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The map label for this gene is tyrA [H]

Identifier: 209694245

GI number: 209694245

Start: 726134

End: 727267

Strand: Direct

Name: tyrA [H]

Synonym: VSAL_I0654

Alternate gene names: 209694245

Gene position: 726134-727267 (Clockwise)

Preceding gene: 209694244

Following gene: 209694248

Centisome position: 21.84

GC content: 38.89

Gene sequence:

>1134_bases
ATGGCGGTAGAACTGAGTCATTTACGCGATAAGATTGATGCGGTTGATAAGCAAATGTTAGATCTTCTTGCTCAACGTTT
ACAATTAGTTGAACAAGTTGGTGAAGTAAAAAGTGCATATGGTTTGCCTATTTATGATCCAAGTCGAGAGGCAGCAATGT
TGGCTTCAAGACGCGAAGAAGCTGAGAGAAAAGGCGTTCCGCCATCTCTTATTGAAGACATTCTTCGTCGTACAATGCGA
GAATCTTACAGCAGTGAAAATGACTCAGGTTTTAAATGTTTAAGACCAGAACTTCGACCGATTGTTATTGTTGGAGGTAA
AGGCCAACTTGGTGGTTTATTCGCAAAAATGTTTAAACTATCTGGTTATGACGTGCGAATTCTTGGCAGTAAAGATTGGG
ATAACGCTGACGTTATTTTAGAAGGTGTGGGAATGGTTGTTGTTACTGTCCCTATTAATCTAACGATTGATGTGATCGGT
AAACTTTCAATGCTACCTGATGATTGTATTCTGTGTGATCTAACGTCAATAAAGCAAAAGCCGCTTGAAGCGATGATGAA
AGTGCATAAGGGTCCGGTTGTTGGCTTACATCCAATGTTCGGTCCAGATGTGCCTAGCCTCGCTAAACAGGTTATTGTAA
TGTGTGATGGGCGTGGTAAAGATGCTTATTCTTGGCTAAAAGATCAGTTTGAAATTTGGGGGGCTATTGTTCGTGATATT
TCTGCAAGTGAACACGATAAAGGCATGACGTTGATCCAAGCACTGCGTCACTTTACTTCTTTTGCTTATGGTCAGCATCT
ATCTAAAGAAAACCCTGATATTGAACAGTTACTTAATTTAAGCTCACCTATTTATCGTTTAGAGTTACTGATGGTTGGAC
GATTGTTTGCTCAAGATCCAAATTTGTACGCGGATATTATTCTTTCTTCTGAAGAGAATATTGAAATGATAAAACGTTTC
CATCAGCGTTTTGGTGATGCAATTTTATTATTAGAAAATCATAATCGTGTTGGATTTATTGAAAGCTTTGAAGAAGTTGA
AACGTGGTTTGGTGATTACGCGGAGCAGTTTTTAGTTGAAAGCAAAGGCTTACTTCGACAGGCAAATGATTCGATACATC
GAGAAAGAAACTAG

Upstream 100 bases:

>100_bases
TGATGCGTGTATCAATTGGGCATCAACTGAGGCACTATTACGTCATACTCATGAAGAATTAATTCCTGTATTGGAAGATC
GTTTAAAAGGATAGAACGAG

Downstream 100 bases:

>100_bases
TTTAGTAAAAAAGGTGAGTATCTACTCACCTTTTTTAGCAGAATATATTATTGGGTAAGTTGTTGATTATTTTTTTGTTC
CGCTTTTACCGTATTAATCG

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAVELSHLRDKIDAVDKQMLDLLAQRLQLVEQVGEVKSAYGLPIYDPSREAAMLASRREEAERKGVPPSLIEDILRRTMR
ESYSSENDSGFKCLRPELRPIVIVGGKGQLGGLFAKMFKLSGYDVRILGSKDWDNADVILEGVGMVVVTVPINLTIDVIG
KLSMLPDDCILCDLTSIKQKPLEAMMKVHKGPVVGLHPMFGPDVPSLAKQVIVMCDGRGKDAYSWLKDQFEIWGAIVRDI
SASEHDKGMTLIQALRHFTSFAYGQHLSKENPDIEQLLNLSSPIYRLELLMVGRLFAQDPNLYADIILSSEENIEMIKRF
HQRFGDAILLLENHNRVGFIESFEEVETWFGDYAEQFLVESKGLLRQANDSIHRERN

Sequences:

>Translated_377_residues
MAVELSHLRDKIDAVDKQMLDLLAQRLQLVEQVGEVKSAYGLPIYDPSREAAMLASRREEAERKGVPPSLIEDILRRTMR
ESYSSENDSGFKCLRPELRPIVIVGGKGQLGGLFAKMFKLSGYDVRILGSKDWDNADVILEGVGMVVVTVPINLTIDVIG
KLSMLPDDCILCDLTSIKQKPLEAMMKVHKGPVVGLHPMFGPDVPSLAKQVIVMCDGRGKDAYSWLKDQFEIWGAIVRDI
SASEHDKGMTLIQALRHFTSFAYGQHLSKENPDIEQLLNLSSPIYRLELLMVGRLFAQDPNLYADIILSSEENIEMIKRF
HQRFGDAILLLENHNRVGFIESFEEVETWFGDYAEQFLVESKGLLRQANDSIHRERN
>Mature_376_residues
AVELSHLRDKIDAVDKQMLDLLAQRLQLVEQVGEVKSAYGLPIYDPSREAAMLASRREEAERKGVPPSLIEDILRRTMRE
SYSSENDSGFKCLRPELRPIVIVGGKGQLGGLFAKMFKLSGYDVRILGSKDWDNADVILEGVGMVVVTVPINLTIDVIGK
LSMLPDDCILCDLTSIKQKPLEAMMKVHKGPVVGLHPMFGPDVPSLAKQVIVMCDGRGKDAYSWLKDQFEIWGAIVRDIS
ASEHDKGMTLIQALRHFTSFAYGQHLSKENPDIEQLLNLSSPIYRLELLMVGRLFAQDPNLYADIILSSEENIEMIKRFH
QRFGDAILLLENHNRVGFIESFEEVETWFGDYAEQFLVESKGLLRQANDSIHRERN

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=371, Percent_Identity=65.7681940700809, Blast_Score=504, Evalue=1e-144,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42543; Mature: 42412

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVELSHLRDKIDAVDKQMLDLLAQRLQLVEQVGEVKSAYGLPIYDPSREAAMLASRREE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AERKGVPPSLIEDILRRTMRESYSSENDSGFKCLRPELRPIVIVGGKGQLGGLFAKMFKL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHC
SGYDVRILGSKDWDNADVILEGVGMVVVTVPINLTIDVIGKLSMLPDDCILCDLTSIKQK
CCCCEEEECCCCCCCHHHHHCCCCEEEEEEECEEEHHHHHHHHCCCCCCEEECHHHHHHH
PLEAMMKVHKGPVVGLHPMFGPDVPSLAKQVIVMCDGRGKDAYSWLKDQFEIWGAIVRDI
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHC
SASEHDKGMTLIQALRHFTSFAYGQHLSKENPDIEQLLNLSSPIYRLELLMVGRLFAQDP
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCC
NLYADIILSSEENIEMIKRFHQRFGDAILLLENHNRVGFIESFEEVETWFGDYAEQFLVE
CCEEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
SKGLLRQANDSIHRERN
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVELSHLRDKIDAVDKQMLDLLAQRLQLVEQVGEVKSAYGLPIYDPSREAAMLASRREE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AERKGVPPSLIEDILRRTMRESYSSENDSGFKCLRPELRPIVIVGGKGQLGGLFAKMFKL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHC
SGYDVRILGSKDWDNADVILEGVGMVVVTVPINLTIDVIGKLSMLPDDCILCDLTSIKQK
CCCCEEEECCCCCCCHHHHHCCCCEEEEEEECEEEHHHHHHHHCCCCCCEEECHHHHHHH
PLEAMMKVHKGPVVGLHPMFGPDVPSLAKQVIVMCDGRGKDAYSWLKDQFEIWGAIVRDI
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHC
SASEHDKGMTLIQALRHFTSFAYGQHLSKENPDIEQLLNLSSPIYRLELLMVGRLFAQDP
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCC
NLYADIILSSEENIEMIKRFHQRFGDAILLLENHNRVGFIESFEEVETWFGDYAEQFLVE
CCEEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
SKGLLRQANDSIHRERN
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1512561 [H]