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The map label for this gene is cysG [H]

Identifier: 209694377

GI number: 209694377

Start: 880601

End: 881428

Strand: Reverse

Name: cysG [H]

Synonym: VSAL_I0795

Alternate gene names: 209694377

Gene position: 881428-880601 (Counterclockwise)

Preceding gene: 209694378

Following gene: 209694370

Centisome position: 26.51

GC content: 40.82

Gene sequence:

>828_bases
ATGGAGTCAGCATCAATATTCATCATATTATTCTGGAACCCTATTATGCCAAGTATTCAAGCTCAGTCTGAGCAAAAAAA
ACAAAACGGATTTGTTTCTCTTGTTGGTCCAGGTCCTGGTGATGCCGATCTCTTAACCGTAAAAGGTTACCGCTTAATAC
AACAAGCCGATGTGGTTGTGTATGATCGCCTTGTCTCTAAAGAAATCTTAGCGCTCGCAAATGATACTGCTGAAATGATT
TATGTCGGTAAGAAACTCGATTTTCATTTCGTCCCTCAAGACAAAATTAATCAAATATTGGTTGATAAAGCCCAAGAAGG
TAAACACGTTGTTCGCCTTAAGGGGGGAGATTCTTTTATCTTTGGCCGTGGTGGTGAAGAATTAGAAACGCTTGCAGAAA
ATGGGGTTCGATTTGAAGTCGTTCCTGGTATTACAGCCGCAGCAGGCGCGACCTCTTATGCAGGGATCCCACTAACACAT
CGAGATCATGCTCAAAGCGTGCAATTTATTACGGCTCATGTCCAAAAAGATGGGGCTGAAATTGAATGGGATGCATTGGT
TCGTTCAAACAACACTCTGGTATTTTATATGGGACTAAAACAATCGTCTCATATTTCAACTCAACTGATCGAGCACGGTT
TAGCTGCGGATACCCCTTGCGCTATTATTGAACGTGGTACGACTCAAAAACAAAAAGTCTTTACCGGTACTATTTCAGAA
TTAGCTCAAATGGCAAAAAATGCGATTAGTCCTTCTTTAATTGTCGTCGGTAGCGTAACTACATTGCATCATAAGTTAGA
TTGGTTTACTCCAACAAATGCTGAGTAA

Upstream 100 bases:

>100_bases
AATAACAGTAAAATAAGTCATCACATTTGTTATAACTCATTCAAATAAAATCACTCTTGATCAGGTATTAAGGGTGATTT
TTTTTATCGACTCTTACATA

Downstream 100 bases:

>100_bases
TGAATAAATAAGTAAGCACGCCCTATTCTAAATACAAAAAAGCCCAAGAAAATCTCTTAGGCTTTTTTATTTATAGACTC
GCAACAATATTATTTAATAT

Product: siroheme synthase (Includes: Uroporphyrin-III C-methyltransferase, Precorrin-2 dehydrogenase,Sirohydrochlorin ferrochelatase)

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MESASIFIILFWNPIMPSIQAQSEQKKQNGFVSLVGPGPGDADLLTVKGYRLIQQADVVVYDRLVSKEILALANDTAEMI
YVGKKLDFHFVPQDKINQILVDKAQEGKHVVRLKGGDSFIFGRGGEELETLAENGVRFEVVPGITAAAGATSYAGIPLTH
RDHAQSVQFITAHVQKDGAEIEWDALVRSNNTLVFYMGLKQSSHISTQLIEHGLAADTPCAIIERGTTQKQKVFTGTISE
LAQMAKNAISPSLIVVGSVTTLHHKLDWFTPTNAE

Sequences:

>Translated_275_residues
MESASIFIILFWNPIMPSIQAQSEQKKQNGFVSLVGPGPGDADLLTVKGYRLIQQADVVVYDRLVSKEILALANDTAEMI
YVGKKLDFHFVPQDKINQILVDKAQEGKHVVRLKGGDSFIFGRGGEELETLAENGVRFEVVPGITAAAGATSYAGIPLTH
RDHAQSVQFITAHVQKDGAEIEWDALVRSNNTLVFYMGLKQSSHISTQLIEHGLAADTPCAIIERGTTQKQKVFTGTISE
LAQMAKNAISPSLIVVGSVTTLHHKLDWFTPTNAE
>Mature_275_residues
MESASIFIILFWNPIMPSIQAQSEQKKQNGFVSLVGPGPGDADLLTVKGYRLIQQADVVVYDRLVSKEILALANDTAEMI
YVGKKLDFHFVPQDKINQILVDKAQEGKHVVRLKGGDSFIFGRGGEELETLAENGVRFEVVPGITAAAGATSYAGIPLTH
RDHAQSVQFITAHVQKDGAEIEWDALVRSNNTLVFYMGLKQSSHISTQLIEHGLAADTPCAIIERGTTQKQKVFTGTISE
LAQMAKNAISPSLIVVGSVTTLHHKLDWFTPTNAE

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=251, Percent_Identity=56.5737051792829, Blast_Score=295, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6322922, Length=242, Percent_Identity=35.9504132231405, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 30011; Mature: 30011

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESASIFIILFWNPIMPSIQAQSEQKKQNGFVSLVGPGPGDADLLTVKGYRLIQQADVVV
CCCCEEEEEEEECCCCCCCHHHHHHHHHCCEEEEECCCCCCCCEEEECCEEEEHHCCHHH
YDRLVSKEILALANDTAEMIYVGKKLDFHFVPQDKINQILVDKAQEGKHVVRLKGGDSFI
HHHHHHHHHHHHCCCCEEEEEEECCCEEEECCHHHHHHHHHCCCCCCCEEEEEECCCEEE
FGRGGEELETLAENGVRFEVVPGITAAAGATSYAGIPLTHRDHAQSVQFITAHVQKDGAE
ECCCCHHHHHHHHCCCEEEEECCCCHHCCCCCCCCCCCCCCCHHHHHHEEEEEECCCCCC
IEWDALVRSNNTLVFYMGLKQSSHISTQLIEHGLAADTPCAIIERGTTQKQKVFTGTISE
EEEEEEEECCCEEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCCCCHHHEEHHHHHH
LAQMAKNAISPSLIVVGSVTTLHHKLDWFTPTNAE
HHHHHHHCCCCCEEEEECCHHHHHEECCCCCCCCC
>Mature Secondary Structure
MESASIFIILFWNPIMPSIQAQSEQKKQNGFVSLVGPGPGDADLLTVKGYRLIQQADVVV
CCCCEEEEEEEECCCCCCCHHHHHHHHHCCEEEEECCCCCCCCEEEECCEEEEHHCCHHH
YDRLVSKEILALANDTAEMIYVGKKLDFHFVPQDKINQILVDKAQEGKHVVRLKGGDSFI
HHHHHHHHHHHHCCCCEEEEEEECCCEEEECCHHHHHHHHHCCCCCCCEEEEEECCCEEE
FGRGGEELETLAENGVRFEVVPGITAAAGATSYAGIPLTHRDHAQSVQFITAHVQKDGAE
ECCCCHHHHHHHHCCCEEEEECCCCHHCCCCCCCCCCCCCCCHHHHHHEEEEEECCCCCC
IEWDALVRSNNTLVFYMGLKQSSHISTQLIEHGLAADTPCAIIERGTTQKQKVFTGTISE
EEEEEEEECCCEEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCCCCHHHEEHHHHHH
LAQMAKNAISPSLIVVGSVTTLHHKLDWFTPTNAE
HHHHHHHCCCCCEEEEECCHHHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA