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The map label for this gene is fkpB [H]

Identifier: 209694174

GI number: 209694174

Start: 640621

End: 641052

Strand: Direct

Name: fkpB [H]

Synonym: VSAL_I0582

Alternate gene names: 209694174

Gene position: 640621-641052 (Clockwise)

Preceding gene: 209694173

Following gene: 209694175

Centisome position: 19.27

GC content: 37.96

Gene sequence:

>432_bases
ATGTCAAAAATTGAAAGTAACAGTGAAGTAACCTTACACTTCACTATAAAATTAAAAGATGGCTCGATCGCAGATAGTAC
CCAGACATCAGGAAAAGCCGCTAAGTTTACAATGGGTGATGGCAGTTTAAGTGAGAATTTTGAACAGTGTTTATTGGGTT
TAGAAGCGAATCAGTCTAAGAGCATTGAATTAAATACAGTTGATGCATTTGGTTTACCTAATCCTGATAATATTCATCAT
ATGGATCGTAATCGATTTGTAGGTGATGCAGCAGCTGAAGTTGGTACTATTATGGCATTCACCGGACCTGATGGTGTTGA
TATTCCGGGGATCATTACTGATATTGCCGGAGATTCCGTTACTGTCGATTTTAATCACCCATTATCTGGTCAAGATGTTA
TCTTTGACGTAGAAATCGTAGCGGTTGGATAA

Upstream 100 bases:

>100_bases
CAATAAGATAAAGTAAAAACATAAGCGCTGCCCGTGAATTCGAGGTGGCGTTTTTTTTAAGTGTTATACCAATATTATTG
GTGTTATCTAAGGAAAGACA

Downstream 100 bases:

>100_bases
CCCAACAAAAAGTAGAGATAAAAGATGAAAATAGTATTAGCGAACCCTCGTGGATTTTGTGCCGGTGTTGATCGTGCCAT
CAGTATTGTTGAACGAGCGC

Product: FkbP-type 16 kDa peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MSKIESNSEVTLHFTIKLKDGSIADSTQTSGKAAKFTMGDGSLSENFEQCLLGLEANQSKSIELNTVDAFGLPNPDNIHH
MDRNRFVGDAAAEVGTIMAFTGPDGVDIPGIITDIAGDSVTVDFNHPLSGQDVIFDVEIVAVG

Sequences:

>Translated_143_residues
MSKIESNSEVTLHFTIKLKDGSIADSTQTSGKAAKFTMGDGSLSENFEQCLLGLEANQSKSIELNTVDAFGLPNPDNIHH
MDRNRFVGDAAAEVGTIMAFTGPDGVDIPGIITDIAGDSVTVDFNHPLSGQDVIFDVEIVAVG
>Mature_142_residues
SKIESNSEVTLHFTIKLKDGSIADSTQTSGKAAKFTMGDGSLSENFEQCLLGLEANQSKSIELNTVDAFGLPNPDNIHHM
DRNRFVGDAAAEVGTIMAFTGPDGVDIPGIITDIAGDSVTVDFNHPLSGQDVIFDVEIVAVG

Specific function: PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide', where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786211, Length=139, Percent_Identity=49.6402877697842, Blast_Score=146, Evalue=5e-37,
Organism=Escherichia coli, GI1789748, Length=141, Percent_Identity=29.7872340425532, Blast_Score=59, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15112; Mature: 14981

Theoretical pI: Translated: 4.07; Mature: 4.07

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIESNSEVTLHFTIKLKDGSIADSTQTSGKAAKFTMGDGSLSENFEQCLLGLEANQSK
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCC
SIELNTVDAFGLPNPDNIHHMDRNRFVGDAAAEVGTIMAFTGPDGVDIPGIITDIAGDSV
CEEEEEEEECCCCCCCCCEECCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCEE
TVDFNHPLSGQDVIFDVEIVAVG
EEEECCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure 
SKIESNSEVTLHFTIKLKDGSIADSTQTSGKAAKFTMGDGSLSENFEQCLLGLEANQSK
CCCCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCC
SIELNTVDAFGLPNPDNIHHMDRNRFVGDAAAEVGTIMAFTGPDGVDIPGIITDIAGDSV
CEEEEEEEECCCCCCCCCEECCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCEE
TVDFNHPLSGQDVIFDVEIVAVG
EEEECCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]