Click here to switch to the map view.

The map label for this gene is ydiD [C]

Identifier: 209694222

GI number: 209694222

Start: 697136

End: 698812

Strand: Reverse

Name: ydiD [C]

Synonym: VSAL_I0631

Alternate gene names: 209694222

Gene position: 698812-697136 (Counterclockwise)

Preceding gene: 209694223

Following gene: 209694221

Centisome position: 21.02

GC content: 38.64

Gene sequence:

>1677_bases
ATGAGTCAGTCAGTATTCGATCACAAACAAAATCCATCGCTTCCACATGAAGCAATACTTCAATGGGCCGAAGAAAAACC
AAATTCAATTTTCTTACGACAAGTCATAAATAGAGAATTTGTAGATTACACTTTTGCAGAAGTCGTCGATAAAGCGCTTC
GCTTAGTCTCTGCATTACAAGATTTAGGGCTTAACCCTAAAGATCGTGTTGCGTTGATTTCGAAAAATTGTGCGGAATGG
TTTATTACTGACCTTGCGTTAATGCTCGGGGATTTTGTCAGCGTTCCTATTTTTCCGACTGCCGGATTAGAGACAATTGA
ACACTGCTTAACACACAGTGACAGTAAAGTATTAATCGCAGGAAAACTTGATAATAGTGATGCTACTACACAGGTAATTG
AAAAATTAGATTATCTTTCAACGATCGCTTTTAATTATGATTCCGCACCGAAATGCCAACTTCAATTTGAAGATATTGTC
CAACAACATCAACCTTCATCGTCTAGGCCAAGTCATCATGACAATACACTCATGTCGATTGTTTATACTTCGGGCACTTC
CGGGCTGCCTAAAGGTGCAATGCTGACTTATGGTGGTTTTAGTACCTCAGCAAAACATCTCATTAACCATATAGGTATGA
AACCCGATGATCGTCTTTTTTCATACCTTCCTCTCGCTCATATTACTGAGCGTGTTTATATTTTAGGATCAGCATTCTTT
GGCGGAATACAGACCGCTTTCCCTGAATCTTTAGATACGTTTATCGACGACGTAAAAATGCACCGACCGACATTATTTAT
TTCAGTACCGAGATTATGGACCGTCTTTCAACAACGAATCCAAGATAAATTACCTCAGAAAAAACTCAATATTTTACTTA
AAATTCCATTTGTTAATGGCATCATAAAACGTAAATTAGCCGACGGATTAGGGTTAGATAAAGCCAGAGTACTTGGTTGT
GGTTCAGCTCCCGTCTCTGCCGGATTACTTAAATGGTATGAAAGTATTGGATTGAATATTACCGAAGCGTGGGGCATGAC
TGAAACCTTTGCCTACAGTACTCTTAATCACCCTTATCGCTCAGATAAAGTAGGTACCGTTGGAGCAGCTGGCCCTGGCG
TCGAATTAAAAATAGCCCAAGACGAAGAAATACTGGTCAGAGGGGACGGAATCTTCGCCGGTTACTACAAAAATGATGGA
GCGACTGCTGAAAGTTTTAATAAAGACGGCTGGTTGCATACTGGCGATATTGGTTCAATTGATGCAGAAGGCTTTCTTAC
TATTCAAGGTCGTAAAAAAGACACCTTTAAAACCGCAAAAGGGAAATTCGTTGCTCCTGTACCCATTGAAAAACGTATTT
TTGATTTAAGTAATCTAGAAATGATGTGCCTAATTGGATCGGGATTAACTGGCCCTATTCTCTTAGCTATTCCTCATACT
TACCCTAACTTTGATCAAAAGAGATATGAACGAACAGCCCTTAAAAACTTAGAAACAATTAATAGTGGCTTAGAGTCTCA
TGAAAAGCTCAAAGGTATACTAATGGTTAAAGAACCATGGACAATTGAAAATGGAATATTAACCCCGACATTGAAGATAA
AACGCCATATTTTAGAAAAAAAATACCACGACTTTGCATCTCAATGGCCAAAAGACAAAAAAATCATCTGGGAATAA

Upstream 100 bases:

>100_bases
ATTATTTCAAACCAAATTTGACTATTTACTCGAAAGATCTTTTACTTAACATTAAATTAACAATAACGATAAATAACAAC
TCTTAATTTAGGATGTCGCT

Downstream 100 bases:

>100_bases
CGTTAAAAACAGACAGTTAATTGATAAAAATAGCAACGTAACATCAAATCAGGCCTAAACACTTTATAACACAAAGTTTT
AGGCCTTTTTATTGAAAAAA

Product: AMP-binding acetyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MSQSVFDHKQNPSLPHEAILQWAEEKPNSIFLRQVINREFVDYTFAEVVDKALRLVSALQDLGLNPKDRVALISKNCAEW
FITDLALMLGDFVSVPIFPTAGLETIEHCLTHSDSKVLIAGKLDNSDATTQVIEKLDYLSTIAFNYDSAPKCQLQFEDIV
QQHQPSSSRPSHHDNTLMSIVYTSGTSGLPKGAMLTYGGFSTSAKHLINHIGMKPDDRLFSYLPLAHITERVYILGSAFF
GGIQTAFPESLDTFIDDVKMHRPTLFISVPRLWTVFQQRIQDKLPQKKLNILLKIPFVNGIIKRKLADGLGLDKARVLGC
GSAPVSAGLLKWYESIGLNITEAWGMTETFAYSTLNHPYRSDKVGTVGAAGPGVELKIAQDEEILVRGDGIFAGYYKNDG
ATAESFNKDGWLHTGDIGSIDAEGFLTIQGRKKDTFKTAKGKFVAPVPIEKRIFDLSNLEMMCLIGSGLTGPILLAIPHT
YPNFDQKRYERTALKNLETINSGLESHEKLKGILMVKEPWTIENGILTPTLKIKRHILEKKYHDFASQWPKDKKIIWE

Sequences:

>Translated_558_residues
MSQSVFDHKQNPSLPHEAILQWAEEKPNSIFLRQVINREFVDYTFAEVVDKALRLVSALQDLGLNPKDRVALISKNCAEW
FITDLALMLGDFVSVPIFPTAGLETIEHCLTHSDSKVLIAGKLDNSDATTQVIEKLDYLSTIAFNYDSAPKCQLQFEDIV
QQHQPSSSRPSHHDNTLMSIVYTSGTSGLPKGAMLTYGGFSTSAKHLINHIGMKPDDRLFSYLPLAHITERVYILGSAFF
GGIQTAFPESLDTFIDDVKMHRPTLFISVPRLWTVFQQRIQDKLPQKKLNILLKIPFVNGIIKRKLADGLGLDKARVLGC
GSAPVSAGLLKWYESIGLNITEAWGMTETFAYSTLNHPYRSDKVGTVGAAGPGVELKIAQDEEILVRGDGIFAGYYKNDG
ATAESFNKDGWLHTGDIGSIDAEGFLTIQGRKKDTFKTAKGKFVAPVPIEKRIFDLSNLEMMCLIGSGLTGPILLAIPHT
YPNFDQKRYERTALKNLETINSGLESHEKLKGILMVKEPWTIENGILTPTLKIKRHILEKKYHDFASQWPKDKKIIWE
>Mature_557_residues
SQSVFDHKQNPSLPHEAILQWAEEKPNSIFLRQVINREFVDYTFAEVVDKALRLVSALQDLGLNPKDRVALISKNCAEWF
ITDLALMLGDFVSVPIFPTAGLETIEHCLTHSDSKVLIAGKLDNSDATTQVIEKLDYLSTIAFNYDSAPKCQLQFEDIVQ
QHQPSSSRPSHHDNTLMSIVYTSGTSGLPKGAMLTYGGFSTSAKHLINHIGMKPDDRLFSYLPLAHITERVYILGSAFFG
GIQTAFPESLDTFIDDVKMHRPTLFISVPRLWTVFQQRIQDKLPQKKLNILLKIPFVNGIIKRKLADGLGLDKARVLGCG
SAPVSAGLLKWYESIGLNITEAWGMTETFAYSTLNHPYRSDKVGTVGAAGPGVELKIAQDEEILVRGDGIFAGYYKNDGA
TAESFNKDGWLHTGDIGSIDAEGFLTIQGRKKDTFKTAKGKFVAPVPIEKRIFDLSNLEMMCLIGSGLTGPILLAIPHTY
PNFDQKRYERTALKNLETINSGLESHEKLKGILMVKEPWTIENGILTPTLKIKRHILEKKYHDFASQWPKDKKIIWE

Specific function: Unknown

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42794756, Length=578, Percent_Identity=30.2768166089965, Blast_Score=210, Evalue=4e-54,
Organism=Homo sapiens, GI42794760, Length=578, Percent_Identity=30.2768166089965, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI42794758, Length=578, Percent_Identity=30.2768166089965, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI40807491, Length=573, Percent_Identity=28.4467713787086, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI57165412, Length=567, Percent_Identity=30.1587301587302, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI57165410, Length=567, Percent_Identity=29.6296296296296, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI27477105, Length=461, Percent_Identity=26.4642082429501, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI42794754, Length=612, Percent_Identity=25.8169934640523, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI42794752, Length=612, Percent_Identity=25.8169934640523, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI83745141, Length=628, Percent_Identity=23.8853503184713, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI12669909, Length=628, Percent_Identity=25.1592356687898, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI4758332, Length=628, Percent_Identity=25.1592356687898, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI187761345, Length=506, Percent_Identity=22.5296442687747, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI187761343, Length=506, Percent_Identity=22.5296442687747, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI145693145, Length=486, Percent_Identity=22.4279835390947, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788107, Length=484, Percent_Identity=24.7933884297521, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17510401, Length=566, Percent_Identity=28.4452296819788, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17556552, Length=578, Percent_Identity=26.9896193771626, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17541856, Length=585, Percent_Identity=28.034188034188, Blast_Score=165, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17564090, Length=595, Percent_Identity=25.0420168067227, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI25147511, Length=577, Percent_Identity=24.9566724436742, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI193204819, Length=596, Percent_Identity=26.3422818791946, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32563687, Length=292, Percent_Identity=35.6164383561644, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17558820, Length=462, Percent_Identity=25.7575757575758, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17553312, Length=632, Percent_Identity=24.6835443037975, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17557194, Length=433, Percent_Identity=27.0207852193995, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=397, Percent_Identity=23.1738035264484, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17559526, Length=317, Percent_Identity=25.2365930599369, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71985884, Length=288, Percent_Identity=26.3888888888889, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115534440, Length=477, Percent_Identity=21.5932914046122, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320852, Length=568, Percent_Identity=26.9366197183099, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6323903, Length=450, Percent_Identity=26.2222222222222, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324893, Length=589, Percent_Identity=24.1086587436333, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322182, Length=444, Percent_Identity=27.2522522522523, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319699, Length=285, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24666501, Length=575, Percent_Identity=26.9565217391304, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24666497, Length=575, Percent_Identity=26.9565217391304, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI281366413, Length=575, Percent_Identity=26.9565217391304, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI17933690, Length=587, Percent_Identity=25.2129471890971, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI19921316, Length=611, Percent_Identity=24.7135842880524, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI62471689, Length=585, Percent_Identity=25.6410256410256, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI62471681, Length=585, Percent_Identity=25.6410256410256, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI62471687, Length=585, Percent_Identity=25.6410256410256, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24586634, Length=585, Percent_Identity=25.6410256410256, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI22026970, Length=585, Percent_Identity=25.6410256410256, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI62471679, Length=585, Percent_Identity=25.6410256410256, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI62471683, Length=585, Percent_Identity=25.6410256410256, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI62471685, Length=585, Percent_Identity=25.6410256410256, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24586636, Length=585, Percent_Identity=25.6410256410256, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24581924, Length=456, Percent_Identity=25.219298245614, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21355181, Length=451, Percent_Identity=25.2771618625277, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922652, Length=461, Percent_Identity=25.5965292841649, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24648260, Length=475, Percent_Identity=24.8421052631579, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648255, Length=438, Percent_Identity=23.0593607305936, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24648253, Length=438, Percent_Identity=22.8310502283105, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356947, Length=457, Percent_Identity=22.7571115973742, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 62321; Mature: 62190

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00178 AA_TRNA_LIGASE_I ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSVFDHKQNPSLPHEAILQWAEEKPNSIFLRQVINREFVDYTFAEVVDKALRLVSALQ
CCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLGLNPKDRVALISKNCAEWFITDLALMLGDFVSVPIFPTAGLETIEHCLTHSDSKVLIA
HCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEE
GKLDNSDATTQVIEKLDYLSTIAFNYDSAPKCQLQFEDIVQQHQPSSSRPSHHDNTLMSI
EECCCCHHHHHHHHHHHHHHHHEECCCCCCCCEEEHHHHHHHCCCCCCCCCCCCCCEEEE
VYTSGTSGLPKGAMLTYGGFSTSAKHLINHIGMKPDDRLFSYLPLAHITERVYILGSAFF
EEECCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHEEEHHHH
GGIQTAFPESLDTFIDDVKMHRPTLFISVPRLWTVFQQRIQDKLPQKKLNILLKIPFVNG
CCHHHHCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCCCEEEEEEECHHHH
IIKRKLADGLGLDKARVLGCGSAPVSAGLLKWYESIGLNITEAWGMTETFAYSTLNHPYR
HHHHHHHHCCCCCCHHEEECCCCCHHHHHHHHHHHHCCEEEHHCCCHHHHHHHHCCCCCC
SDKVGTVGAAGPGVELKIAQDEEILVRGDGIFAGYYKNDGATAESFNKDGWLHTGDIGSI
CCCCCCCCCCCCCEEEEEECCCEEEEECCCEEEEEEECCCCCHHCCCCCCCEEECCCCCC
DAEGFLTIQGRKKDTFKTAKGKFVAPVPIEKRIFDLSNLEMMCLIGSGLTGPILLAIPHT
CCCCEEEEECCCCCCHHHCCCCEECCCCHHHHHCCCCCCEEEEEECCCCCCCEEEEECCC
YPNFDQKRYERTALKNLETINSGLESHEKLKGILMVKEPWTIENGILTPTLKIKRHILEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCEECCCEECCHHHHHHHHHHH
KYHDFASQWPKDKKIIWE
HHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SQSVFDHKQNPSLPHEAILQWAEEKPNSIFLRQVINREFVDYTFAEVVDKALRLVSALQ
CCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLGLNPKDRVALISKNCAEWFITDLALMLGDFVSVPIFPTAGLETIEHCLTHSDSKVLIA
HCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEE
GKLDNSDATTQVIEKLDYLSTIAFNYDSAPKCQLQFEDIVQQHQPSSSRPSHHDNTLMSI
EECCCCHHHHHHHHHHHHHHHHEECCCCCCCCEEEHHHHHHHCCCCCCCCCCCCCCEEEE
VYTSGTSGLPKGAMLTYGGFSTSAKHLINHIGMKPDDRLFSYLPLAHITERVYILGSAFF
EEECCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHEEEHHHH
GGIQTAFPESLDTFIDDVKMHRPTLFISVPRLWTVFQQRIQDKLPQKKLNILLKIPFVNG
CCHHHHCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCCCEEEEEEECHHHH
IIKRKLADGLGLDKARVLGCGSAPVSAGLLKWYESIGLNITEAWGMTETFAYSTLNHPYR
HHHHHHHHCCCCCCHHEEECCCCCHHHHHHHHHHHHCCEEEHHCCCHHHHHHHHCCCCCC
SDKVGTVGAAGPGVELKIAQDEEILVRGDGIFAGYYKNDGATAESFNKDGWLHTGDIGSI
CCCCCCCCCCCCCEEEEEECCCEEEEECCCEEEEEEECCCCCHHCCCCCCCEEECCCCCC
DAEGFLTIQGRKKDTFKTAKGKFVAPVPIEKRIFDLSNLEMMCLIGSGLTGPILLAIPHT
CCCCEEEEECCCCCCHHHCCCCEECCCCHHHHHCCCCCCEEEEEECCCCCCCEEEEECCC
YPNFDQKRYERTALKNLETINSGLESHEKLKGILMVKEPWTIENGILTPTLKIKRHILEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCEECCCEECCHHHHHHHHHHH
KYHDFASQWPKDKKIIWE
HHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]