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The map label for this gene is argH [H]

Identifier: 209694273

GI number: 209694273

Start: 768445

End: 769827

Strand: Reverse

Name: argH [H]

Synonym: VSAL_I0684

Alternate gene names: 209694273

Gene position: 769827-768445 (Counterclockwise)

Preceding gene: 209694274

Following gene: 209694272

Centisome position: 23.15

GC content: 38.76

Gene sequence:

>1383_bases
ATGTCTTCTAAATTATGGGGTGGTAGATTTGATCTACCAACAAATAAACTTGTTGAAGAATTCAACGCAACAATTTTAAT
TGAAAAACGTCTATTCCCAGTAGATATTAAAGGAAGTATTGCTCATGCTACTATGCTGGAGAAACAAAAAATAATCACTC
AAATAGAAGCTGAACAGATTATTTCTGGCCTACAAGCTGTAGCAAAAGAAATAGAAGAAGGTTCATTTGTTTATGATACA
GCGGATGAAGATGTTCACATGTCTATCGAGAAACGCATGACAGAGATTATAGGCTCTGTCGGCGGGAAACTACATACAGC
CCGTAGCCGTAATGACCAAACTACACTCGATTCAAAAATACACATGCGAGCAACGATTAAAGAGAACCTCGCACTTATTC
GTCAAATGCAAGAAATAATAATCCAGCGTGCTAAAGGCGAAATTAACGTAATTATGCCTGGTTATACACACCTTCAAACG
GGCCAACCAATTCTATTTTCACATTGGATCATGGCTTATTTTTGGATGTTAGAACGTGATTATTCTCGTTTCCAAGATCT
GTACAGACGTATGGGACAATGCCCACTAGGAGCCGCCGCATTAGCTGGTACAACTTTCCCAATAGATCGCTTCTATACTG
CAGAACTATTAGGTTTTGATGAACCTACACCAAATAGCATTGACTCAGTGAGTGATCGCGATCATATGGTCGAATTCAAC
TCTACAGCAGCAATTTGCTTTATGCACCTAAGTCGCCTCTCTGAAGAAATAGTATTATTTTCTAGTCAGGACTTTAAGTT
TATTGAACTATCAGACGATTTCTGTACTGGTTCAAGTATTATGCCACAAAAGAAAAATCCTGATATCGCAGAAAAAATTC
GTGGTAAAACCGGTCGTATGTACGGCAACCTAATGGCCATATTAACAACAATGAAAGGTCTACCACTGGCTTATAATACA
GACATGAGTGAAGATAAAGAAGCCGTATACGATTCAATGGATACGCTACAATTGTCACTTCAAGTAATGACGCCAATGAT
TGAAAAAATGATAATTATTGAAGCTAACACTCGCAATGCAGCAGACCGTGGTTTCTCAACCGCAACTGACATGGCTGATT
ACTTAGTACGTAAAGGATTACCTTTCCGAGAAGCTCACCATATTGTCGGTTCTACGGTTAATTACTGTATCAAACACGAC
AAAAAACTGGATGATCTAACCATTGATGAATTCCGTTCATTTAGTAATCTAATTGAAGATGACATCTATCAAAATATAAC
TTTAGAAGCTTGCGTATCTGCCCGTGGCTCATATGGCGGTACTGCACCACAAGCTGTTGAAGCCCAAATCCAACACGCTG
AATCTATTGTTACTGCGGGTTAA

Upstream 100 bases:

>100_bases
AGCGTGATAATTAGTCACGCCTGTATTAATAATTATTTTTAAATTATCATTTACTTTATACCATTGCATTAACAACATTG
GTTTATATACGAGGTTTTAT

Downstream 100 bases:

>100_bases
TTAGAACAACACAGGCTACTCGCTGGAATTCGGCTAGTAGCCTCCCTTCTTATTTTTAATTATTAACAACTACTTAACCG
TATGATAGGTATTTCTTTAT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSSKLWGGRFDLPTNKLVEEFNATILIEKRLFPVDIKGSIAHATMLEKQKIITQIEAEQIISGLQAVAKEIEEGSFVYDT
ADEDVHMSIEKRMTEIIGSVGGKLHTARSRNDQTTLDSKIHMRATIKENLALIRQMQEIIIQRAKGEINVIMPGYTHLQT
GQPILFSHWIMAYFWMLERDYSRFQDLYRRMGQCPLGAAALAGTTFPIDRFYTAELLGFDEPTPNSIDSVSDRDHMVEFN
STAAICFMHLSRLSEEIVLFSSQDFKFIELSDDFCTGSSIMPQKKNPDIAEKIRGKTGRMYGNLMAILTTMKGLPLAYNT
DMSEDKEAVYDSMDTLQLSLQVMTPMIEKMIIIEANTRNAADRGFSTATDMADYLVRKGLPFREAHHIVGSTVNYCIKHD
KKLDDLTIDEFRSFSNLIEDDIYQNITLEACVSARGSYGGTAPQAVEAQIQHAESIVTAG

Sequences:

>Translated_460_residues
MSSKLWGGRFDLPTNKLVEEFNATILIEKRLFPVDIKGSIAHATMLEKQKIITQIEAEQIISGLQAVAKEIEEGSFVYDT
ADEDVHMSIEKRMTEIIGSVGGKLHTARSRNDQTTLDSKIHMRATIKENLALIRQMQEIIIQRAKGEINVIMPGYTHLQT
GQPILFSHWIMAYFWMLERDYSRFQDLYRRMGQCPLGAAALAGTTFPIDRFYTAELLGFDEPTPNSIDSVSDRDHMVEFN
STAAICFMHLSRLSEEIVLFSSQDFKFIELSDDFCTGSSIMPQKKNPDIAEKIRGKTGRMYGNLMAILTTMKGLPLAYNT
DMSEDKEAVYDSMDTLQLSLQVMTPMIEKMIIIEANTRNAADRGFSTATDMADYLVRKGLPFREAHHIVGSTVNYCIKHD
KKLDDLTIDEFRSFSNLIEDDIYQNITLEACVSARGSYGGTAPQAVEAQIQHAESIVTAG
>Mature_459_residues
SSKLWGGRFDLPTNKLVEEFNATILIEKRLFPVDIKGSIAHATMLEKQKIITQIEAEQIISGLQAVAKEIEEGSFVYDTA
DEDVHMSIEKRMTEIIGSVGGKLHTARSRNDQTTLDSKIHMRATIKENLALIRQMQEIIIQRAKGEINVIMPGYTHLQTG
QPILFSHWIMAYFWMLERDYSRFQDLYRRMGQCPLGAAALAGTTFPIDRFYTAELLGFDEPTPNSIDSVSDRDHMVEFNS
TAAICFMHLSRLSEEIVLFSSQDFKFIELSDDFCTGSSIMPQKKNPDIAEKIRGKTGRMYGNLMAILTTMKGLPLAYNTD
MSEDKEAVYDSMDTLQLSLQVMTPMIEKMIIIEANTRNAADRGFSTATDMADYLVRKGLPFREAHHIVGSTVNYCIKHDK
KLDDLTIDEFRSFSNLIEDDIYQNITLEACVSARGSYGGTAPQAVEAQIQHAESIVTAG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=41.4847161572052, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=41.4847161572052, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=39.7379912663755, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=39.5196506550218, Blast_Score=350, Evalue=2e-96,
Organism=Escherichia coli, GI1790398, Length=452, Percent_Identity=42.9203539823009, Blast_Score=406, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321806, Length=461, Percent_Identity=39.4793926247288, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221473854, Length=448, Percent_Identity=38.1696428571429, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI78706858, Length=448, Percent_Identity=38.1696428571429, Blast_Score=328, Evalue=4e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51779; Mature: 51648

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKLWGGRFDLPTNKLVEEFNATILIEKRLFPVDIKGSIAHATMLEKQKIITQIEAEQI
CCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHH
ISGLQAVAKEIEEGSFVYDTADEDVHMSIEKRMTEIIGSVGGKLHTARSRNDQTTLDSKI
HHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHCCHH
HMRATIKENLALIRQMQEIIIQRAKGEINVIMPGYTHLQTGQPILFSHWIMAYFWMLERD
EEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
YSRFQDLYRRMGQCPLGAAALAGTTFPIDRFYTAELLGFDEPTPNSIDSVSDRDHMVEFN
HHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEC
STAAICFMHLSRLSEEIVLFSSQDFKFIELSDDFCTGSSIMPQKKNPDIAEKIRGKTGRM
CHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHH
YGNLMAILTTMKGLPLAYNTDMSEDKEAVYDSMDTLQLSLQVMTPMIEKMIIIEANTRNA
HHHHHHHHHHHCCCCEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEECCCCC
ADRGFSTATDMADYLVRKGLPFREAHHIVGSTVNYCIKHDKKLDDLTIDEFRSFSNLIED
HHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
DIYQNITLEACVSARGSYGGTAPQAVEAQIQHAESIVTAG
HHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSKLWGGRFDLPTNKLVEEFNATILIEKRLFPVDIKGSIAHATMLEKQKIITQIEAEQI
CCCCCCCCCCCCHHHHHHHCCCEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHH
ISGLQAVAKEIEEGSFVYDTADEDVHMSIEKRMTEIIGSVGGKLHTARSRNDQTTLDSKI
HHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHCCHH
HMRATIKENLALIRQMQEIIIQRAKGEINVIMPGYTHLQTGQPILFSHWIMAYFWMLERD
EEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
YSRFQDLYRRMGQCPLGAAALAGTTFPIDRFYTAELLGFDEPTPNSIDSVSDRDHMVEFN
HHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEC
STAAICFMHLSRLSEEIVLFSSQDFKFIELSDDFCTGSSIMPQKKNPDIAEKIRGKTGRM
CHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHH
YGNLMAILTTMKGLPLAYNTDMSEDKEAVYDSMDTLQLSLQVMTPMIEKMIIIEANTRNA
HHHHHHHHHHHCCCCEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEECCCCC
ADRGFSTATDMADYLVRKGLPFREAHHIVGSTVNYCIKHDKKLDDLTIDEFRSFSNLIED
HHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
DIYQNITLEACVSARGSYGGTAPQAVEAQIQHAESIVTAG
HHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA