Click here to switch to the map view.

The map label for this gene is dsbC [H]

Identifier: 209694156

GI number: 209694156

Start: 617137

End: 617913

Strand: Direct

Name: dsbC [H]

Synonym: VSAL_I0563

Alternate gene names: 209694156

Gene position: 617137-617913 (Clockwise)

Preceding gene: 209694155

Following gene: 209694157

Centisome position: 18.56

GC content: 39.51

Gene sequence:

>777_bases
ATGTCTTTTATTCGCCGTACTAGCGCAATGATTATTGCTCTATTGAGCGTCGCTTCTTTTACTGCTTGTTCTGATGAGCA
AGTAAAAGAAACTGCAACACCGGCTTCTCCTGTAGTGGCATCTAATAGTGATTCAACAATTGCGATTACTCAACGATTAA
CGACATTAGGTTTACCTGTTGAAGCCATTCATGATTCTGATATTGATGGCTTCAAACAAGTTGAAACCCCATTTGGTATT
TTTTACGTCTCTGATGACGGTAAGCACTTTATTCAAGGTCGAATTTTTGAGTTTGATGAAAATGGCAATATGAAAGATTT
GTTAGCGGCTCGTTTCGCTAAGCTAGTCGATAGCCAAAGTGAGAACATGATCGTGTTCCCTGCAAAAAACGAAAAGTATG
TGATTACCGTCTTTACCGACATCACCTGTGGTTACTGTACAAAACTGCATAAAGAGATGAAAGATTATAATGATGCAGGA
ATTACGGTTCGTTATTTAGCGTATCCTCGTCAGGGCTACCAAGGTTCAGTTGCCGATAAAATGGCGCAAGTTTGGTGTGC
TGATGATAAACAGCAAGCGATGGAAGATGCGAAATCGAATCGCCCAATAAATGGTTCAAAACCCGCGACTGCTCAGTGTA
AAAATATCATTAAAGAGCAATATCTTTTAGGTCGTAAAATGGGTGTAAATGGCACTCCAGCTATTGTTTTACCTAATGGC
GATTTAGTTCCTGGTTACAAACCTGCGAAAGAATTGCTTGCCGATTTAGAAAAATAA

Upstream 100 bases:

>100_bases
GAGCATCACCCCCGTTCTTAATGAATGGGAACTTCTTGGTTTTTCTAAACTCTAATGATTTAAACGTTCTTACATCACAC
TTTTTTATAGGTAACCTTTT

Downstream 100 bases:

>100_bases
TTTCTCTTTCTTTAATCGAAATCCCCGTCTTGTTACGGGGATTTTTTGTATTTAATAAACGTAATGTTAGGCCAATATCA
TGATTGAAGTGAAACGTCGT

Product: thiol/disulfide interchange protein DsbC precursor

Products: 3-oxo-D 4-steroid; protein with oxidized disulfide bonds [C]

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MSFIRRTSAMIIALLSVASFTACSDEQVKETATPASPVVASNSDSTIAITQRLTTLGLPVEAIHDSDIDGFKQVETPFGI
FYVSDDGKHFIQGRIFEFDENGNMKDLLAARFAKLVDSQSENMIVFPAKNEKYVITVFTDITCGYCTKLHKEMKDYNDAG
ITVRYLAYPRQGYQGSVADKMAQVWCADDKQQAMEDAKSNRPINGSKPATAQCKNIIKEQYLLGRKMGVNGTPAIVLPNG
DLVPGYKPAKELLADLEK

Sequences:

>Translated_258_residues
MSFIRRTSAMIIALLSVASFTACSDEQVKETATPASPVVASNSDSTIAITQRLTTLGLPVEAIHDSDIDGFKQVETPFGI
FYVSDDGKHFIQGRIFEFDENGNMKDLLAARFAKLVDSQSENMIVFPAKNEKYVITVFTDITCGYCTKLHKEMKDYNDAG
ITVRYLAYPRQGYQGSVADKMAQVWCADDKQQAMEDAKSNRPINGSKPATAQCKNIIKEQYLLGRKMGVNGTPAIVLPNG
DLVPGYKPAKELLADLEK
>Mature_257_residues
SFIRRTSAMIIALLSVASFTACSDEQVKETATPASPVVASNSDSTIAITQRLTTLGLPVEAIHDSDIDGFKQVETPFGIF
YVSDDGKHFIQGRIFEFDENGNMKDLLAARFAKLVDSQSENMIVFPAKNEKYVITVFTDITCGYCTKLHKEMKDYNDAGI
TVRYLAYPRQGYQGSVADKMAQVWCADDKQQAMEDAKSNRPINGSKPATAQCKNIIKEQYLLGRKMGVNGTPAIVLPNGD
LVPGYKPAKELLADLEK

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=205, Percent_Identity=44.8780487804878, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: NA

Molecular weight: Translated: 28408; Mature: 28276

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIRRTSAMIIALLSVASFTACSDEQVKETATPASPVVASNSDSTIAITQRLTTLGLPV
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEECCCCCEEEEEEHHHHHCCCH
EAIHDSDIDGFKQVETPFGIFYVSDDGKHFIQGRIFEFDENGNMKDLLAARFAKLVDSQS
HHHCCCCCCCHHHHCCCEEEEEECCCCCEEEECEEEEECCCCCHHHHHHHHHHHHHCCCC
ENMIVFPAKNEKYVITVFTDITCGYCTKLHKEMKDYNDAGITVRYLAYPRQGYQGSVADK
CCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHH
MAQVWCADDKQQAMEDAKSNRPINGSKPATAQCKNIIKEQYLLGRKMGVNGTPAIVLPNG
HHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
DLVPGYKPAKELLADLEK
CCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SFIRRTSAMIIALLSVASFTACSDEQVKETATPASPVVASNSDSTIAITQRLTTLGLPV
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEECCCCCEEEEEEHHHHHCCCH
EAIHDSDIDGFKQVETPFGIFYVSDDGKHFIQGRIFEFDENGNMKDLLAARFAKLVDSQS
HHHCCCCCCCHHHHCCCEEEEEECCCCCEEEECEEEEECCCCCHHHHHHHHHHHHHCCCC
ENMIVFPAKNEKYVITVFTDITCGYCTKLHKEMKDYNDAGITVRYLAYPRQGYQGSVADK
CCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHH
MAQVWCADDKQQAMEDAKSNRPINGSKPATAQCKNIIKEQYLLGRKMGVNGTPAIVLPNG
HHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
DLVPGYKPAKELLADLEK
CCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-oxo-D 5-steroid; protein with reduced SH groups [C]

Specific reaction: 3-oxo-D 5-steroid = 3-oxo-D 4-steroid protein with reduced SH groups = protein with oxidized disulfide bonds [C]

General reaction: Isomerases; Intramolecular Oxidoreductases; Transposing S-S Bonds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609; 9370270 [H]