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The map label for this gene is guaB [H]

Identifier: 209694326

GI number: 209694326

Start: 821451

End: 822914

Strand: Direct

Name: guaB [H]

Synonym: VSAL_I0737a

Alternate gene names: 209694326

Gene position: 821451-822914 (Clockwise)

Preceding gene: 209694324

Following gene: 209694327

Centisome position: 24.7

GC content: 45.15

Gene sequence:

>1464_bases
ATGCTACGAATCGCAAAAGAAGCTTTAACCTTCGATGACGTTTTACTCGTCCCAGCACACTCTACTGTTCTTCCTAACAC
CGCTGATATTCGCACTCAGTTAACGAAGAGCATCTCTCTAAATATCCCAATGATTTCAGCATCAATGGATACCGTGACAG
AAGCGCGTCTTGCTATTGCGTTAGCGCAAGAGGGTGGCATCGGTTTTATCCACAAAAACATGTCAATTGAACAGCAAGCT
GAAGAAGTTCGCTTAGTAAAAATCTTTGAAGCAGGCGTTGTCTCTGCTCCAGTAACCGTTCGTCCTGACGCAACTATTCA
AGATGTGAAAGATCTGACTGAAAAACACGGTTTTGCTGGCTTCCCTGTAGTAACTGAAACTAACGAACTAGTTGGTATCA
TTACTGGTCGTGATGTTCGTTTCGTAACAGACTTATCTAAGAAAGTTGACGTTGTAATGACGCCAAAATCACGCTTAGCT
TCTGTTAAAGAAGGAGCAACTCGTGAAGAAGTTCAAGAGAAAATGCATGAAGCTCGCGTTGAGAAAGTATTGGTAGTGAA
CGATGAGTTCCAACTAACTGGTATGATCACAGCAAAAGATTTCCATAAAGCAGAACGTAAACCGAATGCATGTAAAGACG
AACGTGGTCGTCTACGTGTTGGTGCTGCTGTTGGTGCGGGTGCTGGTAACGAAGAGCGTGTTGCTGCTCTTGTTGAAGCG
GGTGTTGACGTTCTACTTATCGATTCATCACACGGTCACTCAGAAGGCGTTTTACAACGTATTCGTGAAACTCGTGCTGC
TTTCCCTGATCTACAAATCATTGGTGGTAACGTTGCGACTGGTTTAGGCGCTCAAGCATTAATCGATGCTGGCGTAAGTG
CGGTTAAAGTCGGTATTGGCCCGGGTTCAATTTGTACTACTCGCATTGTAACTGGTGTTGGTGTTCCTCAAATTACGGCA
ATTTCAGACGCAGCTGAAGTGGCAAATGCTCACGGCATTCCTGTTATTGCAGATGGCGGTATTCGTTACTCTGGTGATAT
TTGTAAAGCAATCGCAGCTGGCGCATCATGCGTTATGGTTGGCTCAATGTTTGCTGGTACAGAGGAAGCTCCGGGTGAAG
TCATTCTTTTCCAAGGTCGTTCATACAAATCTTACCGTGGAATGGGCTCTCTGGGTGCAATGTCTCAAGGCTCTTCAGAC
CGTTACTTCCAATCCGATAATGCAGCGGACAAACTTGTCCCTGAAGGTATTGAAGGCCGCATCGCGTATCGCGGTCGTCT
AAAAGAGATCGTTCACCAACAAATGGGTGGTTTACGCTCAAGCATGGGCCTAACGGGTTCTGCAACGATTGAAGACATGC
GTACTAAAGCAGAATTTGTAATAATCTCAGGTGCGGGTATGAAAGAATCACACGTACATGATGTTCAGATCACAAAAGAA
GCACCAAACTACCGTTTAGGTTAG

Upstream 100 bases:

>100_bases
GTATAATCCGTCTGCAATATCAAATCCAAAACACTTTATTATGCGAAACGATAAAGTGGGATTTATTTCTTTTAACACCT
TATGTTGTGAGATATTGCAA

Downstream 100 bases:

>100_bases
AAAAAGCGCCTAGGTTAATTTTTCTTAGTTTTTGTAGAATCTTACGGTTTCGTTGTTAAAGGTACTCGTTTGCACATTGT
AAATGTTGTACCTTCTCTTC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTADIRTQLTKSISLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQQA
EEVRLVKIFEAGVVSAPVTVRPDATIQDVKDLTEKHGFAGFPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKSRLA
SVKEGATREEVQEKMHEARVEKVLVVNDEFQLTGMITAKDFHKAERKPNACKDERGRLRVGAAVGAGAGNEERVAALVEA
GVDVLLIDSSHGHSEGVLQRIRETRAAFPDLQIIGGNVATGLGAQALIDAGVSAVKVGIGPGSICTTRIVTGVGVPQITA
ISDAAEVANAHGIPVIADGGIRYSGDICKAIAAGASCVMVGSMFAGTEEAPGEVILFQGRSYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRIAYRGRLKEIVHQQMGGLRSSMGLTGSATIEDMRTKAEFVIISGAGMKESHVHDVQITKE
APNYRLG

Sequences:

>Translated_487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTADIRTQLTKSISLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQQA
EEVRLVKIFEAGVVSAPVTVRPDATIQDVKDLTEKHGFAGFPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKSRLA
SVKEGATREEVQEKMHEARVEKVLVVNDEFQLTGMITAKDFHKAERKPNACKDERGRLRVGAAVGAGAGNEERVAALVEA
GVDVLLIDSSHGHSEGVLQRIRETRAAFPDLQIIGGNVATGLGAQALIDAGVSAVKVGIGPGSICTTRIVTGVGVPQITA
ISDAAEVANAHGIPVIADGGIRYSGDICKAIAAGASCVMVGSMFAGTEEAPGEVILFQGRSYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRIAYRGRLKEIVHQQMGGLRSSMGLTGSATIEDMRTKAEFVIISGAGMKESHVHDVQITKE
APNYRLG
>Mature_487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTADIRTQLTKSISLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQQA
EEVRLVKIFEAGVVSAPVTVRPDATIQDVKDLTEKHGFAGFPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKSRLA
SVKEGATREEVQEKMHEARVEKVLVVNDEFQLTGMITAKDFHKAERKPNACKDERGRLRVGAAVGAGAGNEERVAALVEA
GVDVLLIDSSHGHSEGVLQRIRETRAAFPDLQIIGGNVATGLGAQALIDAGVSAVKVGIGPGSICTTRIVTGVGVPQITA
ISDAAEVANAHGIPVIADGGIRYSGDICKAIAAGASCVMVGSMFAGTEEAPGEVILFQGRSYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRIAYRGRLKEIVHQQMGGLRSSMGLTGSATIEDMRTKAEFVIISGAGMKESHVHDVQITKE
APNYRLG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=463, Percent_Identity=41.2526997840173, Blast_Score=335, Evalue=6e-92,
Organism=Homo sapiens, GI34328928, Length=463, Percent_Identity=41.2526997840173, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI34328930, Length=463, Percent_Identity=41.2526997840173, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI156616279, Length=463, Percent_Identity=41.2526997840173, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI66933016, Length=457, Percent_Identity=40.7002188183807, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI217035152, Length=452, Percent_Identity=41.5929203539823, Blast_Score=328, Evalue=9e-90,
Organism=Homo sapiens, GI217035148, Length=463, Percent_Identity=40.3887688984881, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI217035150, Length=463, Percent_Identity=37.7969762419007, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI156104880, Length=249, Percent_Identity=35.7429718875502, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=34.0080971659919, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=34.0080971659919, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=34.0080971659919, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=34.0080971659919, Blast_Score=152, Evalue=9e-37,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=81.9301848049281, Blast_Score=756, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=219, Percent_Identity=35.1598173515982, Blast_Score=142, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=481, Percent_Identity=37.8378378378378, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=40.2843601895735, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=35.2941176470588, Blast_Score=151, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=38.5093167701863, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=37.888198757764, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=38.7163561076605, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=39.9408284023669, Blast_Score=252, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=101, Percent_Identity=39.6039603960396, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641071, Length=460, Percent_Identity=40.2173913043478, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24641073, Length=460, Percent_Identity=40.2173913043478, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI28571163, Length=418, Percent_Identity=40.9090909090909, Blast_Score=283, Evalue=2e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51624; Mature: 51624

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAKEALTFDDVLLVPAHSTVLPNTADIRTQLTKSISLNIPMISASMDTVTEARLAIA
CCEEHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHEEECCEEEECCHHHHHHHHEEEE
LAQEGGIGFIHKNMSIEQQAEEVRLVKIFEAGVVSAPVTVRPDATIQDVKDLTEKHGFAG
EECCCCEEEEECCCCHHHHHHHHEEEEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCCC
FPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKSRLASVKEGATREEVQEKMHEARV
CCEEECCCCEEEEEECCCEEEEEHHCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHH
EKVLVVNDEFQLTGMITAKDFHKAERKPNACKDERGRLRVGAAVGAGAGNEERVAALVEA
CEEEEECCCEEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAAFPDLQIIGGNVATGLGAQALIDAGVSAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHCCCEEEEEECC
PGSICTTRIVTGVGVPQITAISDAAEVANAHGIPVIADGGIRYSGDICKAIAAGASCVMV
CCCHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCEEECCCEEECCHHHHHHHCCCCEEEE
GSMFAGTEEAPGEVILFQGRSYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCE
IAYRGRLKEIVHQQMGGLRSSMGLTGSATIEDMRTKAEFVIISGAGMKESHVHDVQITKE
EEEHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHCCCCCEEEEECCCCCCCCCEEEEEECC
APNYRLG
CCCCCCC
>Mature Secondary Structure
MLRIAKEALTFDDVLLVPAHSTVLPNTADIRTQLTKSISLNIPMISASMDTVTEARLAIA
CCEEHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHEEECCEEEECCHHHHHHHHEEEE
LAQEGGIGFIHKNMSIEQQAEEVRLVKIFEAGVVSAPVTVRPDATIQDVKDLTEKHGFAG
EECCCCEEEEECCCCHHHHHHHHEEEEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCCC
FPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKSRLASVKEGATREEVQEKMHEARV
CCEEECCCCEEEEEECCCEEEEEHHCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHH
EKVLVVNDEFQLTGMITAKDFHKAERKPNACKDERGRLRVGAAVGAGAGNEERVAALVEA
CEEEEECCCEEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAAFPDLQIIGGNVATGLGAQALIDAGVSAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHCCCEEEEEECC
PGSICTTRIVTGVGVPQITAISDAAEVANAHGIPVIADGGIRYSGDICKAIAAGASCVMV
CCCHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCEEECCCEEECCHHHHHHHCCCCEEEE
GSMFAGTEEAPGEVILFQGRSYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCE
IAYRGRLKEIVHQQMGGLRSSMGLTGSATIEDMRTKAEFVIISGAGMKESHVHDVQITKE
EEEHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHCCCCCEEEEECCCCCCCCCEEEEEECC
APNYRLG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]