATTGAAGAATATAAAGATCACCCACGCATTACGCCAGCTTTTGCTCCACATGCGC
CATACACCAATACAACCGAAGTACTGCAAAAGATTGCTAAATTATCGTTAGAGTTGGATGTTCCGGTAATGATCCACCTA
GCTGAATCTCATCGTGAAGAAGAAGTGATTGCAGAACGTGCGAACGGCATGTCTCCAGTAGAATATATGCATAGTATTGG
TGCGCTTAATAAAAACCTTATTGGTGCACACATGATTTTGATTGATGATAAAGACATTGAACTAGTAAAAGAATCAGACA
TGGGTGTTGCTCATAATATGAGTGCAAACATCAAATCAGCAAAAGGGGTATCTCCTGCGCTTAAAATGTATGACGAAGGT
GTTCGTATTGGTTTAGGAACGGATGGGCCAATGTCAGGCAATACGCTAAGTATTATTGATGAGTTCAACCAAGTCGCTAA
AGTACACAAATTAGTGAATAAAGATCGAGCCGCCATGCCTCCAATCAAAGTGATTGATATGGCGACAATGGGCGCTGCGA
AAGCGCTTCATATGGAAGATAAAATTGGTTCTATCGAAGTAGGAAAATTAGCGGATATCATTGTTGTTGATACCAAAGCA
CCGAACATGTTGCCAGTATATAACCCATATTCTGCATTGGTTTACTCTGCAAATTCAAGCAATGTTCGTCATACGATTGT
TGATGGCAAAATATTGATGAAAGATCGTGAAATGCTGACGGTTGATGAAGAGCAGATCAGGCAGGAAGTGCTCGAGTTTA
CCAAGATTGTACGTAAAACGGTTATTGAAAGTGGTGAAATTGTTCAATAA

Upstream 100 bases:

>100_bases
AAATGTGAAGGGTGCCATATATATTATTGACAATATACTTGATATAAAAATAATAGCGTATACCATTCACGCCAATATTT
TACTATTGATGAGTTTATTC

Downstream 100 bases:

>100_bases
TATTTGACCTATAACCGAATTTAAATAGAGAGTTAGCTTAGGCGGCTCTCTTTTTTATACTCGCTAATTTAAATAAAAAC
GGTGCACTTTGTTCTTATTT

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MYLRKSLLAVAIAAGSLFSFSASSAQQVDLMITDATLLTMNDSKETFENGVVVISGNKIIAVGDKSIASKYAAKTVLDVD
GDIVLPGLINTHTHASMTVFRSLGDDVLDRLHRYVFPLEKKLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKT
VDKIGMRAILGESVIKFPVADAANAEEGIQYAVNFIEEYKDHPRITPAFAPHAPYTNTTEVLQKIAKLSLELDVPVMIHL
AESHREEEVIAERANGMSPVEYMHSIGALNKNLIGAHMILIDDKDIELVKESDMGVAHNMSANIKSAKGVSPALKMYDEG
VRIGLGTDGPMSGNTLSIIDEFNQVAKVHKLVNKDRAAMPPIKVIDMATMGAAKALHMEDKIGSIEVGKLADIIVVDTKA
PNMLPVYNPYSALVYSANSSNVRHTIVDGKILMKDREMLTVDEEQIRQEVLEFTKIVRKTVIESGEIVQ

Sequences:

>Translated_469_residues
MYLRKSLLAVAIAAGSLFSFSASSAQQVDLMITDATLLTMNDSKETFENGVVVISGNKIIAVGDKSIASKYAAKTVLDVD
GDIVLPGLINTHTHASMTVFRSLGDDVLDRLHRYVFPLEKKLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKT
VDKIGMRAILGESVIKFPVADAANAEEGIQYAVNFIEEYKDHPRITPAFAPHAPYTNTTEVLQKIAKLSLELDVPVMIHL
AESHREEEVIAERANGMSPVEYMHSIGALNKNLIGAHMILIDDKDIELVKESDMGVAHNMSANIKSAKGVSPALKMYDEG
VRIGLGTDGPMSGNTLSIIDEFNQVAKVHKLVNKDRAAMPPIKVIDMATMGAAKALHMEDKIGSIEVGKLADIIVVDTKA
PNMLPVYNPYSALVYSANSSNVRHTIVDGKILMKDREMLTVDEEQIRQEVLEFTKIVRKTVIESGEIVQ
>Mature_469_residues
MYLRKSLLAVAIAAGSLFSFSASSAQQVDLMITDATLLTMNDSKETFENGVVVISGNKIIAVGDKSIASKYAAKTVLDVD
GDIVLPGLINTHTHASMTVFRSLGDDVLDRLHRYVFPLEKKLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKT
VDKIGMRAILGESVIKFPVADAANAEEGIQYAVNFIEEYKDHPRITPAFAPHAPYTNTTEVLQKIAKLSLELDVPVMIHL
AESHREEEVIAERANGMSPVEYMHSIGALNKNLIGAHMILIDDKDIELVKESDMGVAHNMSANIKSAKGVSPALKMYDEG
VRIGLGTDGPMSGNTLSIIDEFNQVAKVHKLVNKDRAAMPPIKVIDMATMGAAKALHMEDKIGSIEVGKLADIIVVDTKA
PNMLPVYNPYSALVYSANSSNVRHTIVDGKILMKDREMLTVDEEQIRQEVLEFTKIVRKTVIESGEIVQ

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=342, Percent_Identity=25.1461988304094, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1789249, Length=408, Percent_Identity=24.0196078431373, Blast_Score=111, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6319963, Length=353, Percent_Identity=25.4957507082153, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24643849, Length=430, Percent_Identity=26.046511627907, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 51291; Mature: 51291

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLRKSLLAVAIAAGSLFSFSASSAQQVDLMITDATLLTMNDSKETFENGVVVISGNKII
CCHHHHHHHHHHHHCCCEECCCCCCCEEEEEEECEEEEEECCCHHHHHCCEEEEECCEEE
AVGDKSIASKYAAKTVLDVDGDIVLPGLINTHTHASMTVFRSLGDDVLDRLHRYVFPLEK
EECCHHHHHHHHHHHEEECCCCEEECCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHH
KLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKTVDKIGMRAILGESVIKFPVA
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCC
DAANAEEGIQYAVNFIEEYKDHPRITPAFAPHAPYTNTTEVLQKIAKLSLELDVPVMIHL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEECCCCEEEEE
AESHREEEVIAERANGMSPVEYMHSIGALNKNLIGAHMILIDDKDIELVKESDMGVAHNM
HHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEECCCCCEEECC
SANIKSAKGVSPALKMYDEGVRIGLGTDGPMSGNTLSIIDEFNQVAKVHKLVNKDRAAMP
CCCCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PIKVIDMATMGAAKALHMEDKIGSIEVGKLADIIVVDTKAPNMLPVYNPYSALVYSANSS
CCCEEEHHHHCHHHHEEHHCCCCCEEECCCEEEEEEECCCCCCCCCCCCCEEEEEECCCC
NVRHTIVDGKILMKDREMLTVDEEQIRQEVLEFTKIVRKTVIESGEIVQ
CCEEEEECCEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYLRKSLLAVAIAAGSLFSFSASSAQQVDLMITDATLLTMNDSKETFENGVVVISGNKII
CCHHHHHHHHHHHHCCCEECCCCCCCEEEEEEECEEEEEECCCHHHHHCCEEEEECCEEE
AVGDKSIASKYAAKTVLDVDGDIVLPGLINTHTHASMTVFRSLGDDVLDRLHRYVFPLEK
EECCHHHHHHHHHHHEEECCCCEEECCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHH
KLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKTVDKIGMRAILGESVIKFPVA
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCC
DAANAEEGIQYAVNFIEEYKDHPRITPAFAPHAPYTNTTEVLQKIAKLSLELDVPVMIHL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEECCCCEEEEE
AESHREEEVIAERANGMSPVEYMHSIGALNKNLIGAHMILIDDKDIELVKESDMGVAHNM
HHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEECCCCCEEECC
SANIKSAKGVSPALKMYDEGVRIGLGTDGPMSGNTLSIIDEFNQVAKVHKLVNKDRAAMP
CCCCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PIKVIDMATMGAAKALHMEDKIGSIEVGKLADIIVVDTKAPNMLPVYNPYSALVYSANSS
CCCEEEHHHHCHHHHEEHHCCCCCEEECCCEEEEEEECCCCCCCCCCCCCEEEEEECCCC
NVRHTIVDGKILMKDREMLTVDEEQIRQEVLEFTKIVRKTVIESGEIVQ
CCEEEEECCEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA