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The map label for this gene is folP [H]

Identifier: 209694185

GI number: 209694185

Start: 654843

End: 655676

Strand: Direct

Name: folP [H]

Synonym: VSAL_I0593

Alternate gene names: 209694185

Gene position: 654843-655676 (Clockwise)

Preceding gene: 209694184

Following gene: 209694186

Centisome position: 19.69

GC content: 40.17

Gene sequence:

>834_bases
ATGAAATTGATAAGCAAAGAGAAGACGTTAATATTAGATCGCTCTCATGTAATGGGGATCCTTAATGTGACGCCTGATTC
TTTTTCTGATGGTGGTAAATTTACTGATTTAGAGGCTGCTTTAAGGCAAGTTGAAAAAATGGTAAATGCTGGTGTTAGCT
TTATTGATATTGGTGGTGAGTCAACCAGACCAGGCGCACCTGAGGTTGGGGTTCAGCAAGAATTGGATCGGGTGATTCCG
ATCATTGAGGCTATTCATCAGCGATTTGATACATGGATATCAATTGATACCAGTAAAGCGGTCGTAATGGATGAAGCCGT
AAAGTTTGGTGCAGATTTAATTAATGATGTGCGGGCATTACAAGAGCCTAATGCGCTAGAGGTTGCGGCAAAAGCGAATG
TACCAATTTGCTTGATGCATATGCAAGGTCAACCAAGAACGATGCAATCAAACCCTACTTATGAAAACGTATTTTCAGAT
GTTTCTCTTTTTTTAGAAGAAAGAATAGCGGCTTGCCAATCGATTGGTATCACAAAAGATAAATTAATTCTCGATCCTGG
GTTTGGATTTGGGAAAAGCTTGGCGCATAATTACCAATTACTTACTGAATTAGAACGTTTCCATCAATTTGGGCTTCCTA
TATTGGCGGGAATGTCTCGTAAATCAATGATTTTTAAATTGCTGGATATTGAGCCCCAGGAGGCTATTTCTGGAAGCTTG
GCGTGCGCGACTATTGCAGCAATGAAAGGCGCGCAAATTATCCGAGTTCATGATTTTGAACAAACAATGGATATTGTGAA
AGTTTGCCAAGCAACATTGGAGCAAGCTTCTTAG

Upstream 100 bases:

>100_bases
GAAACGAAAAAAGATTCCGATTCATCAGAAAAATAAGATGAGTTGAGTAAAAACAAACCCCGAGTTCTGCTTGGGGTTTT
TGTATTTAAAAGGACTGATC

Downstream 100 bases:

>100_bases
TGAGAAGCATGCTCATTTAAAGAATAAATTATTAAAATTAAAACATGGAGTACAACATGGCTGAGCGTAAATATTTTGGA
ACAGATGGAGTTCGTGGGTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKLISKEKTLILDRSHVMGILNVTPDSFSDGGKFTDLEAALRQVEKMVNAGVSFIDIGGESTRPGAPEVGVQQELDRVIP
IIEAIHQRFDTWISIDTSKAVVMDEAVKFGADLINDVRALQEPNALEVAAKANVPICLMHMQGQPRTMQSNPTYENVFSD
VSLFLEERIAACQSIGITKDKLILDPGFGFGKSLAHNYQLLTELERFHQFGLPILAGMSRKSMIFKLLDIEPQEAISGSL
ACATIAAMKGAQIIRVHDFEQTMDIVKVCQATLEQAS

Sequences:

>Translated_277_residues
MKLISKEKTLILDRSHVMGILNVTPDSFSDGGKFTDLEAALRQVEKMVNAGVSFIDIGGESTRPGAPEVGVQQELDRVIP
IIEAIHQRFDTWISIDTSKAVVMDEAVKFGADLINDVRALQEPNALEVAAKANVPICLMHMQGQPRTMQSNPTYENVFSD
VSLFLEERIAACQSIGITKDKLILDPGFGFGKSLAHNYQLLTELERFHQFGLPILAGMSRKSMIFKLLDIEPQEAISGSL
ACATIAAMKGAQIIRVHDFEQTMDIVKVCQATLEQAS
>Mature_277_residues
MKLISKEKTLILDRSHVMGILNVTPDSFSDGGKFTDLEAALRQVEKMVNAGVSFIDIGGESTRPGAPEVGVQQELDRVIP
IIEAIHQRFDTWISIDTSKAVVMDEAVKFGADLINDVRALQEPNALEVAAKANVPICLMHMQGQPRTMQSNPTYENVFSD
VSLFLEERIAACQSIGITKDKLILDPGFGFGKSLAHNYQLLTELERFHQFGLPILAGMSRKSMIFKLLDIEPQEAISGSL
ACATIAAMKGAQIIRVHDFEQTMDIVKVCQATLEQAS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=273, Percent_Identity=59.3406593406593, Blast_Score=355, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=28.3018867924528, Blast_Score=119, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30432; Mature: 30432

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLISKEKTLILDRSHVMGILNVTPDSFSDGGKFTDLEAALRQVEKMVNAGVSFIDIGGE
CCCCCCCCEEEEEHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCC
STRPGAPEVGVQQELDRVIPIIEAIHQRFDTWISIDTSKAVVMDEAVKFGADLINDVRAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHH
QEPNALEVAAKANVPICLMHMQGQPRTMQSNPTYENVFSDVSLFLEERIAACQSIGITKD
CCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
KLILDPGFGFGKSLAHNYQLLTELERFHQFGLPILAGMSRKSMIFKLLDIEPQEAISGSL
CEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCHHHHHCCHH
ACATIAAMKGAQIIRVHDFEQTMDIVKVCQATLEQAS
HHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLISKEKTLILDRSHVMGILNVTPDSFSDGGKFTDLEAALRQVEKMVNAGVSFIDIGGE
CCCCCCCCEEEEEHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCC
STRPGAPEVGVQQELDRVIPIIEAIHQRFDTWISIDTSKAVVMDEAVKFGADLINDVRAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHH
QEPNALEVAAKANVPICLMHMQGQPRTMQSNPTYENVFSDVSLFLEERIAACQSIGITKD
CCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
KLILDPGFGFGKSLAHNYQLLTELERFHQFGLPILAGMSRKSMIFKLLDIEPQEAISGSL
CEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCHHHHHCCHH
ACATIAAMKGAQIIRVHDFEQTMDIVKVCQATLEQAS
HHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]